Multi-criteria decision analysis (MCDA) methods have become increasingly popular in decision-making for sustainable energy because of the multi-dimensionality of the sustainability goal and the ...complexity of socio-economic and biophysical systems. This article reviewed the corresponding methods in different stages of multi-criteria decision-making for sustainable energy, i.e., criteria selection, criteria weighting, evaluation, and final aggregation. The criteria of energy supply systems are summarized from technical, economic, environmental and social aspects. The weighting methods of criteria are classified into three categories: subjective weighting, objective weighting and combination weighting methods. Several methods based on weighted sum, priority setting, outranking, fuzzy set methodology and their combinations are employed for energy decision-making. It is observed that the investment cost locates the first place in all evaluation criteria and CO
2 emission follows closely because of more focuses on environment protection, equal criteria weights are still the most popular weighting method, analytical hierarchy process is the most popular comprehensive MCDA method, and the aggregation methods are helpful to get the rational result in sustainable energy decision-making.
The technical, economical and environmental performances of combined cooling, heating and power (CCHP) system are closely dependent on its design and operation strategy. This paper analyzes the ...energy flow of CCHP system and deduces the primary energy consumption following the thermal demand of building. Three criteria, primary energy saving (PES), annual total cost saving (ATCS), and carbon dioxide emission reduction (CDER) are selected to evaluate the performance of CCHP system. Based on the energy flow of CCHP system, the capacity and operation of CCHP system are optimized by genetic algorithm (GA) so as to maximize the technical, economical and environmental benefits achieved by CCHP system in comparison to separation production system. A numerical example of gas CCHP system for a hotel building in Beijing is given to ascertain the effectiveness of the optimal method. Furthermore, a sensitivity analysis is presented in order to show how the optimal operation strategy would vary due to the changes of electricity price and gas price.
The design and operation of combined cooling, heating and power (CCHP) systems are greatly dependent upon the seasonal atmospheric conditions, which determine thermal and power demands of buildings. ...This paper presents a mathematical analysis of CCHP system in comparison to separate system. The corresponding primary energy consumption in thermal demand management (TDM) and electrical demand management (EDM) operation modes are deduced. Three relative criteria, primary energy saving (PES), CO
2 emission reduction (CO
2ER), and annual total cost saving (ATCS) are employed to evaluate the respective performances of CCHP systems for a hypothetical building in five different climate zones from the technical, environmental and economic aspects. The results indicate that CCHP system in TDM mode in the cold area, where the building requires more heating during the year, achieves more benefit over separate system while CCHP system in EDM mode suits the building having stable thermal demand in mild climate zone.
Glucoregulatory efficiency and ATP production are key regulators for neuronal plasticity and memory formation. Besides its chemotactic and neuroinflammatory functions, the CC chemokine--CCL5 displays ...neurotrophic activity. We found impaired learning-memory and cognition in CCL5-knockout mice at 4 months of age correlated with reduced hippocampal long-term potentiation and impaired synapse structure. Re-expressing CCL5 in knockout mouse hippocampus restored synaptic protein expression, neuronal connectivity and cognitive function. Using metabolomics coupled with FDG-PET imaging and seahorse analysis, we found that CCL5 participates in hippocampal fructose and mannose degradation, glycolysis, gluconeogenesis as well as glutamate and purine metabolism. CCL5 additionally supports mitochondrial structural integrity, purine synthesis, ATP generation, and subsequent aerobic glucose metabolism. Overexpressing CCL5 in WT mice also enhanced memory-cognition performance as well as hippocampal neuronal activity and connectivity through promotion of de novo purine and glutamate metabolism. Thus, CCL5 actions on glucose aerobic metabolism are critical for mitochondrial function which contribute to hippocampal spine and synapse formation, improving learning and memory.
► The performances of CCHP system in different operation modes are compared. ► The CCHP system following electrical load and thermal loads are analyzed. ► The instantaneous performances of CCHP ...system with loads are obtained. ► The sensitivity of CCHP system to the technical parameters are analyzed.
Operation mode of combined cooling heating and power (CCHP) system determines its energetic and environmental performances. This paper analyzes the energy flows of CCHP system and separated production (SP) system. The fuel energy consumptions of CCHP system following electrical demand management (EDM) and thermal demand management (TDM) are deduced respectively. Three indicators: primary energy saving, exergy efficiency and CO
2 emission reduction, are employed to evaluate the performances of CCHP system for a commercial building in Beijing, China. The feasibility analysis shows that the performance of CCHP system is strictly dependent upon building energy demands. The selection of CCHP operation modes is systemically based on building loads, CCHP system and local SP system. The calculation results conclude that CCHP system in winter under EDM achieves more benefits than in summer. The sensitivity discussion indicates that the coefficient of performance for cooling and the efficiency of electricity generation are the most sensitive variables to the energetic and environmental performances of CCHP system.
Because of its energy-saving and pollutant emission reduction potentials, combined cooling, heating and power (CCHP) system has been widely used in different kinds of buildings to solve ...building-related energetic problems and environmental issues. As various kinds of clean energy and renewable energy have been focused and applied to CCHP systems, it is urgent to find a practical decision making methodology for CCHP systems driven by different energy sources. In this paper, an evaluation model which integrates fuzzy theory with multi-criteria decision making process is proposed to assess the comprehensive benefits of CCHP systems from technology, economic, society and environment criterions. Grey relation analysis and combination weighting method are also employed to compare the integrated performances of CCHP systems driven by natural gas, fuel cell, biomass energy and combined gas-steam cycle respectively with a separation production system. Finally, a baseline residential building in Beijing, China is selected as a case to obtain the optimal CCHP system alternative. The results indicate that gas–steam combined cycle CCHP system is the optimum scheme among the five options.
A fuzzy multi-criteria decision-making model combined with combination weighting method and grey system theory is presented in this paper, which can be used to evaluate CCHP systems driven by different energy sources from technology, economic, environment and society criteria. Display omitted
► The integrated benefits of CCHP systems driven by different energy sources are evaluated. ► A fuzzy multi-criteria model combined with combination weighting method is proposed. ► Environment evaluation criteria play an important role in the decision-making process. ► CCHP system driven by gas–steam combined cycle is the optimal alternative.
► The design of a novel BCHP system driven by solar energy and natural gas is optimized. ► The contribution of operation and fuel stages is more important than other stages in LCA. ► The life cycle ...prime energy consumption of FTL operation strategy is less than FEL mode. ► The environmental issues caused by FTL operation strategy are more serious than FEL mode.
A novel solar building cooling heating and power (BCHP) system driven by solar energy and natural gas is proposed in this paper. The performance of the presented system is greatly dependent upon the operation strategy. The primary energy consumption (PEC) and pollutant emissions of the solar BCHP system in following the electricity loads (FEL) and following the thermal loads (FTL) operation strategies are estimated based on life cycle assessment (LCA). Furthermore, three most important energy-related environment problems and human health issues, global warming, acid precipitation and respiratory effects, are considered to assess the environmental impacts of the system. In order to evaluate the comprehensive benefits achieved by the solar BCHP system in different operation modes, grey relation theory is employed to integrate the energetic benefits with environmental performances. Finally, a numerical case of the solar BCHP system for a commercial office building in Beijing, China is applied to compare the integrated performance in the FEL operation strategy with that of the FTL operation strategy. The results indicate that the energy saving and pollutant emissions reduction potentials of the FTL operation mode are the better than that of the FEL mode.
The promising energetic and environmental benefits of building cooling heating and power (BCHP) system are greatly dependent upon its design and operation strategy. In this paper, the energy and ...emission flows and different operation strategies of a BCHP system driven by gas engine are analyzed. Life cycle assessment (LCA) is employed to assess and compare the whole life energy saving potentials and pollutant emission reductions of BCHP system with the traditional energy system. Furthermore, energy consumption and three pollutant-related impacts, global warming, acid precipitation and respiratory effects, are selected as objective functions to optimize the gas engine capacity of BCHP system in different operation strategies. A numerical case of BCHP system for a commercial office building in Beijing, China is applied to obtain the optimum BCHP alternative in terms of the comprehensive energy and environment performance. The uncertainty of different evaluation criteria weights is also analyzed to show their influences on the optimal design and operation strategy. The results show that a reasonably sized BCHP system with an electric load-following strategy has the best performance under a wide interval of criteria weights, when the energetic and environmental benefits of producing excess electricity for nearby users are not considered.
► System size and operation mode are optimized to obtain the best integrated performance. ► System operation and fuel acquisition are important to the life cycle assessment result. ► When BCHP system runs following thermal load, the maximum energy saving can be achieved. ► When BCHP system runs following electricity load, the environment benefits are friendly. ► Influences of different evaluation criteria weights on the optimal result is analyzed.
New therapies are urgently needed for Alzheimer's disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with a novel proposed mechanism of action. The first phase 3 clinical ...trial of GV-971 has been completed in China.
We conducted a phase 3, double-blind, placebo-controlled trial in participants with mild-to-moderate AD to assess GV-971 efficacy and safety. Participants were randomized to placebo or GV-971 (900 mg) for 36 weeks. The primary outcome was the drug-placebo difference in change from baseline on the 12-item cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog12). Secondary endpoints were drug-placebo differences on the Clinician's Interview-Based Impression of Change with caregiver input (CIBIC+), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale, and Neuropsychiatric Inventory (NPI). Safety and tolerability were monitored.
A total of 818 participants were randomized: 408 to GV-971 and 410 to placebo. A significant drug-placebo difference on the ADAS-Cog12 favoring GV-971 was present at each measurement time point, measurable at the week 4 visit and continuing throughout the trial. The difference between the groups in change from baseline was - 2.15 points (95% confidence interval, - 3.07 to - 1.23; p < 0.0001; effect size 0.531) after 36 weeks of treatment. Treatment-emergent adverse event incidence was comparable between active treatment and placebo (73.9%, 75.4%). Two deaths determined to be unrelated to drug effects occurred in the GV-971 group.
GV-971 demonstrated significant efficacy in improving cognition with sustained improvement across all observation periods of a 36-week trial. GV-971 was safe and well-tolerated.
ClinicalTrials.gov, NCT0229391 5. Registered on November 19, 2014.
PDF
