Most previous work has focused on a single-nutrient, bottom-up approach when examining the influence of diet on neurocognition. Thus, the impact of dietary patterns on cognitive health is ...underinvestigated.
We aimed to investigate the relation between different diet indices i.e., Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index-2015 (HEI-2015), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) and attentional inhibition and neuroelectric function.
We undertook a cross-sectional analysis of adults aged 34.1 ± 6.0 y (n = 207, 116 females) with a BMI of 18.5 to >40 kg/m2 who completed the Dietary History Questionnaire II (DHQII) FFQ (Past Month and Year with Serving Sizes) to assess adherence to different diet quality indices. Attentional inhibition was assessed using a modified Eriksen flanker task during which event-related potentials (ERPs) were recorded. The amplitude and latency of the P3/P300 ERP were used to index attentional resource allocation and information processing speed, respectively.
P3 peak latency was inversely associated with greater adherence to the MIND dietary pattern during incongruent flanker trials (∆R2 = 0.02, β = -0.14, P = 0.043) but not during congruent trials. Adherence to the Mediterranean, DASH, and HEI-2015 patterns was not associated with P3 latency (P > 0.05). No associations were observed between the diet indices and attentional inhibition at the behavioral level (i.e., accuracy or reaction time) or P3 amplitude (all P values >0.05).
Greater adherence to the MIND diet was selectively associated with faster information processing speed in middle-aged adults with healthy to obese BMI. Further, the influence of the MIND diet for faster information processing speed might be particularly beneficial when cognitive control demands are increased. Future intervention trials testing the effects of consuming a MIND diet on cognitive function are warranted to help inform dietary recommendations for healthy cognitive aging.
Most previous work has focused on a single-nutrient, bottom-up approach when examining the influence of diet on neurocognition. Thus, the impact of dietary patterns on cognitive health is ...underinvestigated.
We aimed to investigate the relation between different diet indices i.e., Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index-2015 (HEI-2015), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) and attentional inhibition and neuroelectric function.
We undertook a cross-sectional analysis of adults aged 34.1 ± 6.0 y (n = 207, 116 females) with a BMI of 18.5 to >40 kg/m
who completed the Dietary History Questionnaire II (DHQII) FFQ (Past Month and Year with Serving Sizes) to assess adherence to different diet quality indices. Attentional inhibition was assessed using a modified Eriksen flanker task during which event-related potentials (ERPs) were recorded. The amplitude and latency of the P3/P300 ERP were used to index attentional resource allocation and information processing speed, respectively.
P3 peak latency was inversely associated with greater adherence to the MIND dietary pattern during incongruent flanker trials (∆R
= 0.02, β = -0.14, P = 0.043) but not during congruent trials. Adherence to the Mediterranean, DASH, and HEI-2015 patterns was not associated with P3 latency (P > 0.05). No associations were observed between the diet indices and attentional inhibition at the behavioral level (i.e., accuracy or reaction time) or P3 amplitude (all P values >0.05).
Greater adherence to the MIND diet was selectively associated with faster information processing speed in middle-aged adults with healthy to obese BMI. Further, the influence of the MIND diet for faster information processing speed might be particularly beneficial when cognitive control demands are increased. Future intervention trials testing the effects of consuming a MIND diet on cognitive function are warranted to help inform dietary recommendations for healthy cognitive aging.
Given that previous research has disproportionately focused on individual nutrients, knowledge of diet patterns and cognitive health is limited. Thus, we investigated the relationship between ...different diet indices (Mediterranean, Dietary Approaches to Stop Hypertension DASH, Healthy-Eating-Index-2015 HEI-2015, and Mediterranean-DASH Intervention for Neurodegenerative Delay MIND) and attentional inhibition and neuroelectric function.
Adults aged 34.1 ± 6.0 years old (N = 207) completed the Dietary History Questionnaire II (DHQII, Past Year and Past Month with Portion Size) to assess adherence to different diet indices. Attentional inhibition was assessed using a modified Eriksen Flanker task while event-related potentials (ERPs) were recorded. The amplitude and latency of the P3 ERP component were used to index attentional resource allocation and information processing speed, respectively. Stepwise linear regression modeling was used to assess the influence of each dietary index on behavioral performance and neuroelectric function following adjustment for significant covariates (e.g., age, sex, intelligence quotient, and body mass index).
Greater adherence to the MIND diet was associated with an earlier incongruent P3 peak latency (ΔR2 = 0.02, β = –0.14, p = 0.04) but not congruent peak latency (ΔR2 = 0.02, β = –0.12, p = 0.07). Adherence to the Mediterranean, DASH, and HEI-2015 patterns was not correlated with P3 latency (p > 0.05). No associations were observed between the diet indices and attentional inhibition at the behavioral level (i.e., accuracy or reaction time) or P3 amplitude (all p’s > 0.05).
Greater adherence to the MIND diet was selectively related to faster information processing speed. This relationship was only evident during incongruent trials, suggesting that the influence of greater MIND diet adherence is particularly beneficial when upregulation of cognitive control is required. Future MIND diet intervention trials are warranted to help inform dietary recommendations for healthy cognitive aging.
This work was funded by the Department of Kinesiology and Community Health at the University of Illinois, Division of Nutritional Sciences, and Hass Avocado Board.
Lutein and zeaxanthin are xanthophyll carotenoids that comprise macular pigment in the eye and disproportionately accumulate in brain tissue. While the link between serum xanthophylls and macular ...pigment has received considerable investigation, comparatively less is known regarding the relationship between circulating xanthophylls and retinal morphology. This knowledge gap is significant since deterioration of the morphometric measures of the retina (e.g., retinal nerve fiber layer, RNFL) is a feature of age-neurodegenerative diseases. This project aimed to understand the relationship between serum xanthophylls and retinal morphology.
Subjects included 84 individuals (30 males) with overweight and obesity (BMI ≥ 25 kg/m2) between 25–45 years. Macular pigment optical density (MPOD) was measured using heterochromatic flicker photometry. Optical coherence tomography (OCT) was used to assess RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL). Venous blood draws were used to assess serum lutein and zeaxanthin. Covariates assessed included demographic factors, adiposity (DXA), and dietary intake (7d food records).
Serum lutein (r = 0.32, P < 0.01) and zeaxanthin (r = 0.23, P = 0.01) concentrations were associated with greater MPOD. There were no significant associations between serum xanthophyll concentrations and morphological values. Similarly, there was no influence of adiposity or dietary lutein and zeaxanthin on retinal morphological measures. However, overall diet quality, assessed using Healthy Eating Index (HEI) was positively associated with IPL (r = 0.35, P < 0.01) and GCL (r = 0.32, P < 0.01) thickness.
Although circulating carotenoids were associated with macular pigment, this relationship did not extend to morphological measures in the retina. However, overall dietary quality was significantly associated with retinal morphological measures. These findings suggest that macular pigment and retinal morphology may be influenced by nutritional factors.
Hass Avocado Board.
Self‐assembly of nanoparticles provides unique opportunities as nanoplatforms for controlled delivery. By exploiting the important role of noncovalent hydrophobic interactions in the engineering of ...stable assemblies, nanoassemblies were formed by the self‐assembly of fluorinated quantum dots in aqueous medium through fluorine–fluorine interactions. These nanoassemblies encapsulated different enzymes (laccase and α‐galactosidase) with encapsulation efficiencies of ≥74 %. Importantly, the encapsulated enzymes maintained their catalytic activity, following Michaelis–Menten kinetics. Under an acidic environment the nanoassemblies were slowly disassembled, thus allowing the release of encapsulated enzymes. The effective release of the assayed enzymes demonstrated the feasibility of this nanoplatform to be used in pH‐mediated enzyme delivery. In addition, the as‐synthesized nanoassemblies, having a diameter of about 50 nm, presented high colloidal stability and fluorescence emission, which make them a promising multifunctional nanoplatform.
Connecting the dots: Self‐assembly of quantum dots driven by fluorine–fluorine interactions led to efficient formation of nanoassemblies. These assemblies were shown to efficiently carry and deliver enzymes in a controlled fashion, in particular, pH‐mediated enzyme delivery.
Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the ...internalization in cells via receptor-mediated endocytosis has been widely studied, the conjugation of antibodies to larger NP assemblies has been much less explored. Taking into account that NP assemblies may be advantageous for some specific applications, the possibility of incorporating targeting ligands is quite important. Herein, we performed the effective conjugation of antibodies onto a fluorescent NP assembly, which consisted of fluorinated Quantum Dots (QD) self-assembled through fluorine–fluorine hydrophobic interactions. Cellular uptake studies by confocal microscopy and flow cytometry revealed that the NP assembly underwent the same uptake procedure as individual NPs; that is, the antibodies retained their targeting ability once attached to the nanoassembly, and the NP assembly preserved its intrinsic properties (i.e., fluorescence in the case of QD nanoassembly).
Self‐assembly of nanoparticles provides unique opportunities as nanoplatforms for controlled delivery. By exploiting the important role of noncovalent hydrophobic interactions in the engineering of ...stable assemblies, nanoassemblies were formed by the self‐assembly of fluorinated quantum dots in aqueous medium through fluorine–fluorine interactions. These nanoassemblies encapsulated different enzymes (laccase and α‐galactosidase) with encapsulation efficiencies of ≥74 %. Importantly, the encapsulated enzymes maintained their catalytic activity, following Michaelis–Menten kinetics. Under an acidic environment the nanoassemblies were slowly disassembled, thus allowing the release of encapsulated enzymes. The effective release of the assayed enzymes demonstrated the feasibility of this nanoplatform to be used in pH‐mediated enzyme delivery. In addition, the as‐synthesized nanoassemblies, having a diameter of about 50 nm, presented high colloidal stability and fluorescence emission, which make them a promising multifunctional nanoplatform.
Punkte verbinden: Die durch F‐F‐Wechselwirkungen getriebene Selbstorganisation von Quantenpunkten führte zur effizienten Bildung von Nanoassemblaten. Die Assemblate erwiesen sich als effiziente Träger für den kontrollierten Transport von Enzymen, insbesondere für die pH‐vermittelte Enzymfreisetzung.
This conference proceedings summarizes invited publications from the two IDES (Institute of Doctors Engineers and Scientists) International conferences, both held in Bangalore/ India.
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