There is substantial and promising evidence on the health benefits of consuming broccoli and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin, is metabolized to ...SFN by the thioglucosidase enzyme myrosinase. SFN is the major mediator of the health benefits that have been recognized for broccoli consumption. SFN represents a phytochemical of high interest as it may be useful in preventing the occurrence and/or mitigating the progression of cancer. Although several prior publications provide an excellent overview of the effect of SFN in cancer, these reports represent narrative reviews that focused mainly on SFN’s source, biosynthesis, and mechanisms of action in modulating specific pathways involved in cancer without a comprehensive review of SFN’s role or value for prevention of various human malignancies. This review evaluates the most recent state of knowledge concerning SFN’s efficacy in preventing or reversing a variety of neoplasms. In this work, we have analyzed published reports based on in vitro, in vivo, and clinical studies to determine SFN’s potential as a chemopreventive agent. Furthermore, we have discussed the current limitations and challenges associated with SFN research and suggested future research directions before broccoli-derived products, especially SFN, can be used for human cancer prevention and intervention.
El debate actual sobre la democracia de partidos, tanto en Alemania como en el resto de las democracias representativas, ha puesto de manifiesto una pérdida de confianza en los partidos y en la ...democracia representativa, así como otros cambios en los sistemas de partidos establecidos: hay mayor fragmentación, han aparecido nuevos partidos antisistema y la formación de gobiernos es más complicada. Asimismo, se constata un cambio de poder en el interior de los partidos, a causa, entre otros, de la digitalización, a la vez que cobran fuerza otras formas de participación política. Todo ello hace que la democracia de partidos se ponga en cuestión, también desde el punto de vista de la teoría constitucional. Ante ello, se señalan algunos elementos jurídicos que pueden considerarse problemáticos: la financiación de los partidos, los derechos de la oposición, la democracia intrapartidista, los elementos de democracia directa, como los consejos ciudadanos elegidos por sorteo, la prohibición de partidos o el control jurídico del discurso de odio y las noticias falsas.
The relationship of pedagogy with literature emerges as decisive during the Century of Goethe, that of the German Neuhumanismus, which centers on the idea of Bildung. It, like every current of ...thought and ideas, takes its origin from the visions of the world, from ideals, from the criticalities that, in the previous decades, have been elaborated. In the first half of the eighteenth century, enlightenment and pietism are intertwined, with their pedagogical inspiration that leads to the Germanization of culture; Lessing, Klopstock and Wieland write, bearers of a pedagogical telos station; the German literary revolution begins with the Sturm und Drang, apt to express, albeit chaotically, the anthropological nature in its frankness, even formative. Keywords. Neuhumanismus--German Neuhumanismus--literature and pedagogy --Germanization of culture--Strum und Drang
Carl Schmitt, the chameleon Kaiser, Anna-Bettina
Philosophy & social criticism,
02/2021, Letnik:
47, Številka:
2
Journal Article
Recenzirano
This comment focuses on part III of the book, ‘Carl Schmitt’s 21st Century’, by William Scheuerman. It raises two points. The first point concerns the author’s continuity thesis. According to ...Scheuerman, Schmitt’s ideas ‘exhibit more continuity than widely asserted’. This has consequences both for how we should read Schmitt and for how we should approach authors who use his concepts (such as in the US counterterrorism debate Scheuerman discusses in chapter 10). This comment wants to question this view and instead wants to propose what might be called a chameleon thesis. Schmitt’s thinking contains repeated shifts that are not accidental (1). This may also have implications for how we view attempts to use Schmitt in contemporary thought (2).
The Canterbury earthquake sequence beginning with the 2010
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7.2 Darfield earthquake is one of the most notable and well-recorded crustal earthquake sequences in a low-strain-rate region worldwide ...and as such provides a unique opportunity to better understand earthquake source physics and ground motion generation in such a tectonic setting. Ground motions during this sequence ranged up to extreme values of 2.2 g, recorded during the February 2011
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6.2 event beneath the city of Christchurch. A better understanding of the seismic source signature of this sequence, in particular the stress release and its scaling with earthquake size, is crucial for future ground motion prediction and hazard assessment in Canterbury, but also of high interest for other low-to-moderate seismicity regions where high-quality records of large earthquakes are lacking. Here we present a source parameter study of more than 200 events of the Canterbury sequence, covering the magnitude range
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3–7.2. Source spectra were derived using a generalized spectral inversion technique and found to be well characterized by the
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source model. We find that stress drops range between 1 and 20 MPa with a median value of 5 MPa, which is a factor of 5 larger than the median stress drop previously estimated with the same method for crustal earthquakes in much more seismically active Japan. Stress drop scaling with earthquake size is nearly self-similar, and we identify lateral variations throughout Canterbury, in particular high stress drops at the fault edges of the two major events, the
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7.2 Darfield and
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6.2 Christchurch earthquakes.
The relation between incident cardiovascular disease (CVD) and sugar might not only depend on the quantity consumed but also on its source. This study aims to assess the association between various ...sources of dietary sugars and CVD incidence in the prospective population-based UK Biobank cohort.
A total of 176,352 participants from the UK Biobank with at least one web-based dietary questionnaire (Oxford WebQ) for assessment of sugar intake were included in this study. Mean follow-up lasted 10.9 years (standard deviation 2.0), with 12,355 incident cases of CVD. To determine the association of free sugar (FS) and intrinsic sugar intake with incident CVD, hazard ratios (HR) were calculated using Cox proportional hazard regression models. FS intake from beverages and beverage subtypes, i.e., soda/fruit drinks, juice, milk-based drinks, and tea/coffee, as well as from solid foods and solids subtypes, i.e., treats, cereals, toppings, and sauces, was included as penalised cubic splines.
FS intake showed a J-shaped relationship with CVD risk, reaching the lowest HR (HR-nadir) at 9 %E, while intrinsic sugars displayed a non-linear descending association, with the HR-nadir at 14 %E. FS in beverages demonstrated a significant linear relationship with CVD with the HR-nadir at 3 %E, while FS in solids exhibited a significant non-linear U-shaped relationship with the HR-nadir at 7 %E. Within the beverage subtypes, soda/fruit drinks displayed a linear relationship, as did to a lesser extent FS in milk-based drinks and tea/coffee. Juice, however, showed a significant U-shaped relationship with CVD risk. Among solid foods subtypes, FS in treats had a J-shaped relation with the HR-nadir at 5 %E, and FS in cereals showed a linear association. In comparison, FS in toppings and sauces exhibited a U-shaped pattern with HR-nadir at 3 %E and 0.5 %E, respectively. All major results remained similar in various sensitivity analyses and were more robust for ischemic heart disease compared to stroke.
Only some sources of FS exhibit a robust positive association with CVD incidence. Public health efforts aiming at the reduction of CVD risk should prioritise the reduction of sugary beverages with an emphasis on soda/fruit drinks.
Per una pedagogia del dono Kaiser, Anna
Studi sulla formazione,
09/2017, Letnik:
20, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The act of giving, in a pedagogical point of view, interlaces often with the act of giving himself and with the free and responsable will of encountering the other by his humanity. The main ...characteristic of giving is the gratuitousness: the human being can be educated aim for freedom and generosity about being able to give and give himself without fee. He who instead receives the gift had to be grateful: the gratification takes shape as an essential element in the educational life of the subject. Keywords. gift, giving, humanity, gratuitousness, freedom
Dementia is a common disease with around 55 million cases worldwide. Therefore, dietary changes and lifestyle interventions are important approaches to delay the progress of a decline in cognitive ...function. The study aims to explore the association of various sources of free sugars (FS) and intrinsic sugars with dementia risk in the prospective population-based UK Biobank cohort. Sugar consumption was assessed in 186,622 UK Biobank participants with at least one web-based dietary questionnaire (Oxford WebQ). Over a mean follow-up of 10.6 (standard deviation 1.1) years, 1498 incident dementia cases occurred. The hazard ratios (HR) for incident dementia were assessed with Cox proportional hazard regression models including sugar intake from different sources as penalized cubic splines to allow for non-linear predictor effects. The intake of FS and intrinsic sugar was significantly associated with dementia risk in a J-shaped fashion with the HR-nadir observed at 9% and 8% total energy (%E), respectively. FS in beverages were significantly associated with dementia risk in an ascending approximately linear way, whereas no significant association was found for FS in solids. Assessing beverage subtypes, FS in soda/fruit drinks, milk-based drinks and to a lesser extent in juice were significantly and positively related to dementia risk, whereas no association was found for FS in tea/coffee. The association between sugar subtype consumption and dementia risk remained consistent in most sensitivity analyses but changed from a J-shape to a more linear shape when the analysis was restricted to participants with at least two Oxford WebQs. A linear-shaped association between sugar subtype intake and dementia risk is most consistently found for FS in beverages and more specifically for FS in soda/fruit drinks, as well as in milk-based drinks.
Due to climate change, it is foreseen that the frequency and magnitude of extreme climate events such as heavy precipitation, flooding and drought will increase throughout Europe. In recent times, ...numerous areas suffered from disasters that produced significant damage to cultural heritage. Although different risk management strategies are currently enforced in Central Europe, there still exist many challenges that undermine their effectiveness. This study reviews the necessary points to be addressed for strengthening existing management strategies within the region and the characteristics of potential resilience building measures. It presents feasible and tailored ICT solutions (e.g. a web GIS platform) and decision support tools (e.g. a manual for cultural heritage resilience and a handbook on transnational rescue procedures) for the protection of cultural heritage against floods, heavy rain and fire. These tools result from the Interreg Central Europe project ProteCHt2save, concentrating on risk assessment and sustainable protection of cultural heritage in changing environments. The proposed measures are tested at pilot sites and successfully integrated in local risk management plans. Future work is also proposed for further implementation of the results.
Assessment and intervention in the early years should ideally be based on evidence-based models describing the structure and development of students’ skills. Mathematical word problems have been ...identified as a challenge for mathematics learners for a long time and in many countries. We investigate flexibility in dealing with additive situations as a construct that develops during grades 1 through 3 and contributes to the development of students’ word problem solving skills. We introduce the construct based on prior research on the difficulty of different situation structures entailed in word problems. We use data from three prior empirical studies with N = 383 German grade 2 and 3 students to develop a model of discrete levels of students’ flexibility in dealing with additive situations. We use this model to investigate how the learners in our sample distribute across the different levels. Moreover, we apply it to describe students’ development over several weeks in one study comprising three measurements. We derive conclusions about the construct in terms of determinants of task complexity, and about students’ development and then provide an outlook on potential uses of the model in research and practice.
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