The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through disruption of daily living. Long-term ...adverse outcomes have been reported with similar diseases from other coronaviruses, namely Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). Emerging evidence suggests that COVID-19 adversely affects different systems in the human body. This review summarizes the current evidence on the short-term adverse health outcomes and assesses the risk of potential long-term adverse outcomes of COVID-19. Major adverse outcomes were found to affect different body systems: immune system (including but not limited to Guillain-Barré syndrome and paediatric inflammatory multisystem syndrome), respiratory system (lung fibrosis and pulmonary thromboembolism), cardiovascular system (cardiomyopathy and coagulopathy), neurological system (sensory dysfunction and stroke), as well as cutaneous and gastrointestinal manifestations, impaired hepatic and renal function. Mental health in patients with COVID-19 was also found to be adversely affected. The burden of caring for COVID-19 survivors is likely to be huge. Therefore, it is important for policy makers to develop comprehensive strategies in providing resources and capacity in the healthcare system. Future epidemiological studies are needed to further investigate the long-term impact on COVID-19 survivors.
Preliminary observational evidences are presented showing that the Indian subcontinent and surrounding regions are subject to heavy loading of absorbing aerosols, i.e., dust and black carbon, which ...possess spatial and temporal variability that are closely linked to those of the Asian monsoon water cycle. Consistent with the Elevated Heat Pump hypothesis, we find that increased loading of absorbing aerosols over the Indo‐Gangetic Plain in the pre‐monsoon season is associated with a) increased heating of the upper troposphere, with the formation of a warm‐core upper level anticyclone over the Tibetan Plateau in April–May, b) an advance of the monsoon rainy season in northern India in May, and c) subsequent increased rainfall over the Indian subcontinent, and decreased rainfall over East Asia in June–July.
Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of the machinery. There are ...approximately seven scanners per million inhabitants and over 90% are concentrated in high-income countries. We describe an ultra-low-field brain MRI scanner that operates using a standard AC power outlet and is low cost to build. Using a permanent 0.055 Tesla Samarium-cobalt magnet and deep learning for cancellation of electromagnetic interference, it requires neither magnetic nor radiofrequency shielding cages. The scanner is compact, mobile, and acoustically quiet during scanning. We implement four standard clinical neuroimaging protocols (T1- and T2-weighted, fluid-attenuated inversion recovery like, and diffusion-weighted imaging) on this system, and demonstrate preliminary feasibility in diagnosing brain tumor and stroke. Such technology has the potential to meet clinical needs at point of care or in low and middle income countries.
Microwave power transfer (MPT) delivers energy wirelessly from stations called power beacons (PBs) to mobile devices by microwave radiation. This provides mobiles practically infinite battery lives ...and eliminates the need of power cords and chargers. To enable MPT for mobile recharging, this paper proposes a new network architecture that overlays an uplink cellular network with randomly deployed PBs for powering mobiles, called a hybrid network. The deployment of the hybrid network under an outage constraint on data links is investigated based on a stochastic-geometry model where single-antenna base stations (BSs) and PBs form independent homogeneous Poisson point processes (PPPs) with densities λ b and λ p , respectively, and single-antenna mobiles are uniformly distributed in Voronoi cells generated by BSs. In this model, mobiles and PBs fix their transmission power at p and q, respectively; a PB either radiates isotropically, called isotropic MPT, or directs energy towards target mobiles by beamforming, called directed MPT. The model is used to derive the tradeoffs between the network parameters (p, λ b , q, λ p ) under the outage constraint. First, consider the deployment of the cellular network. It is proved that the outage constraint is satisfied so long as the product pλ b α/2 is above a given threshold where α is the path-loss exponent. Next, consider the deployment of the hybrid network assuming infinite energy storage at mobiles. It is shown that for isotropic MPT, the product qλ p λ b α/2 has to be above a given threshold so that PBs are sufficiently dense; for directed MPT, z m qλ p λ b α/2 with z m denoting the array gain should exceed a different threshold to ensure short distances between PBs and their target mobiles. Furthermore, similar results are derived for the case of mobiles having small energy storage.
The increasing severity of droughts/floods and worsening air quality from increasing aerosols in Asia monsoon regions are the two gravest threats facing over 60% of the world population living in ...Asian monsoon regions. These dual threats have fueled a large body of research in the last decade on the roles of aerosols in impacting Asian monsoon weather and climate. This paper provides a comprehensive review of studies on Asian aerosols, monsoons, and their interactions. The Asian monsoon region is a primary source of emissions of diverse species of aerosols from both anthropogenic and natural origins. The distributions of aerosol loading are strongly influenced by distinct weather and climatic regimes, which are, in turn, modulated by aerosol effects. On a continental scale, aerosols reduce surface insolation and weaken the land‐ocean thermal contrast, thus inhibiting the development of monsoons. Locally, aerosol radiative effects alter the thermodynamic stability and convective potential of the lower atmosphere leading to reduced temperatures, increased atmospheric stability, and weakened wind and atmospheric circulations. The atmospheric thermodynamic state, which determines the formation of clouds, convection, and precipitation, may also be altered by aerosols serving as cloud condensation nuclei or ice nuclei. Absorbing aerosols such as black carbon and desert dust in Asian monsoon regions may also induce dynamical feedback processes, leading to a strengthening of the early monsoon and affecting the subsequent evolution of the monsoon. Many mechanisms have been put forth regarding how aerosols modulate the amplitude, frequency, intensity, and phase of different monsoon climate variables. A wide range of theoretical, observational, and modeling findings on the Asian monsoon, aerosols, and their interactions are synthesized. A new paradigm is proposed on investigating aerosol‐monsoon interactions, in which natural aerosols such as desert dust, black carbon from biomass burning, and biogenic aerosols from vegetation are considered integral components of an intrinsic aerosol‐monsoon climate system, subject to external forcing of global warming, anthropogenic aerosols, and land use and change. Future research on aerosol‐monsoon interactions calls for an integrated approach and international collaborations based on long‐term sustained observations, process measurements, and improved models, as well as using observations to constrain model simulations and projections.
Key Points
The fast‐developing Asia has suffered severe air pollution problem
Aerosol affects the Asian monsoon
Aerosol‐monsoon interactions dictate the climate change in the region
The South Asian haze builds up from December to May, is mostly of anthropogenic origin, and absorbs part of the solar radiation. The influence of interannual variations of absorbing aerosols over the ...Indo- Gangetic Plain in May on the Indian summer monsoon is characterized by means of an observational analysis. Insight into how the aerosol impact is generated is also provided.
It is shown that anomalous aerosol loading in late spring leads to remarkable and large-scale variations in the monsoon evolution. Excessive aerosols in May lead to reduced cloud amount and precipitation, increased surface shortwave radiation, and land surface warming. The June (and July) monsoon anomaly associated with excessive May aerosols is of opposite sign over much of the subcontinent (although with a different pattern) with respect to May. The monsoon strengthens in June (and July).
The analysis suggests that the significant large-scale aerosol influence on monsoon circulation and hydroclimate is mediated by the heating of the land surface, pursuant to reduced cloudiness and precipitation in May. The finding of the significant role of the land surface in the realization of the aerosol impact is somewhat novel.
Fundamental to the onset of the Indian Summer Monsoon is the land‐sea thermal gradient from the Indian Ocean to the Himalayas‐Tibetan Plateau (HTP). The timing of the onset is strongly controlled by ...the meridional tropospheric temperature gradient due to the rapid pre‐monsoon heating of the HTP compared to the relatively cooler Indian Ocean. Analysis of tropospheric temperatures from the longest available record of microwave satellite measurements reveals widespread warming over the Himalayan‐Gangetic region and consequent strengthening of the land‐sea thermal gradient. This trend is most pronounced in the pre‐monsoon season, resulting in a warming of 2.7°C in the 29‐year record (1979–2007), when this region is strongly influenced by dust aerosols at elevated altitudes. The enhanced tropospheric warming is accompanied by increased atmospheric loading of absorbing aerosols, particularly vertically extended dust aerosols, raising the possibility that aerosol solar heating has amplified the seasonal warming and in turn strengthened the land‐sea gradient.
The Himalayas have a profound effect on the South Asian climate and the regional hydrological cycle, as it forms a barrier for the strong monsoon winds and serves as an elevated heat source, thus ...controlling the onset and distribution of precipitation during the Indian summer monsoon. Recent studies have suggested that radiative heating by absorbing aerosols, such as dust and black carbon over the Indo‐Gangetic Plains (IGP) and slopes of the Himalayas, may significantly accelerate the seasonal warming of the Hindu Kush–Himalayas–Tibetan Plateau (HKHT) and influence the subsequent evolution of the summer monsoon. This paper presents a detailed characterization of aerosols over the IGP and their radiative effects during the premonsoon season (April‐May‐June) when dust transport constitutes the bulk of the regional aerosol loading, using ground radiometric and spaceborne observations. During the dust‐laden period, there is a strong response of surface shortwave flux to aerosol absorption indicated by the diurnally averaged forcing efficiency of −70 Wm−2 per unit optical depth. The simulated aerosol single‐scattering albedo, constrained by surface flux and aerosol measurements, is estimated to be 0.89 ± 0.01 (at ∼550 nm) with diurnal mean surface and top‐of‐atmosphere forcing values ranging from −11 to −79.8 Wm−2 and +1.4 to +12 Wm−2, respectively, for the premonsoon period. The model‐simulated solar heating rate profile peaks in the lower troposphere with enhanced heating penetrating into the middle troposphere (5–6 km), caused by vertically extended aerosols over the IGP with peak altitude of ∼5 km as indicated by spaceborne Cloud‐Aerosol Lidar with Orthogonal Polarization observations. On a long‐term climate scale, our analysis, on the basis of microwave satellite measurements of tropospheric temperatures from 1979 to 2007, indicates accelerated annual mean warming rates found over the Himalayan–Hindu Kush region (0.21°C/decade ± 0.08°C/decade) and underscores the potential role of enhanced aerosol solar absorption in the maximum warming localized over the western Himalayas (0.26°C/decade ± 0.09°C/decade) that significantly exceed the entire HKHT and global warming rates. We believe the accelerated warming rates reported here are critical to both the South Asian summer monsoon and hydro‐glaciological resource variability in the Himalayan–Hindu Kush snowpack and therefore to the densely populated downstream regions.
The gold standard for clinical assessment of Autism Spectrum Disorders (ASD) relies on assessing behavior via semi-structured play-based interviews and parent interviews. Although these methods show ...good sensitivity and specificity in diagnosing ASD cases, behavioral assessments alone may hinder the identification of asymptomatic at-risk group. Resting-state functional magnetic resonance imaging (rs-fMRI) could be an appropriate approach to produce objective neural markers to supplement behavioral assessments due to its non-invasive and task-free nature. Previous neuroimaging studies reported inconsistent resting-state abnormalities in ASD, which may be explained by small sample sizes and phenotypic heterogeneity in ASD subjects, and/or the use of different analytical methods across studies. The current study aims to investigate the local resting-state abnormalities of ASD regardless of subject age, IQ, gender, disease severity and methodological differences, using activation likelihood estimation (ALE). MEDLINE/PubMed databases were searched for whole-brain rs-fMRI studies on ASD published until Feb 2018. Eight experiments involving 424 subjects were included in the ALE meta-analysis. We demonstrate two ASD-related resting-state findings: local underconnectivity in the dorsal posterior cingulate cortex (PCC) and in the right medial paracentral lobule. This study contributes to uncovering a consistent pattern of resting-state local abnormalities that may serve as potential neurobiological markers for ASD.
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