ABSTRACT
We present rotation period measurements for 107 M dwarfs in the mass range $0.15\!-\!0.70 \, \mathrm{M}_\odot$ observed within the context of the APACHE photometric survey. We measure ...rotation periods in the range 0.5–190 d, with the distribution peaking at ∼30 d. We revise the stellar masses and radii for our sample of rotators by exploiting the Gaia DR2 data. For ${\sim}20{{\ \rm per\ cent}}$ of the sample, we compare the photometric rotation periods with those derived from different spectroscopic indicators, finding good correspondence in most cases. We compare our rotation periods distribution to the one obtained by the Kepler survey in the same mass range, and to that derived by the MEarth survey for stars in the mass range $0.07\!-\!0.25 \, \mathrm{M}_\odot$. The APACHE and Kepler periods distributions are in good agreement, confirming the reliability of our results, while the APACHE distribution is consistent with the MEarth result only for the older/slow rotators, and in the overlapping mass range of the two surveys. Combining the APACHE/Kepler distribution with the MEarth distribution, we highlight that the rotation period increases with decreasing stellar mass, in agreement with previous work. Our findings also suggest that the spin-down time scale, from fast to slow rotators, changes crossing the fully convective limit at ${\approx}0.3 \, \mathrm{M}_\odot$ for M dwarfs. The catalogue of 107 rotating M dwarfs presented here is particularly timely, as the stars are prime targets for the potential identification of transiting small planets with TESS and amenable to high-precision mass determination and further atmospheric characterization measurements.
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs ...cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomeric antisense oligonucleotides (tASOs) prevents full DDR activation and premature cellular senescence in various HGPS cell systems, including HGPS patient fibroblasts. We also show in vivo that tASO treatment significantly enhances skin homeostasis and lifespan in a transgenic HGPS mouse model. In summary, our results demonstrate an important role for telomeric DDR activation in HGPS progeroid detrimental phenotypes in vitro and in vivo.
We present the results of a site characterization study carried out at the Astronomical Observatory of the Autonomous Region of the Aosta Valley (OAVdA), in the western Italian Alps, aimed at ...establishing its potential to host a photometric transit search for small-size planets around a statistically significant sample of nearby cool M dwarfs. For the purpose of the site testing campaign, we gathered photometric and seeing measurements utilizing different instruments available at the site. As in any search for new locations for astronomical observations, we gauged site-dependent observing conditions such as night-sky brightness, photometric precision, and seeing properties. Public meteorological data were also used in order to help in the determination of the actual number of useful observing nights per year. The measured zenithal -band night-sky brightness is typical of that of very good, very dark observing sites. The extinction registered at the -band is not dissimilar from that of other sites. The median seeing over the period of in situ observations is found to be approx1.7 . Given the limited duration of the observations, we did not probe any possible seeing seasonal patterns or the details of its possible dependence on other meteorological parameters, such as wind speed and direction. Moreover, our data show that the seeing at the observatory was reasonably stable during most of the nights. The fraction of fully clear nights per year amounts to 39%, while the total of useful nights increases to 57%, assuming a (conservative) cloud cover of not more than 50% of the night. Based on the analysis of photometric data collected over the period of 2009 May-August for three stellar fields centered on the transiting planet hosts WASP-3, HAT-P-7, and Gliese 436, we achieve seeing-independent best-case photometric precision IeA apptA2 3 mmag (rms) in several nights for bright stars (apptA2 11 mag). A median performance IeA approx 6 mmag during the observing period is obtained for stars with apptA2 13 mag . A by-product of the significant amount of photometric data collected in the stellar fields of WASP-3 and HAT-P-7 was the identification of a handful of new variable stars, four of which are presented and discussed here. Our results demonstrate that the OAVdA site is well poised to conduct an upcoming long-term photometric survey for transiting low-mass, small-size planets around a well-defined sample of M dwarfs in the solar neighborhood.
Type 2 familial partial lipodystrophy (FPLD2) is characterised by loss of fat in the limbs and buttocks and results from mutations in the LMNA gene.
To evaluate the role of several genes involved in ...adipogenesis in order to better understand the underlying mechanisms of regional loss of subcutaneous adipose tissue (scAT) in patients with FPLD2.
In total, 7 patients with FPLD2 and 10 healthy control participants were studied. A minimal model was used to calculate the insulin sensitivity (IS). scAT was obtained from abdomen and thigh by biopsy. Relative gene expression was quantified by real-time reverse transcription PCR in a thermal cycler. Prelamin A western blot analysis was carried out on scAT and prelamin A nuclear localisation was determined using immunofluorescence. Adipocyte nuclei were examined by electron microscopy.
Patients with FPLD2 were found to have significantly lower IS. The expression of LMNA was similar in both groups. The expression of PPARG2, RB1, CCND3 and LPL in thigh but not in abdomen scAT was significantly reduced (67%, 25%, 38% and 66% respectively) in patients with FPLD2. Significantly higher levels of prelamin A were found in peripheral scAT of patients with FPLD2. Defects in the peripheral heterochromatin and a nuclear fibrous dense lamina were present in the adipocytes of patients with FPLD2.
In FPLD2 participants, prelamin A accumulation in peripheral scAT is associated with a reduced expression of several genes involved in adipogenesis, which could perturb the balance between proliferation and differentiation in adipocytes, leading to less efficient tissue regeneration.
Context. A key objective of the ESA Gaia satellite is the realization of a quasi-inertial reference frame at visual wavelengths by means of global astrometric techniques. This requires accurate ...mathematical and numerical modeling of relativistic light propagation, as well as double-blind-like procedures for the internal validation of the results, before they are released to the scientific community at large. Aims. We aim to specialize the time transfer functions (TTF) formalism to the case of the Gaia observer and prove its applicability to the task of global sphere reconstruction (GSR), in anticipation of its inclusion in the GSR system, already featuring the Relativistic Astrometric MODel (RAMOD) suite, as an additional semi-external validation of the forthcoming Gaia baseline astrometric solutions. Methods. We extended the current GSR framework and software infrastructure (GSR2) to include TTF relativistic observation equations compatible with Gaia’s operations. We used simulated data generated by the Gaia Data Processing and Analysis Consortium (DPAC) to obtain different least-squares estimations of the full (five-parameter) stellar spheres and gauge results. These were compared to analogous solutions obtained with the current RAMOD model in GSR2 (RAMOD@GSR2) and to the catalog generated with the Gaia RElativistic Model (GREM), the model baselined for Gaia and used to generate the DPAC synthetic data. Results. Linearized least-squares TTF solutions are based on spheres of about 132 000 primary stars uniformly distributed on the sky and simulated observations spanning the entire 5 yr range of Gaia’s nominal operational lifetime. The statistical properties of the results compare well with those of GREM. Finally, comparisons to RAMOD@GSR2 solutions confirmed the known lower accuracy of that model and allowed us to establish firm limits on the quality of the linearization point outside of which an iteration for non-linearity is required for its proper convergence. This has proved invaluable as RAMOD@GSR2 is prepared to go into operations on real satellite data.
The global sphere reconstruction (GSR) Vecchiato, A.; Bucciarelli, B.; Lattanzi, M. G. ...
Astronomy and astrophysics (Berlin),
12/2018, Letnik:
620
Journal Article
Recenzirano
Odprti dostop
Context. The Gaia ESA mission will estimate the astrometric and physical data of more than one billion objects, providing the largest and most precise catalog of absolute astrometry in the history of ...astronomy. The core of this process, the so-called global sphere reconstruction, is represented by the reduction of a subset of these objects which will be used to define the celestial reference frame. As the HIPPARCOS mission showed, and as is inherent to all kinds of absolute measurements, possible errors in the data reduction can hardly be identified from the catalog, thus potentially introducing systematic errors in all derived work. Aims. Following up on the lessons learned from HIPPARCOS, our aim is thus to develop an independent sphere reconstruction method that contributes to guarantee the quality of the astrometric results without fully reproducing the main processing chain. Methods. Indeed, given the unfeasibility of a complete replica of the data reduction pipeline, an astrometric verification unit (AVU) was instituted by the Gaia Data Processing and Analysis Consortium (DPAC). One of its jobs is to implement and operate an independent global sphere reconstruction (GSR), parallel to the baseline one (AGIS, namely Astrometric Global Iterative Solution) but limited to the primary stars and for validation purposes, to compare the two results, and to report on any significant differences. Results. Tests performed on simulated data show that GSR is able to reproduce at the sub-μas level the results of the AGIS demonstration run. Conclusions. Further development is ongoing to improve on the treatment of real data and on the software modules that compare the AGIS and GSR solutions to identify possible discrepancies above the tolerance level set by the accuracy of the Gaia catalog.
Aims.Chromatic effects are usually associated with refractive optics, so reflective telescopes are assumed to be free from them. We show that all-reflective optics still bears significant levels of ...such perturbations, which are especially critical to modern micro-arcsecond astrometric experiments.Methods.We analyze the image formation and measurement process to derive a precise definition of the chromatic variation of the image position, and we evaluate the key aspects of optical design with respect to chromaticity.Results. The fundamental requirement related to chromaticity is the symmetry of the optical design and of the wavefront errors. Finally, we address some optical engineering issues, such as manufacturing and alignment, providing recommendations to minimize the degradation that chromaticity introduces into astrometry.
Context. The mechanism responsible for the warp of our Galaxy, as well as its dynamical nature, continues to remain unknown. With the advent of high precision astrometry, new horizons have been ...opened for detecting the kinematics associated with the warp and for constraining possible warp formation scenarios for the Milky Way. Aims. The aim of this contribution is to establish whether the first Gaia data release (DR1) shows significant evidence of the kinematic signature expected from a long-lived Galactic warp in the kinematics of distant OB stars. As the first paper in a series, we present our approach for analyzing the proper motions and apply it to the subsample of Hipparcos stars. Methods. We select a sample of 989 distant spectroscopically-identified OB stars from the new reduction of Hipparcos, of which 758 are also in the first Gaia data release (DR1), covering distances from 0.5 to 3 kpc from the Sun. We develop a model of the spatial distribution and kinematics of the OB stars from which we produce the probability distribution functions of the proper motions, with and without the systematic motions expected from a long-lived warp. A likelihood analysis is used to compare the expectations of the models with the observed proper motions from both Hipparcos and Gaia DR1. Results. We find that the proper motions of the nearby OB stars are consistent with the signature of a kinematic warp, while those of the more distant stars (parallax <1 mas) are not. Conclusions. The kinematics of our sample of young OB stars suggests that systematic vertical motions in the disk cannot be explained by a simple model of a stable long-lived warp. The warp of the Milky Way may either be a transient feature, or additional phenomena are acting on the gaseous component of the Milky Way, causing systematic vertical motions that are masking the expected warp signal. A larger and deeper sample of stars with Gaia astrometry will be needed to constrain the dynamical nature of the Galactic warp.
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