This book offers an account of perceptual experience—its intrinsic nature, its engagement with the world, its relations to mental states of other kinds, and its role in epistemic norms. One of the ...book’s main claims is that perceptual experience constitutively involves representations of worldly items. A second claim is that the relevant form of representation can be explained in broadly biological terms. After defending these foundational doctrines, the book proceeds to give an account of perceptual appearances and how they are related to the objective world. Appearances turn out to be relational, viewpoint dependent properties of external objects. There is also a complementary account of how the objects that possess these properties are represented. Another major concern is the phenomenological dimension of perception. The book maintains that perceptual phenomenology can be explained reductively in terms of the representational contents of experiences, and it uses this doctrine to undercut the traditional arguments for dualism. This treatment of perceptual phenomenology is then expanded to encompass cognitive phenomenology, the phenomenology of moods and emotions, and the phenomenology of pain. The next topic is the various forms of consciousness that perceptual experience can possess. A principal aim is to show that phenomenology is metaphysically independent of these forms of consciousness, and another is to de-mystify the form known as phenomenal consciousness. The book concludes by discussing the relations of various kinds that perceptual experiences bear to higher level cognitive states, including relations of format, content, and justification or support.
Scalar fields, ϕi, can be coupled nonminimally to curvature and satisfy the general criteria: (i) the theory has no mass input parameters, including MP=0; (ii) the ϕi have arbitrary values and ...gradients, but undergo a general expansion and relaxation to constant values that satisfy a nontrivial constraint, K(ϕi)=constant; (iii) this constraint breaks scale symmetry spontaneously, and the Planck mass is dynamically generated; (iv) there can be adequate inflation associated with slow roll in a scale-invariant potential subject to the constraint; (v) the final vacuum can have a small to vanishing cosmological constant; (vi) large hierarchies in vacuum expectation values can naturally form; (vii) there is a harmless dilaton which naturally eludes the usual constraints on massless scalars. These models are governed by a global Weyl scale symmetry and its conserved current, Kμ. At the quantum level the Weyl scale symmetry can be maintained by an invariant specification of renormalized quantities.
Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. However, specific characteristics of dysregulated immune cells within ...atherosclerotic lesions that lead to clinical events such as ischemic stroke or myocardial infarction are poorly understood. Here, using single-cell proteomic and transcriptomic analyses, we uncovered distinct features of both T cells and macrophages in carotid artery plaques of patients with clinically symptomatic disease (recent stroke or transient ischemic attack) compared to asymptomatic disease (no recent stroke). Plaques from symptomatic patients were characterized by a distinct subset of CD4
T cells and by T cells that were activated and differentiated. Moreover, some T cell subsets in these plaques presented markers of T cell exhaustion. Additionally, macrophages from these plaques contained alternatively activated phenotypes, including subsets associated with plaque vulnerability. In plaques from asymptomatic patients, T cells and macrophages were activated and displayed evidence of interleukin-1β signaling. The identification of specific features of innate and adaptive immune cells in plaques that are associated with cerebrovascular events may enable the design of more precisely tailored cardiovascular immunotherapies.
A cosmic axion, via the electromagnetic anomaly, induces an oscillating electric dipole for the electron of frequency m sub(a)and strength ~(few)x10 super(-32)e-cm, two orders of magnitude above the ...nucleon, and within a few orders of magnitude of the present standard model constant limit. We give a detailed study of this phenomenon via the interaction of the cosmic axion, through the electromagnetic anomaly, with particular emphasis on the decoupling limit of the axion, partialdifferential sub()tat)infinitym sub(a)10. The analysis is subtle, and we find the general form of the action involves a local contact interaction and a nonlocal contribution, analogous to the "transverse current" in QED, that enforces the decoupling limit. We carefully derive the effective action in the Pauli-Schrodinger nonrelativistic formalism, and in Georgi's heavy quark formalism adapted to the "heavy electron" (m sub(e)> m sub(a). We compute the electric dipole radiation emitted by free electrons, magnets and currents, immersed in the cosmic axion field, and discuss experimental configurations that may yield a detectable signal.
Dual numbers allow for automatic, exact evaluation of the numerical derivative of high-dimensional functions at an arbitrary point with minimal coding effort. We use dual numbers to construct tangent ...linear and adjoint model code for a biogeochemical ocean model and apply it to a variational (4D-Var) data assimilation system when coupled to a realistic physical ocean circulation model with existing data assimilation capabilities. The resulting data assimilation system takes modestly longer to run than its hand-coded equivalent but is considerably easier to implement and updates automatically when modifications are made to the biogeochemical model, thus making its maintenance with code changes trivial.
I argue for three claims. (1) The phenomenology of visual experience is exhausted by awareness of appearance properties (i.e., certain constantly changing characteristics of external objects that are ...relational and viewpoint‐dependent). (2) Cognition differs from perception in that it has a purely discursive or linguistic dimension, whereas perception is pervasively analog and iconic; but this does not determine a border between the two domains, for cognition also has a massive iconic dimension. And (3) certain raging debates in teleosemantics can be resolved by acknowledging that perceptual representations in more primitive organisms tend to have dual contents (e.g., both small, moving black object, and food).
The highly anticipated transition from next generation sequencing (NGS) to third generation sequencing (3GS) has been difficult primarily due to high error rates and excessive sequencing cost. The ...high error rates make the assembly of long erroneous reads of large genomes challenging because existing software solutions are often overwhelmed by error correction tasks. Here we report a hybrid assembly approach that simultaneously utilizes NGS and 3GS data to address both issues. We gain advantages from three general and basic design principles: (i) Compact representation of the long reads leads to efficient alignments. (ii) Base-level errors can be skipped; structural errors need to be detected and corrected. (iii) Structurally correct 3GS reads are assembled and polished. In our implementation, preassembled NGS contigs are used to derive the compact representation of the long reads, motivating an algorithmic conversion from a de Bruijn graph to an overlap graph, the two major assembly paradigms. Moreover, since NGS and 3GS data can compensate for each other, our hybrid assembly approach reduces both of their sequencing requirements. Experiments show that our software is able to assemble mammalian-sized genomes orders of magnitude more quickly than existing methods without consuming a lot of memory, while saving about half of the sequencing cost.
Polyoxygenated hydrocarbons that bear one or more hydroxyl groups comprise a large set of natural and synthetic compounds, often with potent biological activity. In synthetic chemistry, alcohols are ...important precursors to carbonyl groups, which then can be converted into a wide range of oxygen- or nitrogen-based functionality. Therefore, the selective conversion of a single hydroxyl group in natural products into a ketone would enable the selective introduction of unnatural functionality. However, the methods known to convert a simple alcohol, or even an alcohol in a molecule that contains multiple protected functional groups, are not suitable for selective reactions of complex polyol structures. We present a new ruthenium catalyst with a unique efficacy for the selective oxidation of a single hydroxyl group among many in unprotected polyol natural products. This oxidation enables the introduction of nitrogen-based functional groups into such structures that lack nitrogen atoms and enables a selective alcohol epimerization by stepwise or reversible oxidation and reduction.
This book presents a comprehensive theory of consciousness. The initial chapter distinguishes six main forms of consciousness and sketches an account of each one. Later chapters focus on phenomenal ...consciousness, consciousness of, and introspective consciousness. In discussing phenomenal consciousness, Hill develops the representational theory of mind in new directions, arguing that all awareness involves representations, even awareness of qualitative states like pain. He then uses this view to undercut dualistic accounts of qualitative states. Other topics include visual awareness, visual appearances, emotional qualia, and meta-cognitive processing. This important work will interest a wide readership of students and scholars in philosophy of mind and cognitive science.
We give a bilocal field theory description of a composite scalar with an extended binding potential that reduces to the Nambu-Jona-Lasinio (NJL) model in the pointlike limit. This provides a ...description of the internal dynamics of the bound state and features a static internal wave function, ϕ(r→), in the center-of-mass frame that satisfies a Schrödinger-Klein-Gordon equation with eigenvalues m2. We analyze the "coloron" model (single perturbative massive gluon exchange) which yields a UV completion of the NJL model. This has a BCS-like enhancement of its interaction, ∝Nc the number of colors, and is
with gcritical remarkably close to the NJL quantum critical coupling. Negative eigenvalues for m2 lead to spontaneous symmetry breaking, and the Yukawa coupling of the bound state to constituent fermions is emergent.
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