HUBS: Hot Universe Baryon Surveyor Cui, W.; Chen, L.-B.; Gao, B. ...
Journal of low temperature physics,
04/2020, Letnik:
199, Številka:
1-2
Journal Article
Recenzirano
Hot Universe Baryon Surveyor (HUBS) is proposed in China as a major X-ray mission for the next decade. It is designed to be highly focused scientifically, with two primary objectives: (1) detecting ...X-ray emission from hot baryons in intergalactic medium and circumgalactic medium (CGM), and characterizing their physical and chemical properties; (2) studying, based on the observations, the accretion and feedback processes that are thought to be highly relevant to the heating and chemical enrichment of the baryons in the CGM. Because of very low densities, the signal is expected to be very weak and thus technically difficult to detect. On the other hand, the spectrum of the emission is expected to be line rich, so it would be effective for detecting the hot baryons in bright emission lines. For that, an instrument with high spectral resolution, large effective area and large field of view (FoV) would be required. HUBS will couple a TES-based X-ray imaging spectrometer to a large FoV X-ray telescope to satisfy these requirements. A preliminary design of HUBS is presented.
Zein nanoparticles could be distributed significantly in liver after intravenous administration to mice and adequately remained in blood for at least 24h.
This study proposes a new zein nanoparticle ...(ZP) encapsulated 5-fluorouracil (5-FU) that target liver through intravenous delivery. The ZPs were prepared by phase separation process and optimized using uniform experimental design. The physical properties, in vitro drug release and stability of optimal drug-loaded ZPs were studied. The biodistribution and the target efficiency of the particles were investigated in a mouse model. The highest drug loading was obtained using zein: 5-FU, 3:1 (v/v); zein concentration, 12.5mg/ml, pH 9.18, mixing time, 3h and ethanol concentration, 40%. The encapsulation efficiency and the drug loading were 60.7±1.74 and 9.17±0.11 respectively. The size of ZPs and zeta potential were 114.9±59.4nm and −45±0.3mV respectively. Differential scanning calorimetry (DSC) demonstrated that the drug was encapsulated within the ZPs. A sustained release profile of 5-FU was observed from ZPs. The more stable storage condition of ZPs was at a temperature of 4°C. In vivo, ZPs was mostly accumulated in liver following intravenous injection, and the targeting efficiency increased 31.33%. The relative uptake rate of liver was 2.79. Also, nano-sized ZPs were beneficial for prolonged blood residence (7.2-fold increase). These demonstrated that the drug-loaded ZPs could be efficiently targeted at the liver by intravenous delivery.
Summary Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, northern-east to ...southern-west belt in China and North Korea. In 1990's, it was estimated that in China 1–3 million people had some degree of symptoms of the disease, although even higher estimates have been presented. In China, the extensive prevalence peaked in the late 1950's, but since then, in contrast to the global trend of the osteoarthritis (OA), the number of cases has been dramatically falling. Up to 2013, there are 0.64 millions patients with the KBD and 1.16 millions at risk in 377 counties of 13 provinces or autonomous regions. This is obviously thanks to the preventive efforts carried out, which include providing millions of people with dietary supplements and clean water, as well as relocation of whole villages in China. However, relatively little is known about the molecular mechanisms behind the cartilage damage, the genetic and the environmental risk factors, and the rationale of the preventive effects. During the last decade, new data on a cellular and molecular level has begun to accumulate, which hopefully will uncover the grounds of the disease.
This study explored the relationship between visceral adiposity index (VAI) and cervical arterial atherosclerosis in a total of 3688 residents aged ≥40 in northeast China. The VAI could be a ...practical indicator for cervical artery atherosclerosis, especially for carotid plaque and moderate‐to‐severe atherosclerosis (multiple plaques and stenosis). The correlations were more significant in non‐overweight or obese, non‐central obesity and non‐hypertriglyceridemic waist phenotype (HTWP) participants
Background and purpose
The burden of cervical arterial atherosclerosis, which is an important risk factor of stroke, is huge in China. The visceral adiposity index (VAI) is a convenient index that is related to a series of metabolic abnormalities and a variety of diseases, including cerebrovascular diseases. This study aimed to explore the relationship between VAI and cervical arterial atherosclerosis.
Methods
This cross‐sectional study used the multistage stratified random cluster sampling method to acquire a representative sample of residents aged ≥40 in the general population of northeast China. All participants completed a detailed questionnaire and provided blood samples. Cervical vascular ultrasound was performed by experienced ultrasound doctors. VAI was calculated by a well‐established formula and analyzed by quartiles (Q1–Q4).
Results
A total of 3688 people aged ≥40 years who underwent cervical arterial ultrasound were finally included, amongst whom 3.2% had increased intima‐media thickness (IMT), 48.6% had carotid plaque and 4.0% had cervical artery stenosis (CAS). After adjusting for several parameters, little statistical significance was found between VAI and increased IMT; compared with the VAI‐Q1 group, the VAI‐Q2, VAI‐Q3 and VAI‐Q4 groups were more likely to have CAS odds ratio (OR) 2.01, 95% confidence interval (CI) 1.17–3.43; OR 1.82, 95% CI 1.05–3.15; OR 1.79, 95% CI 1.03–3.12 and the VAI‐Q3 and VAI‐Q4 groups were at greater risk of carotid plaque (OR 1.30, 95% CI 1.05–1.62; OR 1.34, 95% CI 1.07–1.67).
Conclusions
The VAI was related to carotid plaque and CAS in the general population that is older than 40 years.
We have combined hard X-ray photoelectron spectroscopy with angular dependent O K-edge and V L-edge X-ray absorption spectroscopy to study the electronic structure of metallic and insulating end ...point phases in 4.1 nm thick (14 units cells along the c-axis of VO2) films on TiO2(001) substrates, each displaying an abrupt MIT centered at ∼300 K with width <20 K and a resistance change of ΔR/R > 103. The dimensions, quality of the films, and stoichiometry were confirmed by a combination of scanning transmission electron microscopy with electron energy loss spectroscopy, X-ray spectroscopy, and resistivity measurements. The measured end point phases agree with their bulk counterparts. This clearly shows that, apart from the strain induced change in transition temperature, the underlying mechanism of the MIT for technologically relevant dimensions must be the same as the bulk for this orientation.
This work proposes a T6-like heat treatment, including solid-solution treatment at 535 °C and an artificial aging treatment for 10 h at 158 °C, to control the mechanical behavior of selective-laser- ...melting (SLM)-produced AlSi10Mg alloys. The mechanical properties of the AlSi10Mg alloys, such as densification, hardness, and tensile/bending strength, were investigated, and the microstructure of the alloys was analyzed. The results reveal that the tensile strength of the heat-treated samples slightly decreased by 19.97% (from 334 MPa to 267.3 MPa of the as-fabricated samples), while the elongation showed a remarkable increase by up to 155% (from 3.64% to 9.28%). Likewise, the bending strength slightly decreased by 6.1%, while the fracture deflection dramatically increased by up to 122.9% after T6 heat treatment. Thus, the T6 heat treatment can critically enhance plasticity/ductility without any significant loss in the tensile/bending strength of the alloy. The corresponding mechanism is also elucidated based on the spheroidization and diffusion of silicon precipitation during the T6 heat treatment. The results of this study offer an intriguing insight to tailor the mechanical properties of SLM-fabricated AlSi10Mg alloys using suitable solid solutions and artificial aging treatment.
Background
Several previous researches had found artery stiffness associated skeletal muscle mass, but not considering muscle strength and physical performance, which also were compositions of ...sarcopenia. This study aims to reveal the relationship of artery stiffness and sarcopenia using the Asian Working Group for Sarcopenia criteria.
Methods
Study was performed on 1002 Chinese community dwelling participants aged ≥65 years from November 2016 to March 2017. Body composition, muscle strength, physical performance, and brachial-ankle pulse wave velocity (baPWV) considering as artery stiffness index were measured.
Results
In multiple regression analysis, baPWV was associated with handgrip (β=−0.13, P=0.04) and Relative skeletal muscle mass index (ASM/Ht
2
) (β=−0.02, P<0.01), but not with 4-meter velocity (P=0.21). Multiple logistic regression analysis showed that 1-SD (3.50m/s) increased in baPWV was still associated with a 11% (CI, 4%–20%; P<0.01) higher odds of being sarcopenia. In the gender subgroup analysis, the relationship of baPWV and sarcopenia remain significant in men (OR, 1.23; 95% CI, 1.07–1.42, P<0.01), but not in women (P=0.07).
Conclusions
High brachial-ankle pulse wave velocity is associated with sarcopenia in Chinese community-dwelling elderly, with gender differences.
Summary Objective To investigate changes in bone structure, turnover, and articular cartilage localized in subchondral bone cyst (SBC) regions associated with knee osteoarthritis (OA). Methods Tibial ...plateaus ( n = 97) were collected from knee OA patients during total knee arthroplasty (TKA). SBCs were identified using micro-computed tomography, and the specimens were divided into non-cyst ( n = 25) and bone cyst ( n = 72) groups. Microstructure of subchondral bone was assessed using bone volume fraction (BV/TV), trabecular number (Tb.N), structure model index (SMI) and bone mineral density (BMD). In bone cyst group, the cyst subregion, which contained at least one cyst, and the peri-cyst subregion, which contained no cysts, were further selected for microstructure analysis. Articular cartilage damage was estimated using the Osteoarthritis Research Society International (OARSI) score. The numbers of TRAP+ osteoclasts, Osterix+ osteoprogenitors, Osteocalcin+ osteoblasts and expression of SOX9 were evaluated by immunohistochemistry. Results Bone cyst group presented higher BV/TV, Tb.N and SMI at subchondral bone than non-cyst group. Furthermore, cyst subregion displayed increased BV/TV and Tb.N but lower BMD and SMI than peri-cyst subregion. Histology revealed a higher OARSI score in bone cyst group. SBC exhibited a weak relationship with BV/TV, etc . The numbers of TRAP+ osteoclasts, Osterix+ osteoprogenitors, Osteocalcin+ osteoblasts and expression of SOX9, were higher in bone cyst group. Conclusion SBCs within knee OA are characterized by focally increased bone turnover, altered bone structure and more severe articular cartilage damage. The increased bone turnover possibly contributes to altered bone structure localized in SBC areas, and thus aggravates articular cartilage degeneration.
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