We analyze the combined Spitzer and ground-based data for OGLE-2017-BLG-1140 and show that the event was generated by a Jupiter-class planet orbiting a mid-late M dwarf that lies in the foreground of ...the microlensed Galactic-bar source star. The planet-host projected separation is , i.e., well beyond the snow line. By measuring the source proper motion from ongoing long-term OGLE imaging and combining this with the lens-source relative proper motion derived from the microlensing solution, we show that the lens proper motion is consistent with the lens lying in the Galactic disk, although a bulge lens is not ruled out. We show that while the Spitzer and ground-based data are comparably well fitted by planetary (i.e., binary-lens (2L1S)) and binary-source (1L2S) models, the combination of Spitzer and ground-based data decisively favors the planetary model. This is a new channel to resolve the 2L1S/1L2S degeneracy, which can be difficult to break in some cases.
Prostate cancer is initially androgen-dependent but, over time, usually develops hormone- and chemo-resistance. The present study investigated a role for p21-activated kinase 4 (PAK4) in prostate ...cancer progression. PAK4 activation was markedly inhibited by H89, a specific protein kinase A (PKA) inhibitor, and PAK4 was activated by the elevation of cAMP. The catalytic subunit of PKA interacted with the regulatory domain of PAK4, and directly phosphorylated PAK4 at serine 474 (S474). Catalytically active PAK4 enhanced the transcriptional activity of CREB independent of S133 phosphorylation. Stable knockdown of PAK4 in PC-3 and DU145 prostate cancer cells inhibited tumor formation in nude mice. Decreased tumorigenicity correlated with decreased expression of CREB and its targets, including Bcl-2 and cyclin A1. Additionally, in androgen-dependent LNCap-FGC cells, PAK4 regulated cAMP-induced neuroendocrine differentiation, which is known to promote tumor progression. Finally, PAK4 enhanced survival and decreased apoptosis following chemotherapy. These results suggested that PAK4 regulates progression toward hormone- and chemo-resistance in prostate cancer, and this study identified both a novel activation mechanism and potential downstream effector pathways. Therefore, PAK4 may be a promising therapeutic target in prostate cancer.
We present an analysis of the binary-lens microlensing event OGLE-2017-BLG-0537. The light curve of the event exhibits two strong caustic-crossing spikes among which the second caustic crossing was ...resolved by high-cadence surveys. It is found that the lens components with a mass ratio ∼0.5 are separated in projection by , where θE is the angular Einstein radius. Analysis of the caustic-crossing part yields mas and a lens-source relative proper motion of = 12.4 1.1 mas yr−1. The measured is the third highest value among the events with measured proper motions and is ∼3 times higher than the value of typical Galactic bulge events, making the event a strong candidate for follow-up observations to directly image the lens by separating it from the source. From the angular Einstein radius combined with the microlens parallax, it is estimated that the lens is composed of two main-sequence stars with masses M1 ∼ 0.4 M and M2 ∼ 0.2 M located at a distance of DL ∼ 1.2 kpc. However, the physical lens parameters are not very secure due to the weak microlens-parallax signal, thus we cross-check the parameters by conducting a Bayesian analysis based on the measured Einstein radius and event timescale, combined with the blending constraint. From this, we find that the physical parameters estimated from the Bayesian analysis are consistent with those based on the measured microlens parallax. Resolving the lens from the source can be done in about 5 years from high-resolution follow-up observations and this will provide a rare opportunity to test and refine the microlensing model.
We evaluated whether ELISPOT assay can predict tuberculosis (TB) development in kidney‐transplantation (KT) recipients with a negative tuberculin skin test (TST). All adult patients admitted to a KT ...institute between June 2008 and December 2009 were enrolled; TB development after KT was observed between June 2008 and December 2010. Isoniazid (INH) was given to those patients with positive TST or clinical risk factors for latent TB infection (LTBI). ELISPOT assay was performed on all patients, and TB development after KT was observed by a researcher blinded to the results of ELISPOT. A total of 312 KT recipients including 242 (78%) living‐donor KT were enrolled. Of the 312 patients, 40 (13%) had positive TST or clinical risk factors for LTBI and received INH; none developed TB after KT. Of the remaining 272 patients, 4 (6%) of 71 with positive ELISPOT assay developed TB after KT, whereas none of the 201 patients with negative (n = 171) or indeterminate ELISPOTs (n = 30) developed TB after KT (rate difference between positive and negative/indeterminate ELISPOT, 3.3 per 100 person‐years 95% CI 1.4–5.1, p<0.001). Positive ELISPOT results predict subsequent development of TB in KT recipients in whom LTBI cannot be detected by TST or who lack clinical risk factors for LTBI.
Positive results of an interferon‐gamma releasing assay anticipate the subsequent development of tuberculosis in kidney transplant recipients in whom latent tuberculosis infection cannot be detected by tuberculin skin test or who lack clinical risk factors for latent tuberculosis infection. See editorial by Torre‐Cisneros and Doblas on page 1769.
Sarcopenia is an important factor of functional impairment related to aging. This study is conducted to investigate the prevalence of sarcopenia and sarcopenic obesity in Korean population.
...Representative Korean men (4,486) and women (5,999) aged 20 years or older were analyzed from the Fourth Korean National Health and Nutritional Examination Surveys. Sarcopenia was classified into Class I defined relative skeletal muscle mass loss within 1-2 SD of the gender-specific mean for healthy young adults and Class II below 2 SD. Relative skeletal muscle mass was represented by the appendicular skeletal muscle mass adjusted by height and body weight. Sarcopenic obesity was considered present in Class II sarcopenic participants whose waist circumference was more than or equal to 90 cm for men and more than or equal to 85 cm for women, respectively.
The prevalence of Class II sarcopenia in the Korean elderly population was 12.4% for men and 0.1% for women by height-adjusted definition and 9.7% for men and 11.8% for women by weight-adjusted definition. The prevalence of sarcopenic obesity was 7.6% for men and 9.1% for women by weight-adjusted definition but nearly zero for men and women by height-adjusted definition. The prevalence of sarcopenia increased with age for men but for women only when applied with weight-adjusted definition.
The prevalence of sarcopenia and sarcopenic obesity differs by gender and definition criteria. The height-adjusted definition may tend to underestimate the prevalence of sarcopenia and sarcopenic obesity, especially in women.
We present the analysis of the event OGLE-2017-BLG-1186 from the 2017 Spitzer microlensing campaign. This is a remarkable microlensing event because its source is photometrically bright and variable, ...which makes it possible to perform an asteroseismic analysis using ground-based data. We find that the source star is an oscillating red giant with average timescale of ∼9 d. The asteroseismic analysis also provides us source properties including the source angular size (∼27 μas) and distance (∼11.5 kpc), which are essential for inferring the properties of the lens. When fitting the light curve, we test the feasibility of Gaussian processes (GPs) in handling the correlated noise caused by the variable source. We find that the parameters from the GP model are generally more loosely constrained than those from the traditional χ(exp 2) minimization method. We note that this event is the first microlensing system for which asteroseismology and GPs have been used to account for the variable source. With both finite-source effect and microlens parallax measured, we find that the lens is likely a ∼0.045 Mʘ brown dwarf at distance ∼9.0 kpc, or a ∼0.073 Mʘ ultracool dwarf at distance ∼9.8 kpc. Combining the estimated lens properties with a Bayesian analysis using a Galactic model, we find a ∼ 35 per cent probability for the lens to be a bulge object and ∼ 65 per cent to be a background disc object.
We report the discovery of a planetary system in which a super-Earth orbits a late M-dwarf host. The planetary system was found from the analysis of the microlensing event OGLE-2017-BLG-0482, wherein ...the planet signal appears as a short-term anomaly to the smooth lensing light curve produced by the host. Despite its weak signal and short duration, the planetary signal was firmly detected from the dense and continuous coverage by three microlensing surveys. We find a planet/host mass ratio of q ∼ 1.4 × 10−4. We measure the microlens parallax from the long-term deviation in the observed lensing light curve, but the angular Einstein radius cannot be measured because the source trajectory did not cross the planet-induced caustic. Using the measured event timescale and the microlens parallax, we find that the masses of the planet and the host are and , respectively, and the projected separation between them is au. The estimated distance to the lens is kpc. The discovery of the planetary system demonstrates that microlensing provides an important method to detect low-mass planets orbiting low-mass stars.
Algol (β Persei) is the prototypical semidetached eclipsing binary and a hierarchical triple system. From 2006 to 2010 we obtained 121 high-resolution and high signal-to-noise ratio échelle spectra ...of this object. Spectral disentangling yields the individual spectra of all three stars, and greatly improved elements both the inner and outer orbits. We find masses of M
A = 3.39 ± 0.06 M⊙, M
B = 0.770 ± 0.009 M⊙ and M
C = 1.58 ± 0.09 M⊙. The disentangled spectra also give the light ratios between the components in the B and V bands. Atmospheric parameters for the three stars are determined, including detailed elemental abundances for Algol A and Algol C. We find the following effective temperatures: T
A = 12 550 ± 120 K, T
B = 4900 ± 300 K and T
C = 7550 ± 250 K. The projected rotational velocities are v
Asin i
A = 50.8 ± 0.8 km s−1, v
Bsin i
B = 62 ± 2 km s−1 and v
Csin i
C = 12.4 ± 0.6 km s−1. This is the first measurement of the rotational velocity for Algol B, and confirms that it is synchronous with the orbital motion. The abundance patterns of components A and C are identical to within the measurement errors, and are basically solar. They can be summarized as mean metal abundances: M/HA = −0.03 ± 0.08 and M/HC = 0.04 ± 0.09. A carbon deficiency is confirmed for Algol A, with tentative indications for a slight overabundance of nitrogen. The ratio of their abundances is (C/N)A = 2.0 ± 0.4, half of the solar value of (C/N)⊙ = 4.0 ± 0.7. The new results derived in this study, including detailed abundances and metallicities, will enable tight constraints on theoretical evolutionary models for this complex system.
Background
Patients with fibromyalgia (FM) exhibit significant clinical heterogeneity, in terms of physical, social and psychological functions, as well as therapeutic responses. Here, we examined FM ...patients in terms of pain, physical, social and psychological variables to identify clinical subgroups that may be predictive of treatment patterns.
Methods
A total of 313 FM patients were interviewed using a structured questionnaire that included sociodemographic data, current or past FM symptoms and current use of relevant medications. A K‐means cluster analysis was conducted using variables reflecting tender points, the Fibromyalgia Impact Questionnaire, Beck Depression Inventory, State‐Trait Anxiety Inventor and Social Support Scale.
Results
Four distinct clusters were identified in these patients. Group 1 was characterized by high pain levels, severe physical and mental impairment and low social support. Group 2 had moderate pain and physical impairment, mild mental impairment and moderate social support. Group 3 had moderate pain, low physical and moderate mental impairment and low social support. Group 4 had low pain levels, nearly normal physical and mental function and high social support. Group 1 was more often a current or past smoker, more likely to have a variety of symptoms, including swelling, cognitive dysfunction, dizziness, syncope, oesophageal dysmotility, dyspepsia, irritable bladder, vulvodynia and restless leg syndrome.
Conclusions
We identified four subgroups of FM patients based on pain, physical, social and psychological function. These subgroups had different clinical symptoms and medication profiles, suggesting that FM may be better managed using a more comprehensive assessment of an individual patient's symptoms.
Significance
FM patients can be clustered into four distinct subgroups based on clinically measurable variables – pain, physical involvement, psychological function and social support. These subgroups had different clinical symptoms and medication profiles.
We report the observation of a gravitational-wave signal produced by the coalescence of two stellar-mass black holes. The signal, GW151226, was observed by the twin detectors of the Laser ...Interferometer Gravitational-Wave Observatory (LIGO) on December 26, 2015 at 03:38:53 UTC. The signal was initially identified within 70 s by an online matched-filter search targeting binary coalescences. Subsequent off-line analyses recovered GW151226 with a network signal-to-noise ratio of 13 and a significance greater than 5(sigma). The signal persisted in the LIGO frequency band for approximately 1 s, increasing in frequency and amplitude over about 55 cycles from 35 to 450 Hz, and reached a peak gravitational strain of 3.4(+0.7/-0.9) x 10(exp -22). The inferred source-frame initial black hole masses are 14.2(+8.3/-3.7 Stellar Mass and 7.5(+2.3/-2.3) Stellar Mass, and the final black hole mass is 20.8(+6.1/-1.7) Stellar Mass. We find that at least one of the component black holes has spin greater than 0.2. This source is located at a luminosity distance of 440(+180/-190) Mpc corresponding to a redshift of 0.090(+.030/-0.04). All uncertainties define a 90% credible interval. This second gravitational-wave observation provides improved constraints on stellar populations and on deviations from general relativity.
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