Eighteen active substances, including 17 organosulfur compounds found in garlic essential oil (T), were identified by GC–MS analysis. For the first time, using the molecular docking technique, we ...report the inhibitory effect of the considered compounds on the host receptor angiotensin-converting enzyme 2 (ACE2) protein in the human body that leads to a crucial foundation about coronavirus resistance of individual compounds on the main protease (PDB6LU7) protein of SARS-CoV-2. The results show that the 17 organosulfur compounds, accounting for 99.4% contents of the garlic essential oil, have strong interactions with the amino acids of the ACE2 protein and the main protease PDB6LU7 of SARS-CoV-2. The strongest anticoronavirus activity is expressed in allyl disulfide and allyl trisulfide, which account for the highest content in the garlic essential oil (51.3%). Interestingly, docking results indicate the synergistic interactions of the 17 substances, which exhibit good inhibition of the ACE2 and PDB6LU7 proteins. The results suggest that the garlic essential oil is a valuable natural antivirus source, which contributes to preventing the invasion of coronavirus into the human body.
Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial‐based SDoH ...data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health‐equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial‐embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted‐in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9–93.1%) over 24 months. Trial‐embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.
Advances in genomics have deepened our understanding of the biology of acute lymphoblastic leukemia (ALL), defined novel molecular leukemia subtypes, discovered new prognostic biomarkers and paved ...the way to emerging molecularly targeted therapeutic avenues. Since its discovery, IKZF1 has generated significant interest within the leukemia scientific community.IKZF1 plays a critical role in lymphoid development and its alterations cooperate to mediate leukemogenesis. IKZF1 alterations are present in approximately 15% of childhood ALL, rise in prevalence among adults with ALL and become highly enriched within kinase-driven ALL. A cumulating body of literature has highlighted the adverse prognostic impact of IKZF1 alterations in both Philadelphia chromosome (Ph)-negative and Ph-driven ALL. IKZF1 alterations thus emerge as an important prognostic biomarker in ALL. This article aims to provide a state-of-the-art review focusing on the prognostic clinical relevance of IKZF1 alterations in ALL, as well as current and future therapeutic strategies targeting IKZF1-altered ALL.
In the present paper, the synthesis of metal-organic framework MIL-101 and its application in the photocatalytic degradation of Remazol Black B (RBB) dye have been demonstrated. The obtained samples ...were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and nitrogen adsorption/desorption isotherms at 77 K. It was found that MIL-101 synthesized under optimal conditions exhibited high crystallinity and specific surface area (3360 m2·g-1). The obtained MIL-101 possessed high stability in water for 14 days and several solvents (benzene, ethanol, and water at boiling temperature). Its catalytic activities were evaluated by measuring the degradation of RBB in an aqueous solution under UV radiation. The findings show that MIL-101 was a heterogeneous photocatalyst in the degradation reaction of RBB. The mechanism of photocatalysis was considered to be achieved by the electron transfer from photoexcited organic ligands to metallic clusters in MIL-101. The kinetics of photocatalytic degradation reaction were analyzed by using the initial rate method and Langmuir-Hinshelwood model. The MIL-101 photocatalyst exhibited excellent catalytic recyclability and stability and can be a potential catalyst for the treatment of organic pollutants in aqueous solutions.
Display omitted
•We have demonstrated a facile method to prepare Fe2O3 nanoparticles.•The gas sensing properties of α-Fe2O3 have been invested.•The results show potential application of α-Fe2O3 NPs ...for CO sensors in environmental monitoring.
Iron oxide nanoparticles (NPs) were prepared via a simple hydrothermal method for high performance CO gas sensor. The synthesized α-Fe2O3 NPs were characterized by X-ray diffraction, nitrogen adsorption/desorption isotherm, scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and selected area electron diffraction (SAED). The SEM, TEM results revealed that obtained α-Fe2O3 particles had a peanut-like geometry with hemispherical ends. The response of the α-Fe2O3 NPs based sensor to carbon monoxide (CO) and various concentrations of other gases were measured at different temperatures. It found that the sensor based on the peanut-like α-Fe2O3 NPs exhibited high response, fast response–recovery, and good selectivity to CO at 300°C. The experimental results clearly demonstrated the potential application of α-Fe2O3 NPs as a good sensing material in the fabrication of CO sensor.
•Facile method has employed to prepare mesoporous Co3O4 nanochains with high specific surface area.•The Co3O4 nanochains has highly sensitive and selective toward H2S gas with rapid response.•Such a ...potential gas sensing strategy can be easily extended to other metal oxides.
In this paper, cobalt carbonate hydroxide (Co(CO3)0.5(OH)..11H2O) nanowires were successfully fabricated by a simple hydrothermal route without using surfactants and by subsequent heat treatment in air at 600 °C for 5 h to obtain mesoporous Co3O4 nanochains. As-synthesized nanochains with length of several micrometers consisted of well-linked Co3O4 nanoparticles with an average size of 50 nm. The sensor based on mesoporous Co3O4 nanochains was used to detect flammable and toxic gases, including H2S, NH3, CO, and H2. Results showed potential of mesoporous Co3O4 nanochains as sensor material for detection of hydrogen sulfides at low concentration with rapid response.
► We have demonstrated a facile method to prepare Fe3O4 nanoparticles and chitosan-coated Fe3O4 nanoparticles. ► α-Fe2O3 sensors prepared from those Fe3O4 materials have been investigated and ...compared. ► The results show potential application of α-Fe2O3 for CO sensors in environmental monitoring.
In this paper, Fe3O4 and chitosan (CS)-coated Fe3O4 nanoparticles were synthesized via co-precipitation method and subsequent covalent binding of CS onto the surface for functionalization, respectively. Characterization of the crystal structures and morphologies of as-synthesized nanoparticles by X-ray diffraction, scanning electron microscopy, and transmission electron microscopy demonstrated that Fe3O4 had a cubic spinal structure with irregular shapes and average diameters of 10–20nm. The surface states and magnetic properties of Fe3O4-CS nanoparticles were characterized by Fourier transform infrared spectra and vibrating sample magnetometry. Results showed that Fe3O4-CS nanoparticles possessed super-paramagnetic properties, with saturated magnetization up to 60emu/g. In addition, Fe3O4 and CS-coated Fe3O4 nanoparticles were used in the fabrication of α-Fe2O3 based gas sensors. Gas sensing measurements revealed that the α-Fe2O3 gas sensor prepared from Fe3O4-CS had a better response to H2, CO, C2H5OH, and NH3 compared with the device prepared from pristine Fe3O4. Furthermore, the α-Fe2O3 sensor prepared from Fe3O4-CS nanoparticles exhibited the highest response to CO among the test gases, suggesting that it has great potential for practical applications in environmental monitoring.
Display omitted
► Single and binary noble metal nanocrystals (NCs) have been of great research interest due to their selectively unique properties. ► Using the efficient aqueous-based synthetic ...approaches as well as understanding of their nucleation and growth kinetics that would allow for the control of uniform morphology of water-dispersed single and binary metal NCs resulting of tailoring their electronic properties. ► The antibody (biomolecule: protein and/or DNA)-conjugated metallic nanocrystals (gold or gold-based materials) with shape, structure, surface modification controls have been utilized as an active agent for a broad range of biomedical applications. ► Particularly they serve as light-activated nanoscopic heaters useful for photothermal cancer treatment and further in optical imaging probes and drug delivery.
Aqueous-dispersed single and binary noble metal nanocrystals have attracted much attention as key materials in many fields, especially in biomedicine, catalysis, etc. Controlled growth of the metal nuclei allow for the manipulation of uniform morphology of final products. This behavior would tailor their unique physiochemical and electronic properties and follows by their practical applications. This review presents an overall picture of kinetic formation of a particle and then summarizes an overview of recent progress in many research groups concerning aqueous- and/or polyol-based syntheses of many types of aqueous-dispersed single metallic and bimetallic nanocrystals with controlled shape. The main advantages in these synthetic approaches for the shape-controlled metal nanocrystals are simple, versatile, environmentally friendly, low cost, pure and single-crystalline products, and high yield. The formed products can be easily dispersed in water medium and compatible for biotechnological field. Particularly the biomolecule (antibody including protein and/or DNA)-conjugated gold nanocrystals have been utilized as an active agent for a broad range of biomedical applications. We expect that this review will have a high potential towards novel materials fabrication and nanotechnological fields.
GC‐MS was applied to identify 24 main substances in Melaleuca cajuputi essential oil (TA) extracted from fresh cajeput leaves through steam distilling. The inhibitory capability of active compounds ...in the TA from Thua Thien Hue, Vietnam over the Angiotensin‐Converting Enzyme 2 (ACE2) protein in human body ‐ the host receptor for SARS‐CoV‐2 and the main protease (PDB6LU7) of the SARS‐CoV‐2 using docking simulation has been studied herein. The results indicate that the ACE2 and PDB6LU7 proteins were strongly inhibited by 10 out of 24 compounds accounting for 70.9% in the TA. The most powerful anticoronavirus activity is expressed in the order: Terpineol (TA2) ≈ Guaiol (TA5) ≈ Linalool (TA19) > Cineol (TA1) > β‐Selinenol (TA3) > α‐Eudesmol (TA4) > γ‐Eudesmol (TA7). Interestingly, the synergistic interactions of these 10 substances of the TA exhibit excellent inhibition into the ACE2 and PDB6LU7 proteins. The docking results orient that the natural Melaleuca cajuputi essential oil is considered as a valuable resource for preventing SARS‐CoV‐2 invasion into human body.
This is the first time to simulate the inhibitory effect of compounds in Melaleuca cajuputi oil to the main proteins of SARS‐CoV‐2 (PDB6LU7) and its host receptor (ACE2). They are strongly inhibited by the individual inhibition as well as the synergistic interaction of 10 out of 24 compounds accounting for 70.9% in this oil. The results orient that Melaleuca cajuputi oil is considered as a valuable resource for SARS‐CoV‐2 prevention.
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a newly identified high-risk (HR) B-lineage ALL subtype, accounting for ∼15% of children with National Cancer ...Institute-defined HR B-ALL. It occurs more frequently in adolescents and adults, having been reported in as much as 27% of young adults with ALL between 21 and 39 years of age. It exhibits adverse clinical features, confers a poor prognosis, and harbors a diverse range of genetic alterations that activate cytokine receptor genes and kinase signaling pathways, making it amenable to treatment with tyrosine kinase inhibitor (TKI) therapy. Multiple groups are currently conducting clinical trials to prospectively screen patients with Ph-like ALL and incorporate the relevant TKI for those harboring ABL-class gene rearrangements or those with JAK-STAT pathway alterations. The success of combinatorial treatment of TKI with chemotherapy in the setting of Ph-positive ALL suggests that this approach may similarly improve outcomes for patients with Ph-like ALL. Hence, Ph-like ALL illustrates the modern treatment paradigm of precision medicine and presents unique opportunities for harnessing international collaborations to further improve outcomes for patients with ALL.
PDF
