This paper presents the results of an analysis of observations of the Crab Nebula gamma-ray source with the first two atmospheric Cherenkov telescopes of the TAIGA (Tunka Advanced Instrument for ...cosmic ray physics and Gamma Astronomy) astrophysical complex in the stereo mode of observations. The article analyzed observational data from 2020 to 2021. Over 36 hours of observations, a signal was obtained at a statistical significance level of 5
and a spectrum of gamma rays was plotted in the energy range from 2 to 70 TeV. The paper describes a technique for gamma–hadron separation and reconstruction of detected gamma-rays energy.
We studied changes in the bone tissue in patients with diffuse large B-cell lymphoma at the onset of the disease (
N
=41; before chemotherapy) and 5-16 years after the end of treatment (
N
=47). ...Osteodensitometry, biochemical markers of osteoporosis in the blood and urine, and gene expression in multipotent mesenchymal stromal cells were analyzed. In multipotent mesenchymal stromal cells of all patients, the expression of genes associated with bone and cartilage differentiation (
FGF2
,
FGFR1
,
FGFR2
,
BGLAP
,
SPP1
,
TGFB1
, and
SOX9
) was changed. In primary patients, the ratio of deoxypyridinoline/creatinine in the urine and blood level of β-cross-laps were increased, while plasma concentration of vitamin D was reduced, which indicates activation of bone resorption. No differences between the groups were revealed by osteodensitometry. No direct relationship between changes in gene expression in multipotent mesenchymal stromal cells and osteoporosis markers was found. The presence of a tumor in the body affects the bone marrow stroma, but achievement of remission and compensatory mechanisms provide age-appropriate condition of the bone tissue.
The article surveys the first
35
Cl NQR results on detecting and characterizing noncovalent interactions in systems assembling B
10
Cl
10
2−
clusters via halogen atoms. A number of compounds of ...decachloro-
closo
-decaborates with alkali metal or organic cations as well as with silver(I), copper(II) and iron(II) complexes were studied using
35
Cl NQR and X-ray diffraction. The main interest of this survey is a capability of chlorine atoms to participate in noncovalent interactions with organic cations, ligand and solvent molecules without touching upon issues of synthesis. Whereas X-ray diffraction establishes the noncovalent interactions relying on the sum of vdW radii which serves as the basic and sometimes the only experimental criterion for identifying such interactions, the
35
Cl NQR technique registers subtle perturbations in electron density distribution on the chlorine site caused by secondary interactions Cl···X. They adequately split the
35
Cl NQR spectra thus selecting from the entire set of interatomic contacts those actually induced by noncovalent interactions.
Cancer stem cells (CSCs) are the most malignant subpopulation of tumor cells that possess a tumorigenic potential and resistantance to chemotherapy. These properties make CSCs a promising target for ...the development of targeted antitumor therapy which is especially in demand in highly aggressive cancers. However, the correct identification of cancer cells with stem properties remains a challenge. A newly developed lentivirus-based reporter SORE6 allows to directly identify CSCs by measuring gene expression of the embryonic stem cell factors SOX2 and OCT4. In the current study the reporter was modified to enable isolation of SOX2
+
/OCT4
+
cells by immunomagnetic separation and then was used to transduce HCC1806 and MDA-MB-453 triple-negative breast cancer (TNBC) cell lines. To validate the modified reporter, SOX2
+
/OCT4
+
populations were isolated and analyzed for the content of NANOG, a key transcription factor of pluropotency which expression is regulated by SOX2/OCT4. The percentage of SOX2
+
/OCT4
+
cells was assessed for each cell line. An increased content of NANOG protein was found in isolated SOX2
+
/OCT4
+
cell fractions indicating that the modified reporter is suitable for further studying the CSC subset.
Translation initiation factors 2 from eukaryotes (eIF2) and archaea (аIF2) mediate the delivery of charged initiator tRNA (Met-tRNAi
Met
) to the small ribosomal subunit. The factor e/аIF2 is ...composed of three subunits (α, β, γ) and functions as a heterotrimeric complex. Previously, it was shown that the homozygous missense mutation Ile222Thr in the γ subunit of human IF2, which impairs the interaction between the β and γ subunits, causes intellectual disability and microcephaly. The present study demonstrates that the corresponding mutation in the γ subunit of archaeal translation initiation factor 2, which is homologous to the eukaryotic protein, changes neither the conformation of this protein nor its affinity for aIF2β.
—The results of studying the technology of layer-by-layer deposition of products made of ABS and PLA plastics are presented. The influence of various technological parameters (type of application of ...layers, direction of laying and thickness of threads, printing speed) on the mechanical characteristics of products (strength, plasticity, anisotropy of properties) and the material (specimen) density is studied. Recommendations on the development of this process are given.
Pottery of Uch-Bash settlement (the end of the 12th — beginning of the 7th century BC) has a variety of decors. Ornamentation on ceramics is represented by different methods of decoration — ...channeled, cut or pressedlines, stripes formed by various shaped stamps, as well as a variety of appliques. Most of the «negatives» and «positives» are part of the compositions that form the motif of the ornament.
But there are a number of images that do not fit into these compositions existing separately even on ornamented vessels.
There are traditional solar symbols — crosses, swastikas, anthropomorphous, as well as several images in the form of an inverted crescent moon with a shoot in the middle or a bird’s paw.
The paper deals with one of the signs on a ceramic ware found on the fortified settlement of Uch-Bash in South-West Crimea. This is the image of inverted crescent moon or a three-edged symbol generally referring to anthropomorphic images.
Chronologically the artefacts are divided into two groups: the early (Ithaca, Troy) and the late (Sborianovo, Sergen-Yurt, Uch-Bash, Kyzyl-Koba, Bulakhivka, Bystrica). The early group generally dates to the final of the Late Helladic period, the later one dates since the 10th till the 8th century BC. Cumulatively the early artefacts in their region (Mediterranean basin) as the late ones in their (the Black Sea basin) coincide with the change of epochs — transition to the iron production and use. The presence of pottery with a three-edged symbol in the necropolises with innovations in custom such as in Sborianovo and Ferigele (Bystrica) testifies to certain changes in the ideology of the population linked with these sites. According to the researchers numerous finds of items with anthropomorphic features are found on the sites where pottery with the three-edged symbol have been found and the three-edged symbol itself is an anthropomorph. Given the fact that such sign on artefacts is not combined with solar symbols, and in the structure of ornamentation the oddness (unlike the parity in the previous horizons) prevails, we can assume that the process of disseminating knowledge and skills in the manufacture of iron and use of iron objects was underway with certain innovations in ideology. However, the fact of such ideological transformations cannot be overlooked because just the Iron Age was the time which eventually formed the main monotheistic concepts and world religions. Absolutely spontaneously this conclusion coincided with the concept of «Axial Age» (Gem. — Achsenzeit) by the German existentialist philosopher K. Jaspers. He defined the beginning of the Iron Age (as a historical era) as the so-called axial time which was marked by the change of outlook that led to the formation of a new ideology of the modern world. In general, the conceptualisation of existential searches is directed at the humanitarian, anthropocentric definition of social order, so, the object and subject of these searches is a human. Considering the absolute difference between the methods and sources used by archaeologists and philosophers we anyway note the quite not coincidental coincidence of the philosophical concept and the conclusion made on the basis of the analysis of the sign system — the most abstract source that has come to us since that time.
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