The detection of five new fast radio bursts (FRBs) found in the 1.4-GHz High Time Resolution Universe high-latitude survey at Parkes, is presented. The rate implied is 7
$^{+5}_{-3}\times 10^3$
...(95 per cent) FRBs sky−1 d−1 above a fluence of 0.13 Jy ms for an FRB of 0.128 ms duration to 1.5 Jy ms for 16 ms duration. One of these FRBs has a two-component profile, in which each component is similar to the known population of single component FRBs and the two components are separated by 2.4 ± 0.4 ms. All the FRB components appear to be unresolved following deconvolution with a scattering tail and accounting for intrachannel smearing. The two-component burst, FRB 121002, also has the highest dispersion measure (1629 pc cm−3) of any FRB to-date. Many of the proposed models to explain FRBs use a single high-energy event involving compact objects (such as neutron-star mergers) and therefore cannot easily explain a two-component FRB. Models that are based on extreme versions of flaring, pulsing, or orbital events, however, could produce multiple component profiles. The compatibility of these models and the FRB rate implied by these detections is discussed.
Comparing photosynthetic and photovoltaic efficiencies is not a simple issue. Although both processes harvest the energy in sunlight, they operate in distinctly different ways and produce different ...types of products: biomass or chemical fuels in the case of natural photosynthesis and nonstored electrical current in the case of photovoltaics. In order to find common ground for evaluating energy-conversion efficiency, we compare natural photosynthesis with present technologies for photovoltaic-driven electrolysis of water to produce hydrogen. Photovoltaic-driven electrolysis is the more efficient process when measured on an annual basis, yet short-term yields for photosynthetic conversion under optimal conditions come within a factor of 2 or 3 of the photovoltaic benchmark. We consider opportunities in which the frontiers of synthetic biology might be used to enhance natural photosynthesis for improved solar energy conversion efficiency.
Objective
To identify risk factors for fear of childbirth (FOC) according to parity and socioeconomic status, and to evaluate associations between FOC and adverse perinatal outcomes.
Design
A cohort ...study.
Setting
The Finnish Medical Birth Register.
Population
All 788 317 singleton births during 1997–2010 in Finland.
Methods
Fear of childbirth was defined according to the International Classification of Diseases code O99.80, and its associations with several risk factors and perinatal outcomes were analysed by multivariable logistic regression.
Main outcome measures
Prevalence of, risk factors for and outcomes of FOC.
Results
Fear of childbirth was experienced by 2.5% of nulliparous women and 4.5% of multiparous women. The strongest risk factors for FOC in nulliparous women were depression adjusted odds ratio (aOR), 6.35; 95% confidence interval (CI), 5.25–7.68, advanced maternal age (aOR, 3.78; 95% CI, 3.23–4.42) and high or unspecified socioeconomic status. In multiparous women, the strongest risk factors for FOC were depression (aOR, 5.47; 95% CI, 4.67–6.41), previous caesarean section (CS) (aOR, 3.02; 95% CI, 2.93–3.11) and high or unspecified socioeconomic status. Among both nulliparous and multiparous women, FOC was associated with higher rates of CS (3.3‐fold and 4.5‐fold higher, respectively) and a lower incidence of low birthweight (<2500 g), small for gestational age babies, preterm birth and low Apgar scores at 1 minute.
Conclusions
High and unspecified socioeconomic status, advanced maternal age and depression are predisposing factors for FOC regardless of parity. Among multiparous women, a previous CS increases vulnerability to FOC. FOC is associated with increased rates of CS, but does not adversely affect other pregnancy outcomes.
On the origin of a highly dispersed coherent radio burst Keane, E. F.; Stappers, B. W.; Kramer, M. ...
Monthly notices of the Royal Astronomical Society. Letters,
September 2012, 2012-09-01, 20120901, Letnik:
425, Številka:
1
Journal Article
Recenzirano
Odprti dostop
ABSTRACT
We discuss the possible source of a highly dispersed radio transient discovered in the Parkes Multibeam Pulsar Survey (PMPS). The pulse has a dispersion measure of 746 cm−3 pc, a peak flux ...density of 400 mJy for the observed pulse width of 7.8 ms and a flat spectrum across a 288‐MHz band centred on 1374 MHz. The flat spectrum suggests that the pulse did not originate from a pulsar, but is consistent with radio‐emitting magnetar spectra. The non‐detection of subsequent bursts constrains any possible pulsar period to ≳1 s, and the pulse energy distribution to being much flatter than typical giant pulse emitting pulsars. The burst is also consistent with the radio signal theorized from an annihilating mini black hole. Extrapolating the PMPS detection rate provides a limit of on the density of these objects. We investigate the consistency of these two scenarios, plus several other possible solutions, as potential explanations to the origin of the pulse, as well as for another transient with similar properties: the Lorimer burst.
After its formation, a young star spends some time traversing the molecular cloud complex in which it was born. It is therefore not unlikely that, well after the initial cloud collapse event which ...produced the star, it will encounter one or more low mass cloud fragments, which we call “cloudlets” to distinguish them from full-fledged molecular clouds. Some of this cloudlet material may accrete onto the star+disk system, while other material may fly by in a hyperbolic orbit. In contrast to the original cloud collapse event, this process will be a “cloudlet flyby” and/or “cloudlet capture” event: A Bondi–Hoyle–Lyttleton type accretion event, driven by the relative velocity between the star and the cloudlet. As we will show in this paper, if the cloudlet is small enough and has an impact parameter similar or less than GM*/v∞2 $GM_{*}/v^2_{\infty}$ GM*/v∞2 (with v∞ being the approach velocity), such a flyby and/or capture event would lead to arc-shaped or tail-shaped reflection nebulosity near the star. Those shapes of reflection nebulosity can be seen around several transitional disks and FU Orionis stars. Although the masses in the those arcs appears to be much less than the disk masses in these sources, we speculate that higher-mass cloudlet capture events may also happen occasionally. If so, they may lead to the tilting of the outer disk, because the newly infalling matter will have an angular momentum orientation entirely unrelated to that of the disk. This may be one possible explanation for the highly warped/tilted inner/outer disk geometries found in several transitional disks. We also speculate that such events, if massive enough, may lead to FU Orionis outbursts.
The rotation of more than 700 pulsars has been monitored using the 76-m Lovell Telescope at Jodrell Bank. Here we report on a new search for glitches in the observations, revealing 128 new glitches ...in the rotation of 63 pulsars. Combining these new data with those already published, we present a data base containing 315 glitches in 102 pulsars. The data base was used to study the glitch activity among the pulsar population, finding that it peaks for pulsars with a characteristic age τc∼ 10 kyr and decreases for longer values of τc, disappearing for objects with τc > 20 Myr. The glitch activity is also smaller in the very young pulsars (τc≲ 1 kyr). The cumulative effect of glitches, a collection of instantaneous spin-up events, acts to reduce the regular long-term spin-down rate
of the star. The percentage of
reversed by glitch activity was found to vary between 0.5 and 1.6 per cent for pulsars with spin-down rates
between 10−14 and 3.2 × 10−11 Hz s−1, decreasing to less than 0.01 per cent at both higher and lower spin-down rates. These ratios are interpreted in terms of the amount of superfluid involved in the generation of glitches. In this context, the activity of the youngest pulsar studied, the Crab pulsar, may be explained by quake-like activity within the crust. Pulsars with low spin-down rates seem to exhibit mostly small glitches, matching well the decrease of their crustal superfluid.
Through the analysis of glitch sizes, it was found that the particular glitching behaviour of PSR J0537−6910 and the Vela pulsar may be shared by most Vela-like pulsars. These objects present most of their glitches with characteristic frequency and frequency derivative jumps, occurring at regular intervals of time. Their behaviour is different from other glitching pulsars of similar characteristic age.
We provide an analysis of timing irregularities observed for 366 pulsars. Observations were obtained using the 76-m Lovell radio telescope at the Jodrell Bank Observatory over the past 36 years. ...These data sets have allowed us to carry out the first large-scale analysis of pulsar timing noise over time-scales of >10 yr, with multiple observing frequencies and for a large sample of pulsars. Our sample includes both normal and recycled pulsars. The timing residuals for the pulsars with the smallest characteristic ages are shown to be dominated by the recovery from glitch events, whereas the timing irregularities seen for older pulsars are quasi-periodic. We emphasize that previous models that explained timing residuals as a low-frequency noise process are not consistent with observation.
ABSTRACT
We revisit the merger rate for Galactic double neutron star (DNS) systems in light of recent observational insight into the longitudinal and latitudinal beam shape of the relativistic DNS ...PSR J1906 + 0746. Due to its young age and its relativistic orbit, the pulsar contributes significantly to the estimate of the joint Galactic merger rate. We follow previous analyses by modelling the underlying pulsar population of nine merging DNS systems and study the impact and resulting uncertainties when replacing simplifying assumptions made in the past with actual knowledge of the beam shape, its extent, and the viewing geometry. We find that the individual contribution of PSR J1906 + 0746 increases to $\mathcal {R} = 6^{+28}_{-5} \, \mathrm{Myr}^{-1}$ although the values are still consistent with previous estimates, given the uncertainties. We also compute contributions to the merger rates from the other DNS systems by applying a generic beam shape derived from that of PSR J1906 + 0746, evaluating the impact of previous assumptions. We derive a joint Galactic DNS merger rate of $\mathcal {R}^{\mathrm{gen}}_{\mathrm{MW}} = 32^{+19}_{-9}\, \mathrm{Myr}^{-1}$, leading to a LIGO detection rate of $\mathcal {R}^{\mathrm{gen}}_{\mathrm{LIGO}} = 3.5^{+2.1}_{-1.0}\, \mathrm{yr}^{-1}$ (90 per cent conf. limit), considering the upcoming O3 sensitivity of LIGO. As these values are in good agreement with previous estimates, we conclude that the method of estimating the DNS merger and LIGO detection rates via the study of the radio pulsar DNS population is less prone to systematic uncertainties than previously thought.
CXCL13 in Sjögrenˈs syndrome increases with disease progression in mice and is elevated in human sera and saliva; blockade of CXCL13 ameliorates disease in an SS murine model.
SS is an autoimmune ...disease. pSS affects exocrine glands predominantly, whereas sSS occurs with other autoimmune connective tissue disorders. Currently, care for patients with SS is palliative, as no established therapeutics target the disease directly, and its pathogenetic mechanisms remain uncertain. B‐cell abnormalities have been identified in SS. CXCL13 directs B‐cell chemotaxis and is elevated in several autoimmune diseases. In this study, we tested the hypothesis that CXCL13 is elevated in SS in mice and humans and that neutralization of the chemokine ameliorates disease in a murine model. We assayed CXCL13 in mouse models and human subjects with SS to determine whether CXCL13 is elevated both locally and systemically during SS progression and whether CXCL13 may play a role in and be a biomarker for the disease. Cxcl13 expression in salivary tissue increases with disease progression, and its blockade resulted in a modest reduction in glandular inflammation in an SS model. We demonstrate that in humans CXCL13 is elevated in serum and saliva, and an elevated salivary CXCL13 level distinguishes patients with xerostomia. These data suggest a role for CXCL13 as a valuable biomarker in SS, as 74% of patients with SS displayed elevated CXCL13 in sera, saliva, or both. Thus, CXCL13 may be pathogenically involved in SS and may serve as a new marker and a potential therapeutic target.
PDF
