Peri must have faced his final years with considerable equanimity. Music was not going to figure much in them, given that he was too old to perform, and probably even more disinclined to compose (see ...the list of works in Appendix C). He also ran up against typical rivalries among the court musicians, resulting in the disputes overLa regina Sant’Orsolain 1624–25 and what appears to have been a feud between Francesca Caccini and the poet Andrea Salvadori that led to the dropping of the opera proposed for the forthcoming wedding of Margherita de’ Medici and Odoardo Farnese,
Scandals and panics Lamoreaux, Naomi R; Safley, Thomas Max; Sylla, Richard ...
Business history review,
04/2009, Letnik:
83, Številka:
1
Journal Article
Italian maiolica has a long history extending back into the Middle Ages. That history recounts a slow evolutionary process, with its main themes being: first, the importation of tin-glazed pottery ...from the Islamic world in the eleventh and twelfth centuries, which has survived primarily as architectural decoration (the
bacini
inserted into church façades); secondly, the development of the local production of ceramics with lead glazes and then improved tin glazes and with modest painted and incised decoration; thirdly, the diffusion of that production, presumably from Sicily and southern Italy, throughout the rest of the peninsula; and, finally, beginning in the later fourteenth century, the elevation of the quality of production to the level of a veritable art form. Our knowledge of this history has been amply expanded in the last few years by an extraordinary amount of very solid research conducted into the subject by medieval archaeologists and by ceramic scholars—many of the latter talented amateurs who work on their own local traditions in Italy; and this lively interest has had reverberations in both the museum world and the art market.
Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, ...and therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes. RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1. Integration of single-cell and bulk transcriptome data predicts diverse cell-of-origin and clarifies RCC subtype-specific proteogenomic signatures. Expression of biomarkers MAPRE3, ADGRF5, and GPNMB differentiates renal oncocytoma from chromophobe RCC, and PIGR and SOSTDC1 distinguish papillary RCC from MTSCC. This study expands our knowledge of proteogenomic signatures, biomarkers, and potential therapeutic targets in non-ccRCC.
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•Subtype-specific features across a pan-RCC cohort revealed by multi-omics data resources•Diverse cell-of-origin predictions and tumor signatures revealed by snRNA-seq•Proteogenomic, metabolic, glycoproteomic signatures of high-wGII tumors•Biomarkers GPNMB, ADGRF5, MAPRE3 for chRCC/RO and PIGR, SOSTDC1 for pRCC
Li et al. perform comprehensive multi-omics characterization of a broad range of renal cell carcinomas, improving our understanding of the biology, proteogenomics, post-translational modifications, and metabolism of kidney cancer. These findings identify important biomarkers IGF2BP3, PYCR1, GPNMB, ADGRF5, MAPRE3, PIGR, and SOSTDC1 that illuminate molecular differences within renal cell carcinoma.
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