By means of variational methods and systematic numerical analysis, we demonstrate the existence of metastable solitons in three dimensional (3D) free space, in the context of binary atomic ...condensates combining contact self-attraction and spin-orbit coupling, which can be engineered by available experimental techniques. Depending on the relative strength of the intra- and intercomponent attraction, the stable solitons feature a semivortex or mixed-mode structure. In spite of the fact that the local cubic self-attraction gives rise to the supercritical collapse in 3D, and hence the setting produces no true ground state, the solitons are stable against small perturbations, motion, and collisions.
The kinetic‐energy‐releases (KER) distribution function of the fragment is an important observable in the molecular dynamics. In theory, there are several different methods to calculate the KER ...distribution function or spectrum, which could be generally divided into two classes: One is based on the analysis of the asymptotic wavepacket (“projection method”) and the other is on the analysis of the associated flux (“flux method”). By taking the above‐threshold dissociation of the HeH+ (v = 8) molecule as an example, we compared these two classes of methods. Based on evenly separated Fourier grid representation, the KER distribution calculated via the projection method FProj(Ek) is the same as the one calculated via the flux method FFlux(Ek). The relationship between FProj(Ek) and the distribution of the projection of the asymptotic wavepacket onto the energy eigenstates of the quasicontinuum, PProj(Ek), and the relationship between FFlux(Ek) and the distribution of the dissociation probability PFlux(Ek) from the cumulation of the associated flux, are determined.
The kinetic‐energy‐releases (KER) distribution of the fragments is one of the most important.
observables in experiment for us to understand the relevant molecular dynamics, such as the photodissociation, photoionization, or chemical reaction collision. By taking the above‐threshold dissociation of HeH+ (v = 8) as model, the projection method and the flux method for the calculation of KER distribution function F (E
k) have been compared.
The pathogenesis of pulmonary fibrosis (PF) was mediated by the progressive deposition of excessive extracellular matrix, but little is known about the regulatory mechanisms of fibrogenesis by lung ...pericytes. The mouse PF model was established by treatment with bleomycin, followed by isolation of exosomes from mouse broncho‐alveolar lavage fluids by the centrifuge method. Relative mRNA/microRNA levels and protein expression were assessed by qRT‐PCR and Western blotting, respectively. The binding of let‐7d with gene promoter was validated by dual‐luciferase reporter assay. Protein interactions were verified via GST pull‐down and co‐immunoprecipitation. Nuclear retention of Smad3 was analysed by extraction of cytoplasmic and nuclear fraction of pericytes followed by Western blotting. Association of FoxM1 with gene promoter was detected by EMSA and ChIP‐PCR methods. FoxM1 expression is significantly elevated in human lung fibroblasts of PF patients and mouse PF model. The expression of let‐7d is repressed in exosomes derived from broncho‐alveolar lavage fluids of PF mice. Let‐7d or FoxM1 knockdown suppressed the expression of FoxM1, Smad3, β‐catenin, Col1A and α‐SMA expression in mouse lung pericytes under TGF‐β1 treatment. FoxM1 overexpression elevated above gene expression in mouse lung pericytes under TGF‐β1 treatment. Let‐7d directly targets TGFβRI to regulate FoxM1 and downstream gene expression in mouse lung pericytes. FoxM1 directly interacts with Smad3 proteins to promote Smad3 nuclear retention and binds with β‐catenin promoter sequence to promote fibrogenesis. Exosomes with low let‐7d from pulmonary vascular endothelial cells drive lung pericyte fibrosis through activating the TGFβRI/FoxM1/Smad/β‐catenin signalling pathway.
So far, numerous researches on the He2H− system have still been restricted to several analytical forms of the potential energy interaction, where the calculations in the three‐body interaction may be ...not precise. With that in mind, we have provided an accurate, global, full‐dimensional potential energy surface (PES) for the ground state of the He2H− system by the fundamental invariant neural network (FI‐NN) fitting based on roughly 45 000 ab initio data points. The energy points are calculated with the coupled‐cluster singles and doubles with perturbative triples (CCSDT) method using the augmented Dunning‐type correlation‐consistent (aug‐cc‐pVTZ, aug‐cc‐pVQZ and aug‐cc‐pV5Z) basis sets, respectively. Based on adoption and comparison of three different extrapolation formulas, we obtained even accurate data points, which are extrapolated to the complete basis set (CBS) limit. The overall root mean square error of the fitting PES is only about 6.314 × 10−3 cm−1. It can be expected that this accurate PES would provide insights to further interesting discoveries in dynamics or spectroscopies for the relevant molecular systems.
The weak interaction of the He2 dimer, the HeH− anion and the He2H− trimer have recently attracted great attention due to its importance in the interstellar space. An accurate, global potential energy surface (PES) for the ground state of the He2H− system is constructed based on high‐level ab initio data points to the complete basis set (CBS) limit.
The rapid decline of a few Emberiza bunting species is increasing conservation concerns, especially in Asia. However, temporal changes in communities and populations of buntings, ones of the most ...common migratory songbirds in Korea, have not been quantitatively assessed. To understand how the status of buntings has changed over the past 100 years, we collated abundance data from museum collections and bird-banding records between 1910 and 2019. We also used presence-absence data for buntings collected by a nationwide census scheme between 1997 to 2012. Our analysis showed that bunting communities reconstructed from museum-specimen and bird-banding data were not significantly different; however, community composition differed over time. The Meadow (E. cioides), Yellow-throated (E. elegans), Black-faced (E. spodocephala), Rustic (E. rustica) and Chestnut Buntings (E. rutila), which are still common or were once common species, significantly affected the temporal changes in bunting community composition. There were no recent changes in the presence of Rustic and Chestnut Buntings since 1997, but they caused medium-term changes in the bunting community composition, suggesting that there was a sharp to moderate decline in their numbers in the past. The probability of the presence of six bunting species decreased annually, with the most prominent decline in two common breeders, the Meadow (-2.99%/year) and Yellow-throated Buntings (-1.82%/year). This finding suggests that breeding buntings in Korea are under high pressure, as are the migratory buntings. Moreover, despite its recent population decline, the Yellow-throated Bunting was still a major contributor to the community, suggesting that bunting diversity has also been deteriorating while bunting populations are shrinking. Long-term monitoring schemes across their distribution ranges, international cooperation for identifying major threats and key areas of conservation, and law enforcement against illegal hunting and habitat loss are strongly required to mitigate the on-going decline of buntings in Korea and Asia.
Chronic visceral pain is a major challenge for both patients and health providers. Although the central sensitization of the brain is thought to play an important role in the development of visceral ...pain, the detailed neural circuits remain largely unknown. Using a well-established chronic visceral hypersensitivity model induced by neonatal maternal deprivation (NMD) in male mice, we identified a distinct pathway whereby the claustrum (CL) glutamatergic neuron projecting to the anterior cingulate cortex (ACC) is critical for visceral pain but not for CFA-evoked inflammatory pain. By a combination of
circuit-dissecting extracellular electrophysiological approaches and visceral pain related electromyographic (EMG) recordings, we demonstrated that optogenetic inhibition of CL glutamatergic activity suppressed the ACC neural activity and visceral hypersensitivity of NMD mice whereas selective activation of CL glutamatergic activity enhanced the ACC neural activity and evoked visceral pain of control mice. Further, optogenetic studies demonstrate a causal link between such neuronal activity and visceral pain behaviors. Chemogenetic activation or inhibition of ACC neural activities reversed the effects of optogenetic manipulation of CL neural activities on visceral pain responses. Importantly, molecular detection showed that NMD significantly enhances the expression of NMDA receptors and activated CaMKIIα in the ACC postsynaptic density (PSD) region. Together, our data establish a functional role for CL→ACC glutamatergic neurons in gating visceral pain, thus providing a potential treatment strategy for visceral pain.
Studies have shown that sensitization of anterior cingulate cortex (ACC) plays an important role in chronic pain. However, it is as yet unknown whether there is a specific brain region and a distinct neural circuit that helps the ACC to distinguish visceral and somatic pain. The present study demonstrates that claustrum (CL) glutamatergic neurons maybe responding to colorectal distention (CRD) rather than somatic stimulation and that a CL glutamatergic projection to ACC glutamatergic neuron regulates visceral pain in mice. Furthermore, excessive NMDA receptors and overactive CaMKIIα in the ACC postsynaptic density (PSD) region were observed in mice with chronic visceral pain. Together, these findings reveal a novel neural circuity underlying the central sensitization of chronic visceral pain.
Salvage logging following natural disturbances may alter the natural successional trajectories of biological communities by affecting the occurrences of species, functional groups and evolutionary ...lineages. However, few studies have examined whether dissimilarities between bird communities of salvaged and unsalvaged forests are more pronounced for rare species, functional groups and evolutionary lineages than for their more common counterparts.
We compiled data on breeding bird assemblages from nine study areas in North America, Europe and Asia, covering a 17‐year period following wildfire or windstorm disturbances and subsequent salvage logging. We tested whether dissimilarities based on non‐shared species, functional groups and evolutionary lineages (a) decreased or increased over time and (b) the responses of rare, common and dominant species varied, by using a unified statistical framework based on Hill numbers and null models.
We found that dissimilarities between bird communities caused by salvage logging persisted over time for rare, common and dominant species, evolutionary lineages and for rare functional groups. Dissimilarities of common and dominant functional groups increased 14 years post disturbance.
Salvage logging led to significantly larger dissimilarities than expected by chance. Functional dissimilarities between salvaged and unsalvaged sites were lower compared to taxonomic and phylogenetic dissimilarities. In general, dissimilarities were highest for rare, followed by common and dominant species.
Synthesis and applications. Our research demonstrates that salvage logging did not decrease dissimilarities of bird communities over time and taxonomic, functional and phylogenetic dissimilarities persisted for over a decade. We recommend resource managers and decision makers to reserve portions of disturbed forest to enable unmanaged post‐disturbance succession of bird communities, particularly to conserve rare species found in unsalvaged disturbed forests.
Our research demonstrates that salvage logging did not decrease dissimilarities of bird communities over time and taxonomic, functional and phylogenetic dissimilarities persisted for over a decade. We recommend resource managers and decision makers to reserve portions of disturbed forest to enable unmanaged post‐disturbance succession of bird communities, particularly to conserve rare species found in unsalvaged disturbed forests.
Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy due to distant metastasis. RELA, a major component of the NF‐κB pathway, could serve as an oncogene through activating ...proliferation or migration‐related gene expression, including NEAT1, a well‐known oncogenic long noncoding RNA. In the current study, the expression and function of RELA and NEAT1 in PDAC were examined. The potential upstream regulatory microRNAs of RELA were screened and verified for their correlation with RELA and NEAT1. The expression and function of the selected miR‐302a‐3p were evaluated. RELA and NEAT1 expression were upregulated in PDAC tissues, particularly in PDAC tissues with lymph node metastasis, and their expression correlated with clinical parameters. RELA overexpression promoted PDAC cell proliferation and migration, which could be partially attenuated by the NEAT1 knockdown. By binding to RELA, miR‐302a‐3p inhibited RELA expression, as well as PDAC cell proliferation and migration. RELA downstream NEAT1 expression was negatively regulated by miR‐302a‐3p; the suppressive effect of NEAT1 knockdown on PDAC cell proliferation and migration was partially attenuated by miR‐302a‐3p inhibition. Moreover, through direct binding, the expression of miR‐302a‐3p was also negatively regulated by NEAT1. The expression of miR‐302a‐3p was downregulated and negatively correlated with RELA or NEAT1 in tissue samples, indicating that rescuing miR‐302a‐3p expression may inhibit PDAC cell proliferation and migration through RELA/NEAT1. In summary, RELA, NEAT1, and miR‐302a‐3p form a feedback loop in PDAC to modulate PDAC cell proliferation and migration.
The expression of miR‐302a‐3p was down‐regulated and negatively correlated with RELA or NEAT1 in tissue samples, indicating that rescuing miR‐302a‐3p expression may inhibit PDAC cell proliferation and migration through RELA/NEAT1. In summary, RELA, NEAT1 and miR‐302a‐3p form a feedback loop in PDAC to modulate PDAC cell proliferation and migration.
Abstract
The Ruderman–Kittel–Kasuya–Yosida (RKKY) interaction has been extensively explored in isotropic Dirac systems with linear dispersion, which typically follows an exponent decaying rate with ...the impurity distance
R
, i.e.,
J
∝ 1/
R
d
(1/
R
2
d
−1
) in
d
-dimensional systems at finite (zero) Fermi energy. This fast decay makes it rather difficult to be detected and limits its application in spintronics. Here, we theoretically investigate the influence of anisotropic dispersion on the RKKY interaction, and find that the introduction of non-relativistic dispersion in semi-Dirac semimetals (S-DSMs) can significantly prolong the decay of the RKKY interaction and can remarkably enhance the Dzyaloshinskii–Moriya interaction around the relativistic direction. The underlying physics is attributed to the highly increased density of states in the linear-momentum direction as a result of the interplay of relativistic and non-relativistic electrons. Furthermore, we propose a general formula to determine the decaying rate of the RKKY interaction, extending the typical formula for isotropic DSMs. Our results suggest that the S-DSM materials are a powerful platform to detect and control the magnetic exchange interaction, superior to extensively adopted isotropic Dirac systems.
This work explores the role of geometric phase (GP), which results from light induced conical intersection (LICI), in photodissociation process of the D2+ molecule through solving the time‐dependent ...Schrödinger equation. The dissociation results between two cases including GP and excluding GP are compared. Different from the case including GP, the angular distribution of photofragments excluding GP is non‐vanishing at θ=π/2 which is the angle between the molecular axis and the polarization direction of laser field. Furthermore, in strong field, when the initial vibrational energy is higher than the energy of LICI point, not only the photofragments distributions present obvious quantum interference structures, but also the angular distributions of the photofragments of two cases have opposite oscillatory structure around θ=π/2. This also shows that the GP effect and nonadiabatic effect of LICI are unified in photodissociation processes.
The time‐independent Schrödinger equation is solved in two cases including GP and excluding GP for the D2+ molecule. In strong field, when the initial vibrational energy is higher than the energy of LICI point, not only the photofragments distributions present obvious quantum interference structures, but also the angular distribution of photofragments excluding GP is nonvanishing around θ=π/2. We show that the GP effect and nonadiabatic effect of LICI are unified in photodissociation processes.
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