Transiting planets in nearby young clusters offer the opportunity to study the atmospheres and dynamics of planets during their formative years. To this end, we focused on K2-25b-a close-in (P = 3.48 ...days), Neptune-sized exoplanet orbiting a M4.5 dwarf in the 650 Myr Hyades cluster. We combined photometric observations of K2-25 covering a total of 44 transits and spanning >2 yr, drawn from a mix of space-based telescopes (Spitzer Space Telescope and K2) and ground-based facilities (Las Cumbres Observatory Global Telescope network and MEarth). The transit photometry spanned 0.6-4.5 m, which enabled our study of K2-25b's transmission spectrum. We combined and fit each data set at a common wavelength within a Markov Chain Monte Carlo framework, yielding consistent planet parameters. The resulting transit depths ruled out a solar-composition atmosphere for K2-25b for the range of expected planetary masses and equilibrium temperature at a >4 confidence level, and are consistent with a flat transmission spectrum. Mass constraints and transit observations at a finer grid of wavelengths (e.g., from the Hubble Space Telescope) are needed to make more definitive statements about the presence of clouds or an atmosphere of high mean molecular weight. Our precise measurements of K2-25b's transit duration also enabled new constraints on the eccentricity of K2-25's orbit. We find K2-25b's orbit to be eccentric (e > 0.20) for all reasonable stellar densities and independent of the observation wavelength or instrument. The high eccentricity is suggestive of a complex dynamical history and motivates future searches for additional planets or stellar companions.
The abundance of planets with orbital periods of a few to tens of days suggests that exoplanets experience complex dynamical histories. Planets in young stellar clusters or associations have ...well-constrained ages and therefore provide an opportunity to explore the dynamical evolution of exoplanets. K2-25b is a Neptune-sized planet in an eccentric, 3.48 day orbit around an M4.5 dwarf star in the Hyades cluster (650 Myr). In order to investigate its non-zero eccentricity and tight orbit, we analyze transit timing variations (TTVs) which could reveal clues to the migration processes that may have acted on the planet. We obtain 12 nonconsecutive transits using the MEarth observatories and long-term photometric monitoring, which we combine with 10 transits from the Spitzer Space Telescope and 20 transits from K2. Tables of MEarth photometry accompany this work. We fit each transit lightcurve independently. We first investigate whether inhomogeneities on the stellar surface (such as spots or plages) are differentially affecting our transit observations. The measured transit depth does not vary significantly between transits, though we see some deviations from the fiducial transit model. We then looked for TTVs as evidence of a nontransiting perturber in the system. We find no evidence for >1 M⊕ mass companions within a 2:1 period ratio, or for >5 M⊕ mass planets within a 7:2 period ratio.
High-contrast imaging has been used to discover and characterize dozens of exoplanets to date. The primary limiting performance factor for these instruments is contrast, the ratio of exoplanet to ...host star brightness that an instrument can successfully resolve. Contrast is largely determined by wavefront error, consisting of uncorrected atmospheric turbulence and optical aberrations downstream of AO correction. Single-point diamond turning allows for high-precision optics to be manufactured for use in astronomical instrumentation, presenting a cheaper and more versatile alternative to conventional glass polishing. This work presents measurements of wavefront error for diamond-turned aluminum optics in the Slicer Combined with an Array of Lenslets for Exoplanet Spectroscopy (SCALES) instrument, a 2-5 micron coronagraphic integral field spectrograph under construction for Keck Observatory. Wavefront error measurements for these optics are used to simulate SCALES' point spread function using physical optics propagation software poppy, showing that SCALES' contrast performance is not limited by wavefront error from internal instrument optics.
The abundance of planets with orbital periods of a few to tens of days suggests that exoplanets experience complex dynamical histories. Planets in young stellar clusters or associations have ...well-constrained ages and therefore provide an opportunity to explore the dynamical evolution of exoplanets. K2-25b is a Neptune-sized planet in an eccentric, 3.48 day orbit around an M4.5 dwarf star in the Hyades cluster (650 Myr). In order to investigate its non-zero eccentricity and tight orbit, we analyze transit timing variations (TTVs) which could reveal clues to the migration processes that may have acted on the planet. We obtain 12 non-consecutive transits using the MEarth Observatories and long-term photometric monitoring, which we combine with 10 transits from the Spitzer Space Telescope and 20 transits from K2. Tables of MEarth photometry accompany this work. We fit each transit lightcurve independently. We first investigate whether inhomogeneities on the stellar surface (such as spots or plages) are differentially affecting our transit observations. The measured transit depth does not vary significantly between transits, though we see some deviations from the fiducial transit model. We then looked for TTVs as evidence of a non-transiting perturber in the system. We find no evidence for > 1 \(M_\oplus\) companions within a 2:1 period ratio, or for > 5 \(M_\oplus\) planets within a 7:2 period ratio.
Transiting planets in nearby young clusters offer the opportunity to study the atmospheres and dynamics of planets during their formative years. To this end, we focused on K2-25b -- a close-in ...(\(P\)=3.48 days), Neptune-sized exoplanet orbiting a M4.5 dwarf in the 650Myr Hyades cluster. We combined photometric observations of K2-25 covering a total of 44 transits and spanning >2 yr, drawn from a mix of space-based telescopes (Spitzer Space Telescope and K2) and ground-based facilities (Las Cumbres Observatory Global Telescope network and MEarth). The transit photometry spanned 0.6--4.5\(\mu\)m, which enabled our study of K2-25b's transmission spectrum. We combined and fit each dataset at a common wavelength within a Markov Chain Monte Carlo framework, yielding consistent planet parameters. The resulting transit depths ruled out a solar-composition atmosphere for K2-25b for the range of expected planetary masses and equilibrium temperature at a \(>4\sigma\) confidence level, and are consistent with a flat transmission spectrum. Mass constraints and transit observations at a finer grid of wavelengths (e.g., from the Hubble Space Telescope) are needed to make more definitive statements about the presence of clouds or an atmosphere of high mean molecular weight. Our precise measurements of K2-25b's transit duration also enabled new constraints on the eccentricity of K2-25's orbit. We find K2-25b's orbit to be eccentric (\(e>0.20\)) for all reasonable stellar densities and independent of the observation wavelength or instrument. The high eccentricity is suggestive of a complex dynamical history and motivates future searches for additional planets or stellar companions.
Mathematical models of epidemics are important tools for predicting epidemic dynamics and evaluating interventions. Yet, because early models are built on limited information, it is unclear how long ...they will accurately capture epidemic dynamics. Using a stochastic SEIR model of COVID-19 fitted to reported deaths, we estimated transmission parameters at different time points during the first wave of the epidemic (March-June, 2020) in Santa Clara County, California. Although our estimated basic reproduction number (Formula: see text) remained stable from early April to late June (with an overall median of 3.76), our estimated effective reproduction number (Formula: see text) varied from 0.18 to 1.02 in April before stabilizing at 0.64 on 27 May. Between 22 April and 27 May, our model accurately predicted dynamics through June; however, the model did not predict rising summer cases after shelter-in-place orders were relaxed in June, which, in early July, was reflected in cases but not yet in deaths. While models are critical for informing intervention policy early in an epidemic, their performance will be limited as epidemic dynamics evolve. This paper is one of the first to evaluate the accuracy of an early epidemiological compartment model over time to understand the value and limitations of models during unfolding epidemics.
We produce light curves for all ∼34,000 targets observed with K2 in Campaign 17 (C17), identifying planet candidates, eclipsing binaries, and other periodic variables. The forward-facing direction of ...the C17 field means follow-up can begin immediately now that the campaign has concluded and interesting targets have been identified. The C17 field has a large overlap with C6, so this latest campaign also offers an infrequent opportunity to study a large number of targets already observed in a previous K2 campaign. The timing of the C17 data release, shortly before science operations begin with the Transiting Exoplanet Survey Satellite (TESS), also lets us exercise some of the tools and methods developed for identification and dissemination of planet candidates from TESS. We find excellent agreement between these results and those identified using only K2-based tools. Among our planet candidates are several planet candidates with sizes <4 R⊕ and orbiting stars with Kp 10 (indicating good RV targets of the sort TESS hopes to find) and a Jupiter-sized single-transit event around a star already hosting a 6 day planet candidate.
Nephrotic syndrome (NS) is a leading cause of chronic kidney disease. We found recessive
variants in two families with early-onset NS by exome sequencing. Overexpression of wild-type (WT)
, but not ...cDNA constructs bearing patient variants, increased active CDC42 and promoted filopodia and podosome formation. Pharmacologic inhibition of CDC42 or its effectors, formin proteins, reduced NOS1AP-induced filopodia formation.
knockdown reduced podocyte migration rate (PMR), which was rescued by overexpression of WT
but not by constructs bearing patient variants. PMR in
knockdown podocytes was also rescued by constitutively active
or the formin
Modeling a
patient variant in knock-in human kidney organoids revealed malformed glomeruli with increased apoptosis.
mice recapitulated the human phenotype, exhibiting proteinuria, foot process effacement, and glomerulosclerosis. These findings demonstrate that recessive
variants impair CDC42/DIAPH-dependent actin remodeling, cause aberrant organoid glomerulogenesis, and lead to a glomerulopathy in humans and mice.
PDF
