Abstract Chronic stress is a universal condition commonly associated with many psychiatric diseases. An extensive body of evidence discussed hippocampal affection upon chronic stress exposure, ...however, the underlying molecular pathways still need to be identified. We investigated the impact of chronic stress on miR200/BMP/Olig‐2 signaling and hippocampal myelination. We also compared the effects of chronic administration of amitriptyline and cholecalciferol on chronically stressed hippocampi. Both amitriptyline and cholecalciferol significantly decreased serum cortisol levels, reduced immobility time in the forced swim test, increased the number of crossed squares in open field test, decreased the hippocampal expression of bone morphogenetic protein 4 (BMP4) and its messenger RNA (mRNA) levels, reduced miR200 expression as compared to untreated chronically stressed rats. Also, both drugs amended the hippocampal neuronal damage, enhanced the surviving cell count, and increased the pyramidal layer thickness of Cornu Ammonis subregion 1 (CA1) and granule cell layer of the dentate gyrus. Cholecalciferol was more effective in increasing the area percentage of myelin basic protein (MBP) and Olig‐2 positive cells count in hippocampi of chronic stress‐exposed rats than amitriptyline, thus enhancing myelination. We also found a negative correlation between the expression of BMP4, its mRNA, miR200, and the immunoexpression of MBP and Olig‐2 proteins. This work underscores the amelioration of the stress‐induced behavioral changes, inhibition of miR200/BMP4 signaling, and enhancement of hippocampal myelination following chronic administration of either amitriptyline or cholecalciferol, though cholecalciferol seemed more effective in brain remyelination.
Forêt des Pins Reserve, a state-owned natural forest in Haiti, has suffered severe degradation due to an ongoing influx of people seeking fertile agricultural land and off-farm employment ...opportunities. Participation by local communities in management has widely been considered as a means of sustaining protected areas. The purpose of this study is to examine the setting in which farmers are likely to participate in forest management in Forêt des Pins Reserve using factor analysis and multiple regression equations. Data from 243 farmers inside the Reserve were used in the empirical analysis. Results showed that the participatory management process of Forêt des Pins Reserve can be enhanced by providing information about benefits from the forests, increasing annual income, improving education, strengthening organizational memberships, and increase the involvement of women in the forest management process. Results also revealed that policies designed to improve technical assistance is essential to strengthen farmers’ participation in forestry program.
A reduction in daily caloric or nutrient intake has been observed to promote health benefits in mammals and other vertebrates. Feed Restriction (FR), whereby the overall food intake of the organism ...is reduced, has been explored as a method to improve metabolic and immune health, as well as to optimize productivity in farming. However, less is known regarding the molecular and physiological consequences of FR. Using the model organism,
, we investigated the impact of a short-term (month-long) FR on growth, gut morphology and gene expression. Our data suggest that FR has minimal effects on the average growth rates, but it may affect weight and size heterogeneity in a sex-dependent manner. In the gut, we observed a significant reduction in gut circumference and generally lower mucosal heights, whereas other parameters remained unchanged. Gene Ontology (GO), EuKaryotic Orthologous Groups (KOG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified numerous metabolic, reproductive, and immune response pathways that were affected by FR. These results broaden our understanding of FR and contribute towards growing knowledge of its effects on vertebrate health.
Dynamics of aquaculture governance Jolly, Curtis M.; Nyandat, Beatrice; Yang, Zhengyong ...
Journal of the World Aquaculture Society,
April 2023, 2023-04-00, 20230401, 2023-04-01, Letnik:
54, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Aquaculture is a growing industry with an annual growth rate that is far superior to the population growth rate. Most production occurs in lower‐ and middle‐income countries, and therefore, they can ...improve the efficiency and modernize the production systems to increase exports to earn foreign exchange earnings for economic and social development. The institutional arrangements should be part of the mechanisms that ensure sustainable aquaculture growth, through the participation of all stakeholders. Sustainability is possible with good and dynamic governance through which the industry embraces the basic principles of governance, equity, accountability, efficiency, and predictability. Over the past decade, several countries made changes in governance and implemented regulations through their action plans to improve aquaculture productivity, and stakeholders profited from the changes made along the value chain. For the producers to benefit from the value‐added products, they complied with the regulations imposed by the importing countries, international regulatory bodies, or their own consumers. Standards increased, and the implementation of certification resulted in changes in the industrial structure. These standards, which inflict regulatory cost on producers, stimulated an improvement in productivity and product quality. However, during the last decade, production growth declined from 5.8% from 2001 to 2010 to 4.5% from 2011 to 2018, resulting in the elusive realization of the potential of meeting the sustainable development targets. There is a need for a paradigm shift that encourages small‐scale producers to engage in sustainable intensive aquaculture. The challenge is, therefore, to move toward production intensification and expansion, and the harmonization of national and international regulations to ensure the supply of safe and adequate fish to consumers, while maintaining a sustainable production system, and at the same time conserving the environment and maintaining social and economic stability. With good governance and political will, the social, economic, and environmental objectives for attaining the Sustainable Development Goals during the period 2020–2030 are possible if governments integrate sustainable aquaculture developments within an expanded aquatic and terrestrial food security policy framework using systems thinking and open innovation approaches.
Control of sexually transmitted infections and blood-borne pathogens is challenging due to their presence in groups exhibiting complex social interactions. In particular, sharing injection drug use ...equipment and selling sex (prostitution) puts people at high risk. Previous work examining the involvement of risk behaviours in social networks has suggested that social and geographic distance of persons within a group contributes to these pathogens' endemicity. In this study, we examine the role of place in the connectedness of street people, selected by respondent driven sampling, in the transmission of blood-borne and sexually transmitted pathogens. A sample of 600 injection drug users, men who have sex with men, street youth and homeless people were recruited in Winnipeg, Canada from January to December, 2009. The residences of participants and those of their social connections were linked to each other and to locations where they engaged in risk activity. Survey responses identified 101 unique sites where respondents participated in injection drug use or sex transactions. Risk sites and respondents' residences were geocoded, with residence representing the individuals. The sociospatial network and estimations of geographic areas most likely to be frequented were mapped with network graphs and spatially using a Geographic Information System (GIS). The network with the most nodes connected 7.7% of respondents; consideration of the sociospatial network increased this to 49.7%. The mean distance between any two locations in the network was within 3.5 kilometres. Kernel density estimation revealed key activity spaces where the five largest networks overlapped. Here, the combination of spatial and social entities in network analysis defines the overlap of vulnerable populations in risk space, over and above the person to person links. Implications of this work are far reaching, not just for understanding transmission dynamics of sexually transmitted infections by identifying activity "hotspots" and their intersection with each social network, but also for the spread of other diseases (e.g. tuberculosis) and targeting prevention services.
Vaccination is an important strategy in the protection of aquaculture species from major diseases. However, we still do not have a good understanding of the mechanisms underlying vaccine-induced ...disease resistance. This is further complicated by the presence of several lymphoid organs that play different roles when mounting an immune response. In this study, we attempt to elucidate some of these mechanisms using a microarray-based approach. Asian seabass (Lates calcarifer) were vaccinated against Streptococcus iniae and the transcriptomic changes within the spleen and head kidney at one and seven days post-vaccination were profiled. We subsequently challenged the seabass at three weeks post-vaccination with live S. iniae and similarly profiled the transcriptomes of the two organs after the challenge. We found that vaccination induced an early, but transient transcriptomic change in the spleens and a delayed response in the head kidneys, which became more similar to one another compared to un-vaccinated ones. When challenged with the pathogen, the spleen, but not the head kidneys, responded transcriptomically at 25-29 hours post-challenge. A unique set of genes, in particular those involved in the activation of NF-κB signaling, was up-regulated in the vaccinated spleens upon pathogen challenge but not in the un-vaccinated spleens. A semi-quantitative PCR detection of S. iniae using metagenomic DNA extracted from the water containing the seabass also revealed that vaccination resulted in reduction of pathogen shedding. This result indicated that vaccination not only led to a successful immune defense against the infection, but also reduced the chances for horizontal transmission of the pathogen. In conclusion, we have provided a transcriptomic analysis of how the teleost spleen and head kidneys responded to vaccination and subsequent infection. The different responses from the two organs are suggestive of their unique roles in establishing a vaccine-induced disease resistance.
To quantify the age-related risks of adverse outcome during pregnancy in women less than 18 years old.
We analyzed data from 341,708 completed singleton pregnancies in the North West Thames region ...between 1988 and 1997. Pregnancy outcomes were compared by age at delivery in women less than 18 years old (n = 5246) and 18-34 years old (n = 336,462); women 35 years old or older (n = 48,658) were excluded. Data are presented as percentages of women less than 18 and 18-34-year-old women, with adjusted odds ratios (OR) and 99% confidence intervals (CI).
Pregnancy in women less than 18 years old was associated with increased risk of preterm labor before 32 weeks' gestation (OR 1.41, CI 1.02, 1.90), maternal anemia (OR 1.82, CI 1.63, 2.03), chest infection (OR 2.70, CI 1.21, 6.70), and urinary tract infection (OR 1.60, CI 1.11, 2.31), but less obstetric intervention. Operative vaginal delivery (OR 0. 46, CI 0.41, 0.56), elective cesarean (OR 0.47, CI 0.35, 0.65), or emergency cesarean (OR 0.45, CI 0.38, 0.53) were all less likely in women aged less than 18 years. Women less than 18 years old were no more likely to have stillbirths (OR 0.75, CI 0.42, 1.34) or small-for-gestational-age infants (OR 0.95, CI 0.82, 1.09) than women aged 18-34 years.
Pregnant women less than 18 years old were more likely to deliver preterm than older women. In most other respects they have less maternal and perinatal morbidity and were more likely to have normal vaginal deliveries.
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical and genetic mapping ...along with shared synteny from closely related fish species to derive a chromosome-level assembly with a contig N50 size over 1 Mb and scaffold N50 size over 25 Mb that span ~90% of the genome. The population structure of L. calcarifer species complex was analyzed by re-sequencing 61 individuals representing various regions across the species' native range. SNP analyses identified high levels of genetic diversity and confirmed earlier indications of a population stratification comprising three clades with signs of admixture apparent in the South-East Asian population. The quality of the Asian seabass genome assembly far exceeds that of any other fish species, and will serve as a new standard for fish genomics.
Social support at work: An integrative review Jolly, Phillip M.; Kong, Dejun Tony; Kim, Kyoung Yong
Journal of organizational behavior,
February 2021, 2021-02-00, 20210201, Letnik:
42, Številka:
2
Journal Article
Recenzirano
Summary
Social support can have a range of positive outcomes for both employees and organizations. Social support can lead to higher quality relationships, positive affective reactions, and increased ...individual performance and can buffer the negative effects of stressful demands. The power of social support has led to exponential growth in its investigation as a construct of interest in the workplace. However, this growth has come with several issues, which are the focus of this review. First, the literature is fragmented, with multiple conceptual frameworks employed to predict how social support may function in the workplace. Second, many studies are vague when defining social support, leading to diminished conceptual clarity. Third, there is no generally accepted measure of social support, and we describe problems with the structure and/or use of several commonly used measures. Finally, findings regarding the moderating effect of social support are decidedly mixed, calling into question why this might be so. On the basis of an extensive review of social support at work research, we highlight these issues, discuss how they can impede the advancement of understanding regarding social support in organizational settings, and propose an integrative framework to guide the field forward. Finally, we identify multiple areas for future investigation.
Sediments containing Ardipithecus ramidus were deposited 4.4 million years ago on an alluvial floodplain in Ethiopia's western Afar rift. The Lower Aramis Member hominid-bearing unit, now exposed ...across a >9-kilometer structural arc, is sandwiched between two volcanic tuffs that have nearly identical ⁴⁰Ar/³⁹Ar ages. Geological data presented here, along with floral, invertebrate, and vertebrate paleontological and taphonomic evidence associated with the hominids, suggest that they occupied a wooded biotope over the western three-fourths of the paleotransect. Phytoliths and oxygen and carbon stable isotopes of pedogenic carbonates provide evidence of humid cool woodlands with a grassy substrate.
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