One of the new linguocreative practices of organizing the city space as a cultural text is analyzed. The game discourse of polycode texts is considered, which combine elements of different semiotic ...systems: signs of traffic rules, supplemented by visualized symbolic allusions and quotations, collectively referring to the motifs of famous works of art. The constructive principles of modeling the associative context of polycode posters placed in the Literary Quarter of Yekaterinburg are characterized. The universality of the generation of game texts of any semiotic nature on the basis of an operational technique that creates the effects of associative deducibility and associative integration is substantiated. The novelty of the study is related to the description of the algorithm for creating and deciphering a game polycode text of this type, identifying the factors and strategies for reading it by the addressee. The dynamic component of the semantic diversity of the analyzed texts is experimentally verified, taking into account the respondents’ recognition of the prototypes of the game transform, reflection on the connection between its visual and verbal components, and the ability to derive allusive implicatures. Particular attention is paid to the analysis of game transform decoding strategies in the light of the mechanisms of linguocreative thinking based on the switching of associative stereotypes in the language game register.
The mechanism of occurrence of spontaneous self-sustained currents in a multiwire proportional chamber from the experiment at the Large Hadron Collider has been considered. Atomic force microscopy, ...Rutherford backscattering, and Raman spectroscopy on the copper foil of the chamber cathode revealed the formation of nanocarbon structures and their fluorinated compounds, which are well known as low-threshold sources of field emission of electrons.
The morphology of polyvinylidenefluoride (PVDF) and the copolymer of tetrafluoroethylene with ethylene (CTE) were investigated by thermomechanical analysis. Both granules and highly dispersed powders ...of the polymers have similar morphology. Polymer granules contain amorphous and crystalline regions. The morphology of the polymer powders were determined under two analytical conditions: coaxial, when the vectors of polymer loading and vector of compression pressure are in the same plane, or when they are perpendicular to each other. One amorphous and two crystal blocks were found at coaxial orientations of the vectors. Thermomechanical analysis showed that the polymers had a completely amorphous diblock morphology at the perpendicular orientation of the vectors. Parameters that characterize a degree of interchain interaction, such as coefficients of thermal expansion, free volume, and temperatures of polymer transformation into the glassy, high-elastic, or flow-viscous state were determined. PVDF and CTE have similar topographic composition, but different molecular mass and temperatures of phase transitions.
Supramolecular complexes between carotenoids and a triterpene glycoside, β-glycyrrhizic acid (GA), were found to exhibit unusual antioxidant activity. Complexation with GA increases a scavenging rate ...of canthaxanthin and 7′,7′-dicyano-7′-apo-β-carotene toward OOH radicals more than 10 times, but has no effect on the scavenging rate of zeaxanthin. Scavenging rate constants were measured in DMSO solution of carotenoids using the EPR spin-trapping technique. EPR parameters of spin adducts were determined as a(H) = 2.3 G, a(N) = 13.9 G for PBN (
N-
tert-butyl
-α-phenylnitrone)–OOH, and a(H) = 3.4 G, a(N) = 14.9 G for the PBN–CH
3 adduct. Taking into account the previously measured dependence of the scavenging rate constants toward OOH radicals on the oxidation potential of carotenoids, this result can be explained by the hypothesis that the complexation with GA affects the value of oxidation potentials. This hypothesis was confirmed by CV measurements.
A tandem electrostatic accelerator with an original design called a Vacuum Insulated Tandem Accelerator was proposed and developed at the Budker Institute of Nuclear Physics. Unlike conventional ...tandem accelerators, it does not use accelerating tubes—the high-voltage and intermediate electrodes are made in the form of nested cylinders and are fixed at a single feedthrough insulator. This design of the electrodes made it possible to provide a high rate of ion acceleration (up to 25 kV/cm). The accelerator is equipped with a set of diagnostic tools that provide the long-term stable production of a beam of protons or deuterons with an energy varying from 0.6 to 2.3 MeV and with a current varying from 0.1 to 10 mA. The ion beam is characterized by high monochromaticity, energy stability (0.1%), and high current stability (0.4%). The accelerator is used for in situ observations of the blistering of a metal irradiated with protons; for measuring the cross section of the reactions
7
Li(p,p'γ)
7
Li,
7
Li(p,α)α, and
11
B(p,α)αα; for developing boron neutron capture therapy for malignant tumors by using neutrons generated in the
7
Li(p,n)
7
Li reaction; for the radiation testing of promising materials using fast neutrons in the
7
Li(d,n) reaction; and for other applications. The accelerator became an integral part of the medical neutron source for boron neutron capture therapy: the first facility was put into operation in one of the first six BNCT clinics in the world in Xiamen, China; the next two facilities are being made for the National Center of Oncological Hadron Therapy in Pavia (Italy) and for the Blokhin National Medical Research Center of Oncology in Moscow. In this paper, the design of the accelerator and its features and parameters, as well as the results of studies carried out using the accelerator, are presented and discussed.
Methyl (Z)-4-aryl-2-hydroxy-4-oxobut-2-enoates (methyl aroylpyruvates) reacted with 1,3,3-trimethyl- 2-methylidene-2,3-dihydro-1
H
-indole (Fischer’s base) to give (2Z,5
E
...)-1-aryl-3-hydroxy-5-(1,3,3-trimethyl-2,3-dihydro-1
H
-indol-2-ylidene)pent-2-ene-1,4-diones.
Hen’s egg allergy: an update Fedotova, M. M.; Fedorova, O. S.; Konovalova, U. V. ...
Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny,
07/2018, Letnik:
17, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Hen’s egg allergy is one of the most common problems in pediatrics. This pathology is associated with severe clinical manifestations, often with a risk of anaphylactic reactions. This review presents ...current data on the epidemiology and clinical presentation, as well as aspects of the natural history and management of hen’s egg allergy. The paper will provide data on allergenic proteins of hen’s egg, including data on structure, physicochemical properties, IgE-binding capacity, and cross-reactivity. Finally, practical information about egg allergy and immunization will be presented.
Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with
N,N
′-dimethylethylenediamine. These structural analogs of prodimin, a ...water insoluble anticancer drug, are soluble in water, which significantly expands methods for their administration into a body. The compounds obtained and prodimin (as a reference substance) were studied on P388 murine leukemia and some of its drug-resistant strains. The data obtained suggest a high efficacy of one synthesized compound against drug-resistant tumors.
The spin trapping EPR technique was used to study the influence of carotenoids (β-carotene, 8′-apo-β-caroten-8′-al, canthaxanthin, and ethyl 8′-apo-β-caroten-8′-oate) on the yield of free radicals in ...the Fenton reaction (Fe
2+ + H
2O
2 → Fe
3+ +
OH +
−OH) in the organic solvents, DMSO, and methanol. DMPO and PBN were used as spin trapping agents. It was demonstrated that carotenoids could increase or decrease the total yield of free radicals depending on the oxidation potential of the carotenoids and the nature of the radicals. A reaction mechanism is suggested which includes the reduction of Fe
3+ to Fe
2+ by carotenoids. The effectiveness of this carotenoid-driven Fenton reaction increases with a decrease of the scavenging rates for free radicals and with decreasing oxidation potentials of carotenoids.
Infectious diarrhea is one of the leading causes of fatal outcomes in young children. Differential diagnostics of such infections within the first hours of illness poses significant objective ...obstacles. Data from laboratory studies of autopsy material and pathological studies provide valuable information for understanding the spectrum of differential diagnostics and etiological structure of infectious diarrhea with fatal outcomes in young children. Materials and methods. There were analyzed 100 cases of fatal outcomes in children under the age of six years registered in Russia from November 2011 to December 2019, who was diagnosed with infectious diarrhea at different levels of the healthcare system. The data were assessed based on available medical case reports and the laboratory testing of autopsy samples performed by using nucleic acid amplification methods. Results. The diagnosis of infectious diarrhea was revised in 24 patients, based on the data of a set of intravital and post-mortem studies. In patients with unconfirmed diagnosis of acute intestinal infections, pneumonia was the most often detected — in 45.8% (11/24), sepsis — in 29.2% (7/24), meningitis/meningoencephalitis, acute surgical pathology and asphyxiation associated with vomit aspiration — in 16.7 % (4/24) cases. The causative agents of infectious diarrhea were identified in 71 of 76 patients with confirmed diagnosis of acute intestinal infections. Most prevalent were group A rotaviruses — 52.6% (40/76), group F adenoviruses — 17.1% (13/76), and noroviruses — 13.2% (10/76). Combination of pathogens was detected in 29 cases (38.2%). Prehospital lethal outcomes in patients with infectious diarrhea were observed in 17 cases (22.4%). In total, rate of neonatal deaths due to acute intestinal infections accounted for 62.2% and 2-year-old toddlers — 20.3%. 64 of 76 (84%) children had no unfavorable premorbid background. The most common pathologies associated with infectious diarrhea with developing fatal outcomes were pneumonia (including aspiration pneumonia) in 22.4% (17/76) and aspiration asphyxia in 6.6% (5/76). Hemolytic-uremic syndrome associated with diarrhea was diagnosed in 7.9% (6/76) of children. Conclusions. Within the first years of life children comprise a risk group for developing fatal outcomes during infectious diarrhea. Lack of unfavorable premorbid background should not be considered as a reliable positive prognostic criterion. Diagnostics of pneumonia should be included in the mandatory examination plan for children with severe infectious diar rhea. Based on study of clinical and autopsy material, group A rotaviruses were the lead causative agents among those resulting in infectious diarrhea with fatal outcomes in young children. Special attention should be paid to preventing vomit aspiration within the first days after disease onset.
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