Protected areas (PAs) are fundamental for biodiversity conservation, yet their impacts on nearby residents are contested. We synthesized environmental and socioeconomic conditions of >87,000 children ...in >60,000 households situated either near or far from >600 PAs within 34 developing countries. We used quasi-experimental hierarchical regression to isolate the impact of living near a PA on several aspects of human well-being. Households near PAs with tourism also had higher wealth levels (by 17%) and a lower likelihood of poverty (by 16%) than similar households living far from PAs. Children under 5 years old living near multiple-use PAs with tourism also had higher height-for-age scores (by 10%) and were less likely to be stunted (by 13%) than similar children living far from PAs. For the largest and most comprehensive socioeconomic-environmental dataset yet assembled, we found no evidence of negative PA impacts and consistent statistical evidence to suggest PAs can positively affect human well-being.
Dermatophyte infections are the most common fungal infections in humans; among them, tinea capitis (TC) – the most contagious fungal infection – is caused by anthropophilic, zoophilic and geophilic ...dermatophytes. The purpose of this systematic review was to determine the different aetiological variants involved in TC and the overall epidemiology of the causes of this infection in the last two decades. We searched the MEDLINE (PubMed) and Embase databases for articles published from July 2000 to August 2019 using the following search terms: ‘Tinea capitis’, ‘Africa’, ‘America’, ‘Asia’, ‘Europe’, ‘Oceania’, and the names of the countries on each continent. The flow of information through the different phases in this systematic review was depicted using a PRISMA flow diagram, which mapped the number of records identified, included and excluded, and the reasons for exclusion. Our findings indicate that the frequency of different aetiologic agents of TC in the reported studies varied globally, from 0.4–87.7% in Africa, 0.2–74.0% in North America, 0.0–91.2% in Eastern Asia, 0.0–69.0% in Eastern Europe and 2.9–86.4% in Oceania. Microsporum canis is the most frequent reported zoophilic agent worldwide, while Trichophyton violaceum and Trichophyton tonsurans are the predominant anthropophilic agents. Over time, the frequency of these latter fungal infections has increased globally, and these fungi have become the major species globally. Anthropophilic transmission – the most prevalent type of transmission – could be explained by two factors: (i) the socioeconomic status of affected countries and population groups with associated risk factors and (ii) movement of populations importing new causes of infection to areas where they had not been encountered previously. We observed that intercontinental migration and travel; globalization; environmental, climatic and ecological changes; and accelerated evolution of health technologies may influence the observed epidemiological changes and, consequently, contributed to the variations in the global status of TC.
We have fit the far-ultraviolet (FUV) to sub-millimeter (850 μm) spectral energy distributions (SEDs) of the 61 galaxies from the Key Insights on Nearby Galaxies: A Far-Infrared Survey with Herschel ...(KINGFISH). The fitting has been performed using three models: the Code for Investigating GALaxy Evolution (CIGALE), the GRAphite-SILicate approach (GRASIL), and the Multiwavelength Analysis of Galaxy PHYSical properties (MAGPHYS). We have analyzed the results of the three codes in terms of the SED shapes, and by comparing the derived quantities with simple “recipes” for stellar mass (Mstar), star-formation rate (SFR), dust mass (Mdust), and monochromatic luminosities. Although the algorithms rely on different assumptions for star-formation history, dust attenuation and dust reprocessing, they all well approximate the observed SEDs and are in generally good agreement for the associated quantities. However, the three codes show very different behavior in the mid-infrared regime: in the 5–10 μm region dominated by PAH emission, and also between 25 and 70 μm where there are no observational constraints for the KINGFISH sample. We find that different algorithms give discordant SFR estimates for galaxies with low specific SFR, and that the standard recipes for calculating FUV absorption overestimate the extinction compared to the SED-fitting results. Results also suggest that assuming a “standard” constant stellar mass-to-light ratio overestimates Mstar relative to the SED fitting, and we provide new SED-based formulations for estimating Mstar from WISE W1 (3.4 μm) luminosities and colors. From a principal component analysis of Mstar, SFR, Mdust, and O/H, we reproduce previous scaling relations among Mstar, SFR, and O/H, and find that Mdust can be predicted to within ∼0.3 dex using only Mstar and SFR.
We present an update to the ultraviolet-to-radio database of global broadband photometry for the 79 nearby galaxies that comprise the union of the KINGFISH (Key Insights on Nearby Galaxies: A ...Far-Infrared Survey with Herschel) and SINGS (Spitzer Infrared Nearby Galaxies Survey) samples. The 34-band data set presented here includes contributions from observational work carried out with a variety of facilities including GALEX, SDSS, Pan-STARRS1, NOAO, 2MASS, Wide-Field Infrared Survey Explorer, Spitzer, Herschel, Planck, JCMT, and the VLA. Improvements of note include recalibrations of previously published SINGS BVRCIC and KINGFISH far-infrared/submillimeter photometry. Similar to previous results in the literature, an excess of submillimeter emission above model predictions is seen primarily for low-metallicity dwarf or irregular galaxies. This 33-band photometric data set for the combined KINGFISH+SINGS sample serves as an important multiwavelength reference for the variety of galaxies observed at low redshift. A thorough analysis of the observed spectral energy distributions is carried out in a companion paper.
•Cyclic response of Cu-Al-Be SMA wires under multiple environments is investigated.•The ideal superelastic conditions are determined through heat treatment variation.•The evolution of the degradation ...of mechanical properties is characterized.•The effect of temperature, strain amplitude, grain size and time course are addressed.•A low-cycle fatigue model based on the Coffin – Manson relationship is proposed.
Shape memory alloys (SMAs) are smart materials with self-centering characteristics that can be used to reduce the earthquake damage to structures. In this paper, the optimal thermal treatment to obtain the ideal mechanical properties of a CuAlBe SMA wires for seismic protection applications is discussed. For this purpose, the uniaxial cyclic and monotonic stress-strain response of a 1.4 mm-diameter wire subjected to heat treatments applied for different durations is evaluated. Wire specimens are tested in multiple environments at several strain amplitudes and loading protocols. The variation of mechanical properties over time is also addressed. Test results show that a minimum treatment time of 25 min at 750 °C (∼200 μm) is necessary for obtaining superelasticity at all ambient temperatures tested. Also, as the heat treatment time increases, the residual strain, functional fatigue, strength, energy dissipation and hysteresis degradation decrease, but the superelasticity limit and low cycle fatigue life are increased. However, a 35 min treatment (∼400 μm) causes the loops to become unstable at high temperatures and the training process is not efficient. The best conditions for seismic protection purposes are achieved with a 30 min treatment (∼300 μm), due to its maximum recoverable strain of 6.5 %, 3.6 % equivalent viscous damping, negligible residual strain and stable hysteresis under all temperatures evaluated and over time. A low-cycle fatigue model based on the Coffin - Manson relationship is also proposed.
Although the mammalian rest-activity cycle is controlled by a “master clock” in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual SCN neurons gates ...individual features of daily activity. Here, we demonstrate that a specific transcriptomically identified population of mouse VIP+ SCN neurons is active at the “wrong” time of day—nighttime—when most SCN neurons are silent. Using chemogenetic and optogenetic strategies, we show that these neurons and their cellular clocks are necessary and sufficient to gate and time nighttime sleep but have no effect upon daytime sleep. We propose that mouse nighttime sleep, analogous to the human siesta, is a “hard-wired” property gated by specific neurons of the master clock to favor subsequent alertness prior to dawn (a circadian “wake maintenance zone”). Thus, the SCN is not simply a 24-h metronome: specific populations sculpt critical features of the sleep-wake cycle.
•Specific VIP+ neurons of the SCN fire at night when most others are silent•Activating or silencing these VIP+ neurons controls nighttime but not daytime sleep•Circadian clockwork within these specific neurons times the daily “siesta”•The activity of these neurons, in turn, programs subsequent end-of-day alertness
The “master” circadian clock generally indicates day and night by tonic daytime firing. A specific population of neurons, active when the rest of the SCN is silent, directs nighttime “siesta” sleep but not daytime sleep, thereby timing end-of-day alertness.
The effect of graphite, CeO2 and nanohybrid CeO2-graphite on an Al–Mg–Si system (6063 alloys) was studied in this paper. Such alloy was reinforced using mechanical milling, followed by a conventional ...sintering process. Studies for structure, microstructure, and mechanical properties were carried out through X-ray diffraction, electron microscopy, and compression and Vickers microhardness testing. Results showed that the milling process enables homogeneous dispersion of the different reinforcement materials in the Al–Mg–Si matrix. The best performance, concerning reinforcement capacity and microhardness, was obtained with samples reinforced with graphite. The mechanisms involved in enhancing the mechanical properties were active and latent. The first includes grain-size refinement and strengthening by dispersion of a second phase, and the second is related to thermal mismatch.
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•The Gr, CeO2, and nanohybrid CeO2-Gr reinforcements were homogeneously dispersed.•The reinforcements containing Gr presented the formation of Al4C3 during sintering.•The CeO2 presented a partial reduction into Ce7O12 during sintering.•The reinforcements containing Gr showed the best mechanical response.•The active and latent strengthening mechanisms enhanced the mechanical properties.
Background. Mycoplasma pneumoniae continues to be a significant cause of community-acquired pneumonia and, on rare occasions, manifests as fulminant disease that leads to mortality, even in healthy ...individuals. Methods. We conducted a retrospective study on members of a family who were quarantined by the Centers for Disease Control and Prevention in 2002 for respiratory failure and death of a 15-year-old brother (sibling 1) and a 13-year-old sister (sibling 2). Collected airway, cerebrospinal fluid (CSF), and serum samples from both deceased siblings and serum samples from both parents and the remaining 3 ill siblings (sibling 3-5) were tested using a range of diagnostic assays. Autopsy lung tissue samples from sibling 2 were also assessed using immunohistochemical and immunoelectron microscopic methods. Results. Autopsy evaluation of sibling 1 revealed cerebral edema consistent with hypoxic ischemic encepatholopathy and pulmonary findings of bronchiolitis obliterans with organizing pneumonia (BOOP). Postmortem lung examination of sibling 2 revealed lymphoplasmacytic bronchiolitis with intraluminal purulent exudate, BOOP, and pulmonary edema. Results of diagnostic assays implicated the household transmission of M. pneumoniae among all 5 siblings and both parents. Further analysis of lung tissue from sibling 2 demonstrated the presence of M. pneumoniae organisms and community-acquired respiratory distress syndrome toxin. M. pneumoniae was cultured directly from sibling 2 autopsy lung tissue. Conclusion. Evidence is provided that M. pneumoniae was readily transmitted to all members of the household and that the resulting infections led to a spectrum of individual responses with variation in disease progression, including lymphoplasmacytic bronchiolitis, BOOP, and death.
Photodynamic therapy (PDT) is currently limited by the inability of photosensitizers (PSs) to enter cancer cells and generate sufficient reactive oxygen species. Utilizing phosphorescent triplet ...states of novel PSs to generate singlet oxygen offers exciting possibilities for PDT. Here, we report phosphorescent octahedral molybdenum (Mo)‐based nanoclusters (NC) with tunable toxicity for PDT of cancer cells without use of rare or toxic elements. Upon irradiation with blue light, these molecules are excited to their singlet state and then undergo intersystem crossing to their triplet state. These NCs display surprising tunability between their cellular cytotoxicity and phototoxicity by modulating the apical halide ligand with a series of short chain fatty acids from trifluoroacetate to heptafluorobutyrate. The NCs are effective in PDT against breast, skin, pancreas, and colon cancer cells as well as their highly metastatic derivatives, demonstrating the robustness of these NCs in treating a wide variety of aggressive cancer cells. Furthermore, these NCs are internalized by cancer cells, remain in the lysosome, and can be modulated by the apical ligand to produce singlet oxygen. Thus, (Mo)‐based nanoclusters are an excellent platform for optimizing PSs. Our results highlight the profound impact of molecular nanocluster chemistry in PDT applications.
Phosphorescent metal halide nanoclusters have been described for tunable photodynamic therapy. Modulating the short chain fatty acid length on the apical halide ligand of phosphorescent octahedral molybdenum‐based nanoclusters facilitates cellular uptake and improves phototoxicity in photodynamic therapy (PDT). Following photoexcitation, the nanoclusters produce singlet oxygen to cause cancer cell death. Image created with BioRender.com.
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