Ameliorer les soins post-tuberculose au Canada Romanowski, Kamila; Amin, Priya; Johnston, James C
Canadian Medical Association journal (CMAJ),
02/2023, Letnik:
195, Številka:
5
Journal Article
An Economist Best History Book 2017
"History as it should be written."-Barry Cunliffe,
Guardian "Scott hits the nail squarely on
the head by exposing the staggering price our ancestors paid for
...civilization and political order."-Walter Scheidel, Financial
Times Why did humans abandon hunting and gathering
for sedentary communities dependent on livestock and cereal grains,
and governed by precursors of today's states? Most people believe
that plant and animal domestication allowed humans, finally, to
settle down and form agricultural villages, towns, and states,
which made possible civilization, law, public order, and a
presumably secure way of living. But archaeological and historical
evidence challenges this narrative. The first agrarian states, says
James C. Scott, were born of accumulations of domestications: first
fire, then plants, livestock, subjects of the state, captives, and
finally women in the patriarchal family-all of which can be viewed
as a way of gaining control over reproduction. Scott explores why
we avoided sedentism and plow agriculture, the advantages of mobile
subsistence, the unforeseeable disease epidemics arising from
crowding plants, animals, and grain, and why all early states are
based on millets and cereal grains and unfree labor. He also
discusses the "barbarians" who long evaded state control, as a way
of understanding continuing tension between states and nonsubject
peoples.
With an epic career that spanned two-thirds of the twentieth century, C. Vann Woodward (1908-1999) was a historian of singular importance. A brilliant writer, his work captivated both academic and ...public audiences. He also figured prominently in the major intellectual conflicts between left and right during the last half of the twentieth century, although his unwavering commitment to free speech and racial integration that affirmed his liberalism in the 1950s struck some as emblematic of his growing conservatism by the 1990s. Woodward's vision still permeates our understandings of the American South and of the history of race relations in the United States. Indeed, as this fresh and revealing biography shows, he displayed a rare genius and enthusiasm for crafting lessons from the past that seemed directly applicable to the concerns of the present-a practice that more than once cast doubt on his scholarship. James C. Cobb offers many original insights into Woodward's early years and private life, his long career, and his almost mythic public persona. In a time where the study and substance of American history are profoundly contested, Woodward's career is replete with lessons in how myths about the past, some created by historians themselves, come to be enshrined as historical truth.
For two thousand years the disparate groups that now reside in Zomia (a mountainous region the size of Europe that consists of portions of seven Asian countries) have fled the projects of the ...organized state societies that surround them-slavery, conscription, taxes, corvée labor, epidemics, and warfare. This book, essentially an "anarchist history," is the first-ever examination of the huge literature on state-making whose author evaluates why people would deliberately and reactively remain stateless. Among the strategies employed by the people of Zomia to remain stateless are physical dispersion in rugged terrain; agricultural practices that enhance mobility; pliable ethnic identities; devotion to prophetic, millenarian leaders; and maintenance of a largely oral culture that allows them to reinvent their histories and genealogies as they move between and around states.
In accessible language, James Scott, recognized worldwide as an eminent authority in Southeast Asian, peasant, and agrarian studies, tells the story of the peoples of Zomia and their unlikely odyssey in search of self-determination. He redefines our views on Asian politics, history, demographics, and even our fundamental ideas about what constitutes civilization, and challenges us with a radically different approach to history that presents events from the perspective of stateless peoples and redefines state-making as a form of "internal colonialism." This new perspective requires a radical reevaluation of the civilizational narratives of the lowland states. Scott's work on Zomia represents a new way to think of area studies that will be applicable to other runaway, fugitive, and marooned communities, be they Gypsies, Cossacks, tribes fleeing slave raiders, Marsh Arabs, or San-Bushmen.
Bees and the pollination services they deliver are beneficial to both food crop production, and for reproduction of many wild plant species. Bee decline has stimulated widespread interest in ...assessing hazards and risks to bees from the environment in which they live. While there is increasing knowledge on how the use of broad-spectrum insecticides in agricultural systems may impact bees, little is known about effects of other pesticides (or plant protection products; PPPs) such as herbicides and fungicides, which are used more widely than insecticides at a global scale. We adopted a systematic approach to review existing research on the potential impacts of fungicides and herbicides on bees, with the aim of identifying research approaches and determining knowledge gaps. While acknowledging that herbicide use can affect forage availability for bees, this review focussed on the potential impacts these compounds could have directly on bees themselves. We found that most studies have been carried out in Europe and the USA, and investigated effects on honeybees. Furthermore, certain effects, such as those on mortality, are well represented in the literature in comparison to others, such as sub-lethal effects. More studies have been carried out in the lab than in the field, and the impacts of oral exposure to herbicides and fungicides have been investigated more frequently than contact exposure. We suggest a number of areas for further research to improve the knowledge base on potential effects. This will allow better assessment of risks to bees from herbicides and fungicides, which is important to inform future management decisions around the sustainable use of PPPs.
Submesoscale currents in the ocean McWilliams, James C.
Proceedings of the Royal Society. A, Mathematical, physical, and engineering sciences,
05/2016, Letnik:
472, Številka:
2189
Journal Article
Recenzirano
Odprti dostop
This article is a perspective on the recently discovered realm of submesoscale currents in the ocean. They are intermediate-scale flow structures in the form of density fronts and filaments, ...topographic wakes and persistent coherent vortices at the surface and throughout the interior. They are created from mesoscale eddies and strong currents, and they provide a dynamical conduit for energy transfer towards microscale dissipation and diapycnal mixing. Consideration is given to their generation mechanisms, instabilities, life cycles, disruption of approximately diagnostic force balance (e.g. geostrophy), turbulent cascades, internal-wave interactions, and transport and dispersion of materials. At a fundamental level, more questions remain than answers, implicating a programme for further research.
The incidence of incisional hernias (IHs) following midline abdominal incisions is difficult to estimate. Furthermore recent analyses have reported inconsistent findings on the superiority of ...absorbable versus non-absorbable sutures.
To estimate the mean IH rate following midline laparotomy from the published literature, to identify variables that predict IH rates and to analyse whether the type of suture (absorbable versus non-absorbable) affects IH rates.
We undertook a systematic review according to PRISMA guidelines. We sought randomised trials and observational studies including patients undergoing midline incisions with standard suture closure. Papers describing two or more arms suitable for inclusion had data abstracted independently for each arm.
Fifty-six papers, describing 83 separate groups comprising 14,618 patients, met the inclusion criteria. The prevalence of IHs after midline incision was 12.8% (range: 0 to 35.6%) at a weighted mean of 23.7 months. The estimated risk of undergoing IH repair after midline laparotomy was 5.2%. Two meta-regression analyses (A and B) each identified seven characteristics associated with increased IH rate: one patient variable (higher age), two surgical variables (surgery for AAA and either surgery for obesity surgery (model A) or using an upper midline incision (model B)), two inclusion criteria (including patients with previous laparotomies and those with previous IHs), and two circumstantial variables (later year of publication and specifying an exact significance level). There was no significant difference in IH rate between absorbable and non-absorbable sutures either alone or in conjunction with either regression analysis.
The IH rate estimated by pooling the published literature is 12.8% after about two years. Seven factors account for the large variation in IH rates across groups. However there is no evidence that suture type has an intrinsic effect on IH rates.
Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium levels so that ...they are maintained within a very narrow range. To achieve this goal, regulatory events occur in coordination at multiple tissues, e.g. the intestine, kidney, bone, and parathyroid gland. Production of the vitamin D endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH)2 D) is regulated by habitual dietary calcium intake and physiologic states like growth, aging, and the menopause. The molecular actions of 1,25(OH)2 D on calcium regulating target tissues are mediated predominantly by transcription controlled by the vitamin D receptor. A primary role for 1,25(OH)2 D during growth is to increase intestinal calcium absorption so that sufficient calcium is available for bone mineralization. However, vitamin D also has specific actions on kidney and bone.
•Calcium homeostasis controls serum calcium levels within a narrow range.•The vitamin D endocrine system controls whole body calcium homeostasis.•Habitual dietary calcium intake and physiologic states control vitamin D metabolism.•The primary role of vitamin D is to regulate intestinal calcium absorption.•Vitamin D also regulates urinary calcium excretion and bone metabolism.
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition ...of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec family, its roles in regulation of immune cell signaling, current efforts to define its roles in disease processes, and approaches to target Siglecs for treatment of human disease.
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