Aminotriazine 5-HT 7 antagonists Mattson, Ronald J; Denhart, Derek J; Catt, John D ...
Bioorganic & medicinal chemistry letters,
2004, Letnik:
14, Številka:
16
Journal Article
Recenzirano
A series of aminotriazines as novel 5-HT
7 receptor antagonists are discussed. Compounds
10 and
17 have high affinity for the 5-HT
7 receptor, produce no agonist effects by themselves, and shift the ...dose–response curve of 5-CT to the right in the manner of an antagonist.
The present studies have identified a series of aminotriazines as novel 5-HT
7 receptor antagonists. Compounds
10 and
17 have high affinity for the 5-HT
7 receptor and do not bind to either the 5-HT
2C or 5-HT
6 receptors. These compounds produce no agonist effects by themselves, and shift the dose–response curve of 5-CT to the right in the manner of an antagonist.
By analyzing nature condition of Yalu River estuary part and many domestic and overseas rivers esturary regulation experience,the regulation principles are put forward and the regulation aim is ...confirmed according to the requirement of west project of china. By numerical model, the regulation measures on baided channel in Yalu River Estuary have been studied. Two measures are recommended by the research.One which is single dredging way,can be as the 1st stage regulation measure;the other measure which is mixed way of regulation and dredging way,can be as the 2nd stage regulation measure.
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