To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC).
A case-control study.
An academic institute ...laboratory.
Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.
Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.
The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.
The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
Botulinum exotoxin A has been used for the treatment of glabellar frown lines. Despite this fact, the effect of the toxin is sometimes either partial or lost in a short time. The muscles responsible ...for frowning, the corrugator supercilii and depressor supercilii muscles, are attached to the periosteum in the glabellar region under the frontalis muscle deep in the medial aspect. The muscles then course laterally and superficially to insert in the skin superior to the eyebrows. Thus, to get a long-lasting and full effect, the exotoxin has been applied deeply in the medial aspect and superficially in the lateral aspect of the glabellar region. It is concluded that botulinum exotoxin is more effective when it is applied in two planes superficially and deep so that the anatomic course of the corrugator supercilii and the depressor supercilii muscles are followed.
Amazia with midface anomaly: case report Ozsoy, Zafer; Gozu, Aydin; Ozyigit, Murat Turker ...
Aesthetic plastic surgery,
08/2007, Letnik:
31, Številka:
4
Journal Article
Recenzirano
Amazia, the absence of the mammary gland, is a very rare congenital anomaly of the breasts. Bilateral absence of the breasts may occur as an isolated anomaly or may be associated with a syndrome or a ...cluster of other anomalies. Although the literature examining pediatric breast abnormalities is replete with case reports and series, bilateral amazia together with skeletal anomalies has not yet been described. An unusual case of amazia associated with face, limb, and vertebrae anomalies is presented.
Congenital fusion of the maxillary alveolar process and mandible is a very rare entity. A one day old male newborn was referred to our clinic with a diagnosis of a ‘absence of oral cavity’. Physical ...examination revealed that there was no mouth opening bilaterally in the posterior region due to maxillary and mandibular bone fusion; and in the front there was only 1 mm of mouth opening. Examination of the intraoral space could not be achieved. No other congenital anomaly was detected on general examination. The infant, who was fed via a nasogastric tube for 1 month, was operated on. An intra-oral device which separated maxillary and mandibular alveolar arches from each other was designed and used for 8 weeks to avoid recurrence of the fusion: An adequate mouth opening was obtained and the infant could be fed orally.
Vascular malformations in the pediatric upper extremity remain a diagnostic and therapeutic challenge. Recent knowledge about diagnosis and treatment is provided including specific markers, imaging ...techniques, and management.
JUVENILE BREAST HYPERTROPHY Aydın Gözü; Fatma Nilay Yoğun; Zafer Özsoy ...
European journal of breast health,
07/2010, Letnik:
6, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Juvenile breast hypertrophy or juvenile gigantomastia is a rare disease characterized with rapid and excessive growth of the breast during adolescence. Although the deformity is benign, it affects ...patients physically and psychologically. Surgical approach is the primary treatment option, but timing for the operation is highly debated. A twelve year-old girl who is assessed by our institution because of over-growth of breast was followed for three months with a diagnosis of juvenile breast hypertrophy. No growth was observed, therefore reduction mammoplasty was performed. There were no problems during recovery and during two years of follow-up, no recurrence occurred. The treatment plan for giant breast deformity in adolescents should be determined according to the clinical condition of the patient. The end of adolescence may be the best for surgical treatment, however, benefits of early intervention following an appropriate follow-up should be considered as well.
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