We report empirical observations of magnetic island heteroclinic bifurcation for the first time. This behavior is observed in interacting coupled 2/1 tearing modes in the core of a DIII-D tokamak ...plasma. Poincaré maps constrained by measured magnetic amplitudes and phasing show bifurcation from heteroclinic to homoclinic topology in the 2/1 island as the 4/2 relative amplitude (R_{4/2}) decreases. Initially, the local electron temperature peak in the 2/1 island splits, consistent with two O points. As R_{4/2} decreases a single peak forms, consistent with one O point. These call for developing tearing stability theory and control solutions for heteroclinic islands in tokamaks.
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co‐dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, ...homozygous TPMT‐deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30–60% of individuals who are heterozygotes (~3–14% of the population) show moderate toxicity, and homozygous wild‐type individuals (~86–97% of the population) show lower active thioguanine nucleolides and less myelosuppression. We provide dosing recommendations (updates at http://www.pharmgkb.org) for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype.
Clinical Pharmacology & Therapeutics (2011) 89 3, 387–391. doi:10.1038/clpt.2010.320
The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Methyltransferase Genotype and Thiopurine Dosing was originally published in March 2011. We reviewed recent ...literature and concluded that although relevant new evidence has been generated, none of the evidence would change the primary dosing recommendations in the original guideline; therefore, the original publication remains clinically current. Up‐to‐date information on thiopurine methyltransferase (TPMT) gene alleles and nomenclature can be found at PharmGKB (http://www.pharmgkb.org).
Clinical Pharmacology & Therapeutics (2013); 93 4, 324–325. doi:10.1038/clpt.2013.4
ELM mitigation techniques Evans, T.E.
Journal of nuclear materials,
07/2013, Letnik:
438
Journal Article
Recenzirano
Large edge-localized mode (ELM) control techniques must be developed to help ensure the success of burning and ignited fusion plasma devices such as tokamaks and stellarators. In full performance ...ITER tokamak discharges, with QDT=10, the energy released by a single ELM could reach ∼30MJ which is expected to result in an energy density of 10–15MJ/m2on the divertor targets. This will exceed the estimated divertor ablation limit by a factor of 20–30. A worldwide research program is underway to develop various types of ELM control techniques in preparation for ITER H-mode plasma operations. An overview of the ELM control techniques currently being developed is discussed along with the requirements for applying these techniques to plasmas in ITER. Particular emphasis is given to the primary approaches, pellet pacing and resonant magnetic perturbation fields, currently being considered for ITER.
The hysteresis relation between turbulence and temperature modulation during the heat pulse propagation into a magnetic island is studied for the first time in toroidal plasmas. Lissajous curves of ...the density fluctuation (nover ˜/n) and the electron temperature (T_{e}) modulation show that the (nover ˜/n) propagation is faster than the heat pulse propagation near the O point of the magnetic island. This faster nover ˜/n propagation is experimental evidence of the turbulence spreading from the X point to the O point of the magnetic island.
Previous research has indicated the suitability of behavioural activation (BA) as an intervention for reducing depression in older adults. However, little research has investigated the potential of ...BA to increase active engagement and well-being in older adults. The current pilot study sought to investigate the usefulness and acceptability of BA to promote well-being in a group of non-clinical older adults. Participants (N = 18) aged between 65 and 86 (M = 77.82, SD = 5.59) who were retired and living independently in the community were provided a 6-week BA program predominantly delivered online. Treatment retention, self-ratings, and participants' compliance to treatment principles indicate preliminary feasibility for the use of BA as an approach for increasing active engagement in older adult populations. Participants also provided feedback on their experiences with the program post-intervention via individual structured interviews. Thematic analysis of these data revealed that participants found the program to be beneficial in terms of increased self-awareness and social engagement, and provided several recommendations for improving acceptability of the program and workbook. The unexpected events relating to the first wave of the novel coronavirus (COVID-19) led to necessary adaptations to delivery modalities, and provided the researchers with an opportunity to investigate the use of a structured well-being program on a high-risk population during a pandemic. Our findings support the proposition that BA is a suitable intervention for increasing engagement and well-being in older adults, provide insight into adapting programs for older adults, and suggest next steps for testing intervention efficacy.
Aims/hypothesis Improved glucose control in type 2 diabetes is known to reduce the risk of microvascular events. There is, however, continuing uncertainty about its impact on macrovascular disease. ...The aim of these analyses was to generate more precise estimates of the effects of more-intensive, compared with less-intensive, glucose control on the risk of major cardiovascular events amongst patients with type 2 diabetes. Methods A prospectively planned group-level meta-analysis in which characteristics of trials to be included, outcomes of interest, analyses and subgroup definitions were all pre-specified. Results A total of 27,049 participants and 2,370 major vascular events contributed to the meta-analyses. Allocation to more-intensive, compared with less-intensive, glucose control reduced the risk of major cardiovascular events by 9% (HR 0.91, 95% CI 0.84-0.99), primarily because of a 15% reduced risk of myocardial infarction (HR 0.85, 95% CI 0.76-0.94). Mortality was not decreased, with non-significant HRs of 1.04 for all-cause mortality (95% CI 0.90-1.20) and 1.10 for cardiovascular death (95% CI 0.84-1.42). Intensively treated participants had significantly more major hypoglycaemic events (HR 2.48, 95% CI 1.91-3.21). Exploratory subgroup analyses suggested the possibility of a differential effect for major cardiovascular events in participants with and without macrovascular disease (HR 1.00, 95% CI 0.89-1.13, vs HR 0.84, 95% CI 0.74-0.94, respectively; interaction p = 0.04). Conclusions/interpretation Targeting more-intensive glucose lowering modestly reduced major macrovascular events and increased major hypoglycaemia over 4.4 years in persons with type 2 diabetes. The analyses suggest that glucose-lowering regimens should be tailored to the individual.
The UKIDSS Galactic Plane Survey Lucas, P. W.; Hoare, M. G.; Longmore, A. ...
Monthly notices of the Royal Astronomical Society,
11/2008, Letnik:
391, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The UKIDSS Galactic Plane Survey (GPS) is one of the five near-infrared Public Legacy Surveys that are being undertaken by the UKIDSS consortium, using the Wide Field Camera on the United Kingdom ...Infrared Telescope. It is surveying 1868 deg2 of the northern and equatorial Galactic plane at Galactic latitudes −5° < b < 5° in the J, H and K filters and a ∼200-deg2 area of the Taurus–Auriga–Perseus molecular cloud complex in these three filters and the 2.12 μm (1–0) H2 filter. It will provide data on ∼2 × 109 sources. Here we describe the properties of the data set and provide a user's guide for its exploitation. We also present brief Demonstration Science results from DR2 and from the Science Verification programme. These results illustrate how GPS data will frequently be combined with data taken in other wavebands to produce scientific results. The Demonstration Science comprises six studies. (1) A GPS-Spitzer-GLIMPSE cross-match for the star formation region G28.983−0.603 to identify YSOs. This increases the number of YSOs identified by a factor of 10 compared to GLIMPSE alone. (2) A wide-field study of the M17 nebula, in which an extinction map of the field is presented and the effect of source confusion on luminosity functions in different subregions is noted. (3) H2 emission in the ρ Ophiuchi dark cloud. All the molecular jets are traced back to a single active clump containing only a few protostars, which suggests that the duration of strong jet activity and associated rapid accretion in low-mass protostars is brief. (4) X-ray sources in the nuclear bulge. The GPS data distinguishes local main-sequence counterparts with soft X-ray spectra from nuclear bulge giant counterparts with hard X-ray spectra. (5) External galaxies in the zone of avoidance. The galaxies are clearly distinguished from stars in fields at longitudes l > 90°. (6) IPHAS-GPS optical–infrared spectrophotometric typing. The (i′−J) versus (J−H) diagram is used to distinguish A–F type dwarfs, G dwarfs, K dwarfs and red clump giants in a field with high reddening.
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