TOI-5678 b Ulmer-Moll, S.; Olofsson, Göran; Brandeker, Alexis ...
Astronomy and astrophysics (Berlin),
06/2023, Letnik:
674
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Context. A large sample of long-period giant planets has been discovered thanks to long-term radial velocity surveys, but only a few dozen of these planets have a precise radius measurement. ...Transiting gas giants are crucial targets for the study of atmospheric composition across a wide range of equilibrium temperatures and, more importantly, for shedding light on the formation and evolution of planetary systems. Indeed, compared to hot Jupiters, the atmospheric properties and orbital parameters of cooler gas giants are unaltered by intense stellar irradiation and tidal effects. Aims. We aim to identify long-period planets in the Transiting Exoplanet Survey Satellite (TESS) data as single or duo-transit events. Our goal is to solve the orbital periods of TESS duo-transit candidates with the use of additional space-based photometric observations and to collect follow-up spectroscopic observations in order to confirm the planetary nature and measure the mass of the candidates. Methods. We use the CHaracterising ExOPlanet Satellite (CHEOPS) to observe the highest-probability period aliases in order to discard or confirm a transit event at a given period. Once a period is confirmed, we jointly model the TESS and CHEOPS light curves along with the radial velocity datasets to measure the orbital parameters of the system and obtain precise mass and radius measurements. Results. We report the discovery of a long-period transiting Neptune-mass planet orbiting the G7-type star TOI-5678. Our spectroscopic analysis shows that TOI-5678 is a star with a solar metallicity. The TESS light curve of TOI-5678 presents two transit events separated by almost two years. In addition, CHEOPS observed the target as part of its Guaranteed Time Observation program. After four non-detections corresponding to possible periods, CHEOPS detected a transit event matching a unique period alias. Follow-up radial velocity observations were carried out with the ground-based high-resolution spectrographs CORALIE and HARPS. Joint modeling reveals that TOI-5678 hosts a 47.73 day period planet, and we measure an orbital eccentricity consistent with zero at 2s. The planet TOI-5678 b has a mass of 20 +/- 4 Earth masses (M-circle plus) and a radius of 4.91 +/- 0.08 R-circle plus Using interior structure modeling, we find that TOI-5678 b is composed of a low-mass core surrounded by a large H/He layer with a mass of 3.2(-1.3)(+1.7) M-circle plus. Conclusions. TOI-5678 b is part of a growing sample of well-characterized transiting gas giants receiving moderate amounts of stellar insolation (11 S circle plus). Precise density measurement gives us insight into their interior composition, and the objects orbiting bright stars are suitable targets to study the atmospheric composition of cooler gas giants.
HMDB: the Human Metabolome Database Wishart, David S; Tzur, Dan; Knox, Craig ...
Nucleic acids research,
01/2007, Letnik:
35, Številka:
suppl-1
Journal Article
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The Human Metabolome Database (HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world. It contains records for more than ...2180 endogenous metabolites with information gathered from thousands of books, journal articles and electronic databases. In addition to its comprehensive literature-derived data, the HMDB also contains an extensive collection of experimental metabolite concentration data compiled from hundreds of mass spectra (MS) and Nuclear Magnetic resonance (NMR) metabolomic analyses performed on urine, blood and cerebrospinal fluid samples. This is further supplemented with thousands of NMR and MS spectra collected on purified, reference metabolites. Each metabolite entry in the HMDB contains an average of 90 separate data fields including a comprehensive compound description, names and synonyms, structural information, physico-chemical data, reference NMR and MS spectra, biofluid concentrations, disease associations, pathway information, enzyme data, gene sequence data, SNP and mutation data as well as extensive links to images, references and other public databases. Extensive searching, relational querying and data browsing tools are also provided. The HMDB is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. The HMDB is available at: www.hmdb.ca
Patients with Crohn's disease CD carry an 80 - 90 % lifetime risk of undergoing surgery. Many of these patients are on immunosuppressive medication at the time of surgery. The aim of this study was ...to evaluate the effect of immunosuppression on the surgical outcome in CD patients.
We retrospectively analyzed 484 consecutive abdominal operations for CD from 1995 to 2008 for surgical complications.
A total of 241 operations (= 49.8 %) were performed under perioperative immunosuppression (corticoids and thiopurine). The overall complication rate was 18.6 %, the major complication rate was 8.7 % and the anastomotic leakage rate was 3.3 %. No differences were observed between patients without immunosuppression compared to those with immunosuppression. Patients with colo-rectal resections showed a higher complication rate than patients with small bowel resection independently of immunosuppression.
Nearly 50 % of the patients undergoing abdominal surgery for CD are receiving immunosuppressive medication during surgery. However, perioperative immunosuppression with corticoids, thiopurine or the combination of both does not significantly alter the surgical complication rate. Therefore the decision of a required surgery should not be delayed due to the fact that the patient is under immunosuppressive medication.
We present a search for nine lepton-number-violating and three lepton-flavor-violating neutral charm decays of the type D0→h′−h−ℓ′+ℓ+ and D0→h′−h+ℓ′±ℓ∓, where h and h′ represent a K or π meson and ℓ ...and ℓ′ an electron or muon. The analysis is based on 468 fb−1 of e+e− annihilation data collected at or close to the ϒ(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. No significant signal is observed for any of the twelve modes, and we establish 90% confidence level upper limits on the branching fractions in the range (1.0–30.6)×10−7. The limits are between 1 and 3 orders of magnitude more stringent than previous measurements.
Purpose Cardiovascular disease and obstructive lung disease are leading global causes of death. Despite this, the impact of secondhand smoke (SHS) exposure on pulmonary function and cardiovascular ...disease remains uncertain. Our goal was to elucidate the association between baseline SHS exposure and the risk of lung function decline and cardiovascular mortality over a period of nearly a decade. Methods We used data from a longitudinal cohort study of 1,057 older adults to study the association between baseline SHS exposure and the risk of lung function decline and cardiovascular mortality. The effect of SHS exposure on cardiovascular mortality may be mediated by its influence on FEV1 and biological processes captured by measurement of FEV1 . Alternatively, the effect of SHS may be mediated by baseline cardiovascular disease status, which reflects the combined effects of traditional cardiovascular risk factors. To correctly estimate the effect of SHS and FEV1 on cardiovascular mortality, we used marginal structural models (MSMs) that took into account the mediating effects of FEV1 and baseline cardiovascular disease in the causal pathway. Results In longitudinal multivariate analyses, lifetime cumulative home and work SHS exposure were associated with a greater decline of FEV1 (−15 mL/s; 95% CI, −29 to −1.3 mL/s and −41 mL/s; 95% CI, −55 to −28 mL/s per 10-year cumulative exposure, respectively). Lifetime home SHS exposure was associated with a greater risk of cardiovascular mortality in both conventional multivariate analysis (HR, 1.10 per 10 years of exposure; 95% CI, 0.99 to 1.24) and the MSM for FEV1 (HR, 1.06; 95% CI, 0.95 to 1.19) and baseline cardiovascular disease (HR for subjects with no baseline cardiovascular disease, 1.39; 95% CI, 1.17 to 1.66). Conclusions Lifetime SHS exposure appears to result in a greater decline in lung function and risk of cardiovascular mortality, taking into account confounders and the mediating effect of FEV1 and baseline cardiovascular disease.
We report the observation of the rare charm decay D0→K−π+e+e−, based on 468 fb−1 of e+e− annihilation data collected at or close to the center-of-mass energy of the ϒ(4S) resonance with the BABAR ...detector at the SLAC National Accelerator Laboratory. We find the branching fraction in the invariant mass range 0.675<m(e+e−)<0.875 GeV/c2 of the electron-positron pair to be B(D0→K−π+e+e−)=(4.0±0.5±0.2±0.1)×10−6, where the first uncertainty is statistical, the second systematic, and the third due to the uncertainty in the branching fraction of the decay D0→K−π+π+π− used as a normalization mode. The significance of the observation corresponds to 9.7 standard deviations including systematic uncertainties. This result is consistent with the recently reported D0→K−π+μ+μ− branching fraction, measured in the same invariant mass range, and with the value expected in the standard model. In a set of regions of m(e+e−), where long-distance effects are potentially small, we determine a 90% confidence level upper limit on the branching fraction B(D0→K−π+e+e−)<3.1×10−6.
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