Create and deploy production-quality microservices-based applications — New edition updated for the smooth running of Spring, Java, Kubernetes, and Istio, with an introduction to Helm 3 and support ...for Mac and Windows with WSL2Key FeaturesBuild cloud-native production-ready microservices with this comprehensively updated guideUnderstand the challenges of building large-scale microservice architecturesLearn how to get the best out of Spring Cloud, Kubernetes, and Istio in combinationBook DescriptionWant to build and deploy microservices, but don't know where to start? Welcome to Microservices with Spring Boot and Spring Cloud.This edition features the most recent versions of Spring, Java, Kubernetes, and Istio, demonstrating faster and simpler handling of Spring Boot, local Kubernetes clusters, and Istio installation. The expanded scope includes native compilation of Spring-based microservices, support for Mac and Windows with WSL2, and an introduction to Helm 3 for packaging and deployment. A revamped security chapter now follows the OAuth 2.1 specification and makes use of the newly launched Spring Authorization Server from the Spring team.You'll start with a set of simple cooperating microservices, then add persistence and resilience, make your microservices reactive, and document their APIs using OpenAPI.Next, you'll learn how fundamental design patterns are applied to add important functionality, such as service discovery with Netflix Eureka and edge servers with Spring Cloud Gateway. You'll deploy your microservices using Kubernetes and adopt Istio, then explore centralized log management using the Elasticsearch, Fluentd, and Kibana (EFK) stack, and then monitor microservices using Prometheus and Grafana.By the end of this book, you'll be building scalable and robust microservices using Spring Boot and Spring Cloud.What you will learnBuild reactive microservices using Spring BootDevelop resilient and scalable microservices using Spring CloudUse OAuth 2.1/OIDC and Spring Security to protect public APIsImplement Docker to bridge the gap between development, testing, and productionDeploy and manage microservices with KubernetesApply Istio for improved security, observability, and traffic managementWrite and run automated microservice tests with JUnit, testcontainers, Gradle, and bashWho this book is forIf you're a Java or Spring Boot developer learning how to build microservice landscapes from scratch, then this book is for you. You don't need any prior knowledge about microservices architecture to get started, but a solid grasp and enough experience in Java and Spring Boot to build apps autonomously is a must.
This book takes you through tried and tested approaches to building distributed systems and implementing microservices architecture. It follows a single real-world project from start to finish, using ...Spring Boot, Spring Cloud, and a full suite of related tools and frameworks for development, security, testing, and deployment.
Apply microservices patterns to build resilient and scalable distributed systemsKey FeaturesUnderstand the challenges of building large-scale microservice landscapesBuild cloud-native ...production-ready microservices with this comprehensive guideDiscover how to get the best out of Spring Cloud, Kubernetes, and Istio when used togetherBook DescriptionMicroservices architecture allows developers to build and maintain applications with ease, and enterprises are rapidly adopting it to build software using Spring Boot as their default framework. With this book, you’ll learn how to efficiently build and deploy microservices using Spring Boot.
This microservices book will take you through tried and tested approaches to building distributed systems and implementing microservices architecture in your organization. Starting with a set of simple cooperating microservices developed using Spring Boot, you’ll learn how you can add functionalities such as persistence, make your microservices reactive, and describe their APIs using Swagger/OpenAPI. As you advance, you’ll understand how to add different services from Spring Cloud to your microservice system. The book also demonstrates how to deploy your microservices using Kubernetes and manage them with Istio for improved security and traffic management. Finally, you’ll explore centralized log management using the EFK stack and monitor microservices using Prometheus and Grafana.
By the end of this book, you’ll be able to build microservices that are scalable and robust using Spring Boot and Spring Cloud.What you will learnBuild reactive microservices using Spring BootDevelop resilient and scalable microservices using Spring CloudUse OAuth 2.0/OIDC and Spring Security to protect public APIsImplement Docker to bridge the gap between development, testing, and productionDeploy and manage microservices using KubernetesApply Istio for improved security, observability, and traffic managementWho this book is forThis book is for Java and Spring developers and architects who want to learn how to break up their existing monoliths into microservices and deploy them either on-premises or in the cloud using Kubernetes as a container orchestrator and Istio as a service Mesh. No familiarity with microservices architecture is required to get started with this book.
A critical issue in pollination ecology is the evolution of generalist pollination systems, and under which conditions floral specializations evolve from these. The gynodioecious herb Knautia ...arvensis (Dipsacaceae) exhibits a generalized pollination system, but is visited by both generalist and specialist flower-visitors. The present study tested pollinator effectiveness and pollinator importance of the pollen specialist solitary bee Andrena hattorfiana (Andrenidae) vs. the generalist flower-visitors to K. arvensis on the island of Öland, SE Sweden. Females of the specialist bee removed more pollen per inflorescence-visit than the major groups of generalist visitors such as bumblebees and flies. They also deposited more pollen per inflorescence-visit than any of the generalist visitor groups. The females have a preference for pollen-presenting vs. stigma-presenting inflorescences, a pattern shared with most of the generalist flower-visitors. Females of the specialist exert such a strong preference that they, despite their great pollinator effectiveness, make modest contribution to pollen transfer in K. arvensis. The females of A. hattorfiana accounted for 14.2% of the overall visits and 5.8% of the total pollination, the rest being performed by generalist visitors and males of A. hattorfiana. This study shows that pollinator effectiveness of a specialist can be superior while generalist flower-visitors select floral characters towards generalization through their greater contribution to overall pollen flow.
Controllable production of nanometre-sized structures is an important field of research, and synthesis of one-dimensional objects, such as nanowires, is a rapidly expanding area with numerous ...applications, for example, in electronics, photonics, biology and medicine. Nanoscale electronic devices created inside nanowires, such as p-n junctions, were reported ten years ago. More recently, hetero-structure devices with clear quantum-mechanical behaviour have been reported, for example the double-barrier resonant tunnelling diode and the single-electron transistor. The generally accepted theory of semiconductor nanowire growth is the vapour-liquid-solid (VLS) growth mechanism, based on growth from a liquid metal seed particle. In this letter we suggest the existence of a growth regime quite different from VLS. We show that this new growth regime is based on a solid-phase diffusion mechanism of a single component through a gold seed particle, as shown by in situ heating experiments of GaAs nanowires in a transmission electron microscope, and supported by highly resolved chemical analysis and finite element calculations of the mass transport and composition profiles.
Apply microservices patterns to build resilient and scalable distributed systems Key Features * Understand the challenges of building large-scale microservice landscapes * Build cloud-native ...production-ready microservices with this comprehensive guide * Discover how to get the best out of Spring Cloud, Kubernetes, and Istio when used together Book Description Microservices architecture allows developers to build and maintain applications with ease, and enterprises are rapidly adopting it to build software using Spring Boot as their default framework. With this book, you'll learn how to efficiently build and deploy microservices using Spring Boot. This microservices book will take you through tried and tested approaches to building distributed systems and implementing microservices architecture in your organization. Starting with a set of simple cooperating microservices developed using Spring Boot, you'll learn how you can add functionalities such as persistence, make your microservices reactive, and describe their APIs using Swagger/OpenAPI. As you advance, you'll understand how to add different services from Spring Cloud to your microservice system. The book also demonstrates how to deploy your microservices using Kubernetes and manage them with Istio for improved security and traffic management. Finally, you'll explore centralized log management using the EFK stack and monitor microservices using Prometheus and Grafana. By the end of this book, you'll be able to build microservices that are scalable and robust using Spring Boot and Spring Cloud. What you will learn * Build reactive microservices using Spring Boot * Develop resilient and scalable microservices using Spring Cloud * Use OAuth 2.0/OIDC and Spring Security to protect public APIs * Implement Docker to bridge the gap between development, testing, and production * Deploy and manage microservices using Kubernetes * Apply Istio for improved security, observability, and traffic management Who this book is for This book is for Java and Spring developers and architects who want to learn how to break up their existing monoliths into microservices and deploy them either on-premises or in the cloud using Kubernetes as a container orchestrator and Istio as a service Mesh. No familiarity with microservices architecture is required to get started with this book.
Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward ...impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression.
Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T magnetic resonance imaging within 1 week before and after the ECT series. Each hippocampus was manually outlined on coronal slices, and the volume was calculated.
The left as well as the right hippocampal volume increased significantly after ECT.
The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression.
Epitaxial III−V Nanowires on Silicon Mårtensson, Thomas; Svensson, C. Patrik T; Wacaser, Brent A ...
Nano letters,
10/2004, Letnik:
4, Številka:
10
Journal Article
Recenzirano
We present results of ideal epitaxial nucleation and growth of III−V semiconductor nanowires on silicon substrates. This addresses the long-time challenge of integrating high performance III−V ...semiconductors with mainstream Si technology. Efficient room-temperature generation of light on silicon is demonstrated by the incorporation of double heterostructure segments in such nanowires. We expect that advanced heterostructure devices, such as resonant tunneling diodes, superlattice device structures, and heterostructure photonic devices for on-chip communication, could now become available as complementary device technologies for integration with silicon.
Currently used anticoagulants prevent thrombosis but increase bleeding. We show an anticoagulation therapy without bleeding risk based on a plasma protease factor XII function-neutralizing antibody. ...We screened for antibodies against activated factor XII (FXIIa) using phage display and demonstrated that recombinant fully human antibody 3F7 binds into the FXIIa enzymatic pocket. 3F7 interfered with FXIIa-mediated coagulation, abolished thrombus formation under flow, and blocked experimental thrombosis in mice and rabbits. We adapted an extracorporeal membrane oxygenation (ECMO) cardiopulmonary bypass system used for infant therapy to analyze clinical applicability of 3F7 in rabbits. 3F7 provided thromboprotection as efficiently as heparin, and both drugs prevented fibrin deposition and thrombosis within the extracorporeal circuit. Unlike heparin, 3F7 treatment did not impair the hemostatic capacity and did not increase bleeding from wounds. These data establish that targeting of FXIIa is a safe mode of thromboprotection in bypass systems, and provide a clinically relevant anticoagulation strategy that is not complicated by excess bleeding.
