The quasar PKS 1510−089 (z = 0.361) was observed with the H.E.S.S. array of imaging atmospheric Cherenkov telescopes during high states in the optical and GeV bands, to search for very high energy ...(VHE, defined as E ≥ 0.1 TeV) emission. VHE γ-rays were detected with a statistical significance of 9.2 standard deviations in 15.8 h of H.E.S.S. data taken during March and April 2009. A VHE integral flux of I(0.15 TeV < E < 1.0 TeV)= (1.0 ± 0.2stat ± 0.2sys) × 10-11 cm-2 s-1 is measured. The best-fit power law to the VHE data has a photon index of Γ = 5.4 ± 0.7stat ± 0.3sys. The GeV and optical light curves show pronounced variability during the period of H.E.S.S. observations. However, there is insufficient evidence to claim statistically significant variability in the VHE data. Because of its relatively high redshift, the VHE flux from PKS 1510−089 should suffer considerable attenuation in the intergalactic space due to the extragalactic background light (EBL). Hence, the measured γ-ray spectrum is used to derive upper limits on the opacity due to EBL, which are found to be comparable with the previously derived limits from relatively-nearby BL Lac objects. Unlike typical VHE-detected blazars where the broadband spectrum is dominated by nonthermal radiation at all wavelengths, the quasar PKS 1510−089 has a bright thermal component in the optical to UV frequency band. Among all VHE detected blazars, PKS 1510−089 has the most luminous broad line region. The detection of VHE emission from this quasar indicates a low level of γ − γ absorption on the internal optical to UV photon field.
Context. Vela X is a region of extended radio emission in the western part of the Vela constellation: one of the nearest pulsar wind nebulae, and associated with the energetic Vela pulsar (PSR ...B0833-45). Extended very-high-energy (VHE) γ-ray emission (HESS J0835−455) was discovered using the H.E.S.S. experiment in 2004. The VHE γ-ray emission was found to be coincident with a region of X-ray emission discovered with ROSAT above 1.5 keV (the so-called Vela X cocoon): a filamentary structure extending southwest from the pulsar to the centre of Vela X. Aims. A deeper observation of the entire Vela X nebula region, also including larger offsets from the cocoon, has been performed with H.E.S.S. This re-observation was carried out in order to probe the extent of the non-thermal emission from the Vela X region at TeV energies and to investigate its spectral properties. Methods. To increase the sensitivity to the faint γ-ray emission from the very extended Vela X region, a multivariate analysis method combining three complementary reconstruction techniques of Cherenkov-shower images is applied for the selection of γ-ray events. The analysis is performed with the On/Off background method, which estimates the background from separate observations pointing away from Vela X; towards regions free of γ-ray sources but with comparable observation conditions. Results. The γ-ray surface brightness over the large Vela X region reveals that the detection of non-thermal VHE γ-ray emission from the PWN HESS J0835−455 is statistically significant over a region of radius 1.2° around the position α = 08h35m00s, δ = −45°36′00′′ (J2000). The Vela X region exhibits almost uniform γ-ray spectra over its full extent: the differential energy spectrum can be described by a power-law function with a hard spectral index Γ = 1.32 ± 0.06stat ± 0.12sys and an exponential cutoff at an energy of (14.0 ± 1.6stat ± 2.6sys) TeV. Compared to the previous H.E.S.S. observations of Vela X the new analysis confirms the general spatial overlap of the bulk of the VHE γ-ray emission with the X-ray cocoon, while its extent and morphology appear more consistent with the (more extended) radio emission, contradicting the simple correspondence between VHE γ-ray and X-ray emissions. Morphological and spectral results challenge the interpretation of the origin of γ-ray emission in the GeV and TeV ranges in the framework of current models.
Context. Very-high-energy (VHE; E > 100 GeV) γ-ray emission from blazars inevitably gives rise to electron-positron pair production through the interaction of these γ-rays with the extragalactic ...background light (EBL). Depending on the magnetic fields in the proximity of the source, the cascade initiated from pair production can result in either an isotropic halo around an initially beamed source or a magnetically broadened cascade flux. Aims. Both extended pair-halo (PH) and magnetically broadened cascade (MBC) emission from regions surrounding the blazars 1ES 1101-232, 1ES 0229+200, and PKS 2155-304 were searched for using VHE γ-ray data taken with the High Energy Stereoscopic System (H.E.S.S.) and high-energy (HE; 100 MeV < E < 100 GeV) γ-ray data with the Fermi Large Area Telescope (LAT). Methods. By comparing the angular distributions of the reconstructed γ-ray events to the angular profiles calculated from detailed theoretical models, the presence of PH and MBC was investigated. Results. Upper limits on the extended emission around 1ES 1101-232, 1ES 0229+200, and PKS 2155-304 are found to be at a level of a few per cent of the Crab nebula flux above 1 TeV, depending on the assumed photon index of the cascade emission. Assuming strong extra-Galactic magnetic field (EGMF) values, >10-12 G, this limits the production of pair haloes developing from electromagnetic cascades. For weaker magnetic fields, in which electromagnetic cascades would result in MBCs, EGMF strengths in the range (0.3−3)× 10-15 G were excluded for PKS 2155-304 at the 99% confidence level, under the assumption of a 1 Mpc coherence length.
Aims.We present results from deep γ-ray observations of the Galactic pulsar wind nebula HESS J1825–137 performed with the HESS array. Methods. Detailed morphological and spatially resolved spectral ...studies reveal the very high-energy (VHE) γ-ray aspects of this object with unprecedented precision. Results. We confirm previous results obtained in a survey of the Galactic Plane in 2004. The γ-ray emission extends asymmetrically to the south and south-west of the energetic pulsar PSR J1826–1334, that is thought to power the pulsar wind nebula. The differential γ-ray spectrum of the whole emission region is measured over more than two orders of magnitude, from 270 GeV to 35 TeV, and shows indications for a deviation from a pure power law. Spectra have also been determined for spatially separated regions of HESS J1825–137. The photon indices from a power-law fit in the different regions show a softening of the spectrum with increasing distance from the pulsar and therefore an energy dependent morphology. Conclusions. This is the first time that an energy dependent morphology has been detected in the VHE γ-ray regime. The VHE γ-ray emission of HESS J1825–137 is phenomenologically discussed in the scenario where the γ-rays are produced by VHE electrons via Inverse Compton scattering. The high γ-ray luminosity of the source cannot be explained on the basis of constant spin-down power of the pulsar and requires higher injection power in past.
Summary
Background
AZD3514 is a first-in-class, orally bio-available, androgen-dependent and -independent androgen receptor inhibitor and selective androgen-receptor down-regulator (SARD).
Methods
In ...study 1 and 2, castration-resistant prostate cancer (CRPC) patients (pts) were initially recruited into a once daily (QD) oral schedule (A). In study 1, pharmacokinetic assessments led to twice daily (BID) dosing (schedule B) to increase exposure. Study 2 explored a once daily schedule.
Results
In study 1, 49 pts were treated with escalating doses of AZD3514 (
A
35 pts,
B
14 pts). Starting doses were 100 mg (
A
) and 1000 mg (
B
). The AZD3514 formulation was switched from capsules to tablets at 1000 mg QD. 2000 mg BID was considered non-tolerable due to grade (G) 2 toxicities (nausea N, vomiting V). No adverse events (AEs) met the dose-limiting toxicity (DLT) definition. Thirteen pts received AZD3514 in study 2, with starting doses of 250 mg QD. The most frequent drug-related AEs were N: G1/2 in 55/70 pts (79 %); G3 in 1 pt (1.4 %); & V: G1/2 in 34/70 pts (49 %) & G3 in 1 pt (1.4 %). PSA declines (≥50 %) were documented in 9/70 patients (13 %). Objective soft tissue responses per RECIST1.1 were observed in 4/24 (17 %) pts in study 1.
Conclusion
AZD3514 has moderate anti-tumour activity in pts with advanced CRPC but with significant levels of nausea and vomiting. However, anti-tumour activity as judged by significant PSA declines, objective responses and durable disease stabilisations, provides the rationale for future development of SARD compounds.
Aims. The X-ray–TeV connection and the evolution of the emitting particle population is studied in high-energy peaked BL Lac objects, by obtaining spectral information in both bands on sub-hour ...timescales. Methods. Simultaneous observations with HESS, Chandra and the Bronberg optical observatory were performed on the BL Lac object PKS 2155–304 in the night of July 29–30 2006, when the source underwent a major γ-ray outburst during its high-activity state of Summer 2006. This event took place about 44 h after the other major outburst of the night of July 27–28, which is known for its ultrafast variability. An unprecedented 6 to 8 h of simultaneous, uninterrupted coverage was achieved, with spectra and light curves measured down to 7 and 2 min timescales, respectively. Results. The source exhibited one major flare along the night, at high energies. The γ-ray flux reached a maximum of ~11 times the Crab flux (>400 GeV), with rise/decay timescales of ~1 h, plus a few smaller-amplitude flares superimposed on the decaying phase. The emission in the X-ray and VHE γ-ray bands is strongly correlated, with no evidence of lags. The spectra also evolve with similar patterns, and are always soft (photon index Γ > 2), indicating no strong shift of the peaks in the spectral energy distribution towards higher energies. Only at the flare maximum is there evidence that the γ-ray peak is inside the observed passband, at ~400–600 GeV. The VHE spectrum shows a curvature that is variable with time and stronger at higher fluxes. The huge VHE variations (~22$\times$) are only accompanied by small-amplitude X-ray and optical variations (factor 2 and 15% respectively). The source has shown for the first time in a high-energy peaked BL Lac object a large Compton dominance $(L_{\rm C}/L_{\rm S}\sim 10)$ – rapidly evolving – and a cubic relation between VHE and X-ray flux variations, during a decaying phase. These results challenge the common scenarios for the TeV-blazar emission.
Aims. Galaxy clusters are key targets in the search for ultra high energy particle accelerators. The Coma cluster represents one of the best candidates for such a search owing to its high mass, ...proximity, and the established non-thermal radio emission centred on the cluster core. Methods. The HESS (High Energy Stereoscopic System) telescopes observed Coma for ~8 h in a search for γ-ray emission at energies >1 TeV. The large 3.5° FWHM field of view of HESS is ideal for viewing a range of targets at various sizes including the Coma cluster core, the radio-relic (1253+275) and merger/infall (NGC 4839) regions to the southwest, and features greater than $1^\circ$ away. Results. No evidence for point-like nor extended TeV γ-ray emission was found and upper limits to the TeV flux $F(E)$ for $E>1$, >5, and >10 TeV were set for the Coma core and other regions. Converting these limits to an energy flux $E^2F(E)$ the lowest or most constraining is the $E>5$ TeV upper limit for the Coma core (0.2° radius) at ~8% Crab flux units or ${\sim}10^{-13}$ ph cm-2 s-1. Conclusions. The upper limits for the Coma core were compared with a prediction for the γ-ray emission from proton-proton interactions, the level of which ultimately scales with the mass of the Coma cluster. A direct constraint using our most stringent limit for $E>5$ TeV, on the total energy content in non-thermal protons with injection energy spectrum ${\propto} E^{-2.1}$ and spatial distribution following the thermal gas in the cluster, is found to be ~0.2 times the thermal energy, or ${\sim} 10^{62}$ erg. The $E>5$ TeV γ-ray threshold in this case corresponds to cosmic-ray proton energies $\ga$50 TeV. Our upper limits rule out the most optimistic theoretical models for gamma ray emission from clusters and complement radio observations which constrain the cosmic ray content in clusters at significantly lower proton energies, subject to assumptions on the magnetic field strength.
We present results from multiwavelength observations of the BL Lacertae object 1ES 1741 + 196, including results in the very high energy γ-ray regime using the Very Energetic Radiation Imaging ...Telescope Array System (VERITAS). The VERITAS time-averaged spectrum, measured above 180 GeV, is well modelled by a power law with a spectral index of 2.7 ± 0.7stat ± 0.2syst. The integral flux above 180 GeV is (3.9 ± 0.8stat ± 1.0syst) × 10−8 m−2 s−1, corresponding to 1.6 per cent of the Crab nebula flux on average. The multiwavelength spectral energy distribution of the source suggests that 1ES 1741+196 is an extreme-high-frequency-peaked BL Lacertae object. The observations analysed in this paper extend over a period of six years, during which time no strong flares were observed in any band. This analysis is therefore one of the few characterizations of a blazar in a non-flaring state.
ABSTRACT The F-type star KIC 8462852 has recently been identified as an exceptional target for search for extraterrestrial intelligence (SETI) observations. We describe an analysis methodology for ...optical SETI, which we have used to analyze nine hours of serendipitous archival observations of KIC 8462852 made with the VERITAS gamma-ray observatory between 2009 and 2015. No evidence of pulsed optical beacons, above a pulse intensity at the Earth of approximately , is found. We also discuss the potential use of imaging atmospheric Cherenkov telescope arrays in searching for extremely short duration optical transients in general.
Aims. LS 5039 is a High Mass X-ray Binary (HMXRB) comprising a compact object in an eccentric 3.9 day orbit around a massive O6.5V star. Observations at energies above 0.1 TeV (1011 eV) by the High ...Energy Stereoscopic System (HESS) in 2004 revealed that LS 5039 is a source of Very High Energy (VHE) γ-rays and hence, is able to accelerate particles to multi-TeV energies. Deeper observations by HESS were carried out in 2005 in an effort to probe further the high energy astrophysics taking place. In particular, we have searched for orbital modulation of the VHE γ-ray flux, which if detected, would yield new information about the complex variation in γ-ray absorption and production within X-ray binary systems. Methods. Observations at energies above 0.1 TeV (1011 eV), were carried out with the High Energy Stereoscopic System (HESS) of Cherenkov Telescopes in 2005. A timing analysis was performed on the dataset employing the Lomb-Scargle and Normalised Rayleigh statistics, and orbital phase-resolved energy spectra were obtained. Results. The timing analysis reveals a highly significant (post-trial chance probability <10-15) peak in the TeV emission periodogram at a frequency matching that of the 3.9 day orbital motion of the compact object around the massive stellar companion. This is the first time in γ-ray astronomy that orbital modulation has been observed, and periodicity clearly established using ground-based γ-ray detectors. The γ-ray emission is largely confined to half of the orbit, peaking around the inferior conjunction epoch of the compact object. Around this epoch, there is also a hardening of the energy spectrum in the energy range between 0.2 TeV and a few TeV. Conclusions. The γ-ray flux vs. orbital phase profile suggests the presence of γ-ray absorption via pair production, which would imply that a large fraction of the γ-ray production region is situated within ~1 AU of the compact object. This source size constraint can be compared to the collimated outflows or jets observed in LS 5039 resolved down to scales of a few AU. The spectral hardening is however not explained exclusively by the absorption effect, indicating that other effects are present, perhaps related to the γ-ray production mechanism(s). If the γ-ray emission arises from accelerated electrons, the hardening may arise from variations with phase in the maximum electron energies, the dominant radiative mechanism, and/or the angular dependence in the inverse-Compton scattering cross-section. Overall, these results provide new insights into the competing γ-ray absorption and production processes in X-ray binaries.
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