Landscape approaches attempt to achieve balance amongst multiple goals over long time periods and to adapt to changing conditions. We review project reports and the literature on integrated landscape ...approaches, and found a lack of documented studies of their long-term effectiveness. The combination of multiple and potentially changing goals presents problems for the conventional measures of impact. We propose more critical use of theories of change and measures of process and progress to complement the conventional impact assessments. Theories of change make the links between project deliverables, outputs, outcomes, and impacts explicit, and allow a full exploration of the landscape context. Landscape approaches are long-term engagements, but short-term process metrics are needed to confirm that progress is being made in negotiation of goals, meaningful stakeholder engagement, existence of connections to policy processes, and effectiveness of governance. Long-term impact metrics are needed to assess progress on achieving landscapes that deliver multiple societal benefits, including conservation, production, and livelihood benefits. Generic criteria for process are proposed, but impact metrics will be highly situation specific and must be derived from an effective process and a credible theory of change.
Interpreting discourses among implementers of what is termed a "landscape approach" enables us to learn from their experience to improve conservation and development outcomes. We use Q-methodology to ...explore the perspectives of a group of experts in the landscape approach, both from academic and implementation fields, on what hinderances are in place to the realisation of achieving sustainable landscape management in Indonesia. The results show that, at a generic level, "corruption" and "lack of transparency and accountability" rank as the greatest constraints on landscape functionality. Biophysical factors, such as topography and climate change, rank as the least constraining factors. When participants considered a landscape with which they were most familiar, the results changed: the rapid change of regulations, limited local human capacity and inaccessible data on economic risks increased, while the inadequacy of democratic institutions, "overlapping laws" and "corruption" decreased. The difference indicates some fine-tuning of generic perceptions to the local context and may also reflect different views on what is achievable for landscape approach practitioners. Overall, approximately 55% of variance is accounted for by five discourse factors for each trial. Four overlapped and two discourses were discrete enough to merit different discourse labels. We labelled the discourses (1) social exclusionists, (2) state view, (3) community view, (4) integrationists, (5) democrats, and (6) neoliberals. Each discourse contains elements actionable at the landscape scale, as well as exogenous issues that originate at national and global scales. Actionable elements that could contribute to improving governance included trust building, clarified resource rights and responsibilities, and inclusive representation in management. The landscape sustainability discourses studied here suggests that landscape approach "learners" must focus on ways to remedy poor governance if they are to achieve sustainability and multi-functionality.
Network analysis has emerged as a useful practice for characterizing governance relationships and providing insights to the power relations that affect landscapes. We applied actor network analysis ...in two rural Cambodian landscapes to examine decision-making structures that affect conservation and development systems. Using questionnaire data, we analyze structural features of networks of cooperation and exchange to identify patterns of action and processes of change. We supplement our analysis with qualitative information gathered on power and social–ecological components of landscapes to enrich our understanding of natural resource systems. We find that power in Cambodia is concentrated in a central hierarchy, and external actors aiming to influence decision making would benefit from operating at multiple scales; there is no single leverage point for interventions. Cooperation between conservation and development actors is lacking; we observe that actors tend to cluster within similar groups. Cross-sectoral collaboration may be enhanced by knowledge brokers, but current actors lack resources to fulfil this role and require external support. Our study highlights the importance of nongovernment actors as conveners and facilitators to shape natural resource governance in the context of weak institutions. We advocate more institutionalized use of diagnostics, such as actor network analysis, for enhanced natural resource governance.
Integrated approaches to natural resource management are often undermined by fundamental governance weaknesses. We studied governance of a forest landscape in East Lombok, Indonesia. Forest ...Management Units (Kesatuan Pengelolaan Hutan or KPH) are an institutional mechanism used in Indonesia for coordinating the management of competing sectors in forest landscapes, balancing the interests of government, business, and civil society. Previous reviews of KPHs indicate they are not delivering their potential benefits due to an uncertain legal mandate and inadequate resources. We utilized participatory methods with a broad range of stakeholders in East Lombok to examine how KPHs might improve institutional arrangements to better meet forest landscape goals. We find that KPHs are primarily limited by insufficient integration with other actors in the landscape. Thus, strengthened engagement with other institutions, as well as civil society, is required. Although new governance arrangements that allow for institutional collaboration and community engagement are needed in the long term, there are steps that the East Lombok KPH can take now. Coordinating institutional commitments and engaging civil society to reconcile power asymmetries and build consensus can help promote sustainable outcomes. Our study concludes that improved multi-level, polycentric governance arrangements between government, NGOs, the private sector, and civil society are required to achieve sustainable landscapes in Lombok. The lessons from Lombok can inform forest landscape governance improvements throughout Indonesia and the tropics.
To determine the event-free survival (EFS) and overall survival of children with average-risk medulloblastoma and treated with reduced-dose craniospinal radiotherapy (CSRT) and one of two ...postradiotherapy chemotherapies.
Four hundred twenty-one patients between 3 years and 21 years of age with nondisseminated medulloblastoma (MB) were prospectively randomly assigned to treatment with 23.4 Gy of CSRT, 55.8 Gy of posterior fossa RT, plus one of two adjuvant chemotherapy regimens: lomustine (CCNU), cisplatin, and vincristine; or cyclophosphamide, cisplatin, and vincristine. Results Forty-two of 421 patients enrolled were excluded from analysis. Sixty-six of the remaining 379 patients had incompletely assessable postoperative studies. Five-year EFS and survival for the cohort of 379 patients was 81% +/- 2.1% and 86% +/- 9%, respectively (median follow-up over 5 years). EFS was unaffected by sex, race, age, treatment regimen, brainstem involvement, or excessive anaplasia. EFS was detrimentally affected by neuroradiographic unassessability. Patients with areas of frank dissemination had a 5-year EFS of 36% +/- 15%. Sixty-seven percent of progressions had some component of dissemination. There were seven second malignancies. Infections occurred more frequently on the cyclophosphamide arm and electrolyte abnormalities were more common on the CCNU regimen.
This study discloses an encouraging EFS rate for children with nondisseminated MB treated with reduced-dose craniospinal radiation and chemotherapy. Additional, careful, step-wise reductions in CSRT in adequately staged patients may be possible.
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson’s disease (PD). Whether the nerve fibers of the cardiac ...conduction system or the atrial walls are equally affected in this disease process has not yet been well documented. Therefore, the aim of this study was to investigate sympathetic nerves in the cardiac conduction system as well as in the walls of all four heart chambers in patients with PD, in incidental Lewy body disease (iLBD), and in controls. Heart tissue from five PD patients, two iLBD cases, and seven controls were investigated immunohistochemically using antibodies directed against tyrosine hydroxylase (TH) and α-synuclein (syn-1). A marked diminution of TH immunoreactivity (IR) within nerve fibers was observed in four PD patients and in both individuals with iLBD. In contrast, all control subjects displayed dense TH-IR nerve structures. The depletion in TH-IR involved not only the ventricles, but also the conduction system and the atrium showing a global change within cardiac TH-IR nerve fibers in the course of PD. In conclusion, the alterations in cardiac sympathetic nerves of patients with PD or in individuals with iLBD are homogeneous and global within the heart. The clinical implications related to this complete cardiac sympathetic dysfunction, including clinical correlates, diagnostic implications, and treatment, however, remain to be determined in a larger autopsy-controlled cohort of prospectively followed individuals.
Industrial processes to produce ethanol from lignocellulosic materials are available, but improved efficiency is necessary to make them economically viable. One of the limitations for lignocellulosic ...conversion to ethanol is the inaccessibility of the cellulose and hemicelluloses within the tight cell wall matrix. Ferulates (FA) can cross-link different arabinoxylan molecules in the cell wall of grasses via diferulate and oligoferulate bridges. This complex cross-linking is thought to be a key factor in limiting the biodegradability of grass cell walls and, therefore, the reduction in FA is an attractive target to improve enzyme accessibility to cellulose and hemicelluloses. Unfortunately, our knowledge of the genes responsible for the incorporation of FA to the cell wall is limited. A bioinformatics prediction based on the gene similarities and higher transcript abundance in grasses relative to dicot species suggested that genes from the pfam family PF02458 may act as arabinoxylan feruloyl transferases. We show here that the FA content in the cell walls and the transcript levels of rice genes Os05g08640, Os06g39470, Os01g09010 and Os06g39390, are both higher in the stems than in the leaves. In addition, an RNA interference (RNAi) construct that simultaneously down-regulates transcript levels of these four genes is associated with a significant reduction in FA of the cell walls from the leaves of the transgenic plants relative to the control (19% reduction, P < 0.0001). Therefore, our experimental results in rice support the bioinformatics prediction that members of family PF02458 are involved in the incorporation of FA into the cell wall in grasses.
Smallholder farmers and indigenous communities must cope with the opportunities and threats presented by rapidly spreading estate crops in the frontier of the agricultural market economy. Smallholder ...communities are subject to considerable speculation by outsiders, yet large-scale agriculture presents tradeoffs that they must navigate. We initiated a study in Sintang, West Kalimantan in 2012 and have returned annually for the last four years, building the baselines for a longer-term landscape approach to reconciling conservation and development tradeoffs in situ. Here, the stakeholders are heterogeneous, yet the land cover of the landscape is on a trajectory towards homogenous mono-cropping systems, primarily either palm oil or rubber. In one village on the frontier of the agricultural market economy, natural forests remain managed by the indigenous and local community but economics further intrude on forest use decisions. Conservation values are declining and the future of the forest is uncertain. As such, the community is ultimately attracted to more economically attractive uses of the land for local development oil palm or rubber mono-crop farms. We identify poverty as a threat to community-managed conservation success in the face of economic pressures to convert forest to intensive agriculture. We provide evidence that lucrative alternatives will challenge community-managed forests when prosperity seems achievable. To alleviate this trend, we identify formalized traditional management and landscape governance solutions to nurture a more sustainable landscape transition.
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