This paper compares laboratory measurements of the vortex-induced vibrations of a riser in a stepped current with blind predictions obtained with 11 different numerical models. Results are included ...on in-line and transverse displacements and curvatures, and dominant frequencies. In general, empirical models were more successful at predicting cross-flow displacements and curvatures than current codes based on CFD. Overall ratios between predictions and measurements of cross-flow displacements were around 95% and 75%, respectively. Predictions of cross-flow curvatures were more scattered, and almost all were unconservative. In-line vortex-induced curvatures, which may cause as much damage as cross-flow curvatures, could not be computed by any of the empirically based codes, and in general those based on CFD were in very poor agreement with the measurements.
ABSTRACT
This study investigated the main factors contributing to boron toxicity in plants. Growth was rapidly inhibited by internal B concentrations in the range 1–5 m m across a range of plant ...types that included monocot, dicot and algal species. In contrast, mature cells were able to withstand up to 60 m m B for several days. In wheat, rapid inhibition of root growth occurred if high B was applied to the root tip, but not if high B was applied to mature sections of the root. In leaves, there were gradations in B concentrations that correlated with visible symptoms of toxicity. However, there was no evidence to support the hypothesis that toxicity in leaves is due to osmotic stress induced by the accumulation of B. Analysis of the sensitivity to B of a range of metabolic processes including photosynthesis, respiration and protein synthesis leads to the conclusion that growth is not restricted by effects of B on energy supply and not directly by inhibition of protein synthesis. At higher B concentrations, many cellular activities were found to be partially inhibited and the toxicity to mature tissues was therefore considered not to arise from the disruption of a single process, but from the accumulated retardation of many cellular processes, exacerbated in light by photo‐oxidative stress.
Ultrawide‐bandgap (UWBG) semiconductors, with bandgaps significantly wider than the 3.4 eV of GaN, represent an exciting and challenging new area of research in semiconductor materials, physics, ...devices, and applications. Because many figures‐of‐merit for device performance scale nonlinearly with bandgap, these semiconductors have long been known to have compelling potential advantages over their narrower‐bandgap cousins in high‐power and RF electronics, as well as in deep‐UV optoelectronics, quantum information, and extreme‐environment applications. Only recently, however, have the UWBG semiconductor materials, such as high Al‐content AlGaN, diamond and Ga2O3, advanced in maturity to the point where realizing some of their tantalizing advantages is a relatively near‐term possibility. In this article, the materials, physics, device and application research opportunities and challenges for advancing their state of the art are surveyed.
Ultrawide‐bandgap (UWBG) semiconductors, with bandgaps significantly wider than the 3.4 eV of GaN, represent an exciting and challenging new area of research in semiconductor materials, physics, devices and applications. This article surveys and presents an enumerated list of the materials, physics, device and associated application research opportunities and challenges important for advancing the state of their science and technology.
Abstract Ebola virus causes irregular outbreaks of severe hemorrhagic fever in equatorial Africa. Case mortality remains high; there is no effective treatment and outbreaks are sporadic and ...unpredictable. Studies of Ebola virus vaccine platforms in non-human primates have established that the induction of protective immunity is possible and safety and human immunogenicity has been demonstrated in a previous Phase I clinical trial of a 1st generation Ebola DNA vaccine. We now report the safety and immunogenicity of a recombinant adenovirus serotype 5 (rAd5) vaccine encoding the envelope glycoprotein (GP) from the Zaire and Sudan Ebola virus species, in a randomized, placebo-controlled, double-blinded, dose escalation, Phase I human study. Thirty-one healthy adults received vaccine at 2 × 109 ( n = 12), or 2 × 1010 ( n = 11) viral particles or placebo ( n = 8) as an intramuscular injection. Antibody responses were assessed by ELISA and neutralizing assays; and T cell responses were assessed by ELISpot and intracellular cytokine staining assays. This recombinant Ebola virus vaccine was safe and subjects developed antigen specific humoral and cellular immune responses.
The role and properties of lower hybrid waves in the ion diffusion region and magnetospheric inflow region of asymmetric reconnection are investigated using the Magnetospheric Multiscale (MMS) ...mission. Two distinct groups of lower hybrid waves are observed in the ion diffusion region and magnetospheric inflow region, which have distinct properties and propagate in opposite directions along the magnetopause. One group develops near the ion edge in the magnetospheric inflow, where magnetosheath ions enter the magnetosphere through the finite gyroradius effect and are driven by the ion‐ion cross‐field instability due to the interaction between the magnetosheath ions and cold magnetospheric ions. This leads to heating of the cold magnetospheric ions. The second group develops at the sharpest density gradient, where the Hall electric field is observed and is driven by the lower hybrid drift instability. These drift waves produce cross‐field particle diffusion, enabling magnetosheath electrons to enter the magnetospheric inflow region thereby broadening the density gradient in the ion diffusion region.
Key Points
Two groups of lower hybrid waves are observed in the ion diffusion and magnetospheric inflow regions
In the magnetospheric inflow region lower hybrid waves develop when cold magnetospheric ions are present and can heat cold ions
In the diffusion region lower hybrid waves develop at the density gradient and can cause cross‐field particle diffusion
Data from the NASA Magnetospheric Multiscale mission are used to investigate asymmetric magnetic reconnection at the dayside boundary between the Earth's magnetosphere and the solar wind. ...High‐resolution measurements of plasmas and fields are used to identify highly localized (~15 electron Debye lengths) standing wave structures with large electric field amplitudes (up to 100 mV/m). These wave structures are associated with spatially oscillatory energy conversion, which appears as alternatingly positive and negative values of J · E. For small guide magnetic fields the wave structures occur in the electron stagnation region at the magnetosphere edge of the electron diffusion region. For larger guide fields the structures also occur near the reconnection X‐line. This difference is explained in terms of channels for the out‐of‐plane current (agyrotropic electrons at the stagnation point and guide field‐aligned electrons at the X‐line).
Key Points
Energy conversion is highly localized within asymmetric reconnection electron diffusion regions
Oscillatory reconnection electric fields show characteristics of both spatial structures and propagating waves that are consistent with standing oblique quasi‐electrostatic whistlers
Both positive and negative values of J · E result from uniform current and oscillating electric fields
Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness worldwide
. Both IOP and POAG are highly ...heritable
. We report a combined analysis of participants from the UK Biobank (n = 103,914) and previously published data from the International Glaucoma Genetic Consortium (n = 29,578)
that identified 101 statistically independent genome-wide-significant SNPs for IOP, 85 of which have not been previously reported
. We examined these SNPs in 11,018 glaucoma cases and 126,069 controls, and 53 SNPs showed evidence of association. Gene-based tests implicated an additional 22 independent genes associated with IOP. We derived an allele score based on the IOP loci and loci influencing optic nerve head morphology. In 1,734 people with advanced glaucoma and 2,938 controls, participants in the top decile of the allele score were at increased risk (odds ratio (OR) = 5.6; 95% confidence interval (CI): 4.1-7.6) of glaucoma relative to the bottom decile.
On 5 May 2017, MMS observed a crater‐type flux rope on the dawnside tailward magnetopause with fluctuations. The boundary‐normal analysis shows that the fluctuations can be attributed to nonlinear ...Kelvin‐Helmholtz (KH) waves. Reconnection signatures such as flow reversals and Joule dissipation were identified at the leading and trailing edges of the flux rope. In particular, strong northward electron jets observed at the trailing edge indicated midlatitude reconnection associated with the 3‐D structure of the KH vortex. The scale size of the flux rope, together with reconnection signatures, strongly supports the interpretation that the flux rope was generated locally by KH vortex‐induced reconnection. The center of the flux rope also displayed signatures of guide‐field reconnection (out‐of‐plane electron jets, parallel electron heating, and Joule dissipation). These signatures indicate that an interface between two interlinked flux tubes was undergoing interaction, causing a local magnetic depression, resulting in an M‐shaped crater flux rope, as supported by reconstruction.
Plain Language Summary
Magnetic reconnection and Kelvin‐Helmholtz instability (KHI), two of the most fundamental physical processes occurring within the heliosphere and throughout the Universe, often occur simultaneously on the Earth's magnetopause. Previous studies indicate the importance of nonlinearly developed KH waves, which produce multiple kinetic layers facilitating reconnection both in and out of the velocity shear plane and resulting in the magnetic flux rope. However, these studies significantly lacked detailed in situ observations in quantity as well as appropriate 3‐D analyses of the structure of the KH vortex‐induced flux rope. In this paper, we use detailed observations by the MMS spacecraft to investigate both 2‐D and 3‐D structures of the flux rope developed along the KH waves. We found that two flux tubes interact through reconnection to form a single combined structure, which can explain the occurrence of M‐shaped crater flux rope.
Key Points
MMS observed a magnetic flux rope formed on the boundary of a nonlinear Kelvin‐Helmholtz (KH) wave
Both in‐plane and midlatitude reconnection associated with the 3‐D structure of the KH vortex‐inducedflux rope were identified
A current sheet at the flux rope center supported by reconstruction indicates two flux tubes interlinked to form a crater‐type flux rope
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be prevented through timely diagnosis and treatment. We characterize optic nerve photographs of 67,040 UK Biobank ...participants and use a multitrait genetic model to identify risk loci for glaucoma. A glaucoma polygenic risk score (PRS) enables effective risk stratification in unselected glaucoma cases and modifies penetrance of the MYOC variant encoding p.Gln368Ter, the most common glaucoma-associated myocilin variant. In the unselected glaucoma population, individuals in the top PRS decile reach an absolute risk for glaucoma 10 years earlier than the bottom decile and are at 15-fold increased risk of developing advanced glaucoma (top 10% versus remaining 90%, odds ratio = 4.20). The PRS predicts glaucoma progression in prospectively monitored, early manifest glaucoma cases (P = 0.004) and surgical intervention in advanced disease (P = 3.6 × 10
). This glaucoma PRS will facilitate the development of a personalized approach for earlier treatment of high-risk individuals, with less intensive monitoring and treatment being possible for lower-risk groups.
To establish the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) when screening externally validated cognition in Parkinson disease (PD), by comparison with a PD-focused test (Scales ...for Outcomes in Parkinson disease-Cognition SCOPA-COG) and the standardized Mini-Mental State Examination (S-MMSE) as benchmarks.
A convenience sample of 114 patients with idiopathic PD and 47 healthy controls was examined in a movement disorders center. The 21 patients with dementia (PD-D) were diagnosed using Movement Disorders Society criteria, externally validated by detailed independent functional and neuropsychological tests. The 21 patients with mild cognitive impairment (PD-MCI) scored 1.5 SD or more below normative data in at least 2 measures in 1 of 4 cognitive domains. Other patients had normal cognition (PD-N).
Primary outcomes using receiver operating characteristic (ROC) curve analyses showed that all 3 mental status tests produced excellent discrimination of PD-D from patients without dementia (area under the curve AUC, 87%-91%) and PD-MCI from PD-N patients (AUC, 78%-90%), but the MoCA was generally better suited across both assessments. The optimal MoCA screening cutoffs were <21/30 for PD-D (sensitivity 81%; specificity 95%; negative predictive value NPV 92%) and <26/30 for PD-MCI (sensitivity 90%; specificity 75%; NPV 95%). Further support that the MoCA is at least equivalent to the SCOPA-COG, and superior to the S-MMSE, came from the simultaneous classification of the 3 PD patient groups (volumes under a 3-dimensional ROC surface, chance = 17%: MoCA 79%, confidence interval CI 70%-89%; SCOPA-COG 74%, CI 62%-86%; MMSE-Sevens item 56%, CI 44%-68%; MMSE-World item 62%, CI 50%-73%).
The MoCA is a suitably accurate, brief test when screening all levels of cognition in PD.
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