Chronic hypertension is one of the major risk factors for preeclampsia. Pregnancy-specific beta-1-glycoprotein (PSG-1) is a protein that plays a critical role in fetomaternal immune modulation and ...has been shown to be closely associated with pregnancy adverse events such as preeclampsia. It is also known that PSG-1 and its source placenta are associated with many molecular pathways associated with blood pressure regulation. In addition, the nondipping pattern (NDP) of chronic hypertension has been shown to be an independent risk factor for preeclampsia. Dipper individuals experience a notable nighttime drop in blood pressure, typically around 10% or more compared to daytime levels, while nondipper individuals show a smaller nighttime blood pressure decrease, indicating potential circadian blood pressure regulation disruption. In this context, we aimed to reveal the relationship between PSG-1, NDP and preeclampsia in this study. A total of 304 pregnant women who were newly diagnosed in the first trimester and started on antihypertensive medication were included in this study. All subjects performed 24-h ambulatory blood pressure monitoring twice throughout pregnancy, the first in the 1. trimester to confirm the diagnosis of hypertension and the second between 20+0 and 21+1 gestational weeks to determine the dipper-nondipper status of hypertension. Subjects were grouped as dipper and nondipper according to blood pressure, and groups were compared in terms of PSG-1 levels. In this study, low PSG-1 levels and NDP were independently associated with preeclampsia. Findings from this study suggest that PSG-1 may play an important role in the causal relationship between NDP and preeclampsia.
Determination of biomolecules that play a role in the etiopathogenesis of preeclampsia and their application as therapeutic targets may increase surveillance in this patient group. The aim of this ...study was to investigate the relationship between signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1, a marker of endothelial dysfunction and platelet activation, and the development of preeclampsia.
In this observational cross-sectional study conducted between April 2021 and December 2022, 73 consecutive pregnant women with preeclampsia and 73 healthy pregnant women were included. Blood samples were taken from all patients with preeclampsia to measure signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 levels at the time of hospitalization. Excluded from the study were pregnant women with certain medical conditions or treatments, and the signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 levels of the groups were compared according to the development of preeclampsia.
Signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 levels were significantly higher in the preeclampsia group than in the controls (p<0.001). In multivariate analysis, signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 was determined as an independent predictor for preeclampsia (OR: 1.678, 95%CI 1.424-1.979, p<0.001). Receiver operating characteristic curve analysis showed that the best cutoff value of signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 at 3.25 ng/mL predicted the development of preeclampsia with 71% sensitivity and 68% specificity (area under the curve, 0.739; 95% confidence ınterval (95%CI), 0.681-0.798, p<0.001).
Signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 is significantly elevated in pregnant women with preeclampsia compared with healthy controls.
In holometabolous insects, many tissues and organs such as the fat body and midgut undergo a remodeling process during metamorphosis. Larval fat body cells are eliminated by programmed cell death ...(PCD), while tissue cells that adapt to adult life are formed by stem cells. In this study, we analyzed the features of the remodeling period of Galleria mellonella fat body in terms of PCD types, apoptotic and autophagic cell death characteristics. Besides, the effects of juvenile hormone (JH) on these processes were evaluated under the modified hormonal conditions via applications of JH analog, fenoxycarb. Several hallmarks of apoptotic and autophagic cell death were analyzed by morphological, biochemical, and molecular methods. The results of the present study have ascertained that the degeneration process of larval cells occurs via autophagic cell death accompanied by caspase‐3 activity during the pupal period and it is regulated by 20‐hydroxyecdysone (20HE) mediated by ecdysone receptor B1 (EcR‐B1). Increased activity of the acid phosphatase and upregulation of ATG6 and ATG8 in parallel with the formation of autophagosomes in the fat body of Galleria during the pupal period strongly indicated that autophagy was the key player in the remodeling processes.
Programmed cell death characteristics of Galleria mellonella fat body remodeling under the effects of fenoxycarb application.
Research Highlights
Fenoxycarb application on day 0 of the last larval instar (7. instar) caused extra larval molting and prevented the fat body remodeling process.
No acceptable markers of apoptotic cell death properties were detected except for caspase‐3 enzyme activity.
The degeneration process of larval cells occurs via autophagic cell death accompanied by caspase‐3 activity during the pupal period.
The period is regulated by 20‐hydroxyecdysone (20HE) mediated by ecdysone receptor B1 (EcR‐B1).
Insect growth regulators are specific chemicals with hormonal effects on insects and these types of chemicals target to reduce the nonspecific effects of pesticides on nature and living things. In ...this study, we investigated the effects of one of the insect growth regulators, fenoxycarb which mimics the juvenile hormone action, on the growth of a harmful lepidopteran species Galleria mellonella, and it’s some developmental parameters. For this purpose, fenoxycarb was applied on day 0 of 7th instar larvae of the greater wax moth, Galleria mellonella. The treatment with 100 ng fenoxycarb had no developmental effect on Galleria mellonella larvae. The treatment with relatively high doses of fenoxycarb on day 0 induced the supernumerary larvae formation of 99% and larvae which molted extra larval instar formed healthy pupae in the ratio of 98-99%. Consequently, the effects of fenoxycarb on Galleria mellonella larvae occurred in a dose-dependent manner. Although fenoxycarb is a potent insect growth regulator, late Galleria mellonella larvae are not susceptible to this chemical, unlike some other Lepidopter insect species.
In this clinical, randomized, prospective study, we compared the effects of three different analgesia techniques (thoracic epidural analgesia TEA with and without preoperative initiation and IV ...patient-controlled analgesia IV-PCA) on postthoracotomy pain in 69 patients. In two groups, a thoracic epidural catheter was inserted preoperatively. Group Pre-TEA had bupivacaine and morphine solution preoperatively and intraoperatively. Postoperative analgesia was maintained with epidural PCA with a similar solution. Group Post-TEA, with no intraoperative medication, had the same postoperative analgesia as Group Pre-TEA plus the bolus dose. Group IV-PCA received only IV-PCA with morphine for postoperative analgesia. Pain was evaluated every 4 h during the first 48 h at rest, cough, and movement. Pre-TEA was associated with decreased pain compared with the other groups. Six months later, the patients were asked about their pain. The incidence and the intensity of pain were most frequent in Group IV-PCA (78%) and were the least in Group Pre-TEA (45%) (Group Pre-TEA versus Group IV-PCA, P = 0.0233; Group Pre-TEA versus Group IV-PCA, P = 0.014). Patients having pain on the second postoperative day had 83% chronic pain. TEA with preoperative initiation is a preferable method in preventing acute and long-term thoracotomy pain.
Preoperatively initiated thoracic epidural analgesia has the most satisfying results in controlling postthoracotomy pain in the acute and long-term period, and it is associated with a decreased incidence (and intensity) of chronic pain compared with postoperative (epidural or IV) analgesia. Chronic pain has an incidence of 62%.
Paratesticular mesotheliomas are very rare tumors. In this paper, we present the management of a 38-year-old male patient with paratesticular malignant mesothelioma who was initially misdiagnosed and ...treated as recurrent epididymitis. After the final pathology report defining paratesticular mesothelioma during scrotal exploration, he underwent radical orchiectomy and hemiscrotal excision as a complementary, secondary procedure. His metastatic workup did not show any dissemination. Therefore, he did not receive any adjuvant treatment and remained disease-free for more than 2 years.
Coronary subclavian steal syndrome refers to decreased or reversed internal mammary artery flow, which causes angina related to severe subclavian steno-occlusive disease in patients with in situ ...internal mammary-to-coronary artery graft. We present a 48-year-old man with cerebrovascular and peripheral artery disease and the first case in the literature of a saphenous vein graft-coronary-subclavian unidirectional steal syndrome.
Amaç: Sistemik hipotermi terimi insan vücudunun 35° C’den daha aşağı düşecek kadar soğuduğunu belirtmek için kullanılır. Bu durum, vücudun ısı kaybının ısı yapımını aştığı zaman meydana gelir. Kaza ...sonucu meydana gelen hipoterminin en sık nedeni ısı derecesi düşük olan bir ortama maruz kalmadır. Hipotermi tehlikeli fizyolojik değişikliklere ve hatta ölüme neden olabilir. Bu çalışmada hipotermiye bağlı ölüm olgularının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: 2000-2008 yılları arasında Konya Adli Tıp Şube Müdürlüğü tarafından ve Konya’ya bağlı ilçelerde adli tıp uzmanı tarafından otopsileri yapılan olgular retrospektif olarak taranmış ve ölümü hipotermiye bağlı olan olgular çalışma kapsamına alınmıştır. Bulgular: Çalışmaya dahil edilen dönemde 12 hipotermiye bağlı ölüm olgusu saptanmıştır. Olguların 11’i erkek, 1’i kadındır. Olguların yaşları 41 ile 85 arasında değişmekte olup, ortalama yaş 57.0±15.4 bulunmuştur. Ölümler en sık 5 olgu ile Ocak ayında meydana gelmiştir. Olguların 4’ü tarlada, 3’ü metruk binada bulunmuştur. 6 olguda psikiyatrik hastalık öyküsü mevcuttur. Histopatolojik incelemede 5 olguda enzimatik yağ nekrozu bulguları tespit edilmiştir. Sonuç: Hipotermiye bağlı ölümler, toplum sağlığı açısından önemli olduğu gibi, adli tıbbi açıdan da önemlidir. Bu tür olgularda, olay yeri incelemesi, olgunun tıbbi özgeçmişinin ayrıntılı bir şekilde incelenmesi, dikkatli bir şekilde yapılacak otopsi ve histopatolojik inceleme tanı konulmasını kolaylaştırır
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