Electromyographic signals (EMGs) are becoming important as a tool for muscle fatigue monitoring. EMGs measure the electric currents produced in muscle contractions providing information that can be ...analyzed and processed to evaluate the conditions of muscles. In this work, we proposed a real-time system that measures muscle fatigue levels based on Electromyographic signals. We used the Mean Frequency and the Power Spectral Density as features for muscle fatigue determination. A linear regression model determines the levels of muscle fatigue. Moreover, the system is composed of EMG wireless sensors allowing it to be used in common activities in the manufacturing industry as manual handling loads.
A beam–beam monitoring detector for the MPD experiment at NICA Alvarado, Mauricio; Ayala, Alejandro; Ayala-Torres, Marco Alberto ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2020, Letnik:
953
Journal Article
Recenzirano
Odprti dostop
The Multi-Purpose Detector (MPD) is to be installed at the Nuclotron Ion Collider fAcility (NICA) of the Joint Institute for Nuclear Research (JINR). Its main goal is to study the phase diagram of ...the strongly interacting matter produced in heavy-ion collisions. These studies, while providing insight into the physics of heavy-ion collisions, are relevant for improving our understanding of the evolution of the early Universe and the formation of neutron stars. In order to extend the MPD trigger capabilities, we propose to include a high granularity beam–beam monitoring detector (BE–BE) to provide a level-0 trigger signal with an expected time resolution of 30 ps. This new detector will improve the determination of the reaction plane by the MPD experiment, a key measurement for flow studies that provides physics insight into the early stages of the reaction.
In this work, we use simulated Au+Au collisions at NICA energies to show the potential of such a detector to determine the event plane resolution, providing further redundancy to the detectors originally considered for this purpose namely, the Fast Forward Detector (FFD) and the Hadron Calorimeter (HCAL). We also show our results for the time resolution studies of two prototype cells carried out at the T10 beam line at the CERN PS complex.
Biological control with
Cryphonectria hypovirus
CHV1 of the chestnut blight, caused by the fungus
Cryphonectria parasitica,
has reduced the impact of the disease in Europe. The virus reduces the ...virulence of the fungus so that it causes non-lethal cankers, thus enabling the chestnut trees to overcome the disease. The virus can be transmitted horizontally by hyphal anastomosis or vertically to the conidia. In this study, we investigated growth and sporulation of the fungus as well as rates of horizontal transmission of the virus at different temperatures. We used fungal isolates of the vegetative compatibility types (vc types) that are most prevalent in Castilla and León (central northern Spain) to evaluate the effects of fungal strain on the parameters tested. In addition, we infected four isolates of
C. parasitica
with hypovirus subtypes CHV1-F1 and CHV1-I, to determine the influence of virus subtype on growth, sporulation and virus transfer. We assessed growth of fungal colonies and horizontal transmission of the virus at 15 °C and 25 °C. Colony growth was affected by an interaction between fungal isolates included in vc type EU1 or EU11 and virus at both 15 °C and 25 °C. However, horizontal transmission of the virus was only influenced by the fungal genotype of isolates included in vc type EU1 or EU11, and spore production was only affected by the virus subtype. Vertical transmission was also influenced by the fungal isolate and virus subtype. Growth of the fungal isolates varied depending on the virus subtype with which they were infected. This supports the theory that fungal host and virus subtype influence transmission and dissemination of hypovirulence. The fungal genotype affects colony growth and horizontal transmission of the virus. It is common to expect a good dissemination of the hypovirus with a low vc type diversity but the selection of the best combination of hypovirus and fungal isolate is crucial for the success of biological control not only for small areas but in larger chestnut populations as well.
We sought to reproduce with quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) the results obtained with a 70-gene expression profile that has been described previously in breast ...cancer.
Frozen breast cancer samples from patients who were operated on were used to isolate tumor RNA. Ninety-six patients with stage I to II disease were included. Median age was 57 years (range, 27 to 80 years). Forty-eight patients had lymph node-negative and 48 lymph node-positive disease. qRT-PCR amplifications were performed and the results were correlated with clinical data.
After a minimum follow-up of 5 years, 25 patients had a relapse. The gene profile divided patients into two groups with poor and good prognosis. Significant differences with regard to grade of differentiation, size and hormone receptors were seen between the two groups. The gene profile was significantly associated with relapse-free survival and overall survival in the whole group of 96 patients. Multivariate analysis showed that only lymph node status and gene profile were significantly correlated to overall survival.
qRT-PCR reproduced the results obtained with microarrays for a prognostic gene profile in women with early-stage breast cancer.
During clinical practice, it can be challenging, given the lack of response biomarkers, to identify the patients with metastatic breast cancer (mbca) who would benefit most from the addition of ...bevacizumab to first-line standard chemotherapy. The aim of the present review was to summarize the relevant scientific evidence and to discuss the experience of a group of experts in using bevacizumab to treat mbca.
A panel of 17 Spanish oncology experts met to discuss the literature and their experience in the use of bevacizumab as first-line treatment for mbca. During the meeting, discussions focused on three main issues: the profile of the patients who could benefit most from bevacizumab, the optimal bevacizumab treatment duration, and the safety profile of bevacizumab.
The subset of mbca patients who would benefit the most from the addition of bevacizumab to first-line standard chemotherapy are those with clinically defined aggressive disease. Treatment with bevacizumab should be maintained until disease progression or the appearance of unacceptable toxicity. In the mbca setting, the toxicity profile of bevacizumab is well known and can be managed in clinical practice after adequate training.
This expert group recommends administering bevacizumab as first-line treatment in patients with clinically aggressive disease.
RESUMEN Introducción: La lesión medular (LM) es un problema médico contemporáneo caracterizado por datos insuficientes sobre prevalencia y debilidad de modelización en metodología. Objetivo: ...Establecer las interrelaciones del estado nutricional y la condición neurológica-funcional con signos clínicos: tiempo y tipo de lesión, nivel de lesión y severidad del trauma raquimedular dorso lumbar. Material y Métodos: Estudio descriptivo transversal de 102 pacientes con trauma raquimedular al ingreso, 85 hombres y 17 mujeres (febrero 2016 - enero de 2020, CIREN) La Habana, Cuba. Se realizó evaluación nutricional, neurológica (nivel, grado y severidad de lesión) mediante escalas ASIA, Independencia SCIM-III e índice de Barthel. Se obtienen medias, desviación estándar, error estándar y análisis de varianza para distribuciones normales. Se utilizó SPSS versión 26. Resultados: La edad promedio fue 29,7 ± 8,1 años. La antigüedad del trauma fue 3,1 ± 1,4 años. La lesión raquimedular ocurrió en 50,6 % del segmento T7- L3 en pacientes con lesión completa. Hubo deficiencia energética crónica (4,9 %), según Índice de Masa Corporal; el 50,6 % fueron ≥ 22 kg/m2, según criterio de riesgo de Nash. El 73,5 % clasificaban en escala A de ASIA. La correlación entre Catz y Barthel demostró asociación significativa (p< 0,01). La disminución de masa muscular, área muscular del brazo, reflectividad y sensibilidad es significativa según antigüedad, tipo, nivel y severidad de lesiones (p< 0,05). Se discute debilidad metodológica de estimaciones para masa muscular esquelética. Conclusiones: Se caracterizan antigüedad de lesión, tono muscular y nivel neurológico de lesión medular como condicionantes interactivos del diagnóstico.
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