A strategic approach to COVID-19 vaccine R&D Corey, Lawrence; Mascola, John R; Fauci, Anthony S ...
Science (American Association for the Advancement of Science),
05/2020, Letnik:
368, Številka:
6494
Journal Article
Background. Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza ...pandemics. Methods. We examined relevant information from the most recent influenza pandemic that occurred during the era prior to the use of antibiotics, the 1918–1919 “Spanish flu”; pandemic. We examined lung tissue sections obtained during 58 autopsies and reviewed pathologic and bacteriologic data from 109 published autopsy series that described 8398 individual autopsy investigations. Results. The postmortem samples we examined from people who died of influenza during 1918–1919 uniformly exhibited severe changes indicative of bacterial pneumonia. Bacteriologic and histopathologic results from published autopsy series clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory-tract bacteria in most influenza fatalities. Conclusions. The majority of deaths in the 1918–1919 influenza pandemic likely resulted directly from secondary bacterial pneumonia caused by common upper respiratory-tract bacteria. Less substantial data from the subsequent 1957 and 1968 pandemics are consistent with these findings. If severe pandemic influenza is largely a problem of viral-bacterial copathogenesis, pandemic planning needs to go beyond addressing the viral cause alone (e.g., influenza vaccines and antiviral drugs). Prevention, diagnosis, prophylaxis, and treatment of secondary bacterial pneumonia, as well as stockpiling of antibiotics and bacterial vaccines, should also be high priorities for pandemic planning.
Covid-19 - Navigating the Uncharted Fauci, Anthony S; Lane, H Clifford; Redfield, Robert R
The New England journal of medicine,
03/2020, Letnik:
382, Številka:
13
Journal Article
B cells in HIV infection and disease Moir, Susan; Fauci, Anthony S
Nature reviews. Immunology,
200904, 2009-Apr, 2009-04-00, 20090401, Letnik:
9, Številka:
4
Journal Article
Recenzirano
Odprti dostop
In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction ...of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.
SARS-CoV-2 Viral Variants-Tackling a Moving Target Mascola, John R; Graham, Barney S; Fauci, Anthony S
JAMA : the journal of the American Medical Association,
04/2021, Letnik:
325, Številka:
13
Journal Article
Universal Coronavirus Vaccines - An Urgent Need Morens, David M; Taubenberger, Jeffery K; Fauci, Anthony S
The New England journal of medicine,
01/2022, Letnik:
386, Številka:
4
Journal Article
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