The origin of cometary matter and the potential contribution of comets to inner-planet atmospheres are long-standing problems. During a series of dedicated low-altitude orbits, the Rosetta Orbiter ...Spectrometer for Ion and Neutral Analysis (ROSINA) on the Rosetta spacecraft analyzed the isotopes of xenon in the coma of comet 67P/Churyumov-Gerasimenko. The xenon isotopic composition shows deficits in heavy xenon isotopes and matches that of a primordial atmospheric component. The present-day Earth atmosphere contains 22 ± 5% cometary xenon, in addition to chondritic (or solar) xenon.
Abstract
The ESA Rosetta spacecraft followed comet 67P at a close distance for more than 2 yr. In addition, it deployed the lander Philae on to the surface of the comet. The (surface) composition of ...the comet is of great interest to understand the origin and evolution of comets. By combining measurements made on the comet itself and in the coma, we probe the nature of this surface material and compare it to remote sensing observations. We compare data from the double focusing mass spectrometer (DFMS) of the ROSINA experiment on ESA's Rosetta mission and previously published data from the two mass spectrometers COSAC (COmetary Sampling And Composition) and Ptolemy on the lander. The mass spectra of all three instruments show very similar patterns of mainly CHO-bearing molecules that sublimate at temperatures of 275 K. The DFMS data also show a great variety of CH-, CHN-, CHS-, CHO2- and CHNO-bearing saturated and unsaturated species. Methyl isocyanate, propanal and glycol aldehyde suggested by the earlier analysis of the measured COSAC spectrum could not be confirmed. The presence of polyoxymethylene in the Ptolemy spectrum was found to be unlikely. However, the signature of the aromatic compound toluene was identified in DFMS and Ptolemy data. Comparison with remote sensing instruments confirms the complex nature of the organics on the surface of 67P, which is much more diverse than anticipated.
D₂O and HDS in the coma of 67P/Churyumov—Gerasimenko Altwegg, K.; Balsiger, H.; Berthelier, J. J. ...
Philosophical transactions - Royal Society. Mathematical, Physical and engineering sciences/Philosophical transactions - Royal Society. Mathematical, physical and engineering sciences,
07/2017, Letnik:
375, Številka:
2097
Journal Article
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The European Rosetta mission has been following comet 67P/Churyumov-Gerasimenko for 2 years, studying the nucleus and coma in great detail. For most of these 2 years the Rosetta Orbiter Sensor for ...Ion and Neutral Analysis (ROSINA) has analysed the volatile part of the coma. With its high mass resolution and sensitivity it was able to not only detect deuterated water HDO, but also doubly deuterated water, D₂O and deuterated hydrogen sulfide HDS. The ratios for HDO/H₂O, D₂O/HDO and HDS/H₂S derived from our measurements are (1.05 ± 0.14) × 10⁻³, (1.80 ± 0.9) × 10⁻² and (1.2 ± 0.3) × 10⁻³, respectively. These results yield a very high ratio of 17 for D₂O/HDO relative to HDO/H₂O. Statistically one would expect just 1/4. Such a high value can be explained by cometary water coming unprocessed from the presolar cloud, where water is formed on grains, leading to high deuterium fractionation. The high HDS/H₂S ratio is compatible with upper limits determined in low-mass star-forming regions and also points to a direct correlation of cometary H₂S with presolar grain surface chemistry. This article is part of the themed issue 'Cometary science after Rosetta'.
We examine the evolution of the water production of comet 67P/Churyumov-Gerasimenko during the Rosetta mission (June 2014 to May 2016) based on in situ and remote sensing measurements made by Rosetta ...instruments, Earth-based telescopes and through the development of an empirical coma model. The derivation of the empirical model is described and the model is then applied to detrending spacecraft position effects from the ROSINA data. The inter-comparison of the instrument datasets shows a high level of consistency and provides insights into the water and dust production. We examine different phases of the orbit, including the early mission (beyond 3.5 AU) where the ROSINA water production does not show the expected increase with decreasing heliocentric distance. A second important phase is the period around the inbound equinox, where the peak water production makes a dramatic transition from northern to southern latitudes. During this transition, the water distribution is complex, but is driven by rotation and active areas in the north and south. Finally, we consider the perihelion period, where there may be evidence of time dependence in the water production rate. The peak water production, as measured by ROSINA, occurs 18-22 days after perihelion at 3.5 ± 0.5 × 1028 water molecules/s. We show that the water production is highly correlated with ground-based dust measurements, possibly indicating that several dust parameters are constant during the observed period. Using estimates of the dust/gas ratio we use our measured water production rate to calculate a uniform surface loss of 2-4 meters during the current perihelion passage.
The composition of the neutral gas comas of most comets is dominated by H2O, CO and CO2, typically comprising as much as 95 per cent of the total gas density. In addition, cometary comas have been ...found to contain a rich array of other molecules, including sulfuric compounds and complex hydrocarbons. Molecular oxygen (O2), however, despite its detection on other icy bodies such as the moons of Jupiter and Saturn, has remained undetected in cometary comas. Here we report in situ measurement of O2 in the coma of comet 67P/Churyumov-Gerasimenko, with local abundances ranging from one per cent to ten per cent relative to H2O and with a mean value of 3.80 ± 0.85 per cent. Our observations indicate that the O2/H2O ratio is isotropic in the coma and does not change systematically with heliocentric distance. This suggests that primordial O2 was incorporated into the nucleus during the comet's formation, which is unexpected given the low upper limits from remote sensing observations. Current Solar System formation models do not predict conditions that would allow this to occur.
Context. Early measurements of Rosetta's target comet, 67P/Churyumov-Gerasimenko (67P), showed a strongly heterogeneous coma in H sub(2)O, CO, and CO sub(2). Aims. The purpose of this work is to ...further investigate the coma heterogeneity of 67P, and to provide predictions for the near-perihelion outgassing profile based on the proposed explanations. Methods. Measurements of various minor volatile species by ROSINA/DFMS on board Rosetta are examined. The analysis focuses on the currently poorly illuminated winter (southern) hemisphere of 67P. Results. Coma heterogeneity is not limited to the major outgassing species. Minor species show better correlation with either H sub(2)O or CO sub(2). The molecule CH sub(4) shows a different diurnal pattern from all other analyzed species. Such features have implications for nucleus heterogeneity and thermal processing. Conclusions. Future analysis of additional volatiles and modeling the heterogeneity are required to better understand the observed coma profile.
Context. The Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) was designed to measure the composition of the gas in the coma of comet 67P/Churyumov-Gerasimenko, the target of the ...European Space Agency’s Rosetta mission. In addition to the volatiles, ROSINA measured refractories sputtered off the comet by the interaction of solar wind protons with the surface of the comet. Aims. The origin of different solar system materials is still heavily debated. Isotopic ratios can be used to distinguish between different reservoirs and investigate processes occurring during the formation of the solar system. Methods. ROSINA consisted of two mass spectrometers and a pressure sensor. In the ROSINA Double Focusing Mass Spectrometer (DFMS), the neutral gas of cometary origin was ionized and then deflected in an electric and a magnetic field that separated the ions based on their mass-to-charge ratio. The DFMS had a high mass resolution, dynamic range, and sensitivity that allowed detection of rare species and the known major volatiles. Results. We measured the relative abundance of all three stable silicon isotopes with the ROSINA instrument on board the Rosetta spacecraft. Furthermore, we measured 13C/12C in C2H4, C2H5, and CO. The DFMS in situ measurements indicate that the average silicon isotopic composition shows depletion in the heavy isotopes 29Si and 30Si with respect to 28Si and solar abundances, while 13C to 12C is analytically indistinguishable from bulk planetary and meteorite compositions. Although the origin of the deficiency of the heavy silicon isotopes cannot be explained unambiguously, we discuss mechanisms that could have contributed to the measured depletion of the isotopes 29Si and 30Si.
Gene fusion events resulting from chromosomal rearrangements play an important role in initiation of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and ...NTRK1, as lung tumor predictive biomarkers has increased the need for development of up-to-date technologies for detection of these biomarkers in limited amounts of material.
We describe here a multi-institutional study using the Ion AmpliSeq™ RNA Fusion Lung Cancer Research Panel to interrogate previously characterized lung tumor samples.
Reproducibility between laboratories using diluted fusion-positive cell lines was 100%. A cohort of lung clinical research samples from different origins (tissue biopsies, tissue resections, lymph nodes and pleural fluid samples) were used to evaluate the panel. We observed 97% concordance for ALK (28/30 positive; 71/70 negative samples), 95% for ROS1 (3/4 positive; 19/18 negative samples), and 93% for RET (2/1 positive; 13/14 negative samples) between the AmpliSeq assay and other methodologies.
This methodology enables simultaneous detection of multiple ALK, ROS1, RET, and NTRK1 gene fusion transcripts in a single panel, enhanced by an integrated analysis solution. The assay performs well on limited amounts of input RNA (10 ng) and offers an integrated single assay solution for detection of actionable fusions in lung adenocarcinoma, with potential savings in both cost and turn-around-time compared to the combination of all four assays by other methods.
The knowledge about sulphur isotopic fractionation in volatile cometary species is limited as only measurements in five comets have been done and only for 34S/32S. The lack of information about the ...fractionation of 33S/32S makes it impossible to compare them with what is known from refractories. We present results of 34S/32S and for the first time 33S/32S isotopic ratio in H2S, OCS, and CS2 in the coma of comet 67P/Churyumov-Gerasimenko. Observations used for this study were performed with Rosetta Orbiter Spectrometer for Ion and Neutral Analysis/Double Focusing Mass Spectrometer during October 2014 and May 2016. Bulk isotopic 33S/32S and 34S/32S ratio derived from these three species yield δ33S = (-302 ± 29)‰ and δ34S = (-41 ± 17)‰ respectively. The observed isotopic fractionation is significantly different from the solar system standard (V-CDT) and all other reported values for solar system objects, except other comets. Furthermore we show that neither mass dependent nor mass-independent fractionation due to photo dissociation as it has been observed in recent laboratory studies can be the cause of the significant depletion compared to solar system standard. In addition, we conclude that there seems to be an intrinsic difference in sulphur isotopic fractionation in cometary volatiles and refractories while the difference between molecules is most likely due to different chemical pathways. The significant fractionation of sulphur isotopes together with a high D2O/HDO vs. HDO/H2O and non-solar isotopic ratio for xenon (Marty 2017) as well as for Si (Marty 2017) point towards a non-homogeneously mixed protosolar nebula.
The emergence of ABL point mutations is the most frequent cause for imatinib resistance in chronic myelogenous leukemia (CML) patients and can occur during any phase of the disease; however, their ...clinical impact remains controversial. In this study, we retrospectively analyzed the predictive impact of 94 BCR-ABL kinase domain mutations (18 T315I, 26 P-loop, 50 in other sites) found in 89 imatinib-resistant CML patients. At imatinib onset, 64% of patients (57/89) were in chronic phase (CP), 24% (21/89) in accelerated phase (AP) and 12% (11/89) in blastic phase (BP). T315I and P-loop mutations were preferentially discovered in accelerated phase of BP CML, and other types of mutations in CP (P=0.003). With a median follow-up of 39.2 months (6.3-67.2), since imatinib initiation, overall survival (OS) was significantly worse for P-loop (28.3 months) and for T315I (12.6 months), and not reached for other mutations (P=0.0004). For CP only, multivariate analysis demonstrated a worse OS for P-loop mutations (P=0.014), and a worse progression-free survival (PFS) for T315I mutations (P=0.014). Therefore, P-loop and T315I mutations selectively impair the outcome of imatinib-resistant CML patients, in contrast to other mutations, which may benefit from dose escalation of imatinib, able to improve or stabilize disease response.
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