1.
|
-
Single‐Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study
Neutel, Joel M.; Mancia, Giusepe; Black, Henry R. ...
The journal of clinical hypertension (Greenwich, Conn.),
April 2012, Letnik:
14, Številka:
4
Journal Article
Recenzirano
Odprti dostop
J Clin Hypertens (Greenwich). 2012;14:206–215. ©2012 Wiley Periodicals, Inc.
This 8‐week, randomized, double‐blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) ...
single‐pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure SBP/DBP ≥180/95 mm Hg). At 8 weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (−47.5 mm Hg/−18.7 mm Hg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6 weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment‐related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.
|
Celotno besedilo
PDF
|
2.
|
|
Preverite dostopnost
|
3.
|
|
Preverite dostopnost
|
4.
|
|
Preverite dostopnost
|
5.
|
|
Preverite dostopnost
|
6.
|
|
Preverite dostopnost
|
7.
|
|
Preverite dostopnost
|
8.
|
|
Preverite dostopnost
|
9.
|
|
Preverite dostopnost
|
10.
|
|
Preverite dostopnost
|
