Reports on clinical and histologic follicular alterations in patients previously diagnosed with mycosis fungoides (MF) or at the time of MF diagnosis are rare. The clinical and histologic criteria to ...distinguish MF associated with follicular mucinosis from follicular MF are a matter of debate. A patient is described with advanced clinical and histologic alterations predominated by follicular lesions and presence of mucin. In the early stage of the disease, folliculotropism was clinically and histologically present but less pronounced than epidermotropism and classic plaque-like lesions. The patient died four years after the diagnosis. As the term 'folliculotropic' describes a particular histopathologic finding, we consider it correct to use the term "folliculotropic MF" to denote atypical lymphocyte folliculotropism in the absence or presence of mild epidermotropism, presence of mucin, or no evidence for intrafollicular mucin. Folliculotropic MF seems to represent a specific clinicopathologic entity which may have a poorer prognosis than classic MF.
Uvodno su opisane one eflorescencije koje će reumatologu biti dijagnostički korisne. U daljnjem tekstu opisane su četiri skupine reumatskih bolesti. Prva skupina: reumatske, u nas s dermatološkog ...gledišta najčešće bolesti (eritemski lupus, dermatomiozitis, sistemska sklerodermija, miješana bolest vezivnoga tkiva, alergijski vaskulitis, nodozni periarteriitis). Druga skupina: reumatske bolesti (Wegeneroova granulomatoza, reumatoidni artritis, juvenilini reumatoidni artritis, Sjögrenov, Reiterov i Behçetov sindrom te Kawaskijeva bolest) kojima se u nas dermatolozi rijetko bave. Ovdje je uvršten i psorijatički artritis koji u dermatološkoj praksi nije rijedak, no dijagnostika i terapija ove bolesti pripadaju u područje rada reumatologa. Treća skupina: infekcije (reumatska vrućica, diseminirana gonokokna infekcija, subakutni bakterijski endokarditis i Lyme disease). Četvrta skupina: metabolički poremećaji (urički artritis).
Bolesti prve skupine opisane su u potpunosti, dok su za bolesti druge, treće i četvrte skupine opisane samo promjene kože.
The Intruduction includes those eflorescences that might be useful for diagnostics in rheumatology. Further in the text we have described four groups of rheumatic disorders. The first group: ...rheumatic diseases (lupus erythematosus, dermatomyositis, systemic scleroderma, the mixed connective tissue disease, allergic vasculitis, polyarteritis) which are the most common from the dermatological point of view. The second group: rheumatic diseases (Wegener's granulomatosis, rheumatoid arthritis, Sjögren, Reiter and Behçet syndrome and Kawasaki's disease) which are rarely of interest to our dermatologists. In this group there is also psoriatic arthritis, which is not rare in dermatology but its diagnostics and treatment belong to rheumatologists' field of expertise. The third group: infections (rheumatic fever, diseminated gonococcal infection, subacute bacterial endocarditis, Lyme disesease). The fourth group: metabolic disorders (gout). The diseases of the first group are described completely. In the second, third and fourth group of the diseases we have included only skin changes.
Hailey-Hailey disease is a rare autosomal dominant skin disorder that typically affects the intertriginous areas. The responsible defect has been identified in the gene named ATP2C1 on chromosome ...3q21-24. We present a 50-year-old man with a 16-year history of blistering eruptions and positive familial history where this disease had appeared through four generations. The diagnosis was confirmed by histopathologic studies and negative immunofluorescence findings. A combination of topical tacrolimus therapy and oral erythromycin seemed to play a considerable part in this case, in which all of the lesions healed within 2 weeks.
A 40-year-old male patient with primary anetoderma is presented in whom antiphospholipid antibodies were detected while not fulfilling diagnostic criteria for antiphospholipid syndrome. The possible ...pathogenic role of antiphospholipid antibodies in the disease development is postulated.
Hereditary benign telangiectasia is a very uncommon disorder characterized by generalized telangiectasias and angiomatous lesions of the skin. The diagnosis should be suspected in patients with such ...cutaneous signs, positive family history, no associated bleeding problems, and no mucosal involvement. We present a 74-year-old woman with typical clinical features of hereditary benign telangiectasia.
Xanthoma disseminatum is a rare, benign, non-Langerhans' cell histiocytic disorder of unknown etiology. A case is presented of a 71-year-old man with a three-year history of disseminated symmetric ...yellowish papules and plaques on the skin of the face, neck, flexor regions, trunk, extremities and oral mucosa, with fatty infiltration of the liver and pancreas, and cardiac complaints. Xanthomatous rhinophyma predominated on the face. Clinical, immunohistochemistry and histology findings indicated the diagnosis of xanthoma disseminatum. Although the patient had a positive family history of cardiovascular diseases and a number of symptoms that are often associated with hyperlipidemia, repeat plasma levels were always within the normal limits. The case was interesting because of a number of etiologic factors that could be connected with the appearance of xanthomas in our patient. Therefore it was difficult to classify the disease into one of well-defined nosologic entities. The case report is supplemented with a review of relevant literature.
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