•A simple tool is reported to assess feasibility of industrial solar thermal systems.•Various climatic and design scenarios are explored for flat-plate solar collectors.•Added benefits of increasing ...collector area diminish due to high installation costs.•Solar thermal systems with 100% solar fraction may not be economically feasible.•For factors assessed, savings-to-investment ratio was most sensitive to gas price.
Manufacturing industries require process heating for a wide variety of operations, such as drying, cooking, washing, and sterilizing. Studies of industrial energy consumption have shown that more than 50% of industrial heating demand is in the low (<60 °C), medium (60–150 °C), and medium-high (<250 °C) temperature ranges. A significant fraction of this low temperature thermal energy could be generated by commercially available solar flat-plate collector thermal energy systems, which would reduce the use of fossil fuels, energy cost volatility, and carbon emissions. However, manufacturing industries have not been able to take advantage of solar flat-plate collector systems for two main reasons: First, information is not readily available about when and what flat-plate collector system sizes can be economically applied and, second, manufacturers often do not have appropriate personnel or analysis tools to make decisions about installation of solar flat-plate collector systems. The goal of this research is to provide design decision support to small- and medium-sized manufacturers in conducting feasibility analysis for the application of solar flat-plate collector systems in their operations. The ϕ‾,f-chart method and modified ϕ‾,f-chart design method are used to predict the amount of energy collected by solar flat-plate collectors. A simplified model is proposed to assess the cost of solar flat-plate collector energy systems. To demonstrate the presented feasibility analysis methodology, a decision support software application is developed. What-if scenarios are presented for several geographic locations of varying climates. A sensitivity analysis of savings-to-investment ratio (SIR) was performed by changing selected input parameters by ±30% from the base case. It was found that SIR is sensitive to natural gas price, followed by collector area dependent cost, discount rate, cost of the auxiliary gas heater, and cost of the preheating system.
Abstract
BACKGROUND
Middle meningeal artery (MMA) embolization has emerged as a promising treatment for chronic subdural hematoma (cSDH).
OBJECTIVE
To determine the safety and efficacy of MMA ...embolization.
METHODS
Consecutive patients who underwent MMA embolization for cSDH (primary treatment or recurrence after conventional surgery) at 15 centers were included. Clinical details and follow-up were collected prospectively. Primary clinical and radiographic outcomes were the proportion of patients requiring additional surgical treatment within 90 d after index treatment and proportion with > 50% cSDH thickness reduction on follow-up computed tomography imaging within 90 d. National Institute of Health Stroke Scale and modified Rankin Scale were also clinical outcomes.
RESULTS
A total of 138 patients were included (mean age: 69.8, 29% female). A total of 15 patients underwent bilateral interventions for 154 total embolizations (66.7% primary treatment). At presentation, 30.4% and 23.9% of patients were on antiplatelet and anticoagulation therapy, respectively. Median admission cSDH thickness was 14 mm. A total of 46.1% of embolizations were performed under general anesthesia, and 97.4% of procedures were successfully completed. A total of 70.2% of embolizations used particles, and 25.3% used liquid embolics with no significant outcome difference between embolization materials (P > .05). On last follow-up (mean 94.9 d), median cSDH thickness was 4 mm (71% median thickness reduction). A total of 70.8% of patients had >50% improvement on imaging (31.9% improved clinically), and 9 patients (6.5%) required further cSDH treatment. There were 16 complications with 9 (6.5%) because of continued hematoma expansion. Mortality rate was 4.4%, mostly unrelated to the index procedure but because of underlying comorbidities.
CONCLUSION
MMA embolization may provide a safe and efficacious minimally invasive alternative to conventional surgical techniques.
Graphical Abstract
Graphical Abstract
Most species on Earth are insects and thus, understanding their evolutionary relationships is key to understanding the evolution of life. Insect relationships are increasingly well supported, due ...largely to technological advances in molecular sequencing and phylogenetic computational analysis. In this postgenomic era, insect systematics will be furthered best by integrative methods aimed at hypothesis corroboration from molecular, morphological, and paleontological evidence. This review of the current consensus of insect relationships provides a foundation for comparative study and offers a framework to evaluate incoming genomic evidence. Notable recent phylogenetic successes include the resolution of Holometabola, including the identification of the enigmatic Strepsiptera as a beetle relative and the early divergence of Hymenoptera; the recognition of hexapods as a crustacean lineage within Pancrustacea; and the elucidation of Dictyoptera orders, with termites placed as social cockroaches. Regions of the tree that require further investigation include the earliest winged insects (Palaeoptera) and Polyneoptera (orthopteroid lineages).
The two flagella of Chlamydomonas reinhardtii are of the same size and structure but display functional differences, which are critical for flagellar steering movements. However, biochemical ...differences between the two flagella have not been identified. Here, we show that fluorescence protein-tagged carbonic anhydrase 6 (CAH6-mNG) preferentially localizes to the trans-flagellum, which is organized by the older of the two flagella-bearing basal bodies. The uneven distribution of CAH6-mNG is established early during flagellar assembly and restored after photobleaching, suggesting that it is based on preferred entry or retention of CAH6-mNG in the trans-flagellum. Since CAH6-mNG moves mostly by diffusion, a role of intraflagellar transport (IFT) in establishing its asymmetric distribution is unlikely. Interestingly, CAH6-mNG is present in both flagella of the non-phototactic bardet-biedl syndrome 1 (bbs1) mutant revealing that the BBSome is involved in establishing CAH6-mNG flagellar asymmetry. Using dikaryon rescue experiments, we show that the de novo assembly of CAH6-mNG in flagella is considerably faster than the removal of ectopic CAH6-mNG from bbs flagella. Thus, different rates of flagellar entry of CAH6-mNG rather than its export from flagella is the likely basis for its asymmetric distribution. The data identify a novel role for the C. reinhardtii BBSome in preventing the entry of CAH6-mNG specifically into the cis-flagellum.
Remote health assessments that gather real-world data (RWD) outside clinic settings require a clear understanding of appropriate methods for data collection, quality assessment, analysis and ...interpretation. Here we examine the performance and limitations of smartphones in collecting RWD in the remote mPower observational study of Parkinson's disease (PD). Within the first 6 months of study commencement, 960 participants had enrolled and performed at least five self-administered active PD symptom assessments (speeded tapping, gait/balance, phonation or memory). Task performance, especially speeded tapping, was predictive of self-reported PD status (area under the receiver operating characteristic curve (AUC) = 0.8) and correlated with in-clinic evaluation of disease severity (r = 0.71; P < 1.8 × 10
) when compared with motor Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Although remote assessment requires careful consideration for accurate interpretation of RWD, our results support the use of smartphones and wearables in objective and personalized disease assessments.
•In a hybrid system, gas burner efficiency decreases as solar fraction increases.•Gas consumed per degree temperature rise increases with initial tank temperature.•Separating heating systems reduces ...gas consumption for solar fractions from 15 to 50%.•Results enable more accurate cost and feasibility analysis.
In climate regions with large seasonal variations in solar radiation, such as the Pacific Northwest of the United States, a solar thermal energy collector might not economically satisfy year-round domestic water heating demands, requiring an auxiliary unit, such as a natural gas-fired water heater. Previous studies have shown that the burner efficiency of a gas-fired water heater varies depending on the log-mean temperature difference between the cold fluid (water) and the hot fluid (combustion gases). In a solar/gas hybrid water heating system, where solar collectors are used in conjunction with a gas-fired heater, the partial heating of water provided by solar input reduces the log-mean temperature difference value for the gas heater, reducing the efficiency of the gas burner. Since this efficiency reduction varies depending on the amount of pre-heating provided by solar energy input, it is difficult to accurately predict the actual cost and energy savings offered by solar/gas hybrid water heaters in different climates and operation scenarios. Hence, to predict the actual energy and cost savings under various design conditions, the performance of solar/gas hybrid systems must be better understood.
The objective of this work is to experimentally determine the thermal performance of a solar/gas water hybrid water heating system with a 6.44 m2 flat plate solar collector array and a 22.3 kW natural gas burner in Corvallis, Oregon, USA. Under different temperature lifts and solar insolation values, the system was operated at three different modes of heating: solar, gas, and combined solar/gas mode. The overall system thermal efficiency value for each mode is calculated. The efficiency of the solar collector heating system was found to be 41.97%, 39.82%, and 35.05% at initial water temperature of 20, 30, and 51.5 °C, respectively. For initial water temperatures of 20, 30, and 51.5 °C, the efficiency of the gas burner was found to be 69.2%, 66.4%, and 65.5% at the HHV, and 76.7%, 73.6%, and 72.6% at the LHV of natural gas, respectively. In the combined solar/gas heating mode, the efficiency of the gas burner decreased with increasing solar fraction. For solar fractions of 4.93%, 9.40%, 11.39%, and 14.27%, the efficiency of the gas burner in terms of the HHV of natural gas was found to be of 69.08%, 66.80%, 66.17%, and 65.18%, respectively. Based on the experimental results, a configuration that would provide higher overall system efficiency for combined solar/gas heating is suggested.
The development of electronic devices, especially those that involve heterogeneous integration of materials, has led to increased challenges in addressing their thermal operational temperature ...demands. The heat flow in these systems is significantly influenced or even dominated by thermal boundary resistance at the interface between dissimilar materials. However, controlling and tuning heat transport across an interface and in the adjacent materials has so far drawn limited attention. In this work, we grow chemical vapor-deposited diamond on silicon substrates by graphoepitaxy and experimentally demonstrate tunable thermal transport across diamond membranes and diamond–silicon interfaces. We observed the highest diamond–silicon thermal boundary conductance (TBC) measured to date and increased diamond thermal conductivity due to strong grain texturing in the diamond near the interface. Additionally, nonequilibrium molecular dynamics simulations and a Landauer approach are used to understand the diamond–silicon TBC. These findings pave the way for tuning or increasing thermal conductance in heterogeneously integrated electronics that involve polycrystalline materials and will impact applications including electronics thermal management and diamond growth.
The Star Excursion Balance Test (SEBT) is a widely accepted method of assessing dynamic postural stability. The Y Balance Test (YBT) is a commercially available device for measuring balance that uses ...3 (anterior, posteromedial, and posterolateral) of the 8 SEBT directions and has been advocated as a method for assessing dynamic balance. To date, no studies have compared reach performance in these tests in a healthy population.
To determine whether any differences exist between reach distance performance for the anterior, posteromedial, and posterolateral directions of the SEBT and the YBT.
Descriptive laboratory study.
University motion analysis laboratory.
A total of 20 healthy active male participants (age = 22.50 ± 3.05 years, height = 1.78 ± 0.82 m, weight = 79.48 ± 11.32 kg, body mass index = 24.96 ± 2.56 kg/m²).
Participants carried out 3 trials in each reach direction on each leg on the SEBT and the YBT a minimum of 1 week apart.
The means of the 3 trials in each direction on each leg on both tests were calculated. Data were collected after 4 practice trials in each direction. Paired t tests and Bland-Altman plots were used to compare reach distances between the SEBT and the YBT.
Participants reached farther in the anterior direction on the SEBT than on the YBT. No differences were observed in the posteromedial and posterolateral directions.
Differing postural-control strategies may be used to complete these tasks. This finding has implications for the implementation and interpretation of these dynamic balance tests.
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines and has been shown to down-regulate itself. We show, in this study, that treatment of human ...monocyte-derived macrophages with IL-10 induces IL-10 mRNA in a dose- and time-dependent manner with an optimum induction at 100 ng/ml and at 6 h, whereas IL-10-induced IL-10 protein can be detected at 18 h. In the same cells, IL-10 can partially suppress IL-10 mRNA induced by LPS, but only down to the level of IL-10-induced IL-10. An adenoviral luciferase reporter construct driven by the -195 IL-10 promoter, which contains a Stat motif, was readily induced by both IL-10 and LPS. Mutation of this Stat motif ablated IL-10 activation of this promoter, but not the LPS activation. Finally, we show that overexpression of a dominant-negative Stat3 protein will prevent IL-10 induction, but not LPS induction, of IL-10 mRNA. These data show that IL-10 induces IL-10 in monocyte-derived macrophages in an autocrine manner via activation of the transcription factor Stat3.
PDF
