A non-linear procedure is presented for modelling the bond characteristic between concrete and reinforcing steel for reinforced concrete structures in a fire. The accuracy and reliability of the ...model are demonstrated by the analysis of one pull-out test and one beam test at ambient temperature and four full-scale beams tested under two fire conditions. The model is clearly capable of predicting the response of reinforced concrete members and structures in a fire with acceptable accuracy. The bond-link element has been found to have good computational stability and efficiency for 3D analysis of reinforced concrete structures in fires. It is shown that the bond condition between the concrete and reinforcing steel bar has an important influence on the fire resistance of reinforced concrete structures, especially when the temperature of the reinforcing steel bar is high (more than 500 °C). Hence, the current assumption of a perfect bond condition for analysis of reinforced concrete structures under fire conditions is unconservative.
MicroRNA (miRNA) opens up a new field for molecular diagnosis of cancer. However, the role of circulating miRNAs in plasma/serum in cancer diagnosis is not clear. The aim of this study was to ...investigate whether plasma miRNAs can be used as biomarkers for the early detection of colorectal carcinoma (CRC). We measured the levels of 12 miRNAs (miR‐134, −146a, −17‐3p, −181d, −191, −221, −222, −223, −25, −29a, −320a and −92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real‐time RT‐PCR. We found that plasma miR‐29a and miR‐92a have significant diagnostic value for advanced neoplasia. MiR‐29a yielded an AUC (the areas under the ROC curve) of 0.844 and miR‐92a yielded an AUC of 0.838 in discriminating CRC from controls. More importantly, these 2 miRNAs also could discriminate advanced adenomas from controls and yielded an AUC of 0.769 for miR‐29a and 0.749 for miR‐92a. Combined ROC analyses using these 2 miRNAs revealed an elevated AUC of 0.883 with 83.0% sensitivity and 84.7% specificity in discriminating CRC, and AUC of 0.773 with 73.0% sensitivity and 79.7% specificity in discriminating advanced adenomas. Collectively, these data suggest that plasma miR‐29a and miR‐92a have strong potential as novel noninvasive biomarkers for early detection of CRC.
We aimed to determine and compare the effects of music therapy and music medicine on depression, and explore the potential factors associated with the effect.
PubMed (MEDLINE), Ovid-Embase, the ...Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, and Clinical Evidence were searched to identify studies evaluating the effectiveness of music-based intervention on depression from inception to May 2020. Standardized mean differences (SMDs) were estimated with random-effect model and fixed-effect model.
A total of 55 RCTs were included in our meta-analysis. Music therapy exhibited a significant reduction in depressive symptom (SMD = -0.66; 95% CI = -0.86 to -0.46; P<0.001) compared with the control group; while, music medicine exhibited a stronger effect in reducing depressive symptom (SMD = -1.33; 95% CI = -1.96 to -0.70; P<0.001). Among the specific music therapy methods, recreative music therapy (SMD = -1.41; 95% CI = -2.63 to -0.20; P<0.001), guided imagery and music (SMD = -1.08; 95% CI = -1.72 to -0.43; P<0.001), music-assisted relaxation (SMD = -0.81; 95% CI = -1.24 to -0.38; P<0.001), music and imagery (SMD = -0.38; 95% CI = -0.81 to 0.06; P = 0.312), improvisational music therapy (SMD = -0.27; 95% CI = -0.49 to -0.05; P = 0.001), music and discuss (SMD = -0.26; 95% CI = -1.12 to 0.60; P = 0.225) exhibited a different effect respectively. Music therapy and music medicine both exhibited a stronger effects of short and medium length compared with long intervention periods.
A different effect of music therapy and music medicine on depression was observed in our present meta-analysis, and the effect might be affected by the therapy process.
Owing to insufficient active sites, strongly bound excitons and insufficient optical absorption, polymer semiconductors have only shown mild activity as potential candidates for photocatalysis. A ...g-C3N4 with improved optical absorption capacity, charge transfer performance and porosity was successfully prepared by a one-step NH4Cl-assisted route. Interaction of melamine with NH4Cl preparation of Porous g-C3N4(CN-xy) with active functional groups modified pore wall shown to result in highly crystalline species with a maximum π-π layer stacking distance of heptazine units of 0.321 nm, decreases the optical band gap from 2.80 to 2.13 eV and maximum surface area reached 56.485 m2 g−1. The balanced improvement of the multiple defects of g-C3N4 makes the photocatalytic degradation of RhB and the photocatalytic hydrogen production efficiency 4 and 5 times higher than the pristine g-C3N4, respectively.
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•One-step in suit inducing.•Amino and cyano modified porous g-C3N4.•Trade-off in all aspects.•Forming an electronic transmission path for D-π-A.
In this paper a robust model is presented based on the previous layer procedure developed by the author to also take into account the effects of concrete spalling on the behaviour of concrete slabs ...under fire conditions. In this study, a detailed analysis of a uniformly loaded reinforced concrete slab subject to different degrees of concrete spalling under a standard fire regime is first carried out. Further, a series of analysis of floor slabs with different degrees of concrete spalling is also performed on a generic reinforced concrete building. A total of 16 cases have been analysed using different degrees of spalling on the slabs, with different extents and positions of localised fire compartments. It is clear that adjacent cool structures provide considerable thermal restraint to the floor slabs within the fire compartment. And it is evident that the compressive membrane force within the slabs is a major player in reducing the impact of concrete spalling on the structural behaviour of floor slabs in fire.
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and ...molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and mechanism of UCA1 in CRC. We found that UCA1 was up-regulated in CRCs and negatively correlated with survival time in two CRC cohorts. Functional assays revealed the in vitro and in vivo growth-promoting function of UCA1 and revealed that UCA1 can decrease the sensitivity of CRC cells to 5-FU by attenuating apoptosis. Further mechanistic studies revealed that UCA1 could sponge endogenous miR-204-5p and inhibit its activity. We also identified CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. The present work provides the first evidence of a UCA1-miR-204-5p-CREB1/BCL2/RAB22A regulatory network in CRC and reveals that UCA1 and CREB1 are potential new oncogenes and prognostic factors for CRC.
A unique heterostructure is developed based on a 3D photoactive semiconductor and a 0D Cu2O QDs for superb photocatalytic reduction CO2 into CO. It reported a novel and simple method to prepare a 3D ...g-C3N4 foam with micron-sized porous structures using ultrastable foam as a soft template for the first time. Moreover, Cu2O QDs are loaded onto 3D g-C3N4 foam through a simple photodeposition strategy. Systematically characterization demonstrated that g-C3N4 foam not only act as an excellent carrier for Cu2O QDs, but also greatly improve the photocatalytic performance by enhancing CO2 adsorption and gas transfer. Simultaneously, the rationally designed g-C3N4 foam/Cu2O QDs exhibited notablely enhancement in photocatalytic performance with 3.9 times and 11 times higher than that of g-C3N4 foam and bulk g-C3N4 powder. The excellent photocatalytic activity can be attributed to the unique porous structure and the synergistic effect between g-C3N4 foam and Cu2O QDs, which can speed up the transfer of charge carriers and urged the cumulation of photo-generated electrons on the Cu2O QDs. Our work provides new ideas for constructing 0D/3D hierarchical photocatalytic systems, which may provide guidance on designing efficient photocatalysts to maximize photocatalyst kinetics.
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•Cu2O QDs modified 3D g-C3N4 foam was facilely synthesized.•Photocatalytic reduction CO2 was enhanced by excellent CO2 adsorption performance.•Synergistic effect between g-C3N4 foam and Cu2O QDs was proposed in this system.
After the Wenchuan Earthquake on May 12th, 2008, the Wenchuan Earthquake Fault Scientific Drilling Project (WFSD) was initiated in order to investigate the structure of the fault zones and the ...mechanism of the earthquake. The WFSD contains four boreholes (WFSD-1, WFSD-2, WFSD-3 and WFSD-4) lying at the maximum displacement locations along the Yingxiu-Beichuan fault zone and the Guanxian-Anxian fault zone, and WFSD-2 is the second borehole and is still being drilled. Core samples, resistivity and acoustic image logging data were acquired from 50 to 1370m. The natural fractures, borehole breakouts, drilling-induced fractures and drilling-enhanced natural fractures were identified from the cores and the image logs and were statistically analyzed. The strikes of the natural fractures systematically vary and can be sorted into four groups according to depth: (1) above 637m, mainly striking ENE–WSW; (2) in the interval of 637–932.6m, striking NNE–SSW; (3) in the interval of 932.6–1200m, directed ENE–WSW then to WNW–ESE, while striking NE–SW from 1030m to 1150m; (4) from 1200m to 1370m, maintaining a strike of WNW–ESE. The natural fractures from 50m to 637m seem to be reverse faults which strike approximately parallelly to the main fault. Two sets of conjugate fractures around 1002.4m indicating subvertical maximum principal paleo-stress direction may be a subordinate structure of the main fault caused by a local stress field, and it reveals the complex stress field of Yingxiu-Beichuan fault zone when the fractures formed. A total of 12 BOs, 2 sets of DIFs and one set of DEFs with an overall length of 30.4m were interpreted from 960m to 1370m in WFSD-2. The average SHmax orientation interpreted for WFSD-2 (960–1370m) is 120.7°–300.7°N (i.e. WNW–ESE) with the standard deviation of 9.2° and it is consistent with the stress status of Yingxiu-Beichuan fault zone which is one of the main fault zones in the 2008 Wenchuan Earthquake.
•Well logging data and continuous core data were obtained and processed.•The depth and orientation of the cores were restored by using the image logs.•Both image logs and cores were used to identify the geological features.•The direction of stress was determined by drilling-induced failures.
The red-emitting phosphor LaMgAl11O19:Sm3+, Eu3+ was prepared by solid-state reaction at 1600 °C for 4 h. The phase formation, luminescence properties, and energy transfer from Sm3+ to Eu3+ were ...studied. With the addition of 5 mol % Sm3+ as the sensitizer, the excitation wavelength of LaMgAl11O19:Eu3+ phosphor was extended from 464 to 403 nm, and the emission intensity under the excitation at 403 nm was also enhanced. The host material LaMgAl11O19 could contain the high doping content of Eu3+ (20 mol %) without concentration quenching. This energy transfer from Sm3+ to Eu3+ was confirmed by the decay times of energy donor Sm3+. The mechanism of energy transfer (Sm3+ → Eu3+) was proved to be quadrupole–quadrupole interaction. Under the 403 nm excitation at 150 °C, the emission intensities of the characteristic peaks of Sm3+ and Eu3+ in LaMgAl11O19:0.05Sm3+, 0.2Eu3+ phosphor were decreased to 65% and 56% of the initial intensities at room temperature, and the relatively high activation energy proved that this phosphor had a good thermal stability. The CIE coordinate was calculated to be (x = 0.601, y = 0.390). The LaMgAl11O19:0.05Sm3+, 0.2Eu3+ phosphor is a candidate for copper phthalocyanine-based solar cells and white light-emitting diodes.
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