Fibrewise soft ideal topological space Yousif, Yousif Y; Ghafel, Mohammed A H
Journal of physics. Conference series,
05/2018, Letnik:
1003, Številka:
1
Journal Article
Recenzirano
Odprti dostop
In this work we explain and discuss new notion of fibrewise topological spaces, called fibrewise soft ideal topological spaces, Also, we show the notions of fibrewise closed soft ideal topological ...spaces, fibrewise open soft ideal topological spaces and fibrewise soft near ideal topological spaces.
In this work, chitosan/graphene nanocomposite granules with weight percentages of 0.5%, 1%, 2% and 5% were prepared using a solution method. At first, graphene was oxidized with sulfuric and nitric ...acid then triethylenetetramine was grafted on graphene surface. Functionalized graphene was characterized by Fourier-transform infrared spectroscopy (FT-IR), Therapeutic Goods Administration (TGA), X-ray energy diffraction spectroscopy (EDX) and Scanning electron microscope (SEM). Results showed functionalization of graphene was successfully accomplished. The thermogravimetric analysis curves showed the pristine, oxidized and functionalized graphenes are stable up to 400, 250, and 300, respectively. The pristine graphenes are more stable than oxidized graphenes and the oxidized graphenes are more stable than functionalized graphenes. The observed stabilized temperature is known to be strongly influenced by the step of the functionalization. The morphology of nanocomposite was monitored by Scanning electron microscope (SEM). The SEM images showed that the porosity was reduced due to presence of nano graphenes. Results showed that the nanocomposite samples have higher potential for ion metals adsorption than that of neat chitosan. The adsorption of nano samples for cadmium was increased around 20% in comparison to neat chitosan. Atomic adsorption spectrometry showed that the optimal adsorption rate of cadmium ion occurs in a solution of 50 ppm with a pH = 7 and a contact time of 2 hours and an adsorbent of 25 mg.
The current work introduces a new nanostructure of Ce
3+
-doped NiO nanodisks fabricated by a facile hydrothermal protocol, whose characteristics were determined using XRD, SEM and EDX techniques. ...The results confirmed the presence of nanodisk structures, huge surface area and large pore size. Then, the surface of a screen-printed electrode was modified with the as-fabricated nanostructure to achieve a sensitive and selective electrochemical sensor (Ce
3+
-NiO ND/SPE) for determination of Plavix, a cardiovascular drug. Differential pulse voltammetry chronoamperometry and cyclic voltammetry were utilized to monitor the electrochemical behaviors of drug on the surface of modified electrode. The synergetic impact of Ce-doped NiO nanodisks on the Plavix oxidation was due to increased oxidation peak current and decreased oxidation over-potential. Our novel sensor under the optimized experimental and instrumental circumstances could electrochemically determine the study analyte in the range as wide as 0.01 to 700.0 µM and a limit of detection as narrow as 8.3 nM. The practical capability and sensitivity of the proposed sensor were validated by determining the Plavix in real pharmaceutical preparations, with commendable obtains.
Graphical abstract
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor ...growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.
Numerical studies were performed to estimate the heat transfer and hydrodynamic properties of a forced convection turbulent flow using three-dimensional horizontal concentric annuli. This paper ...applied the standard k–ε turbulence model for the flow range 1 × 104 ≤ Re ≥ 24 × 103. A wide range of parameters like different nanomaterials (Al2O3, CuO, SiO2 and ZnO), different particle nanoshapes (spherical, cylindrical, blades, platelets and bricks), different heat flux ratio (HFR) (0, 0.5, 1 and 2) and different aspect ratios (AR) (1.5, 2, 2.5 and 3) were examined. Also, the effect of inner cylinder rotation was discussed. An experiment was conducted out using a field-emission scanning electron microscope (FE-SEM) to characterize metallic oxides in spherical morphologies. Nano-platelet particles showed the best enhancements in heat transfer properties, followed by nano-cylinders, nano-bricks, nano-blades, and nano-spheres. The maximum heat transfer enhancement was found in SiO2, followed by ZnO, CuO, and Al2O3, in that order. Meanwhile, the effect of the HFR parameter was insignificant. At Re = 24,000, the inner wall rotation enhanced the heat transfer about 47.94%, 43.03%, 42.06% and 39.79% for SiO2, ZnO, CuO and Al2O3, respectively. Moreover, the AR of 2.5 presented the higher heat transfer improvement followed by 3, 2, and 1.5.
Pancreatic cancer is one of the most lethal malignancies, with a 5-year survival rate of less than 10 %. One of the major challenges in treating pancreatic cancer is the dense stroma and ...extracellular matrix (ECM) that surrounds the tumor, which creates a physical barrier to drug delivery and promotes tumor progression. This rigid stroma limits the infiltration of cytotoxic immune cells and also the penetration of chemotherapeutic agents or other anticancer drugs like immune checkpoint blockers (ICBs). In recent years, nanoparticle-based targeting of the pancreatic tumor stroma and ECM has emerged as an encouraging approach to overcome these challenges and improve treatment outcomes. Nanoparticles are capable of crossing ECM and rigid stroma, thereby delivering antitumor drugs or cells into tumors. This review article provides an overview of the current state of research on nanoparticle-based targeting of pancreatic tumor stroma and ECM. It discusses the various types of nanoparticles that have been developed for this purpose, including liposomes, polymeric nanoparticles, and inorganic nanoparticles, as well as the different targeting strategies that have been employed, such as ligand-mediated targeting like nanoparticles loaded with peptides and small interference RNAs (siRNAs) and stimuli-responsive nanoparticles like acidic and hypoxic-responsive nanoparticles. This review article also discusses the challenges and future directions in this field, such as the need for a better understanding of the tumor stroma in pancreatic malignancies and the development of more effective targeting strategies.
Display omitted
PDF
