The aim of this study was to examine the effects of high (HPBPT) and low percentage ball possession teams (LPBPT) on physical and technical profiles in elite soccer matches. Match performance data ...were collected from players in the English FA Premier League (n = 810) using a multiple-camera computerised tracking system. Physical indicators such as the total (10690 ± 996 vs 10778 ± 979 m; effect size ES = 0.11) and high-intensity running distance covered in matches (931 ± 299 vs 938 ± 311 m; ES = 0.13) did not differ between HPBPT and LPBPT. However, high-intensity running with ball possession in HPBPT was 31% higher (P < 0.01) than LPBPT (449 ± 266 vs 343 ± 236 m; ES = 0.42) but 22% lower without ball possession (423 ± 153 vs 539 ± 177 m; ES = 0.73). Players in HPBPT performed 44% more (P < 0.01) passes than those in LPBPT (35.3 ± 14.2 vs 24.6 ± 11.2; ES = 0.83). This trend was also evident (P < 0.05) for successful passes, received passes, touches per possession, shots, dribbles and final-third entries (ES range of 0.20-0.94). Central defenders of LPBPT covered 33% less (P < 0.01) high-intensity running with ball possession than central defenders of HPBPT. While fullbacks, attackers, central and wide midfielders of LPBPT covered more (P < 0.01) high-intensity running without and less with ball possession than their HPBPT counterparts (ES range of 0.91-1.23). Technical indicators such as total passes and passes received were higher (P < 0.01) across all positions in HPBPT than LPBPT (ES range of 0.82-1.52). The data demonstrate that percentage ball possession does not influence the overall activity profile of a team but impacts on the composition of high-intensity running efforts (with and without ball) and some technical elements of performance. Position-specific changes in physical and technical profiles were evident for teams employing different ball possession percentages and this information could aid training preparation.
Remarkably simple IrIII catalysts enable the isomerization of primary and sec‐allylic alcohols under very mild reaction conditions. X‐ray absorption spectroscopy (XAS) and mass spectrometry (MS) ...studies indicate that the catalysts, with the general formula Cp*IrIII, require a halide ligand for catalytic activity, but no additives or additional ligands are needed.
The allylic job: A remarkably simple and general family of catalysts for isomerizing both primary and sec‐allylic alcohols is reported. The catalysts, with the general formula Cp*IrIII, only require a halide ligand for optimal activity, with no additional additive or ligand needed. A mechanism is proposed based on kinetic investigations and isotopic labeling experiments.
Distinct DNA methylomes of newborns and centenarians Heyn, Holger; Li, Ning; Ferreira, Humberto J. ...
Proceedings of the National Academy of Sciences - PNAS,
06/2012, Letnik:
109, Številka:
26
Journal Article
Recenzirano
Odprti dostop
Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated alterations. To address this issue, we ...performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centenarian DNA had a lower DNA methylation content and a reduced correlation in the methylation status of neighboring cytosine—phosphate—guanine (CpGs) throughout the genome in comparison with the more homogeneously methylated newborn DNA. The more hypomethylated CpGs observed in the centenarian DNA compared with the neonate covered all genomic compartments, such as promoters, exonic, intronic, and intergenic regions. For regulatory regions, the most hypomethylated sequences in the centenarian DNA were present mainly at CpG-poor promoters and in tissue-specific genes, whereas a greater level of DNA methylation was observed in CpG island promoters. We extended the study to a larger cohort of newborn and nonagenarian samples using a 450,000 CpG-site DNA methylation microarray that reinforced the observation of more hypomethylated DNA sequences in the advanced age group. WGBS and 450,000 analyses of middle-age individuals demonstrated DNA methylomes in the crossroad between the newborn and the nonagenarian/centenarian groups. Our study constitutes a unique DNA methylation analysis of the extreme points of human life at a single-nucleotide resolution level.
The Spanish power generation sector is facing dire problems: generation overcapacity, various tariff hikes over recent years, uncertainty over the financial viability of many power plants and a ...regulatory framework that lacks stability. This situation is the consequence of both poor energy policies and the economic crisis in the late 2000s and early 2010s. In this paper we analyze the following three points from an energy planning perspective: how the country has arrived at this situation; whether other alternatives would have been possible through adequate planning; and the quantitative benefits that would have been accrued from such planning. We do so by developing a LEAP model, and building three scenarios that allow to segregate the costs of the economic crisis from the costs of the lack of planning.
We find that appropriate energy planning could have reduced investments in the Spanish power sector by 2010€28.6 billion without compromising on performance in terms of sustainability or energy security, while improving affordability.
The main causes of these surplus investments were two supply bubbles: those of gas combined cycles and of solar technologies. The results of this work highlight the value of rigorous, quantitative energy planning, and the high costs of not doing it.
•We analyze the costs of the lack of quantitative planning for energy-policy making.•We separate the costs of the economic crisis in Spain from the cost of not planning.•We find the “cost of not doing” energy planning to be 28.6 billion 2010EUR.
Electronic (mobile) payment systems are an important aspect of e-commerce. However, few reviews highlight the most significant findings and challenges. In this article, we have prepared a ...bibliometric analysis to provide a statistical overview of previously published research papers on electronic (mobile) payment systems and user preferences, with a particular emphasis on their diverse techniques and analyses, as well as comprehensive and reliable directions to reveal evolutionary nuances and highlighting emerging areas in this specific research. This study reviewed 177 scientific papers published between 2001 and November 2021 in the Web of Science (WoS) database on the subjects of electronic payment systems (EPS) and mobile payment systems (MPS), payment interface (PI), technology acceptance model (TAM), payment frameworks (PF), and user preferences (UP). The amount of studies using the abovementioned topics (EPS, MPS, TAM, PF, and UP) increases annually. Spain, China, and Malaysia are the three main countries that actively participate, and their international academic partnership is relatively close. We have compiled a list of the most relevant publications, prolific authors, institutions, and leading research topics. The articles were used to evaluate bibliometric indicators, analyze research activity, investigate the subject’s evolution, and identify the most interconnected themes. The findings provide a comprehensive overview of existing thematic studies, with a notable rising trend showing the potential for future research in the field. The study provides a guideline for further research.
The city of Valencia (Spain) is famous for its Gothic bridges, built in the 16th century. Today, the bridges no longer cross over the Turia River but have become walkways over one of the most ...extensive gardens in Europe. One of these bridges is the Serranos Bridge, the oldest bridge in the city and for centuries, it was the only one that existed. This research narrates the evolution of the historical changes related to this bridge, using Historic Building Information Modelling (HBIM) technology. The Serranos Bridge (and related Serranos Towers) were recorded with the help of terrestrial laser scanning, and parametric 3D modelling was followed after scan-to-HBIM. By referring to historical documents and traces from the past, the height of the historic wall of the city was obtained and used to recreate the urban footprint of the area. In addition, the details of the historical bridge components and the subsequent volumetric changes were reconstructed through HBIM. This investigation shows that there is a common symbol in the historical bridges of Valencia, called Casilicium, of which no traces can be identified in the present bridge. The effective integration of historical data, geomatics and HBIM can be used to understand the past and its complex transformation over six centuries with unprecedented expectations.
One of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA methylation profiles is ...increasingly recognized. Much of the research effort in this area has examined proximal promoter regions and epigenetic alterations at other loci are not well characterized.
Using whole genome bisulfite sequencing to examine uncharted regions of the epigenome, we identify a type of far-reaching DNA methylation alteration in cancer cells of the distal regulatory sequences described as super-enhancers. Human tumors undergo a shift in super-enhancer DNA methylation profiles that is associated with the transcriptional silencing or the overactivation of the corresponding target genes. Intriguingly, we observe locally active fractions of super-enhancers detectable through hypomethylated regions that suggest spatial variability within the large enhancer clusters. Functionally, the DNA methylomes obtained suggest that transcription factors contribute to this local activity of super-enhancers and that trans-acting factors modulate DNA methylation profiles with impact on transforming processes during carcinogenesis.
We develop an extensive catalogue of human DNA methylomes at base resolution to better understand the regulatory functions of DNA methylation beyond those of proximal promoter gene regions. CpG methylation status in normal cells points to locally active regulatory sites at super-enhancers, which are targeted by specific aberrant DNA methylation events in cancer, with putative effects on the expression of downstream genes.
Abstract
Background
Myocardial revascularization failure (MRF) and Secondary revascularization (SR) are contemporary interventional cardiology challenges.
Aim
To investigate the characteristics, ...management, and prognosis of patients with myocardial revascularization failure (MRF) and need for secondary revascularization (SR) in contemporary practice.
Methods
The REVASEC study is a prospective registry (NCT03349385), which recruited patients with prior revascularization referred for coronary angiography at 19 centers. The primary endpoint is a patient‐oriented composite (POCE) at 1 year, including death, myocardial infarction, or repeat revascularization.
Results
A total of 869 patients previously revascularized by percutaneous intervention (83%) or surgery (17%) were recruited. MRF was found in 83.7% (41.1% stent/graft failure, 32.1% progression of coronary disease, and 10.5% residual disease). SR was performed in 70.1%, preferably by percutaneous intervention (95%). The POCE rate at 1 year was 14% in the overall cohort, with 6.4% all‐cause death. In the multivariate analysis, lower POCE rates were found in the groups without MRF (9.4%) and with disease progression (11%) compared with graft/stent failure (17%) and residual disease (18%), hazard ratio 0.67 (95% confidence interval: 0.45–0.99),
p
= 0.043. At 1 year, the SR group had less chronic persistent angina (19% vs. 34%,
p
< 0.001), but a higher rate of repeat revascularization (9% vs. 2.9%,
p
< 0.001).
Conclusion
MRF was found in 84% of patients with prior revascularization referred for coronary angiography. Stent/graft failure and residual coronary disease were associated with a worse prognosis. SR provided better symptom control at the expense of a higher rate of new revascularization
The global earthquake history Albini, Paola; Musson, Roger M. W; Rovida, Andrea ...
Earthquake spectra,
05/2014, Letnik:
30, Številka:
2
Journal Article
Recenzirano
The study of earthquakes from historical sources, or historical seismology, was considered an early priority for the Global Earthquake Model (GEM) project, which commissioned a study of historical ...seismicity on a global scale. This was the Global Earthquake History (GEH) project, led jointly by the Istituto Nazionale di Geofisica e Vulcanologia (INGV; Milan, Italy) and the British Geological Survey (BGS; UK). GEH was structured around three complementary deliverables: archive, catalog, and the Web infrastructure designed to store both the archive and catalog. The Global Historical Earthquake Archive (GHEA) provides a complete account of the global situation in historical seismology for large earthquakes. From GHEA, the Global Historical Earthquake Catalogue (GHEC v1.0) was derived-a world catalog of earthquakes for the period 1000-1903, with magnitudes of Mw7 and over. Though much remains to be done, the data here presented show that the compilation of both archive and catalog contribute to an improved understanding of the Global Earthquake History.
The main aim was to determine the differences between four training games and competitive matches (CM) according to position and compared to the most demanding passages (MDP) of competitive match ...play. Global Positioning System data were obtained from 21 football players belonging to the reserve squad of a Spanish La Liga club during the 2015/16 season. The training games were small-sided games (SSGs) with 5 and 6 and large-sided games with 9 and 10 outfield players per team. The players were categorized based on positional groups: full back (FB), central defender (CD), midfielder (MF), offensive midfielder (OMF), and forward (FW). The variables recorded were the distance covered (DIS), DIS at high speed (HSR; >19.8 km·h
), DIS at sprint (SPR; >25.2 km·h
), high metabolic load distance (HMLD; >25.5 W·kg
) all in m·min
, average metabolic power (AMP; W·kg
) and number of high-intensity accelerations (ACC; >3 m·s
) and decelerations (DEC; <-3 m·s
), both in n·min
. The MDP was analysed using a rolling average method for AMP as a criterion variable, where maximal values were calculated for time windows of 5 and 10 minutes of CM and after that compared with the training game formats. As the SSG format increases, all the rest of the variables increase and the number of cases with significant interposition differences also increases (effect size ES: DIS: 0.7-2.2; HSR: 0.7-2.1; SPR: 0.8-1.4; HMLD: 0.9-2.0; AMP: 0.8-1.9; ACC: 0.8-1.7; DEC: 0.5-1.7). The large-sided game 10v10 + 2 goalkeepers over-stimulates sprint values relative to MDP (all: 121.0% of MDP, ES=0.5-1.8). This study provides useful information for coaching staff on the heightened impact of different training game formats on physical load, considering positional differences in relation to the MDP of competitive match play.
PDF
