U 2018. godini industrijska konoplja, kultura višestruke namjene, uzgajala se u Republici Hrvatskoj na 857,27 ha. Cilj ovog rada je utvrditi agrotehničke mjere u ekološkom uzgoju industrijske ...konoplje, sorte „Felina 32“, za zrno na površini od 10 ha na obiteljskom poljoprivrednom gospodarstvu. Nakon berbe kukuruza izvršeno je zaoravanje žetvenih ostataka i duboko oranje uz primjenu organskog gnojiva. Sjetva je izvršena 05. travnja 2019. godine uz utrošak sjemena od 20 kg/ha. Žetva je obavljena 20. rujna 2019. Prinos zrna konoplje iznosio je 930 kg/ha, što je uz poticaje, donijelo dobit od 13.524,80 kn po hektaru.
In 2018, industrial hemp, a multi-purpose crop, was grown in the Republic of Croatia on 857.27 ha. The aim of this paper is to determine agrotechnical measures in organic farming of industrial hemp, variety „Felina 32“, for grain on an area of 10 ha on a family farm. After harvesting the corn, plowing of crop residues and deep plowing were applied with organic fertilizer. Sowing was carried out on April 5, 2019 with a seed consumption of 20 kg ha-1. The harvest was performed on September 20, 2019. The yield of hemp grain was 930 kg ha-1, which, with incentives, brought a profit of HRK 13,524.80 per hectare.
Objectives and scope
Primary mitochondrial diseases (PMDs) are rare genetic disorders resulting from mutations in genes crucial for effective oxidative phosphorylation (OXPHOS) that can affect ...mitochondrial function. In this review, we examine the bioenergetic alterations and oxidative stress observed in cellular models of primary mitochondrial diseases (PMDs), shedding light on the intricate complexity between mitochondrial dysfunction and cellular pathology. We explore the diverse cellular models utilized to study PMDs, including patient‐derived fibroblasts, induced pluripotent stem cells (iPSCs) and cybrids. Moreover, we also emphasize the connection between oxidative stress and neuroinflammation.
Insights
The central nervous system (CNS) is particularly vulnerable to mitochondrial dysfunction due to its dependence on aerobic metabolism and the correct functioning of OXPHOS. Similar to other neurodegenerative diseases affecting the CNS, individuals with PMDs exhibit several neuroinflammatory hallmarks alongside neurodegeneration, a pattern also extensively observed in mouse models of mitochondrial diseases. Based on histopathological analysis of postmortem human brain tissue and findings in mouse models of PMDs, we posit that neuroinflammation is not merely a consequence of neurodegeneration but a potential pathogenic mechanism for disease progression that deserves further investigation. This recognition may pave the way for novel therapeutic strategies for this group of devastating diseases that currently lack effective treatments.
Summary
In summary, this review provides a comprehensive overview of bioenergetic alterations and redox imbalance in cellular models of PMDs while underscoring the significance of neuroinflammation as a potential driver in disease progression.
