Bladder cancer (BC) is the most common urinary malignancy; however accurate diagnosis and prediction of recurrence after therapies remain elusive. This study aimed to develop a biosignature of ...immunotherapy-based responses using gene expression data. Publicly available BC datasets were collected, and machine learning (ML) approaches were applied to identify a novel biosignature to differentiate patient subgroups. Immune phenotyping of BC in the IMvigor210 dataset included three subtypes: inflamed, excluded, and desert immune. Immune phenotypes were analyzed with gene expressions using traditional but powerful classification methods such as random forests, Deep Neural Networks (DNN), Support Vector Machines (SVM) together with boosting and feature selection methods. Specifically, DNN yielded the highest area under the curve (AUC) with precision and recall (PR) curves and receiver operating characteristic (ROC) curves for each phenotype (<inline-formula><tex-math notation="LaTeX">0.711 \pm 0.092</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">0.86 \pm 0.039</tex-math></inline-formula>, respectively) resulting in the identification of gene expression features useful for immune phenotype classification. Our results suggest significant potential to further develop and utilize machine learning algorithms for analysis of BC and its precaution. In conclusion, the findings from this study present a novel gene expression assay that can accurately discriminate BC patients from controls. Upon further validation in independent cohorts, this gene signature could be developed into a predictive test that can support clinical evaluation and patient care.
The design of an ultrathin, conformal electronic device that integrates electrotactile stimulation with electromyography, temperature, and strain sensing in a single, simple platform is reported. ...Experiments demonstrate simultaneous use of multiple modes of operation of this type of device in the sensorimotor control of robotic systems, in the monitoring of lower back exertion and in muscle stimulation.
The design of an ultrathin, conformal electronic device that integrates electrotactile stimulation with electromyography, temperature, and strain sensing in a single, simple platform is reported by ...J. A. Rogers and co‐workers on page 4462. Demonstrated application possibilities include prosthetic control with sensory feedback, monitors, and stimulation signals related to lower back exertion, and electrical muscle stimulation with feedback control.
High-tech markets are unpredictable owing to rapid technology innovation, diverse customer needs, high competition, and other elements. Many scholars have attempted to explain the uncertainty in ...high-tech markets using their own various approaches. However, sufficiently clear ways to predict diverse changes and trends in high-tech markets have yet to be presented. Thus, this paper proposes a new approach model, that is, systematic market segmentation, to give more accurate information. Using an empirical dataset from the mobile handset market in the Republic of Korea, we conduct our research model consisting of three steps. First, we categorize nine basic segments. Second, we test the stability of these segments. Finally, we profile the characteristics of the customers and products. We conclude that the approach is able to offer more diagnostic information to both practitioners and scholars. It is expected to provide rich information for an appropriate marketing mix in practice.
An autonomous vehicle should recognize its position when the vehicle is moving, otherwise the vehicle would not operate correctly. In addition, the “kidnapping“ problem sometimes appears when the ...vehicle starts at an unknown position. The theoretical basis of the solution to this problem, known as simultaneous localization and mapping (SLAM), is now well understood. A number of approaches to SLAM have appeared in the recent literature. The SLAM algorithm consists of two methods. One is a map-building method that makes a map to represent the environment. The other is a mapping method to compute the position of the vehicle in absolute coordinates. However, it is difficult to apply the SLAM algorithm to an actual autonomous vehicle because it needs a certain amount of operating time. In this article, we explain the use of ultrasonic sensors for detecting obstacles in corridors, and a digital magnetic compass, a gyro, and two encoders for immediate localization. Experiments showed that this algorithm can be executed with a high degree of accuracy and reliability in an unknown environment. This algorithm could also solve the “kidnapping“ problem in a fast operating time.
High‐tech markets are unpredictable owing to rapid technology innovation, diverse customer needs, high competition, and other elements. Many scholars have attempted to explain the uncertainty in ...high‐tech markets using their own various approaches. However, sufficiently clear ways to predict diverse changes and trends in high‐tech markets have yet to be presented. Thus, this paper proposes a new approach model, that is, systematic market segmentation, to give more accurate information. Using an empirical dataset from the mobile handset market in the Republic of Korea, we conduct our research model consisting of three steps. First, we categorize nine basic segments. Second, we test the stability of these segments. Finally, we profile the characteristics of the customers and products. We conclude that the approach is able to offer more diagnostic information to both practitioners and scholars. It is expected to provide rich information for an appropriate marketing mix in practice.
In the multi-path planning, every autonomous vehicle normally receives her path from the server and sends her position to the server. If server estimates collision between two vehicles, then the path ...should be re-planned by an algorithm in the server. Path could be compensated by fuzzy expert systems (FESs) that is designed using heuristic method for collision avoidance in multi-path planning. The server calculates the assistance via point and send to each vehicle. The algorithm was evaluated it's stability by simulation test, and then experimented by real autonomous vehicle. The experimental result proved this collision avoidance algorithm is good for multi-path planning.
This paper is proposed about three axis motion control camera design method based on wires. Original motion control camera consists of track, boom, L-Head, Camera and so on and is enormous and ...expensive. But proposed motion control camera adjusts wire length using encoders and motors. And position control use position based straight line of straight-line move method for moving precise position. Pro-posed simple design is able to use various place and inexpensive than original motion control camera. But, camera was vibrated and rotated due to basic property of wire. So we proposed solutions that connected method of wire and using a tensional object for reducing rotation. For proposed algorithm verification, we realized three axis motion control camera based on wire and measured oscillation while moving same trace. We confirmed the results that standard deviation of oscillation was reduced 4.93 degree than before design method.
This paper is proposed about three axis motion control camera design method based on wires. Original motion control camera consists of track, boom, L-Head, Camera and so on and is enormous and expensive. But proposed motion control camera adjusts wire length using encoders and motors. And position control use position based straight line of straight-line move method for moving precise position. Pro-posed simple design is able to use various place and inexpensive than original motion control camera. But, camera was vibrated and rotated due to basic property of wire. So we proposed solutions that connected method of wire and using a tensional object for reducing rotation. For proposed algorithm verification, we realized three axis motion control camera based on wire and measured oscillation while moving same trace. We confirmed the results that standard deviation of oscillation was reduced 4.93 degree than before design method. KCI Citation Count: 0
PDF
