Metamaterials, artificially constructed structures that mimic lattices in natural materials, have made numerous contributions to the development of unconventional optical devices. With an increasing ...demand for more diverse functionalities, terahertz (THz) metamaterials are also expanding their domain, from the realm of mere passive devices to the broader area where functionalized active THz devices are particularly required. A brief review on THz metamaterials is given with a focus on research conducted in the authors' group. The first part is centered on enhanced THz optical responses from tightly coupled meta‐atom structures, such as high refractive index, enhanced optical activity, anomalous wavelength scaling, large phase retardation, and nondispersive polarization rotation. Next, electrically gated graphene metamaterials are reviewed with an emphasis on the functionalization of enhanced THz optical responses. Finally, the linear frequency conversion of THz waves in a rapidly time‐variant THz metamaterial is briefly discussed in the more general context of spatiotemporal control of light.
Passive and active metamaterials are important to the development of unconventional terahertz optical devices due to their engineered optical responses, such as enhanced optical responses, electrical control, and spatiotemporal control. These materials are reviewed, with emphasis on metamaterials for engineering of terahertz waves, from the regime of passive devices to broader areas in which functionalized active terahertz devices are particularly required.
Polymer plastic crystal electrolytes (PPCEs) have garnered significant attention for addressing the challenges associated with succinonitrile (SN), including its inadequate mechanical properties and ...side reactions with electrodes. However, a comprehensive investigation of the influence of the molecular structure of the polymer network on the states of SN within the network and its subsequent impact on ionic conductivities remains largely unexplored. To shed light on this critical aspect, the binding energy between SN and the polymer moiety is investigated as a determining factor in the conformation and crystallization behavior of SNs, through the dispersion‐corrected density functional theory (DFT‐D) simulations. These findings reveal that variations in miscibility resulting from the effects of binding energy significantly affected the formation of the amorphous phase in PPCEs. As a result, vinyl ethylene carbonate (VEC)‐based PPCE exhibits high ionic conductivity at room temperature (2.6 × 10−3 S cm−1 at 25 °C) and possesses a completely amorphous phase, which can be attributed to the optimized miscibility among its components. The feasibility of using a high‐performance solid‐state lithium‐metal battery (LMB) configuration is also examined by combining the PPCE with LiFePO4 (LFP) and LiNi0.8Co0.1Mn0.1O2 (NCM811) cathode materials.
This work innovatively proposes an effective strategy for inducing an amorphous phase in polymer plastic crystal electrolyte (PPCE), consequently achieving high ionic conductivity. These findings emphasize that optimizing the miscibility, which is influenced by the binding energy between succinonitrile (SN) and the polymer moiety, is important in inducing the amorphous states of SN.
Molecular recognition and discrimination of carbohydrates are important because carbohydrates perform essential roles in most living organisms for energy metabolism and cell-to-cell communication. ...Nevertheless, it is difficult to identify or distinguish various carbohydrate molecules owing to the lack of a significant distinction in the physical or chemical characteristics. Although there has been considerable effort to develop a sensing platform for individual carbohydrates selectively using chemical receptors or an ensemble array, their detection and discrimination limits have been as high in the millimolar concentration range. Here we show a highly sensitive and selective detection method for the discrimination of carbohydrate molecules using nano-slot-antenna array-based sensing chips which operate in the terahertz (THz) frequency range (0.5-2.5 THz). This THz metamaterial sensing tool recognizes various types of carbohydrate molecules over a wide range of molecular concentrations. Strongly localized and enhanced terahertz transmission by nano-antennas can effectively increase the molecular absorption cross sections, thereby enabling the detection of these molecules even at low concentrations. We verified the performance of nano-antenna sensing chip by both THz spectra and images of transmittance. Screening and identification of various carbohydrates can be applied to test even real market beverages with a high sensitivity and selectivity.
Owning to their unusual optical properties, such as electrical tunability and strong spatial confinement, two-dimensional surface polaritons (2DSPs) hold great promise for deep sub-wavelength ...manipulation of light in a reduced low-dimensional space. Control of 2DSPs is possible by using their interaction with a boundary between two media, similar to how light behaves in three-dimensional (3D) space. The understanding of the interaction in the 2D case is still in its early stages, unlike the 3D case, as in-depth investigations are only available in a few cases including the interaction of 2DSPs with structured 2D crystals. Here, we extend the scope of our understanding to the interaction of 2DSPs with metallic nano-plates on 2D crystals, focusing on the reflection of 2DSPs. Through our rigorous model, we reveal that, for strongly confined 2DSPs having much larger momentum than free space photons, the interaction results in almost total internal reflection of 2DSPs as the radiative coupling of the 2DSPs to free space is negligible. We also find that the reflection involves an anomalous phase shift dependent on the thickness of the nano-plate, due to the temporary storing of electromagnetic energy in the evanescent waves induced near the edge of the nano-plate. Our theory predicts that the phase shift saturates to an anomalous value, 0.885
, as the nano-plate becomes thicker. Our work provides a detailed understanding of how to manipulate the 2DSPs by using one of the simplest nanostructures, essential for the further development of nanostructure-integrated low-dimensional devices for polariton optics.
As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because ...protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity. A metamaterial sensing chip was designed for increasing of absorption cross section of the target sample, related to the transmitted THz near field enhancement via the composition of metamaterial. The measured THz optical properties were then analyzed in terms of refractive index and absorption coefficient, and compared with simulation results. Also, virus quantification regarding various concentrations of the viruses was performed, showing a clear linearity. The proposed sensitive and selective THz detection method can provide abundant information of detected biomaterials to help deep understanding of fundamental optical characteristics of them, suggesting rapid diagnosis way especially useful for such dangerous and time-sensitive target biomaterials.
Understanding light interaction with metallic structures provides opportunities of manipulation of light, and is at the core of various research areas including terahertz (THz) optics from which ...diverse applications are now emerging. For instance, THz waves take full advantage of the interaction to have strong field enhancement that compensates their relatively low photon energy. As the THz field enhancement have boosted THz nonlinear studies and relevant applications, further understanding of light interaction with metallic structures is essential for advanced manipulation of light that will bring about subsequent development of THz optics. In this review, we discuss THz wave interaction with deep sub-wavelength nano structures. With focusing on the THz field enhancement by nano structures, we review fundamentals of giant field enhancement that emerges from non-resonant and resonant interactions of THz waves with nano structures in both sub- and super- skin-depth thicknesses. From that, we introduce surprisingly simple description of the field enhancement valid over many orders of magnitudes of conductivity of metal as well as many orders of magnitudes of the metal thickness. We also discuss THz interaction with structures in angstrom scale, by reviewing plasmonic quantum effect and electron tunneling with consequent nonlinear behaviors. Finally, as applications of THz interaction with nano structures, we introduce new types of THz molecule sensors, exhibiting ultrasensitive and highly selective functionalities.
Two-dimensional surface polaritons (2DSPs), such as graphene plasmons, exhibit various unusual properties, including electrical tunability and strong spatial confinement with high Q-factor, which can ...enable tunable photonic devices for deep subwavelength light manipulations. Reflection of plasmons at the graphene's edge plays a critical role in the manipulation of 2DSP and enables their direct visualization in near-field infrared microscopy. However, a quantitative understanding of the edge-reflections, including reflection phases and diffraction effects, has remained elusive. Here, we show theoretically and experimentally that edge-reflection of 2DSP exhibits unusual behaviors due to the presence of the evanescent waves, including an anomalous Goos-Hänchen phase shift as in total internal reflections and an unexpected even-odd peak amplitude oscillation from the wave diffraction at the edge. Our theory is not only valid for plasmons in graphene but also for other 2D polaritons, such as phonon polaritons in ultrathin boron nitride flakes and exciton polariton in two-dimensional semiconductors.
The purpose of the present study is to synthesize a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer capable of being immobilized on the tooth surface to prevent oral bacterial adhesion. The ...strategy is to develop an MPC-based polymer with Ca(2+)-binding moieties, i.e., phosphomonoester groups, for stronger binding with hydroxyapatite (HA) of the tooth surface. To this end, a 2-methacryloyloxyethyl phosphate (MOEP) monomer was synthesized and copolymerized with MPC by free radical polymerization. The coating efficiency of the synthesized polymer, MPC-ran-MOEP (abbreviated as PMP) with varied composition, onto a HA surface was estimated by means of contact angle measurement and X-ray photoelectron spectroscopy. The anti-biofouling nature of PMP-coated HA surfaces was estimated by analyzing protein adsorption, cell adhesion, and Streptococcus mutans adhesion. As a result, HA surface coated with a copolymer containing around 50% MPC (PMP50) showed the best performance in preventing protein adsorption and the downstream cell and bacterial adhesion.
Preparation of anti-biofouling surface on the tooth enamel is the key technique to prevent dental and periodontal diseases, which are closely related with the biofilm formation that induced by the adsorption of salivary proteins and the adhesion of oral bacteria on the tooth surface. In this research, a PMP copolymer with an optimized ratio of zwitterionic and Ca(2+)-binding moieties could form a highly effective and robust anti-biofouling surface on HA surfaces by a simple coating method. The PMP-coated surface with high stability can provide a new strategy for an anti-adsorptive and anti-bacterial platform in dentistry and related fields.
The influenza virus is one of the major public health threats. However, the development of efficient vaccines and therapeutic drugs to combat this virus is greatly limited by its frequent genetic ...mutations. Because of this, targeting the host factors required for influenza virus replication may be a more effective strategy for inhibiting a broader spectrum of variants. Here, we demonstrated that inhibition of a motor protein kinesin family member 18A (KIF18A) suppresses the replication of the influenza A virus (IAV). The expression of KIF18A in host cells was increased following IAV infection. Intriguingly, treatment with the selective and ATP‐competitive mitotic kinesin KIF18A inhibitor BTB‐1 substantially decreased the expression of viral RNAs and proteins, and the production of infectious viral particles, while overexpression of KIF18A enhanced the replication of IAV. Importantly, BTB‐1 treatment attenuated the activation of AKT, p38 MAPK, SAPK and Ran‐binding protein 3 (RanBP3), which led to the prevention of the nuclear export of viral ribonucleoprotein complexes. Notably, administration of BTB‐1 greatly improved the viability of IAV‐infected mice. Collectively, our results unveiled a beneficial role of KIF18A in IAV replication, and thus, KIF18A could be a potential therapeutic target for the control of IAV infection.
Abstract
Mechanical forces are pervasive in the inflammatory site where dendritic cells (DCs) are activated to migrate into draining lymph nodes. For example, fluid shear stress modulates the ...movement patterns of DCs, including directness and forward migration indices (FMIs), without chemokine effects. However, little is known about the effects of biomechanical forces on the activation of DCs. Accordingly, here we fabricated a microfluidics system to assess how biomechanical forces affect the migration and activity of DCs during inflammation. Based on the structure of edema, we proposed and experimentally analyzed a novel concept for a microchip model that mimicked such vascular architecture. The intensity of shear stress generated in our engineered chip was found as 0.2–0.6 dyne/cm
2
by computational simulation; this value corresponded to inflammation in tissues. In this platform, the directness and FMIs of DCs were significantly increased, whereas the migration velocity of DCs was not altered by shear stress, indicating that mechanical stimuli influenced DC migration. Moreover, DCs with shear stress showed increased expression of the DC activation markers MHC class I and CD86 compared with DCs under static conditions. Taken together, these data suggest that the biomechanical forces are important to regulate the migration and activity of DCs.
PDF
