The ripple field known as “El Dorado” was a unique stop on Spirit's traverse where dust‐raising, active mafic sand ripples and larger inactive coarse‐grained ripples interact, illuminating several ...long‐standing issues of Martian dust mobility, sand mobility, and the origin of transverse aeolian ridges. Strong regional wind events endured by Spirit caused perceptible migration of ripple crests in deposits SSE of El Dorado, erasure of tracks in sandy areas, and changes to dust mantling the site. Localized thermal vortices swept across El Dorado, leaving paths of reduced dust but without perceptibly damaging nearly cohesionless sandy ripple crests. From orbit, winds responsible for frequently raising clay‐sized dust into the atmosphere do not seem to significantly affect dunes composed of (more easily entrained) sand‐sized particles, a long‐standing paradox. This disparity between dust mobilization and sand mobilization on Mars is due largely to two factors: (1) dust occurs on the surface as fragile, low‐density, sand‐sized aggregates that are easily entrained and disrupted, compared with clay‐sized air fall particles; and (2) induration of regolith is pervasive. Light‐toned bed forms investigated at Gusev are coarse‐grained ripples, an interpretation we propose for many of the smallest linear, light‐toned bed forms of uncertain origin seen in high‐resolution orbital images across Mars. On Earth, wind can organize bimodal or poorly sorted loose sediment into coarse‐grained ripples. Coarse‐grained ripples could be relatively common on Mars because development of durable, well‐sorted sediments analogous to terrestrial aeolian quartz sand deposits is restricted by the lack of free quartz and limited hydraulic sediment processing.
Rectal evacuation disorders are common among constipated patients. We aimed to evaluate the accuracy of an investigational point-of-care test (rectal expulsion device RED) to predict outcomes with ...community-based pelvic floor physical therapy.
We enrolled patients meeting Rome IV criteria for functional constipation failing fiber/laxatives for more than 2 weeks. RED was inserted and self-inflated, and then time-to-expel was measured in a left lateral position. All patients underwent empiric community-based pelvic floor physical therapy in routine care with outcomes measured at 12 weeks. The primary end point was global clinical response (Patient Assessment of Constipation Symptoms score reduction, >0.75 vs baseline). Secondary end points included improvement in health-related quality-of-life (Patient Assessment of Constipation Quality of Life score reduction, >1.0) and complete spontaneous bowel movement frequency (Food and Drug Administration complete spontaneous bowel movement responder definition).
Thirty-nine patients enrolled in a feasibility phase to develop the use-case protocol. Sixty patients enrolled in a blinded validation phase; 52 patients (mean, 46.9 y; 94.2% women) were included in the intention-to-treat analysis. In the left lateral position, RED predicted global clinical response (generalized area under the curve gAUC, 0.67; 95% CI, 0.58-0.76), health-related quality-of-life response (gAUC, 0.67; 95% CI, 0.58-0.77; P < .001), and complete spontaneous bowel movement response (gAUC, 0.63; 95% CI, 0.57-0.71; P < .001). As a screening test, a normal RED effectively rules out evacuation disorders (expected clinical response, 8.9%; P = .042). Abnormal RED in the left lateral position (defined as expulsion within 5 seconds or >120 seconds) predicted 48.9% clinical response to physical therapy. A seated maneuver enhanced the likelihood of clinical response (71.1% response with seated RED retained >13 seconds) but likely is unnecessary in most settings.
RED offers an opportunity to disrupt the paradigm by offering a personalized approach to managing chronic constipation in the community (Clinicaltrials.gov: NCT04159350).
We performed a clinical trial that aimed to inform the clinical utility of anorectal manometry (ARM) and balloon expulsion time (BET) as up-front tests to predict outcomes with community-based pelvic ...floor physical therapy as the next best step to address chronic constipation after failing an empiric trial of soluble fiber supplementation or osmotic laxatives.
We enrolled 60 treatment-naïve patients with Rome IV functional constipation failing 2 weeks of soluble fiber supplementation or osmotic laxatives. All patients underwent ARM/BET (London protocol) followed by community-based pelvic floor physical therapy. Outcomes were assessed at baseline and 12 weeks. The primary end point was clinical response (Patient Assessment of Constipation-Symptoms instrument).
Fifty-three patients completed pelvic rehabilitation and the post-treatment questionnaire. Contemporary frameworks define dyssynergia on balloon expulsion time and dyssynergic patterns (ARM), but these parameters did not inform clinical outcomes (area under the curve AUC, <0.6). Squeeze pressure (>192.5 mm Hg on at least 1 of 3 attempts; sensitivity, 47.6%; specificity, 83.9%) and limited squeeze duration (inability to sustain 50% of squeeze pressure for >20 seconds; sensitivity, 71.4%; specificity, 58.1%) were the strongest predictors of clinical outcomes. Combining BET with squeeze duration (BET greater than 6.5 seconds and limited squeeze duration) improved predictive accuracy (AUC, 0.75; 95% CI, 0.59-0.90). BET poorly predicted outcomes as a single test (AUC, 0.54; 95% CI, 0.38-0.69).
Using ARM to evaluate squeeze profiles, rather than dyssynergia, appears useful to screen patients with chronic constipation for up-front pelvic floor physical therapy based on likelihood of response. BET appears noninformative as a single screening test (ClinicalTrials.gov: NCT04159350).
Erosion rates derived from the Gusev cratered plains and the erosion of weak sulfates by saltating sand at Meridiani Planum are so slow that they argue that the present dry and desiccating ...environment has persisted since the Early Hesperian. In contrast, sedimentary rocks at Meridiani formed in the presence of groundwater and occasional surface water, and many Columbia Hills rocks at Gusev underwent aqueous alteration during the Late Noachian, approximately coeval with a wide variety of geomorphic indicators that indicate a wetter and likely warmer environment. Two-toned rocks, elevated ventifacts, and perched and undercut rocks indicate localized deflation of the Gusev plains and deposition of an equivalent amount of sediment into craters to form hollows, suggesting average erosion rates of approx.0.03 nm/yr. Erosion of Hesperian craters, modification of Late Amazonian craters, and the concentration of hematite concretions in the soils of Meridiani yield slightly higher average erosion rates of 1-10 nm/yr in the Amazonian. These erosion rates are 2-5 orders of magnitude lower than the slowest continental denudation rates on Earth, indicating that liquid water was not an active erosional agent. Erosion rates for Meridiani just before deposition of the sulfate-rich sediments and other eroded Noachian areas are comparable with slow denudation rates on Earth that are dominated by liquid water. Available data suggest the climate change at the landing sites from wet and likely warm to dry and desiccating occurred sometime between the Late Noachian and the beginning of the Late Hesperian (3.7-3.5 Ga).
The morphology and topography of volcanic landforms provide critical information to the investigation of their tectonic setting and the physical characteristics (e.g., rheology) of their eruption ...products. Their investigation is also an important prerequisite for studies of comparative planetology, (e.g., the comparison between surface features of the Earth and other planetary bodies). Numerous small and low shield volcanoes on Mars and associated vents and lava flows have previously been compared to terrestrial plains-style volcanism, which is defined as being an intermediate style between flood basalts and the Hawai'ian shields. This study investigates the topography and morphology of Martian landforms associated with plains volcanism using MOLA, MOC, THEMIS, HRSC, and HiRISE data. Low shields and other landforms of plains volcanism on Mars display similarities with terrestrial basaltic volcanic fields, and we do not observe any features that do not have morphologic analogues on Earth. The most typical landforms of Martian plains-style volcanism are low shields, defined as volcanic shields with diameters of typically less than 50 km, heights of a few hundred meters only, and extremely shallow flank slopes of less than 0.5°. Other surface features related to plains-style volcanism on Mars are craters, fissure vents, cinder and spatter cones, lava flows (that are commonly associated with lava channels and tubes), lava inflation features, and volcanic rift zones. Our results reconfirm the Viking Orbiter-based conclusion that plains volcanism in the eastern Snake River Plains is perhaps the best terrestrial morphological analogue for these Martian surface features. Icelandic shields, distinct structures in Hawai'i, and other basaltic landforms also show similarities to Martian plains volcanism. Sinuous rilles, previously not described in association with plains volcanism on Mars, are interpreted as evidence for high eruption rates. The extremely shallow flank slopes of the low shields suggest the eruption of shield-building lavas with low viscosity, which might be the result of high eruption temperatures, high effusion rates, a low Si- and a high Mg-content along with a possible high Fe-content, or a combination of these factors. The spatial distribution of low shield clusters in Tharsis does not show any obvious association with large-scale tectonic features. Plains volcanism might represent a relatively recent type of volcanism on Mars, which is not related to mantle plumes but to a zone of partial melting in an anomalously warm mantle underneath a thickened crust (Schumacher and Breuer, Geophys. Res. Lett. 34, L14202, doi: 10.1029/2007GL030083, 2007).
The Mars Exploration Rover Spirit and its Athena science payload have been used to investigate a landing site in Gusev crater. Gusev is hypothesized to be the site of a former lake, but no clear ...evidence for lacustrine sedimentation has been found to date. Instead, the dominant lithology is basalt, and the dominant geologic processes are impact events and eolian transport. Many rocks exhibit coatings and other characteristics that may be evidence for minor aqueous alteration. Any lacustrine sediments that may exist at this location within Gusev apparently have been buried by lavas that have undergone subsequent impact disruption.
The martian surface is a natural laboratory for testing our understanding of the physics of aeolian (wind-related) processes in an environment different from that of Earth. Martian surface markings ...and atmospheric opacity are time-variable, indicating that fine particles at the surface are mobilized regularly by wind. Regolith (unconsolidated surface material) at the Mars Exploration Rover Opportunity's landing site has been affected greatly by wind, which has created and reoriented bedforms, sorted grains, and eroded bedrock. Aeolian features here preserve a unique record of changing wind direction and wind strength. Here we present an in situ examination of a martian bright wind streak, which provides evidence consistent with a previously proposed formational model for such features. We also show that a widely used criterion for distinguishing between aeolian saltation- and suspension-dominated grain behaviour is different on Mars, and that estimated wind friction speeds between 2 and 3 m s-1, most recently from the northwest, are associated with recent global dust storms, providing ground truth for climate model predictions.
The Mars Exploration Rover Opportunity has investigated the landing site in Eagle crater and the nearby plains within Meridiani Planum. The soils consist of fine-grained basaltic sand and a surface ...lag of hematite-rich spherules, spherule fragments, and other granules. Wind ripples are common. Underlying the thin soil layer, and exposed within small impact craters and troughs, are flat-lying sedimentary rocks. These rocks are finely laminated, are rich in sulfur, and contain abundant sulfate salts. Small-scale cross-lamination in some locations provides evidence for deposition in flowing liquid water. We interpret the rocks to be a mixture of chemical and siliciclastic sediments formed by episodic inundation by shallow surface water, followed by evaporation, exposure, and desiccation. Hematite-rich spherules are embedded in the rock and eroding from them. We interpret these spherules to be concretions formed by postdepositional diagenesis, again involving liquid water.
Outcrop exposures of sedimentary rocks at the Opportunity landing site (Meridiani Planum) form a set of genetically related strata defined here informally as the Burns formation. This formation can ...be subdivided into lower, middle, and upper units which, respectively, represent eolian dune, eolian sand sheet, and mixed eolian sand sheet and interdune facies associations. Collectively, these three units are at least 7 m thick and define a “wetting-upward” succession which records a progressive increase in the influence of groundwater and, ultimately, surface water in controlling primary depositional processes.
The Burns lower unit is interpreted as a dry dune field (though grain composition indicates an evaporitic source), whose preserved record of large-scale cross-bedded sandstones indicates either superimposed bedforms of variable size or reactivation of lee-side slip faces by episodic (possibly seasonal) changes in wind direction. The boundary between the lower and middle units is a significant eolian deflation surface. This surface is interpreted to record eolian erosion down to the capillary fringe of the water table, where increased resistance to wind-induced erosion was promoted by increased sediment cohesiveness in the capillary fringe. The overlying Burns middle unit is characterized by fine-scale planar-laminated to low-angle-stratified sandstones. These sandstones accumulated during lateral migration of eolian impact ripples over the flat to gently undulating sand sheet surface. In terrestrial settings, sand sheets may form an intermediate environment between dune fields and interdune or playa surfaces. The contact between the middle and upper units of the Burns formation is interpreted as a diagenetic front, where recrystallization in the phreatic or capillary zones may have occurred. The upper unit of the Burns formation contains a mixture of sand sheet facies and interdune facies. Interdune facies include wavy bedding, irregular lamination with convolute bedding and possible small tepee or salt-ridge structures, and cm-scale festoon cross-lamination indicative of shallow subaqueous flows marked by current velocities of a few tens of cm/s. Most likely, these currents were gravity-driven, possibly unchannelized flows resulting from the flooding of interdune/playa surfaces. However, evidence for lacustrine sedimentation, including mudstones or in situ bottom-growth evaporites, has not been observed so far at Eagle and Endurance craters.
Mineralogical and elemental data indicate that the eolian sandstones of the lower and middle units, as well as the subaqueous and eolian deposits of the Burns upper unit, were derived from an evaporitic source. This indirectly points to a temporally equivalent playa where lacustrine evaporites or ground-water-generated efflorescent crusts were deflated to provide a source of sand-sized particles that were entrained to form eolian dunes and sand sheets. This process is responsible for the development of sulfate eolianites at White Sands, New Mexico, and could have provided a prolific flux of sulfate sediment at Meridiani. Though evidence for surface water in the Burns formation is mostly limited to the upper unit, the associated sulfate eolianites provide strong evidence for the critical role of groundwater in controlling sediment production and stratigraphic architecture throughout the formation.
Friedreich ataxia (FRDA) is a neurodegenerative disease caused by mutations in the frataxin (FXN) gene, resulting in reduced expression of the mitochondrial protein frataxin. Improved understanding ...of the pathophysiology of the disease has led to a growing need for informative biomarkers to assess disease progression and response to therapeutic intervention.
To evaluate the performance of frataxin measurements as a diagnostic tool using two different immunoassays.
Clinical and demographic information was provided through an ongoing longitudinal natural history study on FRDA. Frataxin protein levels from multiple cell types in controls, carriers and FRDA patients were measured and compared using a lateral flow immunoassay and a Luminex xMAP-based immunoassay. Receiver operating characteristic curve analyses were then performed to evaluate the sensitivity, specificity, and positive and negative predictive values for each immunoassay.
For whole blood and buccal cells, analysing FRDA patients and carriers together in a cohort resulted in higher sensitivities and positive predictive values compared with analyzing controls and carriers together, with similar results between each tissue type. We then compared the usefulness of a lateral flow immunoassay with a multianalyte Luminex xMAP-based immunoassay, and showed that both assays demonstrate high positive predictive values with low rates of false negatives and false positives.
Frataxin measurements from peripheral tissues can be used to identify FRDA patients and carriers. While multiple cell types and assays may be useful for diagnostic purposes, each assay and cell type used has its advantages and disadvantages depending on study design and scope.
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