Poster SIMPATICO 3D Zumpano, E.; Iaquinta, P.; Caroprese, L. ...
2022 IEEE Symposium on Computers and Communications (ISCC),
2022-June-30
Conference Proceeding
In the recent decade, the amount of digital information recorded in electronic health records (EHRs) has increased dramatically. EHRs are no longer used to store basic patient information and ...administrative activities, but they can now store a wide range of data, from the patient's medical history to images. The issue currently is not so much gathering data as it is analyzing it, that is, converting data into knowledge, conclusions, and actions. The use of innovative technology instruments, such as artificial intelligence (AI) algorithms, to support medical inter-disciplinary collaboration among different teams, geographically distributed in the network, extracting useful information from EHRs, and integrating data from various data sources is a crucial, but still difficult task. SIMPATICO 3D (Sistema Informativo Medico PATologIe COmplesse) is a system that assists scientists and clinicians by offering tools for managing, organizing, analyzing, and disseminating medical data. The project SIMPATICO 3D originates from a collaboration between the software house eway Enterprise Business Solutions, the DIMES Department of the University of Calabria and the DMSC Department of the University Magna Graecia of Catanzaro and it has been selected for funding under the FESR 2014/2020.
The role of nitric oxide and reactive oxygen species is well-demonstrated in inflammation. In this study, we evaluated the effect of aminoguanidine, a nitric oxide synthase inhibitor, in a rat model ...of periodontitis. We induced periodontitis in rats by placing a piece of 2/0 braided silk around the lower left 1st molar. At day 8, the gingivomucosal tissue encircling the mandibular 1st molar was removed for biochemical and histological analysis. Ligation significantly increased inducible nitric oxide synthase activity and expression, and damaged tissue revealed increased neutrophil infiltration, lipid peroxidation, and positive staining for nitrotyrosine formation and poly (ADP-ribose) polymerase activation. Ligation significantly increased Evans blue extravasation in gingivomucosal tissue and alveolar bone destruction. Aminoguanidine (100 mg/kg i.p., daily for 8 days) treatment significantly reduced all these inflammatory parameters, indicating that it protects against the tissue damage associated with periodontitis by reducing nitric oxide production and oxidative stress.
It is uncertain whether synchronous colorectal cancers (S-CRCs) preferentially develop through widespread DNA methylation and whether they have a prognosis worse than solitary CRC. As tumours with ...microsatellite instability (MSI) may confound the effect of S-CRC methylation on outcome, we addressed this issue in a series of CRC characterised by BRAF and MS status.
Demographics, clinicopathological records and disease-specific survival (DSS) were assessed in 881 consecutively resected CRC undergoing complete colonoscopy. All tumours were typed for BRAF(c.1799T>A) mutation and MS status, followed by search of germ-line mutation in patients with MSI CRC.
Synchronous colorectal cancers (50/881, 5.7%) were associated with stage IV microsatellite-stable (MSS) CRC (19/205, 9.3%, P=0.001) and with HNPCC (9/32, 28%, P<0.001). BRAF mutation (60/881, 6.8%) was associated with sporadic MSI CRC (37/62, 60%, P<0.001) but not with S-CRC (3/50, 6.0%, P=0.96). Synchronous colorectal cancer (HR 1.82; 95% CI 1.15-2.87; P=0.01), synchronous advanced adenoma (HR 1.81; 95% CI 1.27-2.58; P=0.001), and BRAF(c.1799T>A) mutation (HR 2.16; 95% CI 1.25-3.73; P=0.01) were stage-independent predictors of death from MSS CRC. Disease-specific survival of MSI CRC patients was not affected by S-CRC (HR 0.74; 95% CI 0.09-5.75; P=0.77).
Microsatellite-stable CRCs have a worse prognosis if S-CRC or synchronous advanced adenoma are diagnosed. The occurrence and the enhanced aggressiveness of synchronous MSS advanced neoplasia are not associated with BRAF mutation.
Abstract We present a measurement of the Cabibbo-Kobayashi-Maskawa unitarity triangle angle ϕ 3 (also known as γ) using a model-independent Dalitz plot analysis of B + → D ( K S 0 $$ {K}_S^0 $$ h + h ...− )h +, where D is either a D 0 or D ¯ $$ \overline{D} $$ 0 meson and h is either a π or K. This is the first measurement that simultaneously uses Belle and Belle II data, combining samples corresponding to integrated luminosities of 711 fb −1 and 128 fb −1, respectively. All data were accumulated from energy-asymmetric e + e − collisions at a centre-of-mass energy corresponding to the mass of the Υ(4S) resonance. We measure ϕ 3 = (78.4 ± 11.4 ± 0.5 ± 1.0)°, where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is from the uncertainties on external measurements of the D-decay strong-phase parameters.
Diagnostic and clinical support is performed by using ever improving DICOM image systems. Huge quantity of clinical images are generated from clinical devices with increasing high performance. ...Nevertheless, extracting useful information from DICOM images for diagnosis as well as integrating information from different data sources is still a complex task.
We present eIMES 3D (standing for Evolution Imaging System 3D), a system that supports clinicians for images studies, diagnostic and images reconstruction. The tool has been developed within a project called ReCaTuR for RAre Cancer Network (i.e., Network of Rare Cancer), aiming to define a network for the management, organization and distribution of medical information. Moreover, it was implemented following the requirements of oncology department of an Italian Hospital.
By using eIMES 3D a cancer network data infrastructure has been defined and implemented aiming to integrate information regarding rare and complex diseases. Data provided by different departments, external structures and research institutes are used to improve knowledge and to support physicians.
eIMES 3D allows (i) full control and management of the data by means of artificial intelligence algorithms; (ii) advanced stereoscopic 3D visualization by using the WebGL innovative technology; (iii) sharing of medical data; (iv) distribution of 3D imaging on different output devices (web, TV, mobile); (v) querying the system through a search of the various case studies.
Abstract We report results from a study of B ± → DK ± decays followed by D decaying to the CP-even final state K + K − and CP-odd final state K S 0 π 0 $$ {K}_S^0{\pi}^0 $$ , where D is an admixture ...of D 0 and D ¯ 0 $$ {\overline{D}}^0 $$ states. These decays are sensitive to the Cabibbo-Kobayashi-Maskawa unitarity-triangle angle ϕ 3. The results are based on a combined analysis of the final data set of 772 × 106 B B ¯ $$ B\overline{B} $$ pairs collected by the Belle experiment and a data set of 198 × 106 B B ¯ $$ B\overline{B} $$ pairs collected by the Belle II experiment, both in electron-positron collisions at the Υ(4S) resonance. We measure the CP asymmetries to be A $$ \mathcal{A} $$ CP+ = (+12.5 ± 5.8 ± 1.4)% and A $$ \mathcal{A} $$ CP− = (−16.7 ± 5.7 ± 0.6)%, and the ratios of branching fractions to be R $$ \mathcal{R} $$ CP+ = 1.164 ± 0.081 ± 0.036 and R $$ \mathcal{R} $$ CP− = 1.151 ± 0.074 ± 0.019. The first contribution to the uncertainties is statistical, and the second is systematic. The asymmetries A $$ \mathcal{A} $$ CP+ and A $$ \mathcal{A} $$ CP− have similar magnitudes and opposite signs; their difference corresponds to 3.5 standard deviations. From these values we calculate 68.3% confidence intervals of (8.5 ° < ϕ 3 < 16.5 ° ) or (84.5 ° < ϕ 3 < 95.5 ° ) or (163.3 ° < ϕ 3 < 171.5 ° ) and 0.321 < r B < 0.465.
Abstract We measure CP asymmetries and branching-fraction ratios for B ± → DK ± and Dπ ± decays with D → K S 0 $$ {K}_{\textrm{S}}^0 $$ K ± π ∓, where D is a superposition of D 0 and D ¯ $$ ...\overline{D} $$ 0. We use the full data set of the Belle experiment, containing 772 × 106 B B ¯ $$ B\overline{B} $$ pairs, and data from the Belle II experiment, containing 387 × 106 B B ¯ $$ B\overline{B} $$ pairs, both collected in electron-positron collisions at the Υ(4S) resonance. Our results provide model-independent information on the unitarity triangle angle ϕ 3.
Gastroesophageal reflux disease (GERD) is a very common disorder. As there is no gold standard diagnostic tool, patient-based strategy is adopted in clinical practice. In this regard, there are ...questionnaires able to easily and rapidly assess symptom severity directly by the patient. The GERD Impact Scale (GIS) and the Reflux Symptom Index (RSI) have been validated as diagnostic tools in routine clinical care. The present study aimed to correlate RIS values with GIS scores in a large cohort of GERD patients visited at gastroenterological clinics. Globally, 785 subjects (51.2% males, 48.8% females, mean age: 49.59 years) were visited in 56 Italian gastroenterological offices. The current study demonstrates that a GIS value >19 may be a reliable cut-off to define the positivity of the test, and GIS and RSI were significantly correlated. Therefore, both tests may be recommended for GERD patients in clinical practice.
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