Summary Duchenne muscular dystrophy (DMD) is a severe, progressive disease that affects 1 in 3600–6000 live male births. Although guidelines are available for various aspects of DMD, comprehensive ...clinical care recommendations do not exist. The US Centers for Disease Control and Prevention selected 84 clinicians to develop care recommendations using the RAND Corporation–University of California Los Angeles Appropriateness Method. The DMD Care Considerations Working Group evaluated assessments and interventions used in the management of diagnostics, gastroenterology and nutrition, rehabilitation, and neuromuscular, psychosocial, cardiovascular, respiratory, orthopaedic, and surgical aspects of DMD. These recommendations, presented in two parts, are intended for the wide range of practitioners who care for individuals with DMD. They provide a framework for recognising the multisystem primary manifestations and secondary complications of DMD and for providing coordinated multidisciplinary care. In part 1 of this Review, we describe the methods used to generate the recommendations, and the overall perspective on care, pharmacological treatment, and psychosocial management.
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Recently, the number of projects has grown connected with the application of high-temperature superconductors (HTSC) with exceptionally high current-carrying characteristics in strong magnetic ...fields. However, the thickness of the RBa
2
Cu
3
O
7–
x
(R = REE, Y) superconducting layer is only 1–2% of the thickness of HTSC tape. Increasing the current-carrying characteristics owing to the thickness of the conducting layer is a promising approach. The fundamental problem of crystallite formation of
a-
oriented crystallites prevents the development of this approach. Such crystallites do not carry superconducting current along the substrate tape and interfere with the growth of
c-
oriented crystallites. This review presents existing methods of suppression of
a
-oriented growth, the basis of the creation of HTSC materials, and prospects of obtaining HTSC materials with high current-carrying characteristics.
Spin Pumping from Lu3Fe5O12 Volkov, D. A.; Gabrielyan, D. A.; Matveev, A. A. ...
JETP letters,
03/2024, Letnik:
119, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Microwave spin pumping from ferromagnetic lutetium iron garnet (Lu
3
Fe
5
O
12
) has been theoretically and experimentally investigated. The magnetization vector precession excited by a microwave ...magnetic field is transformed into a dc voltage due to the inverse spin Hall effect in the lutetium iron garnet/heavy metal heterostructure (Lu
3
Fe
5
O
12
/Pt). In the experiments carried out, the external magnetic field has been varied from 0 to 6 kOe, thus making it possible to tune the resonant frequency in wide ranges. The experimental sensitivity of this heterostructure is 8.2 µV/W. A change in the dc voltage sign with a change in the magnetic field direction confirms the generation of spin current in the Lu
3
Fe
5
O
12
/Pt heterostructure. The results obtained make a significant contribution to insight into spin pumping physics and may be useful for the development of new highly sensitive tunable spintronic devices.
Introduction
This study establishes research priorities for Medically Not Yet Explained Symptoms (MNYES). A significant number of patients suffer from these symptoms, also known as MUS, that are ...likely to cause work disability and impact on quality of life. Research into MNYES in general has been poorly funded over the years, has been primarily researcher-led, and was sometimes controversial.
Objectives
To identify research priorities from the perspective of patients, caregivers and clinicians, following the James Lind Alliance (JLA) priority setting partnership (PSP) method.
Methods
The PSP Steering Group termed these symptoms Medically Not Yet Explained Symptoms (MNYES). This was an operational definition not intended to add to or replace other definitions already in use, that was constructed to embrace the views of all stakeholders. The nomenclature MNYES was chosen to indicate our incomplete understanding of these conditions. This could pertain to biological, psychological and social factors, as well as factors involving the trajectory of patients through various healthcare settings.
The study involved five key stages: defining the appropriate term for the conditions under study by the PSP Steering Group; gathering questions on MNYES from patients, caregivers and clinicians in a publicly accessible survey; checking these research questions against existing evidence; interim prioritisation in a second survey; and a final multi-stakeholder consensus meeting to determine the top 10 unanswered research questions using the modified nominal group methodology.
Results
Over 700 responses from UK patients, caregivers and clinicians were identified in two surveys from a broad range of medical specialities and primary care. Patients prioritised research questions regarding diagnosis and aetiology; clinicians and caregivers prioritised outcomes and treatment, relatively.
The top 10 unanswered research questions cover the domains of: treatment; the role of clinicians; symptoms and outcomes; and recovery.
Conclusions
This JLA PSP may well be the first attempt at capturing the thoughts of a wide group of medical professionals, patients and caregivers in one place with the aim eventually of standardising care and reducing unhelpful variability in the management of MNYES. Following the JLA approach is a strength of the study. The choice of the term MNYES conveys a message of hope, which responds to a need identified by patients, carers and clinicians alike for vigorous research in this domain. The research priorities are expected to generate much-needed, relevant and impactful research into MNYES. Better funding possibilities for MNYES are urgently needed.
Disclosure of Interest
None Declared
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