Health benefits of dietary fiber Anderson, James W; Baird, Pat; Davis, Richard H. Jr ...
Nutrition reviews,
April 2009, Letnik:
67, Številka:
4
Journal Article
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Dietary fiber intake provides many health benefits. However, average fiber intakes for US children and adults are less than half of the recommended levels. Individuals with high intakes of dietary ...fiber appear to be at significantly lower risk for developing coronary heart disease, stroke, hypertension, diabetes, obesity, and certain gastrointestinal diseases. Increasing fiber intake lowers blood pressure and serum cholesterol levels. Increased intake of soluble fiber improves glycemia and insulin sensitivity in non-diabetic and diabetic individuals. Fiber supplementation in obese individuals significantly enhances weight loss. Increased fiber intake benefits a number of gastrointestinal disorders including the following: gastroesophageal reflux disease, duodenal ulcer, diverticulitis, constipation, and hemorrhoids. Prebiotic fibers appear to enhance immune function. Dietary fiber intake provides similar benefits for children as for adults. The recommended dietary fiber intakes for children and adults are 14 g/1000 kcal. More effective communication and consumer education is required to enhance fiber consumption from foods or supplements.
Schistosome infection persists for decades. Parasites are in close contact with host peripheral blood immune cells, yet little is known about the regulatory interactions between parasites and these ...immune cells. Here, we report that extracellular vesicles (EVs) released from Schistosoma japonicum are taken up primarily by macrophages and other host peripheral blood immune cells and their miRNA cargo transferred into recipient cells. Uptake of S. japonicum EV miR-125b and bantam miRNAs into host cells increased macrophage proliferation and TNF-α production by regulating the corresponding targets including Pros1, Fam212b, and Clmp. Mice infected with S. japonicum exhibit an increased population of monocytes and elevated levels of TNF-α. Reduction of host monocytes and TNF-α level in S. japonicum infected mice led to a significant reduction in worm and egg burden and pathology. Overall, we demonstrate that S. japonicum EV miRNAs can regulate host macrophages illustrating parasite modulation of the host immune response to facilitate parasite survival. Our findings provide valuable insights into the schistosome-host interaction which may help to develop novel intervention strategies against schistosomiasis.
This paper provides three results for SVARs under the assumption that the primitive shocks are mutually independent. First, a framework is proposed to accommodate a disaster-type variable with ...infinite variance into a SVAR. We show that the least squares estimates of the SVAR are consistent but have non-standard asymptotics. Second, the disaster shock is identified as the component with the largest kurtosis. An estimator that is robust to infinite variance is used to recover the mutually independent components. Third, an independence test on the residuals pre-whitened by the Choleski decomposition is proposed to test the restrictions imposed on a SVAR. The test can be applied whether the data have fat or thin tails, and to over as well as exactly identified models. Three applications are considered. In the first, the independence test is used to shed light on the conflicting evidence regarding the role of uncertainty in economic fluctuations. In the second, disaster shocks are shown to have short term economic impact arising mostly from feedback dynamics. The third uses the framework to study the dynamic effects of economic shocks post-covid.
Sparse Vector Autoregressive Modeling Davis, Richard A.; Zang, Pengfei; Zheng, Tian
Journal of computational and graphical statistics,
12/2016, Letnik:
25, Številka:
4
Journal Article
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The vector autoregressive (VAR) model has been widely used for modeling temporal dependence in a multivariate time series. For large (and even moderate) dimensions, the number of the AR coefficients ...can be prohibitively large, resulting in noisy estimates, unstable predictions, and difficult-to-interpret temporal dependence. To overcome such drawbacks, we propose a two-stage approach for fitting sparse VAR (sVAR) models in which many of the AR coefficients are zero. The first stage selects nonzero AR coefficients based on an estimate of the partial spectral coherence (PSC) together with the use of BIC. The PSC is useful for quantifying the conditional relationship between marginal series in a multivariate process. A refinement second stage is then applied to further reduce the number of parameters. The performance of this two-stage approach is illustrated with simulation and real data examples. Supplementary materials for this article are available online.
Voting hides a familiar puzzle. Many people take the trouble to vote even though each voter's prospect of deciding the election is nearly nil. Russians vote even when pervasive electoral fraud ...virtually eliminates even that slim chance. The right to vote has commonly been won by protesters who risked death or injury even though any one protester could have stayed home without lessening the protest's chance of success.
Could people vote or protest because they stop considering their own chances and start to think about an identity shared with others? If what they hear or read affects political identity, a shift in political discourse might not just evoke protests and voting but also make the minority that has imposed the dictator's will suddenly lose heart. During the Soviet Union's final years the cues that set communist discourse apart from standard Russian sharply dwindled.
A similar convergence of political discourse with local language has preceded expansion of the right to vote in many states around the globe.
Richard D. Anderson, Jr., presents a groundbreaking theory of what language use does to politics.
Abstract Most DNA double-strand breaks (DSBs) are harmful to genome integrity. However, some forms of DSBs are essential to biological processes, such as meiotic recombination and V(D)J ...recombination. DSBs are also required for programmed DNA elimination (PDE) in ciliates and nematodes. In nematodes, the DSBs are healed with telomere addition. While telomere addition sites have been well characterized, little is known regarding the DSBs that fragment nematode chromosomes. Here, we used embryos from the human and pig parasitic nematode Ascaris to characterize the DSBs. Using END-seq, we demonstrate that DSBs are introduced before mitosis, followed by extensive end resection. The resection profile is unique for each break site, and the resection generates 3′-overhangs before the addition of neotelomeres. Interestingly, telomere healing occurs much more frequently on retained DSB ends than on eliminated ends. This biased repair of the DSB ends may be due to the sequestration of the eliminated DNA into micronuclei, preventing neotelomere formation at their ends. Additional DNA breaks occur within the eliminated DNA in both Ascaris and Parascaris, ensuring chromosomal breakage and providing a fail-safe mechanism for PDE. Overall, our data indicate that telomere healing of DSBs is specific to the break sites responsible for nematode PDE.
Genetic information typically remains constant in all cells throughout the life cycle of most organisms. However, there are exceptions where DNA elimination is an integral, developmental program for ...some organisms, associated with generating distinct germline versus somatic genomes. Programmed DNA elimination occurs in unicellular ciliates and diverse metazoa ranging from nematodes to vertebrates. DNA elimination can occur through chromosome breakage and selective loss of chromosome regions or the elimination of individual chromosomes. Recent studies provide compelling evidence that DNA elimination is a novel form of gene silencing, dosage compensation, and sex determination. Further identification of the eliminated sequences, genome changes, and in depth characterization of this phenomenon in diverse metazoans is needed to shed new light on the functions and mechanisms of this regulated process.
Religiosity plays a prominent spiritual and social role in adolescents’ lives. Yet, despite its developmental salience, few studies have examined normative changes in religiosity or the implications ...of these changes for psychological well-being. We explored longitudinal variation in and associations between religiosity, as defined by private regard, centrality, and participation in religious activities, and diverse indicators of well-being including self-esteem, depressive symptoms, positive and negative affect, and both the presence of and search for meaning in life. The participants were two cohorts of Asian American high school students (
N
= 180; 60 % female) followed for 4 years and living in the southeastern US. Using hierarchical linear modelling and controlling for gender and generational status, results revealed that religious identity (i.e., regard, centrality) did not normatively increase or decrease over time, but participation increased. Religious identity was significantly associated with higher self-esteem, greater positive affect, the presence of meaning in life, and reduced depressive symptoms (for females), and participation was positively associated with positive affect and the presence of meaning. Our results and discussion emphasize the utility of further examining how religion plays a role in health and well-being, particularly among immigrant youth.
Abstract Background Multimodal pain management has had a significant effect on improving total joint arthroplasty recovery and patient satisfaction. There is literature supporting that intravenous ...(IV) acetaminophen reduces postoperative pain and narcotic use in the total joint population. However, there are no studies comparing the effectiveness of IV vs oral (PO) acetaminophen as part of a standard multimodal perioperative pain regimen. Methods One hundred twenty patients undergoing hip and knee arthroplasty surgeries performed by one joint arthroplasty surgeon were prospectively randomized into 2 groups. Group 1 (63 patients) received IV and group 2 (57 patients) received PO acetaminophen in addition to a standard multimodal perioperative pain regimen. Each group received 1 gram of acetaminophen preoperatively and then every 6 hours for 24 hours. Total narcotic use and visual analog scale (VAS) scores were collected every 4 hours postoperatively. Results The 24-hour average hydromorphone equivalents given were not different between groups (3.71 vs 3.48) at 24 hours ( P = .76), or at any of the individual 4-hour intervals. The 24-hour average visual analog scale scores in group 1 (IV) was 3.00 and in group 2 (PO) was 3.40 ( P = .06). None of the 4-hour intervals were significantly different except the first interval (0-4 hour postoperatively), which favored the IV group ( P = .03). Conclusion The use of IV acetaminophen may have a role when given intraoperatively to reduce the immediate pain after surgery. Following that, it does not provide a significant benefit in reducing pain or narcotic use when compared with the much less expensive PO form.
The early detection and accurate histopathological diagnosis of gastric cancer increase the chances of successful treatment. The worldwide shortage of pathologists offers a unique opportunity for the ...use of artificial intelligence assistance systems to alleviate the workload and increase diagnostic accuracy. Here, we report a clinically applicable system developed at the Chinese PLA General Hospital, China, using a deep convolutional neural network trained with 2,123 pixel-level annotated H&E-stained whole slide images. The model achieves a sensitivity near 100% and an average specificity of 80.6% on a real-world test dataset with 3,212 whole slide images digitalized by three scanners. We show that the system could aid pathologists in improving diagnostic accuracy and preventing misdiagnoses. Moreover, we demonstrate that our system performs robustly with 1,582 whole slide images from two other medical centres. Our study suggests the feasibility and benefits of using histopathological artificial intelligence assistance systems in routine practice scenarios.
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