The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta (0νββ) decay of 136Xe using high-pressure xenon gas TPCs with electroluminescent amplification. A scaled-up ...version of this technology with about 1 tonne of enriched xenon could reach in less than 5 years of operation a sensitivity to the half-life of 0νββ decay better than 1027 years, improving the current limits by at least one order of magnitude. This prediction is based on a well-understood background model dominated by radiogenic sources. The detector concept presented here represents a first step on a compelling path towards sensitivity to the parameter space defined by the inverted ordering of neutrino masses, and beyond.
The crystal structure of YAl
(BO
)
is obtained by Rietveld refinement analysis in the present study. The dynamical properties are studied both theoretically and experimentally. The experimental Raman ...and Infrared spectra are interpreted using the results of
calculations within density functional theory. The phonon band gap in the Infrared spectrum is observed in both trigonal and hypothetical monoclinic structures of YAl
(BO
)
. The electronic band structure is studied theoretically, and the value of the band gap is obtained. It was found that the YAl
(BO
)
is an indirect band gap dielectric material.
SCIENTIFIC RELEVANCE. The variability in patient response to non-steroidal anti-inflammatory drugs (NSAIDs) may be due to genetic polymorphisms. Decreased-function or non-functional CYP2C9 alleles ...are known to be significant contributors to response variability, and research is being conducted on the potential contribution of polymorphisms in the PTGS1 and PTGS2 genes that encode for the NSAID targets, cyclooxygenases 1 and 2.AIM. This study aimed to demonstrate the contribution of pharmacogenetic characteristics to the development of adverse reactions to NSAIDs in clinical cases.MATERIALS AND METHODS. This study reports two clinical cases observed in a multidisciplinary hospital in Moscow. The first clinical case demonstrates a neurosurgical patient with spondylodiscitis who showed signs of renal failure associated with ketorolac administration during 13 days of inpatient treatment. The second clinical case presents a patient with gastrointestinal bleeding that developed after 3 weeks of ketorolac self-administration and ultimately required gastric resection surgery. According to real-time polymerase chain reaction results, these patients have single-nucleotide polymorphisms, including rs179985 (CYP2C9*2) and rs1057910 (CYP2C9*3) in the CYP2C9 gene, rs10306135 and rs12353214 in the PTGS1 gene, and rs20417 in the PTGS2 gene.RESULTS. The described adverse reactions to ketorolac are attributable to the patients’ pharmacogenetic characteristics and other factors (exceeding the recommended duration of ketorolac therapy, concomitant conditions, drug interactions, and older age). In the case of nephrotoxicity, the patient has the CYP2C9*1/*2 genotype, which is associated with decreased NSAID metabolism. Additionally, this patient has the PTGS1 (C>T) rs12353214 genotype, which may be associated with variations in the activity of cyclooxygenase 1 and may lead to an increased risk of adverse reactions to NSAIDs. In the case of gastrointestinal bleeding, the patient also has genetic characteristics that affect the response to NSAIDs, as the CYP2C9*1/*3 genotype is associated with significantly decreased NSAID metabolism. Patients with this genotype should take the lowest doses or switch to alternatively metabolised NSAIDs.CONCLUSIONS. To reduce the risk of nephrotoxicity and gastrointestinal bleeding in patients when prescribing ketorolac, healthcare providers should strictly follow the recommended dosing regimen and consider individual comorbidities and potential drug interactions that may potentiate adverse drug reactions. Additionally, patient risk management requires pharmacogenetic testing, including the determination of decreased-function or non-functional CYP2C9 alleles and the rs12353214 polymorphism in the PTGS1 gene.
Glycosylation of 6α,12β-dihydroxy-20R,25-epoxydammaran-3-one (panaxatriol 3-ketone, 2) under Koenigs–Knorr reaction conditions and the Helferich modification was studied. Condensation of 2 with ...2,3,4,6-tetra-O-acetyl-α-D-glucopyranosylbromide (5) in the presence of Ag₂O and 4-Å molecular sieves in CH₂Cl₂ gave acetylated 6α,12β-dihydroxy-20R,25-epoxydammaran-3-one 12-O-β-D-glucopyranoside whereas in the presence of Hg(CN)₂ in nitromethane at 25°C the tetrahydropyran ring opened and, depending on the ratio of reagents, acetylated 12-, 12,25-di-, or 6,12,25-tri-O-β-D-glucopyranosides of 6α,12β,25-trihydroxydammar-20(22)E-en-3-one formed. 6α,12β-Dihydroxy-20R,25-epoxydammaran-3-one 12-O-β-D-glucopyranoside and 12-, 12,25-di-, and 6,12,25-tri-O-β-D-glucopyranosides of 6α,12β,25-trihydroxydammar-20(22)E-en-3-one were synthesized for the first time.
Glycosylation of 3α-acetoxy-12β,25-dihydroxy-20S,24R-epoxydammarane (2) by 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosylbromide (5) in the presence of Hg(CN)₂ in nitromethane at 22°C produced the ...acetylated 12,25-di-O-β-D-glucopyranoside of 3α,12β,25-trihydroxy-20S,24R-epoxydammarane (6) and also formed the side product 3α-acetoxy-12β-(2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranosyloxy)-24-cyano-20S,24S-epoxydammarane (8). Condensation of 3α,12β-diacetoxy-25-hydroxy-20S,24R-epoxydammarane (3) with glycosyl donor (5) under the same conditions gave the hexaacetate of the 25-O-β-D-glucopyranoside of 3α,12β,25-trihydroxy-20S,24R-epoxydammarane and also formed a mixture of C-24-epimers (1:1) of 3α,12β-diacetoxy-24-cyano-20S,24ξ-epoxydammarane (10a,b).
Two lytic double-stranded DNA bacteriophages, VSe11 and VSe102, infecting broad-spectrum
were isolated from the sewage of two different poultry farms. The phage genomes comprise 86,360 bp and 86,365 ...bp, respectively, with a G+C content of 39.0%, and both contain 129 putative coding sequences.
Objective
: monitoring, analysis and forecast of the spread of new coronavirus infection (COVID-19) in the Rostov region.
Materials and methods
: analysis of data on the incidence of COVID-19 in the ...Rostov region, obtained on the basis of agencies: Department of the Federal service for supervision of consumer protection and human welfare in the Rostov region, Center of hygiene and epidemiology in Rostov region, Rostov research Institute of Microbiology and Parasitology, as well as the monitoring of information on the Internet sites of the Government of the Rostov region and the regional headquarters for the fight against the spread of COVID-19. Application of the SEIR analytical platform to build a mathematical model for predicting the spread of infection in the Rostov region.
Results
: the article presents an analysis of the epidemiological situation for the incidence of COVID-19 in the Rostov region, analyzes the effectiveness of preventive and anti-epidemic measures with the ability to predict the development of the epidemiological process in the region.
The accuracies of measuring the velocity field using clinical and research magnetic resonance imagers are compared. The flow velocity of a fluid simulating blood in a carotid artery model connected ...to a programmable pump was measured. Using phase-contrast magnetic resonance tomography, the velocity distributions in the carotid artery model were obtained and compared with the analytical solution for viscous liquid flow in a cylindrical tube (Poiseuille flow). It is found that the accuracy of the velocity measurement does not depend on the field induction and spatial resolution of the imagers.
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