We present the AGILE gamma-ray observations in the energy range 50 MeV-10 GeV of the supernova remnant (SNR) W44, one of the most interesting systems for studying cosmic-ray production. W44 is an ...intermediate-age SNR (~2,000 years) and its ejecta expand in a dense medium as shown by a prominent radio shell, nearby molecular clouds, and bright S II emitting regions. We extend our gamma-ray analysis to energies substantially lower than previous measurements which could not conclusively establish the nature of the radiation. We find that gamma-ray emission matches remarkably well both the position and shape of the inner SNR shocked plasma. Furthermore, the gamma-ray spectrum shows a prominent peak near 1 GeV with a clear decrement at energies below a few hundreds of MeV as expected from neutral pion decay. Here we demonstrate that (1) hadron-dominated models are consistent with all W44 multiwavelength constraints derived from radio, optical, X-ray, and gamma-ray observations; (2) ad hoc lepton-dominated models fail to explain simultaneously the well-constrained gamma-ray and radio spectra, and require a circumstellar density much larger than the value derived from observations; and (3) the hadron energy spectrum is well described by a power law (with index s = 3.0 ? 0.1) and a low-energy cut-off at Ec = 6 ? 1 GeV. Direct evidence for pion emission is then established in an SNR for the first time.
The well-known Crab Nebula is at the center of the SN1054 supernova remnant. It consists of a rotationally powered pulsar interacting with a surrounding nebula through a relativistic particle wind. ...The emissions originating from the pulsar and nebula have been considered to be essentially stable. Here, we report the detection of strong gamma-ray (100 mega-electron volts to 10 giga-electron volts) flares observed by the AGILE satellite in September 2010 and October 2007. In both cases, the total gamma-ray flux increased by a factor of three compared with the non-flaring flux. The flare luminosity and short time scale favor an origin near the pulsar, and we discuss Chandra Observatory x-ray and Hubble Space Telescope optical follow-up observations of the nebula. Our observations challenge standard models of nebular emission and require power-law acceleration by shock-driven plasma wave turbulence within an approximately 1-day time scale.
FRB 180916 is a most intriguing source capable of producing repeating fast radio bursts with a periodic 16.3 day temporal pattern. The source is well positioned in a star-forming region in the ...outskirts of a nearby galaxy at 150 Mpc distance. In this Letter we report on the X-ray and γ-ray observations of FRB 180916 obtained by AGILE and Swift. We focused especially on the recurrent 5 day time intervals of enhanced radio bursting. In particular, we report on the results obtained in the time intervals 2020 February 3-8, 2020 February 25, 2020 March 5-10, and 2020 March 22-28 during a multiwavelength campaign involving high-energy and radio observations of FRB 180916. We also searched for temporal coincidences at millisecond timescales between the 32 known radio bursts of FRB 180916 and X-ray and MeV events detectable by AGILE. We do not detect any simultaneous event or any extended X-ray and γ-ray emission on timescales of hours/days/weeks. Our cumulative X-ray (0.3-10 keV) flux upper limit of 5 × 10−14 erg cm−2 s−1 (obtained during 5 day active intervals from several 1-2 ks integrations) translates into an isotropic luminosity upper limit of LX,UL ∼ 1.5 × 1041 erg s−1. Deep γ-ray observations above 100 MeV over a many-year timescale provide an average luminosity upper limit one order of magnitude larger. These results provide the so-far most stringent upper limits on high-energy emission from the FRB 180916 source. Our results constrain the dissipation of magnetic energy from a magnetar-like source of radius Rm, internal magnetic field Bm, and dissipation timescale τd to satisfy the relation , where Rm,6 is Rm in units of 106 cm, Bm,16 is Bm in units of 1016 G, and τd,8 in units of 108 s.
Background
Inappropriate dietary eliminations may impair quality of life, affect children's growth and unnecessarily impact on healthcare costs. Previous retrospective studies reported that around ...25% of children continue a food‐avoidance diet despite a negative oral food challenge (OFC). A definite pattern has not been found yet for patients not reintroducing the food. This study aimed to examine the role of child's nutritional attitudes and maternal anxiety in reintroducing food after a negative OFC.
Methods
A prospective study was conducted involving 81 mothers of children with IgE‐mediated food allergy. They completed a survey on nutritional behaviour and attitudes and the State‐Trait Anxiety Inventory on the day of OFC and 6 months later.
Results
In total, 11.1% of children never or rarely ate the food after a negative OFC. Consumption of the reintroduced food is positively correlated to child's interest in tasting new foods before and after OFC and to changes in child's nutritional habits after OFC. It is negatively correlated to monotony of the diet after OFC. No correlations were found with other participants’ characteristics or maternal anxiety. State anxiety significantly decreased after the OFC. A correlation was found between trait and state anxiety and the degree of change in nutritional habits after OFC.
Conclusions
Evaluating child's approach towards food before the OFC is a promising approach to identify patients at risk of food reintroduction failure. Furthermore, it underlined the importance of reassessing food consumption in all patients after a negative OFC and supporting patients in the reintroduction of food.
Background
Food allergy is major public health concern affecting nearly 15 million Americans and 80 million Europeans. Risk of anaphylaxis and implications for social activities affect patients' ...quality of life and psychological well‐being. We previously found that young patients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compared with healthy peers and may influence affect, management style and clinical outcomes. This study aimed to explore links between coping strategies, alexithymia and anxiety among food‐allergic adolescents and young adults.
Methods
Ninety‐two patients with IgE‐mediated food allergy (mean age 18.6 years) completed Coping Orientation to Problems Experienced Inventory, Toronto Alexithymia Scale and Trait Anxiety subscale of State‐Trait Anxiety Inventory. Multivariate analyses of variance assessed differences and associations between subgroups on the scales.
Results
Significant differences found between alexithymia levels in coping style were explained by Avoidance strategies. ‘Avoidance’ had the highest contribution in explaining alexithymia, followed by trait anxiety, age, anaphylaxis and social support. Respondents with higher alexithymia use avoidance as coping strategy over and above other coping strategies such as problem‐solving and positive thinking, are younger, will have experienced anaphylaxis and will have lower social support.
Conclusions
Recognizing the specific role of affect regulation in health behaviours may constitute an important step in supporting patients to explore more adaptive strategies.
Background
A major drawback of oral immunotherapy for food allergy is the possibility of severe side‐effects. We assessed both safety and efficacy of a low allergenic hydrolysed egg (HydE) ...preparation used in a double‐blind placebo‐controlled randomized study in egg allergic children.
Methods
In a pilot multicentre study, 29 egg allergic patients (aged 1–5.5 years) were administered daily for 6 months 9 g HydE or placebo in a blinded, randomized manner. Safety was verified by oral food challenge to assess tolerance towards HydE at the start and efficacy by an open oral food challenge (OFC, primary outcome) at the end. Additionally, changes in basophil activation and specific IgE and IgG4 were assessed.
Results
All egg allergic patients randomized to HydE (n = 15) tolerated the full dose at day 1 and received the maintenance dose from the start at home. No statistically significant difference was observed on the final OFC (36% and 21% had a negative OFC in the treatment and placebo groups, respectively). Specific IgG4 levels increased, while both CD203c+ and CD63+ basophils decreased significantly more over time in the treatment than in the placebo group.
Conclusions
HydE can be regarded as a safe, low allergenic product to use in children allergic to egg. Although not significant, HydE given for 6 months increased numerically the proportion of patients becoming tolerant to egg. HydE induced a modulation of the immune response towards better tolerance. A longer treatment period and/or a higher dose may improve the clinical outcome and should be evaluated.
GRB 190114C represents a breakthrough for the physics of gamma-ray bursts (GRBs), being the first GRB with delayed emission above 300 GeV, as reported by MAGIC. We present in this paper the ...sub-MeV/MeV data of the prompt and early afterglow emissions of GRB 190114C, as detected by AGILE and Konus-Wind, in the 20 keV-100 MeV energy range. The first stages of the burst exhibit multiple emission components, associated with an interesting spectral evolution. The first 2 s of the prompt emission can be described by a single "Band-like" spectral component. The successive 4 s show the presence of an additional high-energy spectral component, which quickly evolves into a "hard-flat" component of the F spectrum, extending up to 10-100 MeV and likely produced by inverse Compton radiation, whose onset and evolution are clearly shown in our data. After this phase, the F spectrum evolves into a "V shape," showing the persistence and spectral hardening of the additional high-energy component in substantial agreement with Fermi and Swift results. We also analyze the first ∼200 s of the early afterglow that show a reflaring episode near T0 + 15 s. We identify a new, so-far-unnoticed flux temporal break near T0 + 100 s, which is detected in hard X-rays by both Konus-Wind and INTEGRAL/SPI-ACS. We find this break incompatible with the commonly assumed adiabatic evolution of a fireball in a constant-density medium. We interpret this break as a consequence of radiative evolution of the early afterglow from a fireball expanding in a wind-like circumburst medium.
We report the detection by the Astrorivelatore Gamma a Immagini Leggero (AGILE) satellite of terrestrial gamma ray flashes (TGFs) obtained with the minicalorimeter (MCAL) detector operating in the ...energy range 0.3–100 MeV. We select events typically lasting a few milliseconds with spectral and directional selections consistent with the TGF characteristics previously reported by other space missions. During the period 1 June 2008 to 31 March 2009 we detect 34 high‐confidence events showing millisecond durations and a geographical distribution peaked over continental Africa and Southeast Asia. For the first time, AGILE‐MCAL detects photons associated with TGF events up to 40 MeV. We determine the cumulative spectral properties of the spectrum in the range 0.5–40 MeV, which can be effectively described by a Bremsstrahlung spectrum. We find that both the TGF cumulative spectral properties and their geographical distribution are in good agreement with the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) results.
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