The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up ...infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke.
To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke.
Patient data from 7 randomized multicenter trials were pooled. These trials were conducted between December 2010 and April 2015 and included 1764 patients randomly assigned to receive either EVT or standard care (control). Follow-up infarct volume was assessed on computed tomography or magnetic resonance imaging after stroke onset. Mediation analysis was performed to examine the potential causal chain in which FIV may mediate the relationship between EVT and functional outcome. A total of 1690 patients met the inclusion criteria. Twenty-five additional patients were excluded, resulting in a total of 1665 patients, including 821 (49.3%) in the EVT group and 844 (50.7%) in the control group. Data were analyzed from January to June 2017.
The 90-day functional outcome via the modified Rankin Scale (mRS).
Among 1665 patients, the median (interquartile range IQR) age was 68 (57-76) years, and 781 (46.9%) were female. The median (IQR) time to FIV measurement was 30 (24-237) hours. The median (IQR) FIV was 41 (14-120) mL. Patients in the EVT group had significantly smaller FIVs compared with patients in the control group (median IQR FIV, 33 11-99 vs 51 18-134 mL; P = .007) and lower mRS scores at 90 days (median IQR score, 3 1-4 vs 4 2-5). Follow-up infarct volume was a predictor of functional outcome (adjusted common odds ratio, 0.46; 95% CI, 0.39-0.54; P < .001). Follow-up infarct volume partially mediated the relationship between treatment type with mRS score, as EVT was still significantly associated with functional outcome after adjustment for FIV (adjusted common odds ratio, 2.22; 95% CI, 1.52-3.21; P < .001). Treatment-reduced FIV explained 12% (95% CI, 1-19) of the relationship between EVT and functional outcome.
In this analysis, follow-up infarct volume predicted functional outcome; however, a reduced infarct volume after treatment with EVT only explained 12% of the treatment benefit. Follow-up infarct volume as measured on computed tomography and magnetic resonance imaging is not a valid proxy for estimating treatment effect in phase II and III trials of acute ischemic stroke.
A measurement of the $ZZ$ production in the $\ell^{-}\ell^{+}\ell^{\prime -}\ell^{\prime +}$ and $\ell^{-}\ell^{+}\nu\bar{\nu}$ channels $(\ell = e, \mu)$ in proton--proton collisions at $\sqrt{s} = ...8$ TeV at the Large Hadron Collider at CERN, using data corresponding to an integrated luminosity of 20.3 fb$^{-1}$ collected by the ATLAS experiment in 2012 is presented. The fiducial cross sections for $ZZ\to\ell^{-}\ell^{+}\ell^{\prime -}\ell^{\prime +}$ and $ZZ\to \ell^{-}\ell^{+}\nu\bar{\nu}$ are measured in selected phase-space regions. The total cross section for $ZZ$ events produced with both $Z$ bosons in the mass range 66 to 116 GeV is measured from the combination of the two channels to be $7.3\pm0.4\textrm{(stat)}\pm0.3\textrm{(syst)}\pm0.2\textrm{(lumi)}$ pb, which is consistent with the Standard Model prediction of $6.6^{+0.7}_{-0.6}$ pb. The differential cross sections in bins of various kinematic variables are presented. The differential event yield as a function of the transverse momentum of the leading $Z$ boson is used to set limits on anomalous neutral triple gauge boson couplings in $ZZ$ production.
Two searches for new phenomena in final states containing a same-flavour opposite-lepton (electron or muon) pair, jets, and large missing transverse momentum are presented. These searches make use of ...proton--proton collision data, collected during 2015 and 2016 at a centre-of-mass energy $\sqrt{s}=13$ TeV by the ATLAS detector at the Large Hadron Collider, which correspond to an integrated luminosity of 14.7 fb$^{-1}$. Both searches target the pair production of supersymmetric particles, squarks or gluinos, which decay to final states containing a same-flavour opposite-sign lepton pair via one of two mechanisms: a leptonically decaying Z boson in the final state, leading to a peak in the dilepton invariant-mass distribution around the Z boson mass; and decays of neutralinos (e.g. $\tilde{\chi}_2^0 \rightarrow \ell^+\ell^- \tilde{\chi}_1^0$), yielding a kinematic endpoint in the dilepton invariant-mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted in simplified models of gluino-pair (squark-pair) production, and provide sensitivity to gluinos (squarks) with masses as large as 1.70 TeV (980 GeV).
The top quark mass is measured in the $t\bar{t}\to$ dilepton channel (lepton $= e, \mu$) using ATLAS data recorded in the year 2012 at the LHC. The data were taken at a proton--proton centre-of-mass ...energy of $\sqrt{s}=$ 8 TeV and correspond to an integrated luminosity of about 20.2 fb$^{-1}$. Exploiting the template method, and using the distribution of invariant masses of lepton--b-jet pairs, the top quark mass is measured to be $m_{top} =$ 172.99 $\pm$ 0.41 (stat) $\pm$ 0.74 (syst) GeV, with a total uncertainty of 0.84 GeV. Finally, a combination with previous ATLAS $m_{top}$ measurements from $\sqrt{s}=$7 TeV data in the $t\bar{t}\to$ dilepton and $t\bar{t}\to$ lepton+jets channels results in $m_{top} =$ 172.84 $\pm$ 0.34 (stat) $\pm$ 0.61 (syst) GeV, with a total uncertainty of 0.70 GeV.
This paper describes a measurement of the inclusive top quark pair production cross-section ($\sigma_{t\bar{t}}$) with a data sample of 3.2 fb$^{-1}$ of proton--proton collisions at a centre-of-mass ...energy of $\sqrt{s}$=13 TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron--muon pair in the final state. Jets containing $b$-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two $b$-tagged jets are counted and used to determine simultaneously $\sigma_{t\bar{t}}$ and the efficiency to reconstruct and $b$-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be: $\sigma_{t\bar{t}}$= 818 $\pm$ 8 (stat) $\pm$ 27 (syst) $\pm$ 19 (lumi) $\pm$ 12 (beam) pb, where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented.
A study of the decays B0→μ+μ− and B0s→μ+μ− has been performed using data corresponding to an integrated luminosity of 25 fb−1 of 7 TeV and 8 TeV proton--proton collisions collected with the ATLAS ...detector during the LHC Run 1. For B0, an upper limit on the branching fraction is set at B(B0→μ+μ−)<4.2×10−10 at 95% confidence level. For B0s, the branching fraction B(B0s→μ+μ−)=(0.9+1.1−0.8)×10−9 is measured. The results are consistent with the Standard Model expectation with a p-value of 4.8%, corresponding to 2.0 standard deviations.
This paper reports inclusive and differential measurements of the $t\bar{t}$ charge asymmetry $A_{\textrm{C}}$ in 20.3 fb$^{-1}$ of $\sqrt{s} = 8$ TeV $pp$ collisions recorded by the ATLAS experiment ...at the Large Hadron Collider at CERN. Three differential measurements are performed as a function of the invariant mass, transverse momentum and longitudinal boost of the $t\bar{t}$ system. The $t\bar{t}$ pairs are selected in the single-lepton channels ($e$ or $\mu$) with at least four jets, and a likelihood fit is used to reconstruct the $t\bar{t}$ event kinematics. A Bayesian unfolding procedure is performed to infer the asymmetry at parton level from the observed data distribution. The inclusive $t\bar{t}$ charge asymmetry is measured to be $A_{\textrm{C}} = 0.009 \pm 0.005$ (stat.$+$syst.). The inclusive and differential measurements are compatible with the values predicted by the Standard Model.
Differential cross sections for the production of at least four jets have been measured in proton--proton collisions at $\sqrt{s} = 8$ TeV at the Large Hadron Collider using the ATLAS detector. The ...dataset corresponds to an integrated luminosity of 20.3 $fb^{-1}$. The cross sections, corrected for detector effects, are compared to leading-order and next-to-leading-order calculations as a function of the jet momenta, invariant masses, minimum and maximum opening angles and other kinematic variables.
Measurements of fiducial and differential cross sections of Higgs boson production in the ${H \rightarrow ZZ ^{*}\rightarrow 4\ell}$ decay channel are presented. The cross sections are determined ...within a fiducial phase space and corrected for detection efficiency and resolution effects. They are based on 20.3 fb$^{-1}$ of $pp$ collision data, produced at $\sqrt{s}$=8 TeV centre-of-mass energy at the LHC and recorded by the ATLAS detector. The differential measurements are performed in bins of transverse momentum and rapidity of the four-lepton system, the invariant mass of the subleading lepton pair and the decay angle of the leading lepton pair with respect to the beam line in the four-lepton rest frame, as well as the number of jets and the transverse momentum of the leading jet. The measured cross sections are compared to selected theoretical calculations of the Standard Model expectations. No significant deviation from any of the tested predictions is found.
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