Coffee is one of the most significant beverages consumed worldwide. However, the substantial production and consumption of coffee has led to the generation of large amounts of by-products, such as ...coffee silverskin (CS).The first objective was to study the ultrasound-assisted extraction (UAE) conditions from CS according to a simple factorial design, in order to obtain natural extracts as a source of polyphenols and caffeine with high antioxidant activity. The second objective was to include CS powder (CSP) or ultrasound CS extract (UCSE) in the elaboration of cookies, in order to obtain an enriched food product with potential health benefits for consumers.CS was characterized in terms of moisture, protein, lipids, ash, total dietary fiber, total phenol content (TPC) and antioxidant activity. The UCSE was characterized in terms of extraction yield, TPC, caffeine content and antioxidant activity (ABTS and ORAC assays).The best UCSE used for cookie elaboration was obtained at 60 min and 180 W with the following values: 8.8 %wt; 36.8 mg GAE/g; 62.7 µmol caffeine/g; 491.1 µmol/g (ABTS assay); 1012.4 µmol/g (ORAC assay). Finally, the cookies were sensory and chemically characterized. In the cookies containing UCSE the sensory acceptability was not modified with respect to the control cookies and an increase in TPC and antioxidant activity was achieved. However, the incorporation of CSP lead to a decrease in the acceptability despite the fact that the cookies constitute a source of fiber. Results reinforce the use of green extraction technologies to obtain antioxidants compounds from natural sources.
Highlights • FAAH inhibition reverses the motor symptoms in Parkinson’s disease. • The anti-parkinsonian effects of URB597 involve CB1 and CB2 receptors in the indirect pathway. • AEA and 2-AG ...interact with the dopaminergic circuit by different mechanisms of action.
Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding ...of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 × 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model.
Lynch syndrome accounts for 2–4% of all colorectal cancer, and is mainly caused by germline mutations in the DNA mismatch repair genes. Our aim was to characterize the genetic mutation responsible ...for Lynch syndrome in an extensive Colombian family and to study its prevalence in Antioquia.
A Lynch syndrome family fulfilling Amsterdam criteria II was studied by immunohistochemistry and by multiplex ligation-dependent probe amplification (MLPA). Results were confirmed by additional independent MLPA, Southern blotting, and sequencing.
Index case tumor immunohistochemistry results were MLH1−, MSH2+, MSH6+, and PMS2−. MLPA analysis detected a duplication of exons 12 and 13 of MLH1. This mutation was confirmed and characterized precisely to span 4219 base pairs. Duplication screening in this family led to the identification of six additional carriers and 13 noncarriers. We also screened 123 early-onset independent colorectal cancer cases from the same area and identified an additional unrelated carrier.
A novel duplication of exons 12 and 13 of the MLH1 gene was detected in two independent Lynch syndrome families from Colombia. A putative founder effect and prescreening Lynch syndrome Antioquia families for this specific mutation before thorough mismatch repair mutational screening could be suggested. Genet Med 2011:13(2):155–160.
Money at the margins Maurer, Bill; Musaraj, Smoki; Small, Ivan ...
2018., 2018, 2018-03-28, Letnik:
6
eBook
Mobile money, e-commerce, cash cards, retail credit cards, and more—as new monetary technologies become increasingly available, the global South has cautiously embraced these mediums as a potential ...solution to the issue of financial inclusion. How, if at all, do new forms of dematerialized money impact people’s everyday financial lives? In what way do technologies interact with financial repertoires and other socio-cultural institutions? How do these technologies of financial inclusion shape the global politics and geographies of difference and inequality? These questions are at the heart of Money at the Margins, a groundbreaking exploration of the uses and socio-cultural impact of new forms of money and financial services.
This study describes a series of exploratory and confirmatory factor analyses that were conducted with the 44-item Social Anxiety Questionnaire for Children- 4th version (SAQ-CIV) to identify a ...reduced set of items that might be used to construct a new abbreviated instrument for measuring social anxiety in children and adolescents. The fourth version of the Social Anxiety Questionnaire for Children (SAQ-CIV) was administered to 12,801 non-clinical participants (ages 9 to 15 years) from 12 Latin American countries and Spain. Exploratory and confirmatory factor analysis supported a 6-factor structure of social anxiety in children, replicating a similar structure to that of adults (Caballo et al. in
Behavioral Psychology/Psicología Conductual
,
18
(1), 5–34,
2010
; Caballo et al. in
Behavior Therapy
,
43
(2), 313–328,
2012
): 1) Interactions with the opposite sex, 2) Criticism and embarrassment, 3) Speaking in public/Talking to teachers, 4) Assertive expression of annoyance and disgust, 5) Performing in public, and 6) Interactions with strangers. Each of the factors contains 4 items, yielding an abbreviated 24-item instrument, the Social Anxiety Questionnaire for Children (SAQ-C). The present results suggest this is a reliable, valid, and culturally sensitive instrument to assess social anxiety in youth.
Mobile money, e-commerce, cash cards, retail credit cards, and more -as new monetary technologies become increasingly available, the global South has cautiously embraced these mediums as a potential ...solution to the issue of financial inclusion. How, if at all, do new forms of dematerialized money impact people's everyday financial lives? In what way do technologies interact with financial repertoires and other socio-cultural institutions? How do these technologies of financial inclusion shape the global politics and geographies of difference and inequality? These questions are at the heart ofMoney at the Margins, a groundbreaking exploration of the uses and socio-cultural impact of new forms of money and financial services.
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