Boson sampling is a problem strongly believed to be intractable for classical computers, but can be naturally solved on a specialized photonic quantum simulator. Here, we implement the first ...time-bin-encoded boson sampling using a highly indistinguishable (∼94%) single-photon source based on a single quantum-dot-micropillar device. The protocol requires only one single-photon source, two detectors, and a loop-based interferometer for an arbitrary number of photons. The single-photon pulse train is time-bin encoded and deterministically injected into an electrically programmable multimode network. The observed three- and four-photon boson sampling rates are 18.8 and 0.2 Hz, respectively, which are more than 100 times faster than previous experiments based on parametric down-conversion.
Big Data Analytics for Genomic Medicine He, Karen Y; Ge, Dongliang; He, Max M
International journal of molecular sciences,
02/2017, Letnik:
18, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Genomic medicine attempts to build individualized strategies for diagnostic or therapeutic decision-making by utilizing patients' genomic information. Big Data analytics uncovers hidden patterns, ...unknown correlations, and other insights through examining large-scale various data sets. While integration and manipulation of diverse genomic data and comprehensive electronic health records (EHRs) on a Big Data infrastructure exhibit challenges, they also provide a feasible opportunity to develop an efficient and effective approach to identify clinically actionable genetic variants for individualized diagnosis and therapy. In this paper, we review the challenges of manipulating large-scale next-generation sequencing (NGS) data and diverse clinical data derived from the EHRs for genomic medicine. We introduce possible solutions for different challenges in manipulating, managing, and analyzing genomic and clinical data to implement genomic medicine. Additionally, we also present a practical Big Data toolset for identifying clinically actionable genetic variants using high-throughput NGS data and EHRs.
Abstract
Introduction/Objective
In the field of pediatric pathology, it is vital to find recognize cases that could be associated with cancer predisposition syndromes. PTEN hamartoma tumor syndrome ...(PHTS) is an inherited set of disorders caused by germline inactivating mutations of the PTEN tumor suppressor gene. In the GI tract, PHTS is associated with hamartomatous polyps that can display smooth muscle overgrowth. We therefore present a series of three cases of colonic polyps with smooth muscle overgrowth, mimicking prolapse, in pediatric patients with PTEN mutations.
Methods/Case Report
The first case is a 19-year-old male with PHTS who underwent colonoscopy due to hematochezia. Two pedunculated polyps were removed from the transverse and descending colon. Both polyps showed prominent smooth muscle and ganglion cells in the lamina propria. In the second case, a 9-year-old male with PHTS also underwent colonoscopy due to hematochezia. At least 20 sessile 2-4mm polyps were present in the colon. Histology showed smooth muscle proliferation and ganglion cells in the lamina propria. The third case is a 13-year-old male with undiagnosed PHTS, but a history of Chron’s disease, trichilemmoma, and plantar wart like lesions. He underwent upper and lower endoscopy for Chron’s disease assessment. Three polyps were removed from the descending colon. One was a juvenile polyp while the other two showed prominent smooth muscle proliferation and ganglion cells in the lamina propria.
Results (if a Case Study enter NA)
NA
Conclusion
Histologically, all hamartomatous polyps had smooth muscle overgrowth, confirmed by SMA immunostain, which could easily be confused with prolapse type changes such as in solitary rectal ulcer syndrome. The key in distinguishing between the two is by recognizing ganglion cells within the lamina propria, confirmed by S100 immunostain. Additional clues include identifying mucosal ganglion cells, disarray of crypt architecture, and fibromuscular proliferation as well as considering the location and number of polyps. It is vital for pathologists to recognize the differential diagnosis of polyps with smooth muscle proliferation, especially in pediatric populations where a diagnosis of cancer predisposition syndromes may not be established. Furthermore, is important to discuss pursuing PTEN genetic testing with clinical colleagues as it has immense medical implications and requires a thorough future medical following.
A measurement of the energy dependence of antineutrino disappearance at the Daya Bay reactor neutrino experiment is reported. Electron antineutrinos (ν¯(e)) from six 2.9 GW(th) reactors were ...detected with six detectors deployed in two near (effective baselines 512 and 561 m) and one far (1579 m) underground experimental halls. Using 217 days of data, 41 589 (203 809 and 92 912) antineutrino candidates were detected in the far hall (near halls). An improved measurement of the oscillation amplitude sin(2)2θ(13)=0.090(-0.009)(+0.008) and the first direct measurement of the ν¯(e) mass-squared difference |Δm(ee)2|=(2.59(-0.20)(+0.19))×10(-3) eV2 is obtained using the observed ν¯(e) rates and energy spectra in a three-neutrino framework. This value of |Δm(ee)2| is consistent with |Δm(μμ)2| measured by muon neutrino disappearance, supporting the three-flavor oscillation model.
We report on broadly based systematic investigations of the modeling components for open heavy-flavor diffusion and energy loss in strongly interacting matter in their application to heavy-flavor ...observables in high-energy heavy–ion collisions, conducted within an EMMI Rapid Reaction Task Force framework. Initial spectra including cold-nuclear-matter effects, a wide variety of space-time evolution models, heavy-flavor transport coefficients, and hadronization mechanisms are scrutinized in an effort to quantify pertinent uncertainties in the calculations of nuclear modification factors and elliptic flow of open heavy-flavor particles in nuclear collisions. We develop procedures for error assessments and criteria for common model components to improve quantitative estimates for the (low-momentum) heavy-flavor diffusion coefficient as a long-wavelength characteristic of QCD matter as a function of temperature, and for energy loss coefficients of high-momentum heavy-flavor particles.
Satellite remote sensing provides unmatched spatiotemporal information on vegetation gross primary productivity (GPP). Yet understanding of the relationship between GPP and remote sensing ...observations and how it changes with factors such as scale, biophysical constraint, and vegetation type remains limited. This knowledge gap is especially apparent for dryland ecosystems, which have characteristic high spatiotemporal variability and are under‐represented by long‐term field measurements. Here we utilize an eddy covariance (EC) data synthesis for southwestern North America in an assessment of how accurately satellite‐derived vegetation proxies capture seasonal to interannual GPP dynamics across dryland gradients. We evaluate the enhanced vegetation index, solar‐induced fluorescence (SIF), and the photochemical reflectivity index. We find evidence that SIF is more accurately capturing seasonal GPP dynamics particularly for evergreen‐dominated EC sites and more accurately estimating the full magnitude of interannual GPP dynamics for all dryland EC sites. These results suggest that incorporation of SIF could significantly improve satellite‐based GPP estimates.
Key Points
SIF captures seasonal GPP dynamics better than EVI and PRI, especially for evergreen forest sites
SIF is more sensitive than EVI and PRI to site‐level interannual GPP variability across all southwestern North America ecoregions
Incorporation of SIF could significantly improve satellite‐based GPP estimates for dryland ecosystems
The rock failure process is associated with acoustic emission (AE). Hence, violent rock failure processes such as rock burst under different stress paths in laboratory can be studied using the AE ...monitoring technique. In this paper, single-face dynamic unloading tests under true-triaxial condition were carried out for Paleozonic marine sedimentation limestone samples produced by blocks cored from 1140
m depth in Jiahe coal mine of China. Frequency-spectra analysis was conducted for the full-wave AE data and figures showing the relationship of frequency–amplitude of AE signals in rock burst stages were obtained. The dynamical damage process and characteristics of limestone under the test condition are summarized. It is found from the fast Fourier transformation (FFT) analysis of the AE signals that there exist two main frequency ranges, i.e. lower (60–100
kHz), and higher (170–190
kHz), for the samples. When the limestone samples are under relatively lower stress, the AE signals are characterized by high frequency and low amplitude. As the stress increases, the AE signals tend to shift more towards a signature of high amplitude. Near the bursting failure of the rock samples, it is observed that there are much higher amplitude and lower frequency events. The AE accumulated energy release rapidly increases from the unloading state of the rock samples to its failure. The dynamic unloading test facility provides a useful tool to gain an insight into the characteristics of rock bursts.
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