•Oxidation tests in air on RR1000 at 600–900°C for times to 5000h.•Parabolic weight gain kinetics but Cr, Ti and Al all oxidise.•Protective chromia layer thickens with sub-parabolic kinetics.•Chromia ...thickening rates are initially much higher than expected due to Ti doping.•Ti depletion in the alloy results in the sub-parabolic chromia growth kinetics.
Oxidation of the Ni-based superalloy RR1000 has been undertaken in air over the temperature range 600–900°C for times up to 5000h. The surface oxide consisted of a protective Ti-doped chromia layer but with rutile forming on its outer surface. Sub-surface oxidation of Al and Ti also occurred. The thickening kinetics of the chromia layer were sub-parabolic with initial rates around two orders of magnitude higher than expected for Ti-free chromia. This enhancement and the sub-parabolic kinetics are accounted for by Ti-doping of the chromia layer. Over time the enhancement reduced because of Ti-depletion in the alloy.
Patient blood management (PBM) is the timely application of evidence-informed medical and surgical concepts designed to maintain haemoglobin concentration, optimise haemostasis and minimise blood ...loss in an effort to improve patient outcomes. The aim of this consensus statement is to provide recommendations on the management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period as part of PBM in obstetrics. A multidisciplinary panel of physicians with expertise in obstetrics, anaesthesia, haematology, policymaking and epidemiology was convened by the Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis (NATA) in collaboration with the International Federation of Gynaecology and Obstetrics (FIGO) and the European Board and College of Obstetrics and Gynaecology (EBCOG). Members of the task force assessed the quantity, quality and consistency of the published evidence and formulated recommendations using the system developed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group. The recommendations in this consensus statement are intended for use by clinical practitioners managing the perinatal care of women in all settings and by policymakers in charge of decision making for the update of clinical practice in health-care establishments. They need to be tailored for application in individual patients or any population after consideration of the values and preferences of both health-care providers and patients, as well as equity issues; explicit assessment of harms and benefits of each recommendation; feasibility including resources, capacity and equipment; and implementability.
For more than a decade, researchers have refined criteria for the diagnosis of dementia with Lewy bodies (DLB) and at the same time have recognized that cognitive impairment and dementia occur ...commonly in patients with Parkinson disease (PD). This article addresses the relationship between DLB, PD, and PD with dementia (PDD). The authors agreed to endorse "Lewy body disorders" as the umbrella term for PD, PDD, and DLB, to promote the continued practical use of these three clinical terms, and to encourage efforts at drug discovery that target the mechanisms of neurodegeneration shared by these disorders of alpha-synuclein metabolism. We concluded that the differing temporal sequence of symptoms and clinical features of PDD and DLB justify distinguishing these disorders. However, a single Lewy body disorder model was deemed more useful for studying disease pathogenesis because abnormal neuronal alpha-synuclein inclusions are the defining pathologic process common to both PDD and DLB. There was consensus that improved understanding of the pathobiology of alpha-synuclein should be a major focus of efforts to develop new disease-modifying therapies for these disorders. The group agreed on four important priorities: 1) continued communication between experts who specialize in PDD or DLB; 2) initiation of prospective validation studies with autopsy confirmation of DLB and PDD; 3) development of practical biomarkers for alpha-synuclein pathologies; 4) accelerated efforts to find more effective treatments for these diseases.
We present a long-term programme for timing the eclipses of white dwarfs in close binaries to measure apparent and/or real variations in their orbital periods. Our programme includes 67 close ...binaries, both detached and semi-detached and with M-dwarfs, K-dwarfs, brown dwarfs or white dwarfs secondaries. In total, we have observed more than 650 white dwarf eclipses. We use this sample to search for orbital period variations and aim to identify the underlying cause of these variations. We find that the probability of observing orbital period variations increases significantly with the observational baseline. In particular, all binaries with baselines exceeding 10 yr, with secondaries of spectral type K2 – M5.5, show variations in the eclipse arrival times that in most cases amount to several minutes. In addition, among those with baselines shorter than 10 yr, binaries with late spectral type (>M6), brown dwarf or white dwarf secondaries appear to show no orbital period variations. This is in agreement with the so-called Applegate mechanism, which proposes that magnetic cycles in the secondary stars can drive variability in the binary orbits. We also present new eclipse times of NN Ser, which are still compatible with the previously published circumbinary planetary system model, although only with the addition of a quadratic term to the ephemeris. Finally, we conclude that we are limited by the relatively short observational baseline for many of the binaries in the eclipse timing programme, and therefore cannot yet draw robust conclusions about the cause of orbital period variations in evolved, white dwarf binaries.
Abstract
We present high-precision, model-independent, mass and radius measurements for 16 white dwarfs in detached eclipsing binaries and combine these with previously published data to test the ...theoretical white dwarf mass–radius relationship. We reach a mean precision of 2.4 per cent in mass and 2.7 per cent in radius, with our best measurements reaching a precision of 0.3 per cent in mass and 0.5 per cent in radius. We find excellent agreement between the measured and predicted radii across a wide range of masses and temperatures. We also find the radii of all white dwarfs with masses less than 0.48 M⊙ to be fully consistent with helium core models, but they are on average 9 per cent larger than those of carbon–oxygen core models. In contrast, white dwarfs with masses larger than 0.52 M⊙ all have radii consistent with carbon–oxygen core models. Moreover, we find that all but one of the white dwarfs in our sample have radii consistent with possessing thick surface hydrogen envelopes (10−5 ≥ M
H/M
WD ≥ 10−4), implying that the surface hydrogen layers of these white dwarfs are not obviously affected by common envelope evolution.
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is ...conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP)--an Alzheimer disease risk factor--although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population.
Allvac 718Plus is a newly developed nickel-based superalloy designed to replace Inconel 718 in static and rotating applications in gas turbine engines. Fine γ′ precipitates act as its principal ...strengthening phase and a second plate-like phase is generally present at grain boundaries. This has been reported to be the δ phase (Ni3Nb, D0a, orthorhombic), and is used to pin grain boundaries and improve resistance to intergranular fracture. In Allvac 718Plus non-uniform precipitation of a δ-like phase was observed along the grain boundaries; however, no relation was found between grain-boundary misorientation and the occurrence of precipitation. The crystal structure and chemistry of this phase was found to be different from the orthorhombic Ni3Nb δ phase reported previously in Inconel 718 and Allvac 718Plus. The true structure was found to be consistent with the hexagonal η-Ni3Ti D024 structure, but its chemistry was close to Ni6AlNb with partial ordering of Al and Nb over the prototype Ti sites. It was found that the serrated boundaries observed in the alloy were a result of discontinuous precipitation of η-Ni6AlNb, which was a predominant precipitation mechanism throughout the microstructure.
Physicists have long wondered whether the gravitational interactions between matter and antimatter might be different from those between matter and itself. Although there are many indirect ...indications that no such differences exist and that the weak equivalence principle holds, there have been no direct, free-fall style, experimental tests of gravity on antimatter. Here we describe a novel direct test methodology; we search for a propensity for antihydrogen atoms to fall downward when released from the ALPHA antihydrogen trap. In the absence of systematic errors, we can reject ratios of the gravitational to inertial mass of antihydrogen >75 at a statistical significance level of 5%; worst-case systematic errors increase the minimum rejection ratio to 110. A similar search places somewhat tighter bounds on a negative gravitational mass, that is, on antigravity. This methodology, coupled with ongoing experimental improvements, should allow us to bound the ratio within the more interesting near equivalence regime.
We report on the search for new eclipsing white dwarf plus main-sequence (WDMS) binaries in the light curves of the Catalina surveys. We use a colour-selected list of almost 2000 candidate WDMS ...systems from the Sloan Digital Sky Survey, specifically designed to identify WDMS systems with cool white dwarfs and/or early M-type main-sequence stars. We identify a total of 17 eclipsing systems, 14 of which are new discoveries. We also find three candidate eclipsing systems, two main-sequence eclipsing binaries and 22 non-eclipsing close binaries. Our newly discovered systems generally have optical fluxes dominated by the main-sequence components, which have earlier spectral types than the majority of previously discovered eclipsing systems. We find a large number of ellipsoidally variable binaries with similar periods, near 4 h, and spectral types M2–3, which are very close to Roche lobe filling. We also find that the fraction of eclipsing systems is lower than found in previous studies and likely reflects a lower close binary fraction among WDMS binaries with early M-type main-sequence stars due to their enhanced angular momentum loss compared to fully convective late M-type stars, hence causing them to become cataclysmic variables quicker and disappear from the WDMS sample. Our systems bring the total number of known detached, eclipsing WDMS binaries to 71.
The influence of microstructure on the dwell fatigue crack growth behaviour of an advanced nickel-based superalloy was investigated at a temperature of 700°C. Microstructural variations were induced ...by heat treatment variables: different cooling rates of quenching from super-solvus solution heat treatment, 0.7 and 1.8°Cs−1, and an addition of a high temperature stabilisation heat treatment (2h at 857°C) between the solution treatment and the final ageing treatment. With a one hour dwell introduced at the peak load of the fatigue cycle, such different microstructural conditions can lead to a difference of up to two orders of magnitude in crack growth rates in air, when compared to those obtained under baseline fatigue loading. By performing such dwell fatigue and baseline fatigue tests in vacuum, it is confirmed that such increases in crack growth rates under dwell fatigue loading in air are mainly environmentally related. Transmission electron microscopy (TEM) was utilised to analyse both crack tip oxides and associated deformation mechanisms in the matrix. A novel mechanism taking into account competing interactions of crack tip oxidation (leading to increases in crack growth rates) and stress relaxation (leading to decreases in crack growth rates) is outlined.
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