The Electron-Ion Collider (EIC), planned for construction at Brookhaven National Laboratory, will consist of two intersecting beams of intense electrons and high-energy protons or heavier atomic ...nuclei. The collider will need many demanding components, including high field superconducting magnets for the Interaction Region (IR). It has been decided that a prototype of one such magnet, the B1pF dipole, shall be built, to validate design choices common to all Rutherford cable dipole and quadrupole IR magnets. B1pF is one of several high field magnets in the interaction region whose design is based on the 15.1 mm wide NbTi cable, a cable like the one used in the main dipole coil of the Large Hadron Collider (LHC) at CERN. The current design is based on a single layer coil with an inner diameter of 300 mm and magnetic length of ∼3 m which generates a magnetic field at the center of the magnet of about 3.7 T at a current of ∼11 kA at design. This paper presents the mechanical design of the B1pF dipole magnet, and the R&D effort associated with the development of the prototype, including tests for successfully winding and curing coils of the needed configuration into proper structural and magnetic elements, and including a multilayer magnetic return yoke which meets field requirements while providing an initial reduced structure suitable for operational testing in an existing test facility.
Hybrid magnets are currently under consideration as an economically viable option towards 20 T dipole magnets for next generation of particle accelerators. In these magnets, High Temperature ...Superconducting (HTS) materials are used in the high field part of the coil with so-called "insert coils", and Low Temperature Superconductors (LTS) like Nb 3 Sn and Nb-Ti superconductors are used in the lower field region with so-called "outsert coils". The attractiveness of the hybrid option lays on the fact that, on the one hand, the 20 T field level is beyond the Nb 3 Sn practical limits of 15-16 T for accelerator magnets and can be achieved only via HTS materials; on the other hand, the high cost of HTS superconductors compared to LTS superconductors makes it advantageous exploring a hybrid approach, where the HTS portion of the coil is minimized. We present in this paper an overview of different design options aimed at generating 20 T field in a 50 mm clear aperture. The coil layouts investigated include the Cos-theta design (CT), with its variations to reduce the conductor peak stress, namely the Canted Cos-theta design (CCT) and the Stress Management Cos-theta design (SMCT), and, in addition, the Block-type design (BL) including a form of stress management and the Common-Coil design (CC). Results from a magnetic and mechanical analysis are discussed, with particular focus on the comparison between the different options regarding quantity of superconducting material, field quality, conductor peak stress, and quench protection.
The ferrite core and measuring coil of a cryogenic current comparator have to be shielded against external magnetic fields by a compact, efficient meander structure made of superconducting niobium. A ...design with minimized material and production costs is only feasible when a highly accurate magnetic field simulator is available. 3D field models become prohibitively large. The cylindrical symmetry of the devices motivates to develop a quasi-3D field solver, exploiting the symmetry while still capable of representing 3D field distributions.
Hybrid magnets are currently under consideration as an economically viable option towards 20 T dipole magnets for next generation of particle accelerators. In these magnets, High Temperature ...Superconducting (HTS) materials are used in the high field part of the coil with so-called insert coils, and Low Temperature Superconductors (LTS) like Nb3Sn and Nb-Ti superconductors are used in the lower field region with so-called outsert coils. The attractiveness of the hybrid option lays on the fact that, on the one hand, the 20 T field level is beyond the Nb3Sn practical limits of 15-16 T for accelerator magnets and can be achieved only via HTS materials; on the other hand, the high cost of HTS superconductors compared to LTS superconductors makes it advantageous exploring a hybrid approach, where the HTS portion of the coil is minimized. We present in this paper an overview of different design options aimed at generating 20 T field in a 50 mm clear aperture. The coil layouts investigated include the Cos-theta design (CT), with its variations to reduce the conductor peak stress, namely the Canted Cos-theta design (CCT) and the Stress Management Cos-theta design (SMCT), and, in addition, the Block-type design (BL) including a form of stress management and the Common-Coil design (CC). Results from a magnetic and mechanical analysis are discussed, with particular focus on the comparison between the different options regarding quantity of superconducting material, field quality, conductor peak stress, and quench protection.
Colliders are built on a foundation of superconducting magnet technology that provides strong dipole magnets to maintain the beam orbit and strong focusing magnets to enable the extraordinary ...luminosity required to probe physics at the energy frontier. The dipole magnet strength plays a critical role in dictating the energy reach of a collider, and the superconducting magnets are arguably the dominant cost driver for future collider facilities. As the community considers opportunities to explore new energy frontiers, the importance of advanced magnet technology - both in terms of magnet performance and in the magnet technology's potential for cost reduction - is evident, as the technology status is essential for informed decisions on targets for physics reach and facility feasibility.
The primary aim of this study was to compare the impact of NAVIGATE, a comprehensive, multidisciplinary, team-based treatment approach for first-episode psychosis designed for implementation in the ...U.S. health care system, with community care on quality of life.
Thirty-four clinics in 21 states were randomly assigned to NAVIGATE or community care. Diagnosis, duration of untreated psychosis, and clinical outcomes were assessed via live, two-way video by remote, centralized raters masked to study design and treatment. Participants (mean age, 23) with schizophrenia and related disorders and ≤6 months of antipsychotic treatment (N=404) were enrolled and followed for ≥2 years. The primary outcome was the total score of the Heinrichs-Carpenter Quality of Life Scale, a measure that includes sense of purpose, motivation, emotional and social interactions, role functioning, and engagement in regular activities.
The 223 recipients of NAVIGATE remained in treatment longer, experienced greater improvement in quality of life and psychopathology, and experienced greater involvement in work and school compared with 181 participants in community care. The median duration of untreated psychosis was 74 weeks. NAVIGATE participants with duration of untreated psychosis of <74 weeks had greater improvement in quality of life and psychopathology compared with those with longer duration of untreated psychosis and those in community care. Rates of hospitalization were relatively low compared with other first-episode psychosis clinical trials and did not differ between groups.
Comprehensive care for first-episode psychosis can be implemented in U.S. community clinics and improves functional and clinical outcomes. Effects are more pronounced for those with shorter duration of untreated psychosis.
Sodium-glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight ...without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.
Most pre-clinical studies in cardiac ischemia-reperfusion injury (I/R) are carried out in young or old animals, which does not cater to the adult age in humans who encounter I/R. Not many studies in ...the literature are available that emphasize the sensitivity of the adult heart to injury from the young heart, where there exist distinct alterations in DNA methylation and mitochondrial function that contribute to injury. In the present study, we utilized young (8 weeks old) and adult (24 weeks old) rat hearts to evaluate distinct DNA methylation alterations that contribute to I/R injury. The cardiac basal physiological activities in young and adult rat hearts were insignificantly changed from normal. But the DNA hypermethylation and expression level of mitochondrial genes were slightly higher in adult rat hearts. The consequential effect of these changes was measured in the I/R heart to understand its response to additional stress. Accordingly, we noted an increase in global DNA hypermethylation levels by 40% and 62% in young and adult I/R hearts, respectively, from their respective control. Subsequently, a decline in mitochondrial genes (ND1, ND4L, ND6, Cyt B, COX1, COX2, and ATP8) that regulate cardiac contractility was observed in adult I/R hearts. These changes, in turn, reduced hemodynamics (Rate pressure product) by 51% and 32% in adult and young I/R hearts, respectively, from their controls. Besides, the I/R-linked infarct size was higher in adult hearts (58%) than in young hearts (37%). Correlation analysis showed a significant negative correlation of global DNA methylation with the MT-ND1 expression (r = −0.7591), MFN2 expression (r = −0.8561) and cardiac RPP (r = −0.8015) in adult I/R hearts. Based on the above observations, we concluded that age promoted DNA methylation and deteriorated cardiac responsive ability to resist I/R injury.
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